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鄭敬壽,柳柄泰,金炳珏 충남대학교 약학대학 의약품개발연구소 1985 藥學論文集 Vol.1 No.-
The ether, methanol, and physiological saline extracts of the dried carpophores of ten basidiomycetous fungi, which were collected in the conifer woods of Chungnam National University at Taechon, were subjected to an antibiotic activity test by disc-plate method. Among them, the methanol extracts of Marasmius maximus, Hirschioporus abietinus, and Russula sanguinea and the the ether extracts of M. maximus and H. abietinus showed antibiotic activities against Sarcina lutea; and the methanol and ethanol extract of M. maximus showed antibiotic activity against Staphylococcus aureus. None of the extracts, however, showed any activity against gram negative bacteria, Serratia marcescens and Proteus vulgaris.
鄭敬壽,申明哲,柳柄泰,金炳珏 충남대학교 약학대학 의약품개발연구소 1986 藥學論文集 Vol.2 No.-
The ether, methanol, and physiological saline extracts of the dried carpophores of ten basidiomycetous fungi, which were collected in the conifer woods of Chungnam National University at Taechon and Keyryoung Mountain Area in Chungcheungnamdo, were subjected to an antibiotic activity test by disc-plate method. Among them, the methanol extracts of Inocybe trechispora, Lactarius velumis, and Laccaria laccata and the ether extracts of I.trechispora showed antibiotic activities against Sarcina lutea; and the methanol extracts of I. trechispora and L. velumis and physiological saline extract of Coriolus versicolor showed antibiotic activities against Staphylococcus aureus; and the methanol extract of L. velumis showed antibiotic activity against Escherichia coli. None of the extracts, however, showed any activity against Serratia marcescens and Proteusvulgaris.
韓國産 擔子菌類의 抗菌成分에 관한 硏究 (III) : 10種의 擔子菌에 대한 抗菌成分 檢索
鄭敬壽,白貞花,柳柄泰,金炳珏 충남대학교 약학대학 의약품개발연구소 1987 藥學論文集 Vol.3 No.-
The ether, methanol, and physiological saline extracts of the dried carpophores of ten basidiomycetes, which were collected from several locations of Korea, were subjected to a screening test for antibiotic activity by disc-plate method using Sarcina lutea, Bacillus subtilis, Escherichia coli, and Serratia marcescens as target organisms. As the result, the methanol extract of five basidiomycetes-Amanita rebescens, Amanita solitaria, Lactarius vellereus, Latarius subzonarius and Scleroderma verrucosum-were found te have antibiotic activity. Among them, the methanol extracts of A. rubescens and L. vellereus exerted strong activity against both of the gram positive and negative bacteria. The ether extracts of A. rubescens and S. verrucosum also showed activity against S. lutea. The physiological saline extract, however, showed no activity at all.
Phellinus linteus 균사 배양물로부터 분리한 단백다당체 Kp의 항암활성
정경수,김신숙,김희수,한만우,김병각 충남대학교 약학대학 의약품개발연구소 1994 藥學論文集 Vol.10 No.-
A protein-polysaccaride fraction Kp(53.9% polysaccharide, 14.2% protein) was separated from the shake-cultured mycelia of a basidiomycetous fungus, Phellinus linteus, and its antitumor activity against sarcoma 180 in ICR mice was investigated. When administered after the tumor implantation. Kp exerted antitumor activity by inhibiting the growth of the sarcoma 180 solid tumor by 71.5% and increasing the life span of the sarcoma 180 ascitic mice by 51.5% at 100 ㎎/㎏. In pretreatment tests, in which Kp was administered once daily for 9 days before the tumor implantation. Kp inhibited the growth of the solid and ascites form of sarcoma 180, respectively, by 35.4% and by 80.3% at 100 ㎎/㎏. However, Kp showed no in vitro cytotoxic activity against a murine leukemia L1210 and a human gastric tumor SNU.1 upto the concentration of 200 ㎍/㎖. From these results, it is clear that the antitumor activity of Kp is exerted through its immunomodulating activity on the host's immune system.
Byong Kak Kim,Kyuns Soo Chung,Hee Soo Chung,Eung Chil Choi ) 생화학분자생물학회 1981 BMB Reports Vol.14 No.2
We have reported on the antitumor activities of polysaccharides from Korean higher fungi. This paper reports species of Korean Basidiomycetes containing antitumor polysaccharides. A polysaccharide fraction which was obtained from the carprophores of Cryptoporus volvus (Pk.) Hubb. was found to be highly effective against sarcoma 180 implanted subcutaneously in the left armpits of A-strain mice. The inhibition ratio was 80.4%(50 ㎎/㎏, ten days, i.p.) and 70.3%(20 ㎎/㎏, ten days, i.p.), respectively. This component consisted of a polysaccharide (55.3%) and a protein (12.8%). From the hydrolyzate of this constituent, four monosaccharides and 17 amino acids were identified by the use of GLC and amino acid autoanalyzer.
Immunological Studies on Oriental Pharmaceutical Preparations
Byong Kak Kim 한국생약학회 1985 생약학회지 Vol.16 No.4
Although components of individual botanical drugs that constitute oriental pharmaceutical preparations of traditional recipes have been extensively investigated for chemical structure and pharmacological activity, the concerted efficacy of several drugs in each pperaration has been seldom examined objectively. Particularly those preparations which were used to treat epidemic diseases or weakened conditions in humans have not been studied for plausible mechanism. These facts led the author to presume that such preparations may enhance immunity or that they may restore impaired immune state to normal level. To examine effects of oriental pharmaceutical preparations on immunity, four of such preparations which are currently being used were examined. After their fluid extracts were injected intraperitoneally to ICR mice, the counts of total cell number, PMN and macrophage in the peritoneal cavity were made by using non-specific esterase staining method, and plaque-forming cells (PFC) were measured by using the modified method of Cunningham and Jerne. The results showed that Bo-Jung-Ik-Ki-Tang, Ih-Jung- Tang, Ohn-Kyeong-Tang and Ke-Ji-Bok- Ryeong-Hwan-Ka-Dae-Hwang increased both the macrophages and the total cells of the peritoneal cavity and that these preparations increased the number of PFC in the spleen. Therefore the data indicate that they potentiate both of the cell-mediated and humoral immunities in the mice.
Antitumor Components of Korean Basidiomycetes
Byong Kak Kim,Ji Hyun Kim,Ha Won Kim,Eung Chil Choi 한국생약학회 1986 생약학회지 Vol.17 No.1
To find antitumor components in the shake-cultured mycelia of Volvariella bombycina, the mycelia were extracted with hot water. After the extract was dialyzed. and freeze-dried, a protein-polysaccharide fraction was obtained and examined for antitu mor activity against the solid form of sarcoma 180 in ICR mice. It showed 60.3% inhibition ratio at a dose of 20 ㎎/㎏/day for 10 days. It was found to consist of a polysaccharide moiety and a protein moiety. After gel filtration on Sepharose 4B, Fraction. B was obtained and showed the highest inhibition ratio of 71.1%. When the antitumor component was examined for immunopotentiating activity, it was found to increase the macrophage accumulation in the peritoneal cavity as well as the antibody production o1` the spleen cells of the mice.