증식당뇨망막증에서 아르곤레이저 광응고술의 치료 효과

안병헌,민병무,최시환,서병로,박우찬 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

Vitreous hemorrhage, which is the major cause of blindness in proliferative diabetic retinopathy, has been prevented clinically with laser photocoagulation. We reviewed 57 cases(98 eyes) of proliferative diabetic retinopathy which were treated by argon laser and followed up for more than 6 months. Of these 98 eyes, 81 eyes(83%) showed a satisfactory response after standard panretinal photocoagulation. 14 eyes(14%) revealed the vitreous hemorrhage after panretinal photocoagulation and higher incidence of vitreous hemorrhage in the cases of new vessel on the optic disc. In the cases(26 eyes) of new vessel on the optic disc, 2000 laser burns revealed lower incidence of vitreous hemorrhage(1/5, 20%) in comparison with 1500 laser burns(8/21, 38%). These results indicate that initial augmented laser therapy prevented the vitreous hemorrhage effectively.

韓國의 舞踊藝術政策 變遷에 관한 硏究 : 解放以後를 中心으로

안병헌,고기채 경희대학교 체육대학 한국체육과학연구소 2002 體育學論文集 Vol.30 No.-

In the 21st century, in prospect that cultural creativity will be the core of the development of a country, cultural administration is getting more important. Following this tendency, a great deal of effort is being made for the public relation and strategies concerned with culture and art and also the concern and the rate of participation of people is increasing. Recently, though the social and cultural extents of dance, which is one of the genres of art and culture, have got bigger and more diverse, too, dance is not known well compared with the other kinds of art. It is because the qualitative growth did not go together with the expansion in quantity, and especially, it is due to not so much the creativeness of dance as the defect found in administration or execution that lays the decline of reality. Therefore, in this situation that a solution which prepares the future in which the importance of the cultural administration is embossed and innovation over the base of administration of dance are desperately needed, I attempted to investigate the changing process of the administration of dance-how dance has been reflected in policy as a field that had cultural value until now- and to analyze the present condition of the field of dance and finally tried to find the problems of it expecting that this paper could be used as a guide for the dance cultural policy.

산처리에 의한 정수슬러지 감량화

이병문,권재현,안규홍,이석헌,권대영 대한상하수도학회 2003 상하수도학회지 Vol.17 No.1

The acidic treatment of waterworks sludge released organic materials as well as inorganics such as Al, Fe and Mn. Through solubilization as mentioned above, the content of suspended solids reduced by 18% at final pH 3.5. It also increased thickening efficiency and dewaterability of sludge. However overdosing of H_2SO_4 made dewaterability deteriorated. It showed that the optimal condition of acidic treatment be as follows; 5.5㎖ dose of H_2SO_4(97%)/1 sludge, final pH 3.5 and 15minutes of reaction time. Under these conditions, reduction efficiencies of sludge through thickening and dewatering were 57% and 92.2% respectively and then 7.8% of raw sludge released as cake compared to 10.5% without acidic pre-treatment. Therefore, mass of dewatered cake decreased by 26% through acidic treatment. Water content of dewatered cake was reduced from 71% to 62% due to this treatment. The changes of sludge properties including particle size, zeta-potential and bound water by acidic treatment appear to be important keys in assesment of the improvement of sludge dewaterability.

국소마취하에 시행한 항문 양성 질환의 외래 수술에 관한 고찰

김병철,박상헌,김정용 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2

Purpose : Benign anal disease has been operated in the ambulatory surgical unit. This is the clinical analysis of benign anal disease in the outpatient clinic. Materials ðod : The clinical and statistical observation of 88 patients with anal disease were made, who had been operated at the outpatient clinic of the department of surgery, Chosun University Hospital from September 1998 to August 1999. Hemorrhoids(below third degree of internal hemorrhoid and external hemorrhoid), anal fistulas, anal fissures, and perianal abscess, anal polyps, skin tags were opreated. The operation methods were band ligation, semiclosed hemorrhoidectomy, lateral internal sphincterotomy, fistulotomy, incision and drainage, excision. Local anesthesia by 1% Lidocaine 20ml with 20ml 0.5% bupivacaine of pudendal nerve block were used at the time of opreation in all cases. No premedication and preanesthetic agents were used. Bowel prereration has not been done in all cases. Results : The most common disease was hemorrhoid. The peak incidence was the age group of 40-49years(23%) and the male to female ratio was 1.25:1. The most frequently used operative method was hemorrhoidectomy and band ligation(27%). The most common complication was post-operative pain (40%). The main benefit of out-patient surgery is the possibility of recovery at home, which is more compatible, and cost effective. Conclusion : The ambulatory anorectal surgery under local anesthesia is safe and effective method, with the additional advantage of the cost-saving and increase of available beds for the patients with more complex surgery.

