The Ameliorative Effects of Korean Bean‐Leaves on Inflammation and Liver Injury in Obese Rat Model

Byung?Moon Jin,Seok?Cheol Choi,Hye?Sook Lee,Sang?Bong Jung,Kyung?Yae Hyun 대한의생명과학회 2013 Biomedical Science Letters Vol.19 No.3

Obesity may cause metabolic syndrome and adult diseases. This study was undertaken to investigate the ameliorative or useful effects of beanleaves on inflammation and liver damage in obese rat models. Rats were divided into three groups: a control group (normal diet, n=6), a fat diet group (45%?fat diet, n=7), and a bean leaf group (45%?fat+Korean bean leaves diet, n=7). Body weights in the bean leaf group were lower than those of the fat group (P<0.05). Serum tumor necrosis factor?α (TNF?α) and prostaglandin E₂ (PGE₂) concentrations were lower in both the control and bean leaf groups than in the fat group (P<0.001). TNF?α concentrations in the bean leaf group were slightly higher than in the control group but statistically significant (P<0.05). The bean leaf group histologically exhibited lower fatty degeneration, spotty necrosis, and leukocyte infiltrations in hepatic tissues than those of the fat group. In the homogenized liver tissues, the cyclooxygenase?2 (COX?2) gene was only expressed in the fat group. The gene expression levels of hepatic TNF?α, inducible nitric?oxide synthase, peroxiome proliferator?activated receptor?α (PPAR?α), poly (ADP?ribose) polymerase (PARP), and transforming growth factor?β1 (TGF?β1) were weaker in the bean leaf group than in the fat group. These results suggest that adding bean?leaves to the diet may ameliorate obesity?induced systemic inflammation and liver damage and that bean leaves may be a useful food for preventing obesity and thereby metabolic syndrome and adult diseases

부산·울산·경남지역 직업병 감시체계

김정일,김병권,김정원,채창호,이철호,강동묵,김지홍,김진하,김영욱,이영하,이지호,김정호,윤형렬,유철인,정백근,장태원,김운규,윤동영,강진욱,김종은,안진홍,이동준,장준호,이광영,송혜란,최영희,이용환,조병만,최홍렬,고상백,김은아,이유진,홍영습,정갑열,김정만,김준연 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.1

Objective: Occupational medicine specialists in the Busan, Ulsan and Kyung-Nam areas established an area-based occupational disease surveillance system and used this system to collected case information for the purpose of preventing occupational diseases Methods: l l hospital participated in this system. The authors selected five main diseases, which were hand-arm vibration syndrome (HAVS), work-related musculoskeletal disorder (WRMSD), occupational asthma, occupational skin disease and occupational and occupational lung cancer and established their case definitions. All cases were reported on the web, and real time analysis was conducted. Results: Between April 2001 and April 2003, 192 cases of HAVS, 118 cases of WRMSD, 33 cases of occupational asthma, 17 cases of occupational skin disease and 17 cases of occupational lung cancer (for a total of 377 cases of these five main diseases) were reported. most of the HAVS cases came from shipbuilding, and 172 of them (92.7%) were associated with grinding. Of the four main types of WRMSD, carpal tunnel syndrome (CTS) was the most prevalent with 46 cases and shipbuilding was also the main industry involved (83.9%). The ergonomic risk factors involved mainly associated with the hand. In 19 (57.6%) and 4 (12.1%) cases of occupational asthma, the agents involved. The causative agents of occupational lung cancer included Cr, welding fume, PAH, Ni, etc. 10(58.8%) of the cases were diagnosed as squamous cell carcinoma and 5(29.4%) as adenoma. Conclusion: This result showed that an area-based occupational disease surveillance system might provide an effective method of evaluating the prevalence of such diseases, however the Busan, Ulsan and Kyung-Nam provinces are too large to be treated as individual areas. Therefore, the authors suggest that each province should establish its own surveillance system.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

