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Dry Coated Particle for Plasma Spraying
Briones-Rodriguez C.,Mayagoitia-Barragan V.,Cuenca-Alvarez R 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
The preparation of composite powders for plasma spraying by an in-house designed mechanofusion process is investigated. Results show that dry particle coating depends on the chemical and mechanical properties of powders. In metal/oxide and metal/oxide/carbide powder mixtures, fine ceramic particles coat the surface of the metallic coarser particles. A nearly rounded shape of the final composite particles is induced by the mechanical energy input with no formation of new phases. However with the carbide/metal powdered system, only an intimate mixture of components is achieved. It is suggested that the coating mechanism is governed by agglomeration and rolling phenomena.
Emmanuel Iva´n Morales-Rı´os,Jazmı´n Garcı´a-Machorro,Alfredo Briones-Aranda,Raquel Go´mez-Pliego,Judith Espinosa-Raya 한국식품영양과학회 2022 Journal of medicinal food Vol.25 No.11
This study evaluated the effects of long-term intake of nutritive sweeteners (NSs) and non-nutritive sweeteners (NNSs) on body weight, food and energy intake, blood pressure, metabolic parameters, and memory retention in rats. Sixty male Sprague–Dawley rats were randomly divided into six groups (n = 10 per group): control (water),10% sucrose (SUC), aspartame (ASP), sucralose (SCA), stevia (STV), and 5% xylitol (XYL). Pure NSs (SUC and XYL) and NNSs were added to the drinking water for 18 weeks. ASP, SCA, and STV dosage was based on the estimated daily intake limit: 4.1, 2.0, and 3.4 mg/kg/day, respectively. Chronic access to NNSs did not result in any difference in total weight gain of the rats, while it was significantly elevated in the SUC group compared with the control and NNSs groups. Food intake was significantly lower in all NNSs groups compared with SUC and control groups. Sweetened beverage intake volumes were significantly diminished in all NNSs groups compared with intake in SUC and control groups. Total calories consumed were lower for the STV and XYL groups compared with all other groups. Blood pressure and glucose metabolism did not differ significantly between the groups. All sweeteners increased total cholesterol, low-density lipoprotein, and triglyceride levels. Short-term memory was significantly impaired in the ASP group in the novel object recognition task, while long-term memory was impaired in SUC and STV groups. These metabolic and behavioral results suggest that the long-term intake of NSs or NNSs can be associated with peripheral and central effects.
Phaseolus vulgaris Exerts an Inhibitory Effect on Platelet Aggregation through AKT Dependent Way
Rosio Rodriguez-Azua,Eduardo Fuentes Quinteros,Alexandra Olate-Briones,Rodrigo Moore-Carrasco 한국식품영양과학회 2018 Preventive Nutrition and Food Science Vol.23 No.2
The Phaseolus vulgaris (common bean), a worldwide vegetable of high consumption, can act as a nutritional supplement in the diet of oversized individuals to reduce weight. Studies have demonstrated the existence of molecules capable of inhibiting the breakdown of carbohydrates via inhibition of both α-amylases and glycosidases. Here, we describe a novel property of the Phaseolus vulgaris: inhibition of thrombotic cardiovascular events. Using assays to test platelet aggregation and secretion, and flow cytometry against the surface expression of P-Selectin. We show that bean extracts significantly reduced adenosine 5’-diphosphate and arachidonic acid induced-platelet aggregation. The mechanism underlying such effect appears to be mediated by AKT, since AKT hypo-phosphorylation decreases the “inside out” activation of platelets. In sum, our results support the hypothesis that common beans are nutritional ingredients that help reduce the risk of cardiovascular diseases associated with platelet hyper-reactivity.
Influence of doping on chain-like TiO2 clusters: A DFT study
M. Salazar-Villanueva,A. Bautista Hernandez,J.J. Quijano Briones,E. Chigo Anota,F. Severiano Carrillo 한국물리학회 2016 Current Applied Physics Vol.16 No.2
DFT calculations were carried out to determine the electronic and structural properties of titanium dioxide clusters either pristine or doped. In this work, a maximum size of approximately 1.5 nm for the three cases was considered. There are no drastic changes concerning the geometry for larger clusters; however there is an important reduction of electronic gap for doped clusters compared to pristine ones in all range considered. The pristine clusters enhance the visible-light photocatalytic activity, whereas those of systems doped with one nitrogen and carbon atom exhibit a spectral shift in the near-infra-red region due to the introduction of additional electronic states originating from the N and C 2p orbitals in the band gap.
Marfil-Santana Miguel David,O’Connor-Sánchez Aileen,Ramírez-Prado Jorge Humberto,De los Santos-Briones Cesar,López-Aguiar,Lluvia Korynthia,Rojas-Herrera Rafael,Lago-Lestón Asunción,Prieto-Davó Alejand 한국미생물학회 2016 The journal of microbiology Vol.54 No.11
The need for new antibiotics has sparked a search for the microbes that might potentially produce them. Current sequencing technologies allow us to explore the biotechnological potential of microbial communities in diverse environments without the need for cultivation, benefitting natural product discovery in diverse ways. A relatively recent method to search for the possible production of novel compounds includes studying the diverse genes belonging to polyketide synthase pathways (PKS), as these complex enzymes are an important source of novel therapeutics. In order to explore the biotechnological potential of the microbial community from the largest underground aquifer in the world located in the Yucatan, we used a polyphasic approach in which a simple, non-computationally intensive method was coupled with direct amplification of environmental DNA to assess the diversity and novelty of PKS type I ketosynthase (KS) domains. Our results suggest that the bioinformatic method proposed can indeed be used to assess the novelty of KS enzymes; nevertheless, this in silico study did not identify some of the KS diversity due to primer bias and stringency criteria outlined by the metagenomics pipeline. Therefore, additionally implementing a method involving the direct cloning of KS domains enhanced our results. Compared to other freshwater environments, the aquifer was characterized by considerably less diversity in relation to known ketosynthase domains; however, the metagenome included a family of KS type I domains phylogenetically related, but not identical, to those found in the curamycin pathway, as well as an outstanding number of thiolases. Over all, this first look into the microbial community found in this large Yucatan aquifer and other fresh water free living microbial communities highlights the potential of these previously overlooked environments as a source of novel natural products.
