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Endogenous Sphingolipid Metabolites Related to the Growth in Sphingomonas chungbukensis
Burenjargal, Munkhtsatsral,Lee, Youn-Sun,Yoo, Jae-Myung,Kim, Young-Chang,Lee, Yong-Moon,Oh, Sei-Kwan,Yun, Yeo-Pyo,Hong, Jin-Tae,Chung, Youn-Bok,Moon, Dong-Chu,Yoo, Hwan-Soo 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.3
Sphingolipids are present in animals, plants, fungi, yeasts and some bacteria. In mammalian cells sphingolipids act as lipid mediators for cell growth, differentiation, apoptosis and angiogenesis. In contrast, in bacteria the biological significance of sphingolipids has not beer fully elucidated and sphingolipid metabolism has not been investigated. The aim of this study was to compare the pattern of sphingolipid metabolites in HIT-T15 ${\beta}$ cells originating from hamster pancreas to that in the bacterial strain Sphingomonas chungbukensis DJ77, under various culture conditions. It was found that the concentration of cellular sphinganine (Sa) in S. chungbukensis was higher than that of sphingosine (So), while the level of cellular So In HIT-T15 cells was higher than that of Sa. Aeration and shaking during culture increased bacterial growth in S. chungbukensis, and the contents of So and Sa were also elevated. These results indicate that a do novo sphingolipid pathway appeared to be active in bacteria and that bacterial growth may be closely related to Sa levels.
Endogenous Sphingolipid Metabolites Related to the Growth in Sphingomonas chungbukensis
Munkhtsatsral Burenjargal,이윤선,유재명,김영창,이용문,오세관,윤여표,홍진태,정연복,문동철,유환수 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.3
Sphingolipids are present in animals, plants, fungi, yeasts and some bacteria. In mammalian cells sphingolipids act as lipid mediators for cell growth, differentiation, apoptosis and angiogenesis. In contrast, in bacteria the biological significance of sphingolipids has not been fully elucidated and sphingolipid metabolism has not been investigated. The aim of this study was to compare the pattern of sphingolipid metabolites in HIT-T15 β cells originating from hamster pancreas to that in the bacterial strain Sphingomonas chungbukensis DJ77, under various culture conditions. It was found that the concentration of cellular sphinganine (Sa) in S. chungbukensis was higher than that of sphingosine (So), while the level of cellular So in HIT-T15 cells was higher than that of Sa. Aeration and shaking during culture increased bacterial growth in S. chungbukensis, and the contents of So and Sa were also elevated. These results indicate that a de novo sphingolipid pathway appeared to be active in bacteria and that bacterial growth may be closely related to Sa levels.
Dihyrocramide was Highly Elevated by the Fumonisin B1 and Desipramine in Sphingomonas chungbukensis
Youn Sun Lee,Jae Myung Yoo,Mi Hwa Choi,So Young Ji,Yong Moon Lee,Young Chang Kim,Sei Kwan Oh,Yeo Pyo Yun,Hwan Soo Yoo,Munkhtsatsral Burenjargal 한국응용약물학회 2008 Biomolecules & Therapeutics(구 응용약물학회지) Vol.16 No.2