악성담도폐쇄 환자에서 경피경간 담도배액술과 금속담도배액술 치료의 장기 합병증 비교 연구

윤병철 고신대학교 의과대학 2011 고신대학교 의과대학 학술지 Vol.26 No.1

OBJECTIVES: Several advances in the diagnosis, therapy and palliation of patients affected by malignant biliary obstruction have occurred during the last decades. Unresectable malignant biliary obstruction has usually been treated by percutaneous transhepatic biliary drainage (PTBD) versus metallic biliary drainage (MBD). The optimal management of complications after biliary drainage is still an unresolved problem. To compare the complications of malignant biliary obstruction after PTBD and MBD. METHODS: We enrolled 51 patients of malignant biliary obstruction after biliary drainage. The clinical characteristics and complications of each groups were assessed and compared. RESULTS: The complications after biliary drainage of MBD are lower than those of PTBD (59.1% vs 82.8%, P = 0.06, respectively). Patients with PTBD tended to have a shorter event of complication time compared to MBD patients (2.9 months vs 7.1 months, P < 0.01). Patients with older age in PTBD tended to have a longer event of complication time compared to younger patients (4.6 months vs 2.3 months, P < 0.01). CONCLUSIONS: The method of biliary drainage in malignant biliary obstruction have statistically significant impact on the complication time. The clinical efficacy of metallic stent in patients with malignant biliary obstruction is better than that of PTBD.

T1 강조 영상에서 선조체 고신호강도를 보이는 당뇨 환자에서의 편측무도증

정승철,이병철,김상윤,배재천,황성희,도화범,박종호 대한신경과학회 1997 대한신경과학회지 Vol.15 No.1

效率的인 環境敎育을 위한 敎授·學習方法의 改善에 關限 硏究 : 中學校를 中心으로 in Middle School

김현철,이택순,문병현,서규태 7개 국립대학교 환경연구 논문집 공동발행 위원회 2002 환경연구논문집 Vol.2 No.1

This paper focuses on the development of desirable curriculum for environmental education in middel school. From the questionnaire investigation for teachers and students of 10 middle schools in Gyeongnam-do, it is desirable that the eduaction program should be practical and experiential rather than the current cramming lecture. In addition, environmental education program should be introduced as a compulsory subject through continuous and systematic curriculum. A training program is necessary for specialist group teaching environmental issues too. Institution of regional environmental education center is an appropriate meausre to develop such program. It will be helpful for open communication between school and social community. National support is necessarily required to promote research activity and to develop innovative teaching materials in such center. Consequently the national environmental network will be constructed and effective environmental education will be implemented.

Vortex Tube의 최적화 설계에 관한 연구 : 냉구출 오리피스를 중심으로 focus on cold end orifice

최병철 서라벌대학 1995 논문집 Vol.9 No.-

The vortex tube is simple device which splits a compressed gas stream into a cold stream and a hot steam. The process of energy separation taking place in the vortex tube has been investigated experimentally. The experimental results indicate that there is an optimum diameter of cold end orifice for the best cooling perfomance. The varia-tion of the maximum wall temperature along the vortex tube surface provides useful information about the location of the stagnation point of the flow field at axis of the vortex tube. A. similarity relation for the prediction of the temperature of the cold exit air confirmed by experimental data.

제주지역 만성 B형 간질환 환자에서 임상 양상에 따른 HBV 유전자형의 분포

송병철,김범준,정주영,염충호,이대호,김진석 제주대학교 생명과학연구소 2003 제주생명과학연구 Vol.6 No.1

Background/Aims: The genotype of HBV has been suggested to correlate with the clinical outcome of HBV infection. We analyzed the distribution of HBV genotype according to the clinical outcome of HBV infection in Jeju island. Methods: A total of 145 HBsAg-positive samples were enrolled. To identify specific patterns of HBV genotypes, we performed restriction fragment length polymorphism (RFLP). If typical restriction pattern of RFLP was not determined, phylogenetic analysis was performed. Results: RFLP analysis was possible in 65 patients. Clinical diagnoses of the 65 patients with chronic liver disease were as follows: HBeAg-positive healthy carrier (HBeAg+, anti-HBe-, HBV DNA+, transaminase normal: n=20): HBeAg seroconversion (n=12): chronic hepatitis B (n=14): liver cirrhosis (n=9): hepatocellular carcinoma (n = I0). Sixty-two patients showed typical restriction pattern by HinfI. However, 3 patients showed unique restriction pattern by HinfI, which were not reported in literature. When phylogenetic analysis was performed to classify the genotype of these 3 patients, they were also genotype C. Whereas, all patients showed typical restriction patterns by Tsp509l, which were reported in genotype C. Conclusion: All chronic HBV infection are genotype C in Jeju island regardless of clinical outcome.

