Special Lecture : Modern Treatment of Allergic Rhinitis

( Jean Bousquet ) 대한천식 및 알레르기학회 ( 구 대한알레르기학회 ) 1988 해외문헌 Vol.8 No.2

Pollinosis in Europe

( Jean Bousquet ) 대한천식알레르기학회 1988 해외문헌 Vol.8 No.2

Aligning the Good Practice MASK With the Objectives of the European Innovation Partnership on Active and Healthy Ageing

J Bousquet,J Farrell,M Illario,ARIA-MASK study group 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.2

The reference sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) were renewed in 2019. The DG Santé good practice Mobile Airways Sentinel networK was reviewed to meet the objectives of the EIP on AHA. It included 1) Management of care process, 2) Blueprint of digital transformation, 3) EIP on AHA, innovation to market, 4) Community for monitoring and assessment framework, 5) Political, organizational, technological and financial readiness, 6) Contributing to European co-operation and transferability, 7) Delivering evidence of impact against the triple win approach, 8) Contribution to the European Digital Transformation of Health and Care and 9) scale of demonstration and deployment of innovation

Third-Harmonic Generation Microscopy for Material Characterization

Royon, Arnaud,Bousquet, Bruno,Canioni, Lionel,Treguer, Mona,Cardinal, Thierry,Fargin, Evelyne,Kim, Dae-Geun,Park, Seung-Han Optical Society of Korea 2006 Current Optics and Photonics Vol.10 No.4

Third harmonic generation microscopy is described in the frame work of the theory of harmonic generation with Gaussian focused beams inside a bulk material as well as at the vicinity of an interface. This model is then applied to characterize different types of materials in terms of electronic third-order susceptibility. Examples of bulk glasses, poled glasses, laser-induced modifications in glasses and nanoparticles in solution are given in order to give a survey of the broad application field of THG microscopy in material characterization.

Benefits of mineralized bone cortical allograft for immediate implant placement in extraction sites: an in vivo study in dogs

Orti, Valerie,Bousquet, Philippe,Tramini, Paul,Gaitan, Cesar,Mertens, Brenda,Cuisinier, Frederic Korean Academy of Periodontology 2016 Journal of Periodontal & Implant Science Vol.46 No.5

Purpose: The aim of the present study was to evaluate the effectiveness of using a mineralized bone cortical allograft (MBCA), with or without a resorbable collagenous membrane derived from bovine pericardium, on alveolar bone remodeling after immediate implant placement in a dog model. Methods: Six mongrel dogs were included. The test and control sites were randomly selected. Four biradicular premolars were extracted from the mandible. In control sites, implants without an allograft or membrane were placed immediately in the fresh extraction sockets. In the test sites, an MBCA was placed to fill the gap between the bone socket wall and implant, with or without a resorbable collagenous membrane. Specimens were collected after 1 and 3 months. The amount of residual particles and new bone quality were evaluated by histomorphometry. Results: Few residual graft particles were observed to be closely embedded in the new bone without any contact with the implant surface. The allograft combined with a resorbable collagen membrane limited the resorption of the buccal wall in height and width. The histological quality of the new bone was equivalent to that of the original bone. The MBCA improved the quality of new bone formation, with few residual particles observed at 3 months. Conclusions: The preliminary results of this animal study indicate a real benefit in obtaining new bone as well as in enhancing osseointegration due to the high resorbability of cortical allograft particles, in comparison to the results of xenografts or other biomaterials (mineralized or demineralized cancellous allografts) that have been presented in the literature. Furthermore, the use of an MBCA combined with a collagen membrane in extraction and immediate implant placement limited the extent of post-extraction resorption.

Variability and quasi-decadal changes in the methane budget over the period 2000-2012

Saunois, Marielle,Bousquet, Philippe,Poulter, Ben,Peregon, Anna,Ciais, Philippe,Canadell, Josep G.,Dlugokencky, Edward J.,Etiope, Giuseppe,Bastviken, David,Houweling, Sander,Janssens-Maenhout, Greet,T Copernicus GmbH 2017 Atmospheric Chemistry and Physics Vol.17 No.18

