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RISS 인기검색어
- 검색키워드
- 저자 : C.K.Madheswaran (검색결과 3 건)
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Effect of saturated fatty acids on tacrolimus-loaded liquid crystalline nanoparticles
( R K Thapa ),( R Baskaran ),( T Madheswaran ),( J Y Rhyu ),( J O Kim ),( C S Yong ),( B K Yoo ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
Liquid crystalline nanoparticles are unique structures that can be used in the delivery of a wide range of pharmaceutical actives. Herein, we studied the effect of saturated fatty acids on tacrolimus-loaded monoolein liquid crystalline nanoparticles stabilized with poloxamer 407, Char-acterization of nanoparticles included optical and transmission electron microscopy, particle size, and entrapment efficiency analysis. Microscope data suggested the formation of cubosomes for monoolein dispersions, and of hexosomes for monoolein-fatty caid systems. Entrapment efficiency of tacrolimus was as high as 99% or above. In vitro release study revealed that amount of monoolein and carbon chain lengths of the fatty acid were the factors that affected drug release from the liquid crystalline nanoparticles. Notably, monoolein-fatty acid systems prepared with short chain length, such as lauric and myristic acid, showed markedly sustained release profile of the drug. Hence, appropriate selection of fatty acid can be exploited to achieve desired release profile from monooloein liquid crystalline nanoparticles.
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( R K Thapa ),( R Baskaran ),( T Madheswaran ),( J O Kim ),( C S Yong ),( B K Yoo ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
The objective of the present study was to determine the effect of different ratios of monoolein and oleic aciad on in vitro release and ski permeation of tacrolimus from monoolein-based liquid crystalline nanoparticles. The nanoparticles were prepared by sonicating a mixture of melted monoolein, poloxamer 407, oleic acid and tacrolimus to which distilled water was added. Formation of cubosomes and hexosomes was confirmed by transmission electron microscopy and optical microscopy, and average particle size of the formulations was about 150-200 nm. The encapsulation effeciency for tacrolims in all the formulations was > 99%. In vitro retro release of the drug was proportionally reduced by the amount of monoolein used. Addition of oleic acid further reduced the tacrolimus release. The skin permeation was also in agreement with the vitro release. This study provides a strategy to control the release and skin permeation of tacrolimus from nanoparticles, thus expanding the area of tacrolimus usage.
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Amar Prakash,N.Anandavalli,C.K.Madheswaran,N.Lakshmanan 국제구조공학회 2012 Steel and Composite Structures, An International J Vol.13 No.3
In this paper, experimental investigations on high strength steel (HSS) stud connected steelconcrete composite (SCC) girders to understand the effect of shear connector density on their flexural behaviour is presented. SCC girder specimens were designed for three different shear capacities (100%, 85%,and 70%), by varying the number of stud connectors in the shear span. Three SCC girder specimens were tested under monotonic/quasi-static loading, while three similar girder specimens were subjected to nonreversal cyclic loading under simply supported end conditions. Details of casting the specimens, experimental set-up, and method of testing, instrumentation for the measurement of deflection, interface-slip and strain are discussed. It is found that SCC girder specimen designed for full shear capacity exhibits interface slip for loads beyond 25% of the ultimate load capacity. Specimens with lesser degree of shear connection show lower values of load at initiation of slip. Very good ductility is exhibited by all the HSS stud connected SCC girder specimens. It is observed that the ultimate moment of resistance as well as ductility gets reduced for HSS stud connected SCC girder with reduction in stud shear connector density. Efficiency factor indicating the effectiveness of high strength stud connectors in resisting interface forces is estimated to be 0.8 from the analysis. Failure mode is primarily flexure with fracturing of stud connectors and characterised by flexural cracking and crushing of concrete at top in the pure bending region. Local buckling in the top flange of steel beam was also observed at the loads near to failure, which is influenced by spacing of studs and top flange thickness of rolled steel section. One of the recommendations is that the ultimate load capacity can be limited to 1.5 times the plastic moment capacity of the section such that the post peak load reduction is kept within limits. Load-deflection behaviour for monotonic tests compared well with the envelope of load-deflection curves for cyclic tests. It is concluded from the experimental investigations that use of HSS studs will reduce their numbers for given loading, which is advantageous in case of long spans. Buckling of top flange of rolled section is observed at failure stage. Provision of lips in the top flange is suggested to avoid this buckling. This is possible in case of longer spans, where normally built-up sections are used.
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