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Bruna M. Lazzari,Américo Campos Filho,Paula M. Lazzari,Alexandre R. Pacheco 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.19 No.4
ANSYS is a software well accepted by professionals and academics, since it provides a variety of finite elements, material constitutive models, and linear and nonlinear analysis of structures in general. For the concrete material, for instance, the software uses an elastoplastic model with the Willam-Warnke surface of rupture (1975). However, this model is only available for finite elements that do not offer the possibility of use of the element-embedded model for rebars, demanding a much larger amount of elements to discretize structures, making numerical solutions less efficient. This study is, therefore, about the development of a computational model using the Finite Element Method via ANSYS platform for nonlinear analysis of reinforced and prestressed concrete beams under plane stress states. The most significant advantage of this implementation is the possibility of using the element-embedded rebar model in ANSYS with its 2D eight-node quadratic element PLANE183 for discretization of the concrete together with element REINF263 for discretization of rebars, stirrups, and cables, making the solutions faster and more efficient. For representation of the constitutive equations of the steel and the concrete, a proposed model was implemented with the help of the UPF customization tool (User Programmable Features) of ANSYS, where new subroutines written in FORTRAN were attached to the main program. The numerical results are compared with experimental values available in the technical literature to validate the proposed model, with satisfactory results being found.
( Bruna R. De Lima ),( Felipe M. A. Da Silva ),( Hector H. F. Koolen ),( Richardson A. De Almeida ),( Afonso D. L. De Souza ) 한국질량분석학회 2014 Mass spectrometry letters Vol.5 No.4
The Brazil nut (Bertholletia excelsa - Lecythidaceae) is considered a product with high economic value, being a food widely appreciated for its nutritional qualities. Although previous studies have reported the biochemical composition of Brazil nut oil, the knowledge regarding the phospholipid composition exhibits a disagreement: the composition of fatty acids present in the structures of phospholipids is reported as being different from the composition of the free fatty acids present in the oil. In this work, solid phase extraction (SPE) was employed to provide a fast extraction of the phospholipids from Brazil nuts, in order to compare the phospholipid profile of the in nature nuts and their fatty acids precursor present in the oil. The major phospholipids were characterized by mass spectrometry approach. Their fragmentation pattern through direct infusion electrospray ionization ion-trap tandem mass spectrometry (ESI-IT-MS2) proved to be useful to unequivocal characterization of these substances. High resolution (HR) experiments through ESI using a quadruple time of flight mass spectrometry (QTOF) system were performed to reinforce the identifications.
Emerging functions for ANKHD1 in cancer-related signaling pathways and cellular processes
Bruna Oliveira de Almeida,João Agostinho Machado-Neto 생화학분자생물학회 2020 BMB Reports Vol.53 No.8
ANKHD1 (ankyrin repeat and KH domain containing 1) is a large protein characterized by the presence of multiple ankyrin repeats and a K-homology domain. Ankyrin repeat domains consist of widely existing protein motifs in nature, they mediate protein-protein interactions and regulate fundamental biological processes, while the KH domain binds to RNA or ssDNA and is associated with transcriptional and translational regulation. In recent years, studies containing relevant information on ANKHD1 in cancer biology and its clinical relevance, as well as the increasing complexity of signaling networks in which this protein acts, have been reported. Among the signaling pathways of interest in oncology regulated by ANKHD1 are Hippo signaling, JAK/STAT, and STMN1. The scope of the present review is to survey the current knowledge and highlight future perspectives for ANKHD1 in the malignant phenotype of cancer cells, exploring biological, functional, and clinical reports of this protein in cancer.