가족력이 있는 만성정신분열증 환자의 인간조직적합성 항원(HLA)

강헌구,강병조 大韓神經精神醫學會 1988 신경정신의학 Vol.27 No.6

The authors studied the frequencies of HLA antigens (A,B,C and DR) in 20 chronic schizophrenic patients who had one or more schizophrenic patient(s) among their first degree relatives. The data of these study subjects were compared with those of patient controls and normal controls. The patient controls were composed of 20 chronic schizophrenic patients who had no family history of schizophrenia HLA-A, B, C antigens of normal controls came from 196 healthy Korean volunteers and HLA-DR antigens came from 205 healthy Korean volunteers. The diagnoses of schizophrenics were made according to RDC and Family History-RDC. The results were as follows: 1) The frequencies of B??,B??,DR₃and DR?? antigens were significantly higher in total schizophrnic patients than the control group. 2) The frequencies of A₃,A?? and B??, DR?? antigens were higher in schizophrenic patients with family history than the control group. Especially, the frequency of DR antigen was the highest. 3) The frequencies of B??,C??,DR₂,and DR?? antigens increased significantly in schizophrenic patients without family history. 4) DR?? is the only antigen that showed significantly higher frequency in patients with family history than those without one. 5) Consequently, these results suggest that DR?? locus is probably related to genetic or biological marker of Korean familial chronic schizophrenics

e-PTFE막과 실리콘 관을 이용한 녹내장 수술

안병현,서병로 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

A new glaucoma drainage implant, silicone tube attached to an expanded polytetrafluoroethylene (e-PTFE) membrane, was used in patients with recalcitrant glaucomas. Aqueous was shunted via the silicone tube to reservoir which was formed under the posterior Tenon's capsule by an oval piece of e-PTFE memberane, (Japan Gore-tex Inc., Tokyo) was 0.1mm thick, malleable and foldable. Therefore, the e-PTFE membrane of the implant could be introduced through a small incision of a quadrant conjunctiva in folded form and then spreaded over the sclera. The implant had been placed in 18 eyes of 17 patients with one or more unsuccessful glaucoma filtration surgeries including three neovascular glaucoma (NVG) patients. After follow-up of peroids ranging between seven and 18 months (mean: 10 months), 15 of the 18 eyes (83%) had controlled intraocular pressure (IOP) using 20 mmHg as normal. Three patients were not on any glaucoma medication. Seven patients required one β-blocker. Five patients were on one β-blocker and pilocarpine or a small dose of acetazolamide on their final visits. Three eyes with an unsuccessful surgery had an IOP over 25 mmHg in spite of maximum tolerated medical therapy. A postequatorial filtration bleb was found in each operated eye following removal of 5-0 cat-gut threaded through the silicone tube for the prevention of aqueous overdrainage. Postoperative complications included hyphema and fibrinous aqueous in the eyes with NVG(17%), prolonged shallow chamber(22%), obstruction of the silicone tube in the anterior chamber(6%), and choroidal datachment(6%) silicone tube in the anterior chamber (6%), and choroidal detachment(6%). The required conjuctival incision for the installation of the e-PTFE drainage implant was less than 90° and the overall surgical procedures seemed to be simple.

