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Maria Isabel Sá,nchez Jorge,Jorge Corté,s-Bretó,n Brinkmann,Aranzazu Gonzá,lez Corchó,n,Rosa Acevedo Ocañ,a 대한구강악안면외과학회 2021 대한구강악안면외과학회지 Vol.47 No.4
Hemangioma is a benign tumor characterized by the proliferation of blood vessels. Although it often appears in soft tissues, its occurrence in bone tissue, particularly the mandible, is extremely rare. A 32-year-old female sought attention at the dental clinic complaining of a painless swelling in the posterior region of the left side of the mandible. A panoramic radiograph and computed axial tomography scan were taken, showing honeycomb and sunburst images, respectively, in the affected area. The patient underwent a biopsy, which led to the diagnosis of intraosseous hemangioma. Having assessed the characteristics of the lesion, it was decided to perform complete excision including safety margins, followed by an iliac crest bone graft to reconstruct the mandible. Awareness of the possible clinical and radiographic presentations of intraosseous hemangioma is considered important, as non-diagnosis could have severe consequences given its possible relation to dental structures.
Kyoung-Nam Lee,Hyung-Sup Shin,Bret Andre,In-Chel Jeon,Ki-Choong Mah 대한시과학회 2013 대한시과학회지 Vol.15 No.2
목적: 플라즈마 표면처리가 불화규소 아크릴레이트 재질의 RGP 콘택트렌즈의 물리화학적 특성에 미치는 영향을 분석하였다. 방법: RGP 렌즈 표면의 플라즈마 처리는 공기 중 상온에서 200 W로 수행하였으며, 처리시간은 0∼250초로 다르게 하였다. 습윤성을 평가하기 위해 접촉각을 측정하였다. 표면 성분은 X-선광전자분광분석기(XPS)로 관찰하고, 플라즈마 처리에 의한 실리케이트의 형성을 분석하였다. 표면의 형상과 거칠기는 원자현미경(AFM)으로 관찰하였다. 산소침투성의 변화는 전기분해 분석법으로 얻은 렌즈의 투과 전류값과 중심두께를 측정하여 비교하였다. 결과: 플라즈마로 표면 처리되면 초기에 접촉각이 급격히 감소하였으며, 처리되지 않은 표면에 비해 30%까지 감소하였다. 표면 성분의 탄소와 불소는 70% 이하로 감소했으나, 산소와 실리콘은 150% 이상 증가하였다. 표면에서 탄소가 감소하는 형태는 접촉각의 변화와 직접적으로 관계가 있었다. 플라즈마 표면처리에 의해 표면의 탄소와 불소는 휘발하고, 유리된 실리콘이 산소와 결합하여 표면에 친수성 실리케이트(SiOx, x=1.5∼2.0)가 형성되며, 실리케이트는 50% 이상 크게 증가하였다. 플라즈마 처리된 표면에서 원형이나 직각형의 돌출부가 관찰되고, 거칠기(RMS)는 40% 이상 증가하였다. 결론: RGP 콘택트렌즈를 공기 중에서 플라즈마 처리하면 표면에 친수성인 실리케이트가 형성되어 습윤성은 개선되지만 산소침투성에는 영향을 주지 않았다. 습윤성의 증가는 표면형상의 변화보다는 실리케이트의 형성이 더 큰 영향을 준 것으로 판단되었다. 또한 플라즈마 처리에 의해 표면에 국한되어 형성된 실리케이트가 열린 구조를 갖고 있어 산소침투성에 유의한 변화가 없었던 것으로 생각된다. Purpose: To analyze the effect of plasma surface treatment on the physicochemical properties of various fluorosilicone acrylate-based rigid gas permeable (RGP) contact lenses. Methods: Plasma treatment of the RGP lens surfaces was performed at room temperature using a power of 200W. Lenses were treated for varying durations from 0∼250 seconds. In order to determine wettability of the lens surface, the contact angle was measured. Surface composition was observed using X-ray photoelectron spectroscopy(XPS), and the formation of hydrophilic silica-like structures were measured. Surface morphology and roughness were observed using atomic force microscopy(AFM). Change in oxygen permeability (Dk) was compared using polarography and center thickness measurements. Results: Following plasma surface treatment, the wetting angle decreased sharply in the initial stage and decreased up to 30% compared to untreated surfaces. The carbon and fluorine contents to below 70 at. % (atomic percent); however, oxygen and silicone contents increased to above 150 at. % on the surface. The decrease in surface carbon correlates directly with the decrease in the contact angle. Plasma surface treatments caused carbon and fluorine on the surface to become volatile. Subsequently, extricated silicon and oxygen combined at the surface to form hydrophilic silicate (SiOx, x=1.5∼2.0)-increasing the overall amount of silicate bonds by over 50 at. %. Circular or rectangular projections were observed on plasma-treated surface, and roughness (RMS) increased by over 40%. Conclusions: When RGP contact lenses were treated with plasma in the air, hydrophilic silicate was formed on the surface-improving wettability but without affecting oxygen permeability. It is considered that the increase in wettability was influenced more by the formation of silicate than by a change in surface morphology. Also, it is considered that the changes in oxygen permeability is not significant because silicate, which formed limitedly on the surface by plasma treatment, has an open structure.
One-way membrane for transdermal drug delivery systems : Ⅱ. System optimization
Yuk, Soon Hong,Lee, Seung Jin,Okano, Teruo,Berner, Bret,Kim, Sung Wan 梨花女子大學校 藥學硏究所 1992 藥學硏究論文集 Vol.- No.2
Effective flux of steroid solute through skin can be achieved by the use of ethanol as a co-solvent and penetration enhancer. To maintain constant drug release from a reservoir-type transdermal device and permeation through the skin, the composition of ethanol in the reservoir must remain constant. Ethanol permeability is much higher than that of either drug or water; any decrease in ethanol content may result in decreased drug flux. In an attempt to design a transdermal delivery device with constant ethanol enhancing activity, a model system was designed with separate ethanol reservoir, drug/solvent reservoir and receiver compartments. The ethanol and drug/solvent reservoir compartments were separated by a polydimethylsiloxane copolymer laminate membrane. This 'one-way' rate-controlling membrane(Yuk et al., Int. J. Pharm., 77(1991) 2210229) optimized ethanol flux while preventing drug and water back flux. Permeation studies with model steroid solutes in this system demonstrated consistent ethanol enhancing activity with constant solute flux across the skin.
Jack Jr., Clifford R.,Garwood, Michael,Wengenack, Thomas M.,Borowski, Bret,Curran, Geoffrey L.,Lin, Joseph,Adriany, Gregor,Grö,hn, Olli H. J.,Grimm, Roger,Poduslo, Joseph F. Wiley Subscription Services, Inc., A Wiley Company 2004 Magnetic resonance in medicine Vol.52 No.6
<P>One of the cardinal pathologic features of Alzheimer's disease (AD) is the formation of senile, or amyloid, plaques. Transgenic mice have been developed that express one or more of the genes responsible for familial AD in humans. Doubly transgenic mice develop “human-like” plaques, providing a mechanism to study amyloid plaque biology in a controlled manner. Imaging of labeled plaques has been accomplished with other modalities, but only MRI has sufficient spatial and contrast resolution to visualize individual plaques noninvasively. Methods to optimize visualization of plaques in vivo in transgenic mice at 9.4 T using a spin echo sequence based on adiabatic pulses are described. Preliminary results indicate that a spin echo acquisition more accurately reflects plaque size, while a T<SUB>2</SUB>* weighted gradient echo sequence reflects plaque iron content, not plaque size. In vivo MRI–ex vivo MRI–in vitro histologic correlations are provided. Histologically verified plaques as small as 50 μm in diameter were visualized in living animals. To our knowledge this work represents the first demonstration of noninvasive in vivo visualization of individual AD plaques without the use of a contrast agent. Magn Reson Med 52:1263–1271, 2004. © 2004 Wiley-Liss, Inc.</P>