출판산업에 대한 정부정책에 관한 연구

노병성 서강대학교 언론문화연구소 1991 언론문화연구 Vol.9 No.-

Rat의 복강에 삽입한 Fluorouracil-Polyglycolic acid 제형의 Fluorouracil 용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitoneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adcnocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

韓國産 집먼지진드기類(먼지진드기科)의 分類學的 硏究

盧鏞泰,孫秉玉,申炳湜 건국대학교 교육대학원 1988 敎育論叢 Vol.10 No.-

The house dust mites were isolated from houses, dust of civil house, public facilities and lodging ahouses in Seoul, Chinan, Yungnam and several other areas during the period of June to October, 1985. The isolated house dust mites were identified into 3 species(Dermatophagoides pteronyssinus, D.farinae, Euroglyphus maynei) belonging to 2 genera, 2 subfamilies. Their larvae and nymphs were decribed. Variation of the epigynium of females and other characteristics were examined and redescibed. And the key to korean house dust mites was made.

대형 고무사출기의 구조해석 및 응력측정

노병욱,이태세,최병오,배성인 國立 昌原大學校 産業技術硏究所 1997 産技硏論文集 Vol.11 No.-

The most important structural components of the injection molding machines had been analyzed by using finite element analysis. And the results were compared with strain which were measured by using straingage and data-logger. The position and the value of stress concentration were known by this study. So the optimal design can be expected as possible.

Rat의 복강에 삽입한 Filorouracil-Polyglycolic acid제형의 Fluorouracil용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitioneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adenocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구

민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.

원형 탈모증 환자에서의 감정표현불능증

박두병,전창무,손인기,민경준,김영돈,노병인 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.5

연구목적 : 감정표현불능증이 정신신체질환의 특징적인 성격 경향 인지에 대해 논란이 많이 있어 왔다. 이에 정신신체질환이면서 피부과 외래 환자의 다수를 차지하는 원형탈모증 환자에 있어서의 감정표현불능증에 대해 알아보았다. 방 법 : 원형탈모증 환자군(31명)과 연령, 성별을 대비시킨 정상대조군(31명)에서 MMPI, SCL-90-R, TAS-20K를 시행하였다. 정신신체질환 이외의 질환에 의한 영향을 배제하기 위해 다른 정신과 질환이 있다고 판단되는 경우는 제외시켰다. 집단간의 비교를 위해 paired t-검증을 실시하였다. 결 과 : 원형탈모증 환자군에서 MMPI 결과는 F 척도, K 척도, Hs 척도, D 척도, Hy 척도, Pd 척도, Pa 척도, Pt 척도, Sc 척도의 점수가 정상대조군에 비해 의미있는 차이를 보였고(p<0.05), SCL-90-R 점수에서는 SOM 척도, O-C 척도, I-S 척도, DEP 척도, ANX 척도, HOS 척도, PHOB 척도, PAR 척도, PSY 척도, GSI, PSDI, PST 점수가 정상대조군보다 유의하게 높은 점수를 보였다(p<0.05). 또한 TAS-20K 점수에서는 환자군이 정상대조군에 비해 Factor 1과 총점에서 유의하게 높은 점수를 보였다(p<0.05). 결 론 : 결론적으로, 원형 탈모증 환자군에서 정상 대조군에 비해 감정표현불능증이 더 심하고 특히 자신의 느낌을 잘 알지 못하는 것으로 나타났다 이는 원형탈모증 환자의 심리적인 대처기전을 세워 나가는데 좀더 주의를 기울이고, 더 많은 관심을 가져야 한다는 것을 의미한다. Objectives : Alexithymia has been regarded as the general personality of psychosomatic disease, but it's controversial. The object of the study is to find out the relationship between alexithymia and alopecia areata. Methods : Thirty one alopecia areata patients were compared to 31 normal healthy persons in alexithymic tendency using TAS-20K Also MMPI and SCL-90-R were checked in both groups. Psychiatric diseases were ruled out. Results : The scores of F, K, Hs, D, Hy, Pd, Pa, Pt and Sc of MMPI in alopecia areata patients were different from those in normal healthy persons. The scores of SOM, O-C, I-S, DEP, ANX, HOT, PHOB, PAR, PSY,GSI, PSDI, and PST of SCL-90-R in alopecia areata patients were significantly higher than those in normal healthy persons. In TAS-20K, the scores of Factor I and Total in alopecia areata patients were higher than those in normal healthy persons. Conclusion : Our results suggest that alopecia areata patients are more alexithymic than normal healthy persons.

釜山地域의 交通振動에 관한 硏究

金在雄,盧泌成,林炳道 동아대학교 환경문제연구소 1990 硏究報告 Vol.13 No.2

The concern of traffic-induced vibrations(and noise) becomes more important because of environmental regulations and detrimental effects on structures, etc. However, studies about this subjects are not enough around us to protect people and facilities against it. Accordingly, field surveies over Pusan area are performed to investigate actual conditions of traffic-induced vibrations and noise level. Survey results are analysed to draw characteristics of them and to make a prediction method of vibrations. Conclusions obtained from the study are following : 1. Railroad-induced vibration and noise exceed the environmental criteria, the proper counter plan may be needed. 2. Vibrations induced by total cars traffic are below the criteria, but noise in well over and it may cause negative effects on people near roads. 3. The regression equations deriven in this sutdy may be used to predict vibrations caused by single car and railroad traffic, except by total cars traffic.

생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.