Ricardo Ernesto Ramírez-Orozco,Elena Franco Robles,Victoriano Pérez Vázquez,Joel Ramírez Emiliano,Marco Antonio Hernández Luna,Sergio López Briones 한국미생물학회 2018 The journal of microbiology Vol.56 No.9
Obesity is a chronic disease associated with different metabolic diseases as well as alterations in immune cell function. It is characterized by a chronic systemic low grade inflammation. There are several studies demonstrating the influence of obesity on the impaired immune response to infection. However, it is not completely clear whether the obese environment influences the development or maintenance of the immune response against infections. The aim of this study was to determine how obesity induced by a high-fat diet affects the immune response to an early oral Salmonella infection. Four groups of mice were kept in separate cages. Two of these designated as controls, fed with a normal diet; whereas other two groups were fed with a high fat diet for 10 weeks. Some mice were used for Salmonella oral infection. After 7 days of oral infection with S. Thypimurium the proportions of spleen cell subsets expressing activation markers in normal diet and HFD obese mice were stained with monoclonal antibodies and analyzed by flow cytometry. Also, mRNA levels of different cytokines were quantified by RT-PCR. It was found that obesity affects the function of the immune system against an early oral Salmonella infection, decreasing NK cells, altering the expression of activation molecules as well as cytokines mRNA levels. Interestingly, the expression some activation molecules on T lymphocytes was reestablished after Salmonella infection, but not the CD25 expression. Immune alterations could lead to immunosuppression or increased susceptibility to infections in HFD obese mice.
Factors Associated with Prolonged Patient-Attributable Delay in the Diagnosis of Colorectal Cancer
Irene Zarcos-Pedrinaci,Teresa Téllez,Francisco Rivas-Ruiz,María del Carmen Padilla-Ruiz,Julia Alcaide,Antonio Rueda,María Luisa Baré,María Manuela Morales Suárez-Varela,Eduardo Briones,Cristina Sarasq 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4
Purpose The delayed diagnosis of colorectal cancer (CRC) may be attributable to sociodemographic characteristics, to aspects of tumour histopathology or to the functioning of the health system. We seek to determine which of these factors most influences prolonged patient-attributable delay (PPAD) in the diagnosis and treatment of CRC. Materials and Methods A prospective, multicentre observational study was conducted in 22 Spanish hospitals. In total, 1,785 patients were recruited to the study between 2010 and 2012 and underwent elective or urgent surgery. PPAD is considered to occur when the time elapsed between a patient presenting the symptom and him/her seeking attention from the primary care physician or hospital emergency department exceeds 180 days. A bivariate analysis was performed to assess differences in variables segmented by tumour location and patient delay. Multivariate logistic regression analysis was performed on the outcome variable, PPAD. Results The rate of PPAD among this population was 12.1%. PPAD was significantly associated with altered bowel rhythm (odds ratio [OR], 1.36; 95% confidence interval [CI], 1.02 to 1.83) and with adenocarcinoma histology, in comparison with mucinous adenocarcinoma (OR, 2.03; 95% CI, 1.11 to 3.71). Other sociocultural factors and clinicopathological features were not independent predictors of PPAD. Conclusion Many patients do not consider altered bowel rhythm an alarming symptom, warranting a visit to the doctor. PPAD could be reduced by improving health education, raising awareness of CRC-related symptoms.
Mihale Matobola Joel,Tungaraza Clavery,Baeyens Willy,Brion Natacha 한국해양과학기술원 2021 Ocean science journal Vol.56 No.3
Elemental (C, N) and isotopic (δ13C, δ15N) signatures were used as proxies to identify seasonal changes in proportions of sedimentary organic matter (OM) in the Mtoni estuary and its Kizinga and Mzinga tributary rivers. Depth-averaged values of TOC and TN in the Kizinga River were low in the wet season (TOC: up to 1.0 ± 0.3%; TN: up to 0.1 ± 0.1%) compared to the dry period (TOC: up to 1.9 ± 0.2%; TN: up to 0.2 ± 0.1%), and vice versa in the Mzinga River (wet: up to 5.7 ± 2.8% for TOC and 0.3 ± 0.03% for TN; dry: up to 3.6 ± 0.7% for TOC and 0.2 ± 0.01% for TN). C/N ratios in rivers showed no clear seasonal trend. At all sampling stations, δ13C values were higher in the wet season (up to − 23.9 ± 0.8‰) and low in the dry period (up to − 26.3 ± 1.0‰) whereas δ15N values were low in the wet season (up to 6.6 ± 0.4‰) and high in the dry period (up to 8.1 ± 1.4‰). Spatial gradients of OM during the dry period were observed from upstream to the estuarine mouth for TOC and TN. FRUITS model results revealed that OM in the Mtoni estuary was dominated by anthropogenic sources in both seasons. Total contribution of mangrove, phytoplankton, and macroalgae to the Mtoni OM was relatively high in the wet season. It is concluded that the Mtoni estuary sediment OM was a mixture of different sources. The contribution of OM from phytoplankton and macroalgae was low while the contribution from mangrove OM was restricted to the Mzinga River.