초자체절제술 후 전방깊이의 변화에 관한 실험적 연구

안병헌,민병무,박종문 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.2

The depth of the anterior chamber decreases with aging. Though the increase in the volume "of the lens with aging is a main influential factor to affect the anterior chamber depth, other unknown factors also work. In human the vitreous occupies about 2/3 of the intraocular volume and is confinded within the rigid scleral shell posteriorly. If there were some changes in the volume of the vitreous, these would result in the displacement of the lens and the iris to change the depth of the anterior chamber directly. We performed vitrectomy in 9 rabbits through the peripheral rerina and observed change in the anterior chamber depth. Slit lamp photography was used to measure the anterior chamber depth. To photograph the identical portion of the anterior chamber consecutively, argon laser photocoaglation was applied on the midperipheral iris at 12 and 6 o'clock positions as the Rlandmarks. We measured and compared the depth of anterior chamber image of the positive film with an aid of micrometer attached to light microscope. The measurement was not real depth of the anterior chamber but that of photographic image. Before vitrectomy the mean depth of the anterior chamber was 2.831±0.111mm. At the postvitrectomy 3rd day and the 1st week, the depth was 2.903±0.123 mm and 2.906±0.092 mm respectively. The depth of the anterior chamber became deeper significantly b t-test (5% significance level). But at the 2nd week, the 4th week and 8th week, the mean of the measurements was 2.885±0.083mm, 2.839±0.096mm, and 2.866±0.113mm respectively. These indicated deeper anterior chamber than those of previtrectomy rabbits, but the results were not significant by t-test. The mean number of scales of Goldmann applanation tonometry before the operation was II. The scale readings were 7 at the postoperative 3rd day, 8 at the 1st week and 9 at the 4th week all, 9 at the 8 th week.

신재효의 장르 인식과 서민 가사

정병헌 한국고시가문학회 2004 한국시가문화연구 Vol.0 No.13

Shin Jaehyo rewrote six Pansori works, so we call him as a Shakespeare of Korea. And he wrote many short songs too, but their genre characteristics are ambiguous. This thesis is view to clear the meaning of those songs. His songs are called as Tanga, Heoduga or Kasa, but I think they are his original works which are not limited a special genre. He picked many other's songs in his work. So his work is composed of various songs, many researcher regard it many works. But I think that approach ignored Shin Jae-hyo's intention. Because he ordered us to understand those works with unified viewpoint. Heoduga is composed of thirteen songs. Some songs are made by other people, but the majority are his own works. He expressed nation's blooming future by comparing to China. This vision is very freshness at that time. Oseomga is composed of things which express the emotion of love or sadness with separating. In this work, he showed common people's sight about love emotion directly, and omnibus style experimentally. Shin Jaehyo expressed his mind of love his student Chaisun to distraction. This presention is very curious, so his mind is attention to modern times.

