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Min, ByungSun,Ahn, ByungZun,Bae, KiHwan 충남대학교 약학대학 의약품개발연구소 1996 藥學論文集 Vol.12 No.-
Analogues of 2(S)-5,2',5'-trihydroxy-7,7-dimethoxyflavanone, a naturally-occurring compound, which had been reported to have potent antitumor activity, were synthesized and examined for the cytotoxicity against three cancer cell lines. Among the intermediate chalcones and synthetic 5-hydroxy-7,8-dimethoxyflavanone analogues, (±)2',5'-dibenzyloxy-5,7,8-trimethoxyflavanone exhibited about 2-8 times stronger activity than 2(S)-5,2',5'-trihydroxy-7,8-dimethoxyflavanone against L1210, K562 and A549 cancer cell lines. In the structure-activity relationship, it is suggested that among analogues of 5-hydroxy-7,8-dimethoxyflavanone, the existence of two oxygenated groups of para-relation at C-2' and C-5' positions on flavanone B-ring, may be necessary to exhibit effective cytotoxic activity.
A Cytotoxin Component from Angelicae Koreanae Radix against L1210 and HL-60 Cells
Bae, KiHwan,Ji, JongMyung,Kang, JongSeong,Ahn, ByungZun 충남대학교 약학대학 의약품개발연구소 1994 藥學論文集 Vol.10 No.-
A cytotoxic sesquiterpene against L1210 and HL-60 cells was isolated from Angelicae Koreanae Radix (buk-kang-hwal). The component was identified as bisabolangelone by means of chemical and physical methods. The ED_50 values of it were 1.20 ㎍/㎖ against L1210 cells and 2.30 ㎍/㎖ against HL-60 cells. Bisabolangelone was found in buk-kang-hwal but not in kang-hwal.