새마을運動의 繼承發展方向

高秉浩,南基旻,趙喆柱 청주대학교 새마을연구소 1990 새마을硏究論文集 Vol.7 No.-

Looking back upon the Saemaul Undong, even since it began in the year 1970, it has been developed more powerfully and accomplished community development with the slogan of diligence, self-help and cooperation. As the result, most villages have gotten the improvement of physical environment, income increasing and positive changes in the attitudes and values of inhabitants. However, in spite of the Saemaul Undong's achievements, the movement has been faced to many kind of problems about the middle of the time of 1980's. And so nowadays, Saemaul Undong is not get out of a swamp of stagnation. Of course, it cannot he denied that it has made much contribution to the community development, but it is confronted with many serious problems. The reasons for the decline of Saemaul Undong are mainly the corruption of the headquarters of Saemaul Undong, disordered society, disparity of strata, depersonalization, the lack of new methodologies in the pursuit of Saemaul Undong, and etc. Recognizing these problems and to cope with the newly emerzing situation, a need has arisen for a change in Saemaul Undong. Therefore, these paper aims at researching for a new methodologies and strategies to carry out Saemaul Undong's progams continuously, and intends to suggest a new direction of sustaining Saemaul Undong. For the Purposes of suggesting altternatives continuously sustaining Saemaul Undong, this paper intends to formulate the principles and new directions of Saemaul Undong as follows : (1) The objectives and methodologies of Saemaul Undong should be reorganized in the context of new emerging situations. (2) Revitalizing local towns and rural areas must be pursued with special reference with hometown development. For the purpose, it is proper to organize a society for the support of hometown, and to invest money and resources in trying to help it. (3) In the spiritual aspect, it is desirable that the spirits of Saemaul Undong : diligence, self-help and cooperation should be expanded into a public interest and self-governing. (4) To induce residents to take part in and support Saemaul Undong, Noluntary Systems are formulated for securing public interest and a cultivation of personality. (5) A public movement creating a new nation, to meet a new twenty-frist centry, should be pushed ahead with a nation-wide development. (6) In a dimension of province level Saemaul Undong, the local branch of the headquarters of Saemaul Undong must take the initiative in doing Saemaul projects, and residents show their ability to carry out Saemaul Undong.

국제표준에 따른 사무용 문서의 디코딩 시스템에 관한 연구

金鐵元,權炳宇 湖南大學校 1990 호남대학교 학술논문집 Vol.11 No.1

본 논문에서는 다양한 ODA 데이타 형식을 ASN.1에 따라 정의할 수 있고 이러한 데이타 형식을 받아들여서 원하고자 하는 디코더를 생성시키는 translator를 구성하였다. 이 translator는 C언어로 된 디코더를 생성시킨다. 또한 디코더는 X.209에 정의된 엔코딩 규칙에 따라서 만든 octet 스트림을 입력으로 하고 출력으로써 ASN.1 표기법에 따른 값들을 출력시킨다. 본 논문의 연구가 혼합형 터미널 개발과 PC통신, 다양한 문서 형식의 교환 시스템 개발, MHS 개발에 유용하리라 기대된다. This paper can define raried ODA date formats according to ASN. 1 and compose the translator that produces the decoder which we want after it receives that date format. This translator produces the decoder which is formed in C language. Also, in input the decoder receives octet stream made according to encoding rules defined in X. 209 and in output produces values by ASN. 1 represeatation. The study of this paper is expected to be useful in mixed mode development, PC communication, communication system development of varied document format and MHS development.