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La créativité territoriale de l’identité visuelle à la vision d’une forme de vie
Jean-Jacques Boutaud 고려대학교 응용문화연구소 2015 에피스테메 Vol.0 No.13
Faced with intensifying attractiveness issues (economic, tourist and more broadly at the societal level) and given accelerated polarization phenomena benefiting major cities, many territories find themselves on the sidelines, with a declining economy, an aging population and, the highlight, a real deficit of the future. In this context, it is a new territorial gives possible? How can public communication help give meaning and direction to the community? What signs of change can it bring?The situation of the city of Saint-Etienne will be taken as an example, with a problematic picture, initially, despite a long industrial and human history, and undeniably creative approach to give shape and meaning to a genuine territorial project. An example of a comprehensive, structural and strategic variables that shape an identity, impel a movement, promote what could be defined as a conversion of the gaze on a city territory. We will give the city of Saint-Etienne and testimonial value paradigm, seeking to define, more generally, the main lines of research on the region's attractiveness and the emergence of what one defines sometimes as "creative metropolis". Not a public communication device that would seduction of the metaphor and little basis in reality, but a thorough examination of the potential of a territory, its ability to boost its image, as required by the change. A picture, that is to say, a certain vision of the world and, frankly, the promise of life forms that shape the territory in the imagination of all stakeholders, political, economic, cultural and citizens who chosen to live there and stay there. The semiotic approach therefore leads to demonstrate the link between the gestalt as a logo, and the form of life that proposes or prefigures a City. Face à l’intensification des problématiques d’attractivité (sur le plan économique, touristique et plus largement sur le plan sociétal) et compte-tenu des phénomènes accélérés de polarisation profitant aux principales métropoles, de nombreux territoires se retrouvent à l’écart, avec une économie en déclin, une population vieillissante et, en point d’orgue, un véritable déficit d’avenir. Dans ce cadre, une nouvelle donne territoriale est-elle possible ? Comment la communication publique peut-elle contribuer à redonner un sens et du sens à la collectivité ? Quels signes de changement peut-elle apporter ?La situation de la ville de Saint-Etienne sera prise en exemple, avec une image problématique, au départ, malgré une longue histoire industrielle et humaine, et une démarche indéniablement créative pour donner corps et sens à un véritable projet de territoire. Un exemple d’approche globale, sur les variables structurelles et stratégiques qui façonnent une identité, impulsent un mouvement, favorisent ce que l’on pourrait définir comme une conversion du regard sur une ville, un territoire. Nous donnerons à la ville de Saint-Etienne valeur testimoniale et paradigmatique, en cherchant à définir, plus globalement, les lignes de force d’une recherche sur l’attractivité du territoire et l’émergence de ce que l’on définit, parfois, comme « la métropole créative ». Non pas un artifice de communication publique qui aurait la séduction de la métaphore et peu d’ancrage dans la réalité, mais bien une réflexion de fond sur le potentiel d’un territoire, sa capacité à dynamiser son image, au besoin par le changement. Une image, c’est-à-dire une certaine vision du monde et, disons-le, la promesse de formes de vie que le territoire dessine dans l’imaginaire de tous les acteurs, politiques, économiques, culturels et des citoyens qui ont fait le choix d’y vivre et d’y rester. L’approche sémiotique conduit dès lors à manifester le lien entre la forme gestalt d’un logo et la forme de vie que propose ou préfigure une Cité.
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Figuration du goût et webdesign de la saveur, entre esthésie et esthétique
Jean-Jacques Boutaud 고려대학교 응용문화연구소 2012 에피스테메 Vol.0 No.7
Solid relationships between aesthetics and ethics are always discussed, as so are many complex ramifications between the sensible and the intelligible. The question comes to enrich a third term which is often set back from these basic polarities: the aesthesia, the world of the senses, sensations, which are intended to cooperate. Schematically, it creates a fundamental relationship among aesthesia (sensations), aesthetic (forms) and ethics (values), which governs the approach of the sensible world and directs a complex issue such as the representation taste, the taste sensation, emotion gourmet, in terms of communication. It is understood that the heart of the semiotization process of taste, served by new technologies which are defined as aesthetic, must deal with strategies of the indexical representation in connection with the aesthesia and the sensations of taste. The simplest way is to articulate the purpose of aesthesia, assuming that the logic of representation is deployed in the registered aesthetics in order to represent the flavor and the form of system with guaranteed consistency and uniformity in the figurative strategies. However, it is not able to think a possible system to articulate aesthesia, synesthesia, hyperesthesia, and anesthesia with aesthetic resources outside of food life forms ethically at this time.
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Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues
( Roman V Shchepin ),( Wei Liu ),( Huiyong Yin ),( Irene Zagol Ikapitte ),( Taneem Amin ),( Byeong Seon Jeong ),( Jackson Roberts ),( John A Oates ),( Ned A Porter ),( Olivier Boutaud ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
Acetaminophen (ApAP) is an electron donor capable of reducing radicals generated by redox cycling of hemeproteins. It acts on the prostaglandin H synthases (cyclooxygenases; COXs) to reduce the protoporphyrin radical cation in the peroxidase site of the enzyme, thus preventing the intra-molecular electron transfer that generates the Tyr385 radical required for abstraction of a hydrogen from arachidonic acid to initiate prostaglandin synthesis. Unrelated to this pharmacological action, metabolism of ApAP by CYPs yields an iminoquinone electrophile that is responsible for the hepatotoxicity, which results from high doses of the drug. We synthesized novel heterocyclic phenols predicted to be electron donors. Two of these inhibited the oxygenation of arachidonic acid by PGHS-1 and myoglobin and also were shown to be more metabolically stable and exhibited less direct cytotoxicity than acetaminophen. They are leading candidates for studies to determine whether they are free of the metabolism-based hepatotoxicity produced by acetaminophen.
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