반복적 부동화 스트레스가 신경활성 Steroid의 GABAА 수용체 조절작용에 미치는 영향

강헌구,강병조,하정희 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.2

신경활성 steroid들은 중추신경계의 말초성 benzodiazepine 수용체에서 합성되고, GABAA 수용체 복합체상의 독립적인 인지부위에 작용하여, GABAA 수용체에 대하여 효현활성을 나타내며, 스트레스에 대응하여 유리되는 내인성 조절자로 시사되고 있다. 그러나 신경활성 steroid의 신경전달조절 활성을 스트레스에 대한 반응도(reactivity)와 연관시켜 연구한 것은 아직 미흡한 실정이다. 이에 본 연구에서는 Sprague-Dawley rat에 2주간의 반복적인 부동화 스트레스를 부하한 후 반복적 스트레스에 의한 신경활성 steroid 활성의 변화를 검색하고자 하였다. 그리고 스트레스에 대하여 과도한 반응성을 보일 것으로 보고된 borderline-hypertensive rat을 대상으로 신경활성 steroid의 억제성 신경전달계인 GABA성 신경전달 조절활성을 비교 관찰함으로써, 반복적 부동화 스트레스에 대한 실험동물의 반응성에 대한 연구의 일환으로 신경활성 steroid의 신경조절작용을 검색하고자 하였다. 이를 위하여 Sprague- Dawley rat의 대뇌피질세포막에 있는 GABAA-benzodiazepine 수용체 복합체에서 대하여 신경활성 steroid인 pregnanolone의 [³H]flunitrazepam 결합반응을 항진효과를 비교, 검색하였다. 본 실험결과, Sprague-Dawley rat의 대뇌피질세포막에 있는 GABAA-benzodiazepine 수용체 복합체에서 신경활성 steroid인 pregnanolone은 [³H]flunitrazepam 결합반응을 항진시킴으로써 GABAA 수용체에 대하여 효현 활성을 나타내었으며, 2주간의 반복적인 부동화 스트레스에 의해 이러한 pregnanolone의 활성은 증강되었다. 한편, 스트레스에 대하여 과도한 반응성을 보인다고 알려진 borderline-hypertensive rat의 뇌조직에서도 Sprague-Dawley rat에 비하여 항진된 GABA성 신경조절활성이 관찰되었으며, 스트레스 부하에 대해서도 유사한 반응성을 나타내었다. 이상의 결과로부터 반복적인 부동화 스트레스는 스트레스에 대한 반응성의 일환으로 신경활성 steroid인 pregnanolone의 GABA성 신경전달 항진작용을 증강시킨다고 생각되었으며, 스트레스 유발 고혈압의 질환모델로 보고된 BHR에서는 동일한 스트레스에 대하여 과도한 반응성을 나타냄으로써 스트레스 관련 말초질환에서의 중추성 병인인자의 참여 가능성을 시사해주었다. Pregnanolone[5β-pregnan-3α-ol-one(pregnanolone)] is one of neuroactive steroids that are reduced metabolites of progesterone. Pregnanolone synthesis in the neuron or glia was regulated by peripheral benzodiazepine receptor agonist, which was consistently observed to be upregulated in the acutely stressed animals and humans. Pregnanolone is a potent positive modulator of the γ-aminobutyric acid(GABA) response that enhance the binding of [³H] flunitrazepam to the GABAA receptor. Recently, it was reported that chronic treatment with pregnanolone uncouples allosteric interactions between steroid and benzodiazepine recognition sites in cultured neurons. The present study was designed to assess the effect of repeated stress on the modulation of neuroactive steroid on the GABAA receptor. The effect of steroid on the ligands binding to GABAA receptor was investigated using cerebral cortices of unstressed and repeatedly immobilized Sprague-Dawley rats and borderline-hypertensive rats. Pregnanolone enhanced the binding of [³H]flunitrazepam to GABAA receptor in both of unstressed and repeatedly stressed Sprague-Dawley rats. However, repeatedly stressed rats showed significantly lower values in EC50 and higher values in Emax of enhancement binding of [³H] flunitrazepam than those of unstressed rats. Borderline-hypertensive rats, which are known to be overreactive to stress, showed higher basal binding of [³H]flunitrazepam to GABAA receptor, similar to those of stressed Sprague-Dawley rats. Borderline-hypertensive rats, in both control and stressed groups, showed similar pharmacological activity of pregnanolone with Sprague-Dawley rats. From these findings, it can be concluded that repeated immobilization stress enhanced the positive modulation of neuroactive steroid on the GABAA-receptor complex, and these pharmacological activity of neuroactive steroid might be a defensive reactivity to stress of individuals.

정신분열병의 생물학적 원인

강병조,원승희,김상헌 대한생물치료정신의학회 1998 생물치료정신의학 Vol.4 No.2

The authors reviewed the biological etiologies of schizophrenic disorder such as genetic, viral, neurodevelopmental, neural network, sunspots and cerebral diabetic hypothesis. The etiology of schizophrenic disorder remains to be confirmed. Although genetic possibilities were suggested by many investigators, the genetic genes and their transmission methods have not been clarified yet. The neurodevelopmental hypothesis was reviewed in detail. This hypothesis includes genetic hypothesis, viral hypothesis, obstetrical complication hypothesis, neutritional deficience theory, NMDA receptor hypofunction theory and neural network theory. The neurdevelopmental hypothesis means that several developmental trajectories, related to early brain insults as well as the genetic factors affection postnatal neurodevelopment, possibly lead to this illness. An excessive pruning of the prefrontal corticocortical, and corticosubcortical synapses, perhaps involving the excitatory glutaminergic inputs to pyramidal neurons, may underlie schizophrenia.