S-580 : Vitamin D and carotid subclinical atherosclerosis in SLE

( Chang Bum Bae ),( Ju Yang Jung ),( Bo Ram Go ),( Hyun Ah Kim ),( Chang Hee Suh ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Vitamin D and carotid subclinical atherosclerosis in SLE Chang-Bum Bae, Ju-Yang Jung, Bo-ram Go, Hyun-Ah Kim, Chang-Hee Suh Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea Introduction Atherosclerosis develops earlier in systemic lupus erythematosus (SLE) and is the important cause of mortality. It has been suggested that vitamin D deficiency contributed cardiovascular disease and immune dysregulation in SLE. Methods One-hundred two female patients with SLE and 52 normal controls (NC) were recruited. The carotid artery intima-media thickness (cIMT) and plague were assessed by B-mode ultrasound at the carotid artery level. Vitamin 25(OH)D3 levels were checked by immunoradiometric assay using the Bio-Line 25(OH)D3-Ria CT kit (Bio-Line S.A., Belgium). Disease activity markers were checked at the time of enrollment. Results The cIMT of SLE is 0.41±0.08mm, which is higher than NC (0.37±0.11 mm, p=0.012). Also, carotid artery plague index (PI) of SLE is higher than NC (0.68±1.39 vs 0.26±0.87, p=0.026). The cIMT was correlated with age (r=0.442, p<0.001), body mass index (r=0.246, p=0.013), waist-hip ratio (r=0.245, p=0.013), SLE disease activity index (r=0.239, p=0.016), taking aspirin (r=0.244, p=0.013), and the carotid artery PI was correlated with renal involvement (r=0.224, p=0.023) in patients with SLE. Vitamin 25(OH)D3 was not showed correlation with cIMT and carotid artery PI. Also, it was not correlated with disease activity markers. Conclusion In patients with SLE, the risk of cardiovascular disease measured by cIMT and carotid artery plaque was higher than NC, which may be derived from systemic inflammation. However, vitamin D levels were not showed significant correlations with carotid subclinical atherosclerosis. It may be not suitable to assess vitamin D as marker of disease activity or subclinical atherosclerosis.

수소 자기 공명 분광 영상으로 확인된 후두엽성 중첩성 복합 부분 간질에 의한 뇌신경 세포의 손상

서범천,김옥준,김현숙,최철희,김서현,이병인 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

SCAT와 排球 서어브 記錄의 機能別 要因分析

金昌範,金顯俊 忠北大學校 平生體育硏究所 1987 平生體育硏究所 論文集 Vol.2 No.-

We chose 268 male and female students at random in order to check the influence of axiety in getting scores in the test of Volley Ball service. For this purpose, the Marten's SCAT testing instrument was used, and the testing process was as follows: A------->B------->C A: A student leader takes part of the tester and do the preliminary test of the Volley Ball Serve(Pretest). B: Measurement of SCAT C: The professor takes part of the tester and do the actual test of the Volley Ball serve (posttest) It is the purpose of this study to find out what relationship there is between SCAT and the two kinds of Volley Ball Serve test, and from this we have got the following results: 1. The Relaitionship between Pretest and Posttest The correlation coefficents between pretest and posttest of male students isr=0.330, and this shows low relationship between the two tests, whereas the correlation coefficient of female students is r=0.452, which shows high relationship. 2. The Anxiety Score of the low, middle, and high groups in the pretest. Male students show high anciety score according as they get high score; Female students show anxiety score in the order of the middle, high, and low groups. 3. The anxiety Score of the low, middle, and high groups in the post test. The anxiety score of male and female students has become lowest according as they get high score, while teh anxiety score has turned out highest in the middle group. This means that the exceeding anxiety leads students to get a rather bad result in the actual test.

隔板을 가진 水平環狀空間에서 自然對流에 관한 實驗的 硏究

鄭泰鉉,金善政,李範澈,權純錫 동아대학교 공과대학 부설 한국자원개발연구소 1988 硏究報告 Vol.12 No.2

Natural convection from a horizontal annulus with spacers has been studied on the effects of Rayleigh numbers and position of spacers by experimental method. In case of vertical spacers, the maximum local Nusselt number appears at θ=150° in a conducting tube and θ=30° in a cylinder. The local spacer Nusselt numbers show positive values on the lower spacer, but negative values on the upper spacer. In case of horizontal spacers, the flow over the spacer is more active than that of under the spacer as the Rayleigh number increase. The maximum local Nusselt number appears at θ=180° In a tube and at θ=0° in a cylinder. The local spacer Nusselt number show positive values on the upward surface of spacer, but negative values on the downward surface of spacer. The mean tube Nusselt numbers and mean cylinder Nusselt numbers with vertical spacer are increased 11% And 2.7%, respectively by those of horizontal spacer.

