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BMB Reports : Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses
( Byeongjin Jung ),( Hyejin Kang ),( Wonhwa Lee ),( Hyun Jin Noh ),( You Sun Kim ),( Min Su Han ),( Moon Chang Baek ),( Jaehong Kim ),( Jong Sup Bae ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.4
A nucleosomal protein, high mobility group box 1 (HMGB1) is known to be a late mediator of sepsis. Dabrafenib is a B-Raf inhibitor and initially used for the treatment of metastatic melanoma therapy. Inhibition of HMGB1 and renewal of vascular integrity is appearing as an engaging therapeutic strategy in the administration of severe sepsis or septic shock. Here, we examined the effects of dabrafenib (DAB) on the modulation of HMGB1-mediated septic responses. DAB inhibited the release of HMGB1 and downregulated HMGB1-dependent inflammatory responses by enhancing the expressions of cell adhesion molecules (CAMs) in human endothelial cells. In addition, treatment with DAB inhibited the HMGB1 secretion by CLP and sepsis-related mortality and pulmonary injury. This study demonstrated that DAB could be alternative therapeutic options for sepsis or septic shock via the inhibition of the HMGB1 signaling pathway. [BMB Reports 2016; 49(4): 214-219]
Byeongjin Kim,Hangil Joe,Son-Cheol Yu 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.9
This study proposes a method for generating a high-precision three-dimensional (3D) map using twodimensional (2D) sonar images from an imaging sonar installed on an autonomous underwater vehicle (AUV). The 2D sonar image sequence was analyzed pairwise to estimate the amount of displacement and used to create a 2D mosaic sonar image. The mosaic sonar map contains intensity information in a wide area and precise shape information but has no height information. To overcome this limitation, we can generate a 3D point cloud from 2D sonarimage sequences. This method takes advantage of the mobility of the AUV to reconstruct the height information and partially solves the ambiguity issues in the imaging sonar’s elevation angle. The height map generated from the 3D point cloud contains height information of a wide area, but the shape information is inaccurate. By fusing two maps to complement each other’s imperfections, we can generate a precise 3D sonar map. This map enables the AUV to estimate the pose and recognize the surrounding environment. We verified the proposed method by conducting experiments in an indoor water tank. After placing various objects on the floor, the AUV with the imaging sonar scanned the floor and objects to generate a 3D sonar map. We analyzed the estimated AUV trajectory and the accuracy of the 3D sonar map. This study proposes a method for generating a high-precision three-dimensional (3D) map using twodimensional (2D) sonar images from an imaging sonar installed on an autonomous underwater vehicle (AUV). The 2D sonar image sequence was analyzed pairwise to estimate the amount of displacement and used to create a 2D mosaic sonar image. The mosaic sonar map contains intensity information in a wide area and precise shape information but has no height information. To overcome this limitation, we can generate a 3D point cloud from 2D sonar image sequences. This method takes advantage of the mobility of the AUV to reconstruct the height information and partially solves the ambiguity issues in the imaging sonar’s elevation angle. The height map generated from the 3D point cloud contains height information of a wide area, but the shape information is inaccurate. By fusing two maps to complement each other’s imperfections, we can generate a precise 3D sonar map. This map enables the AUV to estimate the pose and recognize the surrounding environment. We verified the proposed method by conducting experiments in an indoor water tank. After placing various objects on the floor, the AUV with the imaging sonar scanned the floor and objects to generate a 3D sonar map. We analyzed the estimated AUV trajectory and the accuracy of the 3D sonar map.
Byeongjin Jung,Sae Kwang KU,Ming Gao,KYUNG MIN KIM,한민수,Hyukjae Choi,Jong-Sup Bae 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.6
Diketopiperazine is a naturally occurring cyclicdipeptide found from diverse living organisms. The compoundsin this structure class have been known with abroad spectrum of bioactivities including anti-inflammatoryactivities. Transforming growth factor b-inducedprotein (TGFBIp) is an extracellular matrix protein whoseexpression in several cell types is greatly increased byTGF-b. TGFBIp is released by human umbilical veinendothelial cells and functions as a mediator of experimentalsepsis. Here, three (1–3) of diketopiperazines wereisolated from two strains of marine-derived bacteria and wehypothesized that 1–3 could reduce TGFBIp-mediatedsevere inflammatory responses in human endothelial cellsand mice. Here, we investigated the anti-septic effects andunderlying mechanisms of 1–3 against TGFBIp-mediatedseptic responses. 1–3 effectively inhibited lipopolysaccharide-induced release of TGFBIp and suppressedTGFBIp-mediated septic responses. In addition, 1–3 suppressedcecal ligation and puncture (CLP)-induced sepsislethality and pulmonary injury. In conclusion, 1–3 suppressedTGFBIp-mediated and CLP-induced septicresponses. Therefore, 1–3 could be a potential therapeuticagent for treatment of various severe vascular inflammatorydiseases via inhibition of the TGFBIp signalingpathway.
( Byeongjin Jung ),( Sae Kwang Ku ),( Ming Gao ),( Kyung Min Kim ),( Min Su Han ),( Hyukjae Choi ),( Jong Sup Bae ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Diketopiperazine is a naturally occurring cyclic dipeptide found from diverse living organisma. The com-pounds in this structure class have been known with a broad spectrum of bioactivities including anti-inflamma-tory activities. Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein whose expression in several cell types is greatly increased by TGB- β. TGFBIp is released by human umbilical vein endothelica cells and functions as a mediator of experi-mental sepsis. Here, three (1-3) of diketopiperazines were isolated from two strains of marine-derived bacteria and we hypothesized that 1-3 could reduce TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice. Here, we investigated the anti-septic effects and underlying mechanisms of 1-3 effectively inhibited lipopolysac-charide-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. In addition, 1-3 sup-pressed cecal ligation and puncture (CLP)-induced sepsis lethality and pulmonary injury. In conclusion, 1-3 sup-pressed TGFBIp-mediated and CLP-induced septic response. Therefore, 1-3 could be a potential therapeutic agent for treatment of various severe vascular inflamma-tory diseases inhibition of the TGFBIp signaling pathway.
Park, Byeongjin,Sohn, Hoon,Malinowski, Pawel,Ostachowicz, Wieslaw Taylor Francis 2017 Nondestructive testing and evaluation Vol.32 No.1
<P>In this study, a two-level scanning strategy for a noncontact laser ultrasonic measurement system is proposed to expedite the inspection of a wind turbine blade. First, coarse scanning of the entire blade is performed with a low spatial resolution for initial delamination localisation. Then, dense scanning with a high spatial resolution is performed only within the identified delaminated region for delamination visualization. This study especially focuses on the initial delamination localisation using adaptive coarse scanning. Laser ultrasonic responses from two pitch-catch paths, names inspection pairs, are obtained within a specified coarse scanning grid. Then, potential delamination locations within the given grid are estimated through time-of-flight analysis of delamination reflected waves. Once potential delamination locations are estimated, new inspection pairs are placed near the potential locations for precise localisation. These steps are repeated for every coarse scanning grids on the target wind turbine blade. The feasibility of the proposed technique for rapid delamination detection is demonstrated with a 10 kW glass fibre reinforced plastic wind turbine blade.</P>