Bruna Thaisa Martins Ferreira,Fernando Rodolfo Espinoza-Quiñones,Carlos Eduardo Borba,Aparecido Nivaldo Módenes,Washington Luiz Félix Santos,Fabricio Maestá Bezerra 한국섬유공학회 2020 Fibers and polymers Vol.21 No.6
In this work, the substitution of environmentally harmful additives in the industrial dyeing process of polyamide-6microfiber-made knitted fabrics (PA-6μFKF) was studied. Using the disperse red 60 (DR60) dye, kinetic adsorption tests onthe PA-6μFKF dyeing were performed by using either β-cyclodextrin (β-CD) additive, commercial leveling agents, orwithout additives. Equilibrium tests were also performed during 25 h. A modelling based on a dye adsorption processcontrolled by an intraparticle diffusion was proposed to represent the sets of kinetic data. Three isotherm models were alsotested for representing the equilibrium data. The kinetic data have evidenced three main dye diffusion zones. Differentadsorption mechanisms on PA-6μFKF surface dyeing was evidenced, being the data well represented by the two-stepLangmuir isotherm. Finally, the best quality on color uniformity was attained using the β-CD additive, revealing a goodalternative for the substitution of environmentally harmful additives in industrial dyeing processes.
( Bruna M. Giglio ),( Joao F. Mota ),( Benjamin T. Wall ),( Gustavo Duarte Pimentel ) 한국임상영양학회 2018 Clinical Nutrition Research Vol.7 No.2
Type 2 diabetes mellitus (DM) is commonly linked to muscle weakness and metabolic abnormalities which increase healthcare costs. The study was undertaken to investigate if low handgrip strength, as a marker of muscle weakness, is associated with hyperglycemia and/or DM in Brazilian subjects. In a cross-sectional design, 415 individuals of both sexes (46.7% male) were interviewed by a questionnaire and the DM diagnostic was self-reported. Anthropometric measurements, such as weight, height, body mass index (BMI), arm circumference, mid-arm and calf circumference and handgrip strength, were obtained by trained nutritionists. Blood glucose concentrations were determined by portable monitor analysis. Student's t-test was applied to compare DM cases with non-diabetic individuals, and logistic regression analysis was performed to verify the odds for becoming diabetic or having altered glycemia and p < 0.05 was considered as significant. From 415 subjects, 9.2% (n = 35) were classified as DM. DM patients had significantly higher age, BMI, casual glycemia and lower handgrip strength and normalized (to body weight) handgrip strength (NHS) when compared with non-diabetic patients. Individuals with low NHS have 2.7 odds ratio to DM without adjustment for covariate (crude model, p = 0.006) and have 2.7 times higher the likelihood of DM than individuals with high NHS after adjusting for age (model 1, p = 0.006); however, this association disappeared after further adjusting for sex. In conclusion, low handgrip strength normalized or not to body weight, was not associated with hyperglycemia and DM diagnosis.
An overview of the gut side of the SARS-CoV-2 infection
( Bruna Barbosa Da Luz ),( Natalia Mulinari Turin De Oliveira ),( Isabella Wzorek França Dos Santos ),( Luana Zampieron Paza ),( Lara Luisa Valerio De Mello Braga ),( Fernanda Da Silva Platner ),( Mar 대한장연구학회 2021 Intestinal Research Vol.19 No.4
In late 2019, an outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initiated in Wuhan, Hubei province, China. The major clinical symptoms described for coronavirus disease (COVID-19) include respira-tory distress and pneumonia in severe cases, and some patients may experience gastrointestinal impairments. In accordance, viral RNA or live infectious virus have been detected in feces of patients with COVID-19. Binding of SARS-CoV-2 to the angio-tensin-converting enzyme 2 (ACE2) is a vital pathway for the virus entry into human cells, including those of the respiratory mucosa, esophageal epithelium as well as the absorptive enterocytes from ileum and colon. The interaction between SARS- CoV-2 and ACE2 receptor may decrease the receptor expression and disrupt the function of B0AT1 transporter influencing the diarrhea observed in COVID-19 patients. In this context, a fecal-oral transmission route has been considered and points out a role for the digestive tract in disease transmission and severity. Here, in order to further understand the impact of COVID-19 in human physiology, the cellular and molecular mechanisms of SARS-CoV-2 infection and disease severity are discussed in the context of gastrointestinal disturbances. (Intest Res 2021;19:379-385)