成人 排球選手들의 Sports 傷害에 關한 硏究

金昌範,金顯俊,朴鍾振 忠北大學校 平生體育硏究所 1991 平生體育硏究所 論文集 Vol.5 No.-

After I investgated the matters about the sprots injuries of the one hundred and twenty-nine men and women volleyball players who belonged to a business volleyball league and played in the volleyball game of President Cup in 1992, I got the following results. 1. It was found that many player suffered from sports injuries between one and three years after they began the sport, the time when the injuries happened was the middle of the main sport, and the season when the injuries happened is almost winter. 2. It was found that the most state when the injuries happened was in the middle of exericise, the part of body where the injuries happened was mainly hand or ankle, and when the injuries happened, the used sport technique was mainly when the player made a blocking, trained their bodies, made a landing , and so on. 3. It was found that the first aid which was needed when the sport injuries happened was mainly given by the coach, director, or colleague, and after the first aid the players were treated at the hospital or went to the herb doctor. 4. It was found that the length of the time when the players could not take part in the game was mainly below a month and after about seventy of eighty percent recovery, they took part in the game again. 5. It was found that the main causes of injuries accurrences were the carelessness of the players', the lack of warming-up, and so on, and the ways by which injuries could be reduced were the cultivation of the power of concentration and mental power, and the sufficient warming-up.

생물학에 있어서의 취보적 성질에 대한 연구

진범순,박지현 순천향대학교 기초과학연구소 2002 순천향자연과학연구 논문집 Vol.8 No.1

Molecules, subcelluar organelles, and cells 과 같이 운동성을 갖고 있는 particles의 행동에 대한 묘사나 particles 이 평균적으로 얼마만큼 움직이는지를 확률의 성질을 이용하여 수학적인 방법으로 어떻게 묘사할 수 있는지에 대하여 연구하였다. 특히, 운동성이 있는 bacteria의 행동을 random walk와 관련지어 연구하였다.

小兒에 있어서의 우식活動性에 對한 硏究

韓世鉉,李範模 大韓小兒齒科學會 1986 大韓小兒齒科學會誌 Vol.13 No.1

This study was performed to evaluate the caries activity with dental plaque of upper right second primary molar by caries activity tester (suntec) and the author compared this caries activity with deft&s index, rate and caries severity. The selected subjects for this study were 97 children (boys 52, girls 45) aged from 3 to 8. According as the swabbed plaque condition was wet or dry, caries activity degree was evaluated in 18 among 97 children. The obtained results were as follows: 1. Caries activity of boys showed slightly higher than that of girls. Deft&s index, rate were also higher in male than in female. 2. According as the caries activity was slightly increased, deft & s index, rate were slightly increased. (P<0.05) 3. According as the caries severity showed increasing tendency, caries activity was also increased. (P<0.05) 4. There was no difference in the caries activity according to wet or dry condition of plaque sample.

레슬링 그레코-로만형 경기내용에 관한 연구

김현준,김창범,박종진 忠北大學校 平生體育硏究所 1998 平生體育硏究所 論文集 Vol.10 No.-

The present study was to offer basic data on desirable wrestling match management and skill instruction through analysing the Greco-Roman wrestlers' match skills and attack patterns. Analyses on video-taped 105 wrestling matches of 48kg to 130kg weights in1997 wrestling world championship selection match revealed the following results; First, the most frequently used stand skill was waist tackle skill(68times, 20.1%), and its success rate was 22 times(32.3%) and failure rate was 46 times(67.6%). Second, the most frequently used ground skill was waist hold turning with arms skill(150 times, 53.0%), and its success rate was 95 times (63.3%) and failure rate was 55 times(36.7%). Third, wrestles obtaining first merit won 74 matches(70.5%) and lost 31 match(29.5%) among all the 105 match. Fourth, total frequencies of passive were 267 times, and there were more passive in heavy weight matches than in light weight matches.