<P>Abstract. Following the recent Global Carbon Project (GCP) synthesis of the decadal methane (CH4) budget over 2000-2012 (Saunois et al., 2016), we analyse here the same dataset with a focus on quasi-decadal and inter-annual variability in CH4 emissions. The GCP dataset integrates results from top-down studies (exploiting atmospheric observations within an atmospheric inverse-modelling framework) and bottom-up models (including process-based models for estimating land surface emissions and atmospheric chemistry), inventories of anthropogenic emissions, and data-driven approaches. The annual global methane emissions from top-down studies, which by construction match the observed methane growth rate within their uncertainties, all show an increase in total methane emissions over the period 2000-2012, but this increase is not linear over the 13 years. Despite differences between individual studies, the mean emission anomaly of the top-down ensemble shows no significant trend in total methane emissions over the period 2000-2006, during the plateau of atmospheric methane mole fractions, and also over the period 2008-2012, during the renewed atmospheric methane increase. However, the top-down ensemble mean produces an emission shift between 2006 and 2008, leading to 22 [16-32] Tg CH4 yr−1 higher methane emissions over the period 2008-2012 compared to 2002-2006. This emission increase mostly originated from the tropics, with a smaller contribution from mid-latitudes and no significant change from boreal regions. The regional contributions remain uncertain in top-down studies. Tropical South America and South and East Asia seem to contribute the most to the emission increase in the tropics. However, these two regions have only limited atmospheric measurements and remain therefore poorly constrained. The sectorial partitioning of this emission increase between the periods 2002-2006 and 2008-2012 differs from one atmospheric inversion study to another. However, all top-down studies suggest smaller changes in fossil fuel emissions (from oil, gas, and coal industries) compared to the mean of the bottom-up inventories included in this study. This difference is partly driven by a smaller emission change in China from the top-down studies compared to the estimate in the Emission Database for Global Atmospheric Research (EDGARv4.2) inventory, which should be revised to smaller values in a near future. We apply isotopic signatures to the emission changes estimated for individual studies based on five emission sectors and find that for six individual top-down studies (out of eight) the average isotopic signature of the emission changes is not consistent with the observed change in atmospheric 13CH4. However, the partitioning in emission change derived from the ensemble mean is consistent with this isotopic constraint. At the global scale, the top-down ensemble mean suggests that the dominant contribution to the resumed atmospheric CH4 growth after 2006 comes from microbial sources (more from agriculture and waste sectors than from natural wetlands), with an uncertain but smaller contribution from fossil CH4 emissions. In addition, a decrease in biomass burning emissions (in agreement with the biomass burning emission databases) makes the balance of sources consistent with atmospheric 13CH4 observations. In most of the top-down studies included here, OH concentrations are considered constant over the years (seasonal variations but without any inter-annual variability). As a result, the methane loss (in particular through OH oxidation) varies mainly through the change in methane concentrations and not its oxidants. For these reasons, changes in the methane loss could not be properly investigated in this study, although it may play a significant role in the recent atmospheric methane changes as briefly discussed at the end of the paper. </P>

Benefits of mineralized bone cortical allograft for immediate implant placement in extraction sites: an in vivo study in dogs

Valérie Orti,Philippe Bousquet,Paul Tramini,Cesar Gaitan,Brenda Mertens,Frédéric Cuisinier 대한치주과학회 2016 Journal of Periodontal & Implant Science Vol.46 No.5

Purpose: The aim of the present study was to evaluate the effectiveness of using a mineralized bone cortical allograft (MBCA), with or without a resorbable collagenous membrane derived from bovine pericardium, on alveolar bone remodeling after immediate implant placement in a dog model. Methods: Six mongrel dogs were included. The test and control sites were randomly selected. Four biradicular premolars were extracted from the mandible. In control sites, implants without an allograft or membrane were placed immediately in the fresh extraction sockets. In the test sites, an MBCA was placed to fill the gap between the bone socket wall and implant, with or without a resorbable collagenous membrane. Specimens were collected after 1 and 3 months. The amount of residual particles and new bone quality were evaluated by histomorphometry. Results: Few residual graft particles were observed to be closely embedded in the new bone without any contact with the implant surface. The allograft combined with a resorbable collagen membrane limited the resorption of the buccal wall in height and width. The histological quality of the new bone was equivalent to that of the original bone. The MBCA improved the quality of new bone formation, with few residual particles observed at 3 months. Conclusions: The preliminary results of this animal study indicate a real benefit in obtaining new bone as well as in enhancing osseointegration due to the high resorbability of cortical allograft particles, in comparison to the results of xenografts or other biomaterials (mineralized or demineralized cancellous allografts) that have been presented in the literature. Furthermore, the use of an MBCA combined with a collagen membrane in extraction and immediate implant placement limited the extent of post-extraction resorption.

알레르기 비염과 알레르기 비염이 천식에 미치는 영향(ARIA) 2008 한국의 관점

김유영,( Nikolai Khaltaev ),( Jean Bousquet ) 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.4

Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines—2016 revision

Broż,ek, Jan L.,Bousquet, Jean,Agache, Ioana,Agarwal, Arnav,Bachert, Claus,Bosnic-Anticevich, Sinthia,Brignardello-Petersen, Romina,Canonica, G. Walter,Casale, Thomas,Chavannes, Niels H.,Correia Elsevier 2017 The journal of allergy and clinical immunology Vol.140 No.4

<P><B>Background</B></P> <P>Allergic rhinitis (AR) affects 10% to 40% of the population. It reduces quality of life and school and work performance and is a frequent reason for office visits in general practice. Medical costs are large, but avoidable costs associated with lost work productivity are even larger than those incurred by asthma. New evidence has accumulated since the last revision of the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines in 2010, prompting its update.</P> <P><B>Objective</B></P> <P>We sought to provide a targeted update of the ARIA guidelines.</P> <P><B>Methods</B></P> <P>The ARIA guideline panel identified new clinical questions and selected questions requiring an update. We performed systematic reviews of health effects and the evidence about patients' values and preferences and resource requirements (up to June 2016). We followed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) evidence-to-decision frameworks to develop recommendations.</P> <P><B>Results</B></P> <P>The 2016 revision of the ARIA guidelines provides both updated and new recommendations about the pharmacologic treatment of AR. Specifically, it addresses the relative merits of using oral H<SUB>1</SUB>-antihistamines, intranasal H<SUB>1</SUB>-antihistamines, intranasal corticosteroids, and leukotriene receptor antagonists either alone or in combination. The ARIA guideline panel provides specific recommendations for the choice of treatment and the rationale for the choice and discusses specific considerations that clinicians and patients might want to