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광간섭 단층영상기술과 이광자 현미경을 이용한 in-vivo에서의 피부 염증 반응 가시화
김범주(Bumju Kim),이승훈(Seong Hun Lee),김기현(Ki Hean Kim) 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.11
Among the various immune responses of the body, the earliest is the inflammation response. Quantitative measurement of the inflammation response is important for the diagnosis of several diseases and evaluation of new drugs responses. In this study, we induced an acute inflammation response by topical application of LPS on the mouse ear and the resulting characteristics of acute inflammation response such as tissue swelling, blood vessel dilation, immune cell migration were imaged. To do so, we used noninvasive 3D imaging technologies: optical coherence tomography (OCT) and two-photon microscopy (TPM), label free. OCT displayed the increase in thickness of tissue and changes in blood vessel distribution due to the inflammation response. Meanwhile, TPM displayed molecular and cellular information such as immune cell infiltration. Taken together, OCT and TPM provided information about the inflammation response from this model.
Khang, Bumju,Ahn, Joon Young,Song, Dasol,Lee, Gangwoong Korean Society for Atmospheric Environment 2013 Asian Journal of Atmospheric Environment (AJAE) Vol.7 No.2
We constructed and tested an airborne peroxyacetyl nitrate (PAN) monitoring system based on luminol chemiluminescence detection with fast gas chromatography. This system allowed for simultaneous measurement of PAN and nitrogen dioxide ($NO_2$) with a time resolution of <2 min. Actual sample masses within the fixed volume sample loop at various altitudes and temperatures were adjusted to standard atmosphere, using measured pressures and temperatures. The airborne PAN measurement system was evaluated during two field studies above the southern Korean Peninsula in August and October 2009. The detection limit based on the ISO approach was 0.035 ppbv PAN, well below the observed concentrations of 0.185-1.49 ppbv during these studies. Under these conditions, the PAN mixing ratios were positively correlated with $O_x$ ($O_x=O_3+NO_2$), with slopes varying between 0.014 and 0.033 and intercepts between 22.6 and 55.1 ppbv $O_x$. The intercepts corresponded roughly to background $O_x$ mixing ratios in central Europe; however, the slopes were above the range of slopes reported in other studies. We also enhanced the durability, safety, and ease of maintenance of the PAN monitoring system by redesigning the structure of the conventional luminol cell.
Catalytic Electron Transfer at Nanoporous Indium Tin Oxide Electrodes
Seo, Minjee,Bae, Je Hyun,Hwang, Dae Woong,Kwak, Bumju,Yun, Jeongse,Lim, Sung Yul,Chung, Taek Dong Elsevier 2017 ELECTROCHIMICA ACTA Vol.258 No.-
<P><B>Abstract</B></P> <P>We investigated the enhancement of one electron transfer kinetics at the nanoporous indium tin oxide (ITO) electrodes. In this study, the origin of the catalytic activity in nanoporous electrodes was explored with regard to the effects of confined morphology of the electrode to the heterogeneous electron transfer enhancements. In order to look into the geometric contribution to electrocatalytic activity, we chose ITO as the electrode material due to its chemically inert surface on which most electron transfer reactions occur very slowly. Systematic variation of nanoporous ITO layer thickness allows us to effectively exclude the surface-originated electrocatalytic effects of the nanoporous electrodes such as defects. It was clearly found that the single electron transfer of Fe<SUP>2+/3+</SUP> involving no proton transfer is more facilitated at thicker ITO nanoporous layers, which has longer pores, and this geometric enhancement was more evident at lower temperatures.</P>
Park, Joonhyuck,Lee, Junhwa,Kwag, Jungheon,Baek, Yeonggyeong,Kim, Bumju,Yoon, Calvin Jinse,Bok, Seoyeon,Cho, So-Hye,Kim, Ki Hean,Ahn, G-One,Kim, Sungjee American Chemical Society 2015 ACS NANO Vol.9 No.6
<P>Amphiphilic polyethyleneimine derivatives (amPEIs) were synthesized and used to encapsulate dozens of quantum dots (QDs). The QD–amPEI composite was ∼100 nm in hydrodynamic diameter and had the slightly positive outer surface that suited well for cellular internalization. The QD–amPEI showed very efficient QD cellular labeling with the labeled cell fluorescence intensity more than 10 times higher than conventional techniques such as Lipofectamine-assisted QD delivery. QD–amPEI was optimal for maximal intracellular QD delivery by the large QD payload and the rapid endocytosis kinetics. QD–amPEI platform technology was demonstrated for gene delivery, cell-specific labeling, and ratiometric oxygen sensing. Our QD–amPEI platform has two partitions: positive outer surface and hydrophobic inside pocket. The outer positive surface was further exploited for gene delivery and targeting. Co-delivery of QDs and GFP silencing RNAs was successfully demonstrated by assembling siRNAs to the outer surfaces, which showed the transfection efficiency an order of magnitude higher than conventional gene transfections. Hyaluronic acids were tethered onto the QD–amPEI for cell-specific targeted labeling which showed the specific-to-nonspecific signal ratio over 100. The inside hydrophobic compartment was further applied for cohosting oxygen sensing phosphorescence Ru dyes along with QDs. The QD-Ru-amPEI oxygen probe showed accurate and reversible oxygen sensing capability by the ratiometric photoluminescence signals, which was successfully applied to cellular and spheroid models.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-6/acsnano.5b02357/production/images/medium/nn-2015-02357j_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b02357'>ACS Electronic Supporting Info</A></P>
소프트웨어 재활기법을 적용한 (n,k) 클러스터 시스템의 가용도 향상 모델
이재성(Chaesung Lee),박기진(Kiejin Park),강창훈(Changhun Kang),박범주(Bumju Park),김성수(Sungsoo Kim) 한국정보과학회 2003 정보과학회논문지 : 시스템 및 이론 Vol.30 No.5·6
인터넷 기반 시스템에서는 고가용도와 고성능을 제공해야하며, 클러스터 시스템 기술은 이에 대한 하나의 해결책으로 떠오르고 있다. 클러스터 시스템을 사용하는 중요한 목적은 성능과 가용도의 확보에 있으며, 고가용도 클러스터 시스템은 구성 노드들 중 일부에 결함이 발생했을 때 이를 비용·효율적으로 해결한다. 본 논문은 (n,k) 클러스터 시스템의 성능을 고려한 가용도 개선과 손실비용 분석에 관한 연구로 소프트웨어 재활 기법을 적용한 (n,k) 클러스터 시스템의 가용도 모델을 제안하였으며, 고가용도가 요청되는 시스템에서 소프트웨어 재활은 가용도 향상을 가져오는 유용한 기법 중의 하나임을 파악하였다. Internet-based computer systems have to provide both high-availability andhigh-performance. Cluster technology has been used to obtain availability and performance simultaneously. Generally, high-availability cluster systems tolerate a failure of a cluster node and cost-effectively solve it. In this paper, we study availability and downtime cost of (n,k) cluster systems. By considering performance, we model state transition of (n,k) cluster systems and apply software rejuvenation technique to improve availability of the system. We find that software rejuvenation can be used to improve availability of (n,k) cluster systems.