주의력 결핍 과잉행동장애 아동의 평가를 위한 정지신호 과제의 적용

시현석,이종범,박형배,사공정규,송창진,배진우 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.1

연구목적 및 방법 : ADHD환아에 있어 뇌의 전두엽의 기능인 실행기능 중 특히 억제기능을 가장 잘 측정하는 것으로 알려진 정지신호과제를 사용하여 실제로 정지신호를 ADHD환아에게 적용하였을 때 정상 아동과 비교하였을 때 ADHD의 전두엽의 실행기능 중 억제 기능의 이상을 실질적으로 반영하는 검사인지, 증상의 정도와 수행결과는 어떤 연관성을 보이는지, 현재 가장 널리 사용되고 있는 연속수행 검사와는 어떤 차이를 보이는지, 과잉행동의 유무와 수행의 연관성은 어떠한지 그리고 부가적으로 정지신호과제의 ADHD진단에 있어서의 판별력은 어느 정도인지를 알아보기 위해 본 연구를 시행하였다. 전두엽의 기능을 반영하는지와 임상에서의 유용성을 알아보기 위해 ADHD군 40명과 대조군 18명을 대상으로 연구하여 다음과 같은 결과를 얻었다. 결 과 : 대조군과 ADHD군의 비교에서는 정지신호과제의 수행 성적은 상대적 종결속도의 Z점수(ZRFT)와 블록당 평균 지연시간(mean delay×block), 그리고 일차 반응시간(primary-RT)에 있어서 유의한 차이가 있는 것으로 나타났다(p<0.05), ADHD군과 대조군의 연속수행검사(CPT)의 수행에 있어 유의한 차이가 나는 변인은 없었다. 또한 두 검사간의 상관성에 있어서는 정지신호반응시간(SSRT)와 CPT의 정반응시간이 그리고 primary-RT와 일차반응시간의 표준 편차(primary-SD)가 CPT의 민감도와 정반응시간과 상관성이 있는 것으로 나타났다(p<0.05). 정지신호과제 수행과 한국형 주의력결핍 장애 평가 척도 - 가정판(ADDES-HV)과의 상관도에서는 유의한 상관성을 나타낸 것은 없었다. 나이와 지능에 따른 정지신호과제의 경향분석에서 유의하게 경향성을 나타낸 것은 지에 따른 차이에서는 primary-SD였으며 나이에 따른 차이에서는 SSRT였다(p<0.05). 여기에서 지능과 primary-SD와의 관계는 지능이 증가함에 따라 감소하다 어느 정도에서 더 이상 감소하지 않았으며, 나이와 정지신호반응시간과의 관계는 나이가 증가함에 따라 반응시간이 짧아지다가 어느 정도에서 더 이상 감소하지 않는 추세를 보였다. 정지신호과제의 판별력 검증에서 mean delay×block과 primary-RT가 가장 높은 판별력(각각 75%)을 나타냈으며 그 외 억제율(P-inhibit)은 63.89%, SSRT는 58%, ZRFT는 67%, primary-SD는 58%의 판별력을 보였다. ADDH 환아를 대상으로 과잉행동이 있는 군과 없는 군으로 나누어 수행의 정도를 비교하였다. 여기에서는 두 군 사이에 유의한 차이가 있는 변인은 없었다. 결 론 : 이러한 결과로 볼 때 정지신호과제가 국내에서 사용된다면 향후 임상에서의 ADHD의 선별검사로서 뿐만 아니라 연구에 있어서도 기여하는 바가 크다고 생각된다. Objectives and Methods : The purpose of this study was to examine availabilities of stop-signal task as a screening test for ADHD and as a research tool. Stop-signal task was applied to 40 ADHD patients and 18 normal children. Followings are the results of this study. Results : There were significant differences between ADHD group and control group in ZRFT, mean delay×block and primary-RT of stop-signal task performance(p<0.05). There was no significant difference in results of continuous performance test. SSRT of stop-signal task had significant correlation with hit reaction time of continuous performance test, and primary-RT and primary-SD with attentiveness and hit reaction time of continuous performance test. There was no significant correlation between scores of ADDES-HV and stop-signal task performance. In change of primary-SD according to intelligence, primary-SD decreased as intelligence increased but made plateau after IQ 110, and in change of SSRT according to age, SSRT decreased as intelligence increased but made plateau after 10 year-old. In discriminant ability, mean delay×block and primary-RT showed highest discriminant ability(each 75%). In addition P-inhibit showed 63.89%, SSRT showed 58%, ZRFT showed 67%, and primary-SD showed 58% in discriminant ability. There was no significant difference in stop-signal task performance between ADHD with hyperactivity and ADHD without hyperactivity. Conclusions : In this point of view, stop-signal task was proved to be useful research tool for attention deficit hyperactivity disorder as well as useful screening test tool.

외상환자에서 전신성 염증 반응 증후군 (Systemic Inflammatory Response Syndrome)의 발생과 혈청 TNF-α와의 관계

김현,이강현,임종천,조준휘,오범진,황성오 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.4

Background and purpose: The systemic inflammatory response syndrome(SIRS), as defined recently by critical-care specialists, may result from various etiologies including infection, burn, or trauma. The purpose of this study was to determine whether TNF-αis associated with the development of systemic inflammatory response syndrome caused by multiple trauma. Methods: The study population consisted of 21 patients with multiple trauma presented emergency department within 2 hours after insult were enrolled in this study. Multiple blood samples were serially drawn to measure serum TNF-αlevel on admission, 12 hours, 24 hours, and every day until 5 days after injury. Serum TNF-αwas measured by ELISA ("Sandwich type"). Blood samples of fifteen volunteers were used as a reference value for serum TNF-α. Results: Serum TNF-αlevels of SIRS group were persistently elevated above reference value until 3 days after on admission. Peak serum TNF-αlevel at 12 hours after admission was higher in SIRS group than non-SIRS group(p<0.05). There was no significant correlation between injury severity score and TNF-αlevels on regression analysis, all patients with ISS higher than 16 had SIRS. No one had SIRS among patients with ISS less than 16. Conclusion: The result of this study suggests that persistent elevation of TNF-αand degree of injury severity are associated with the development of systemic inflammatory response syndrome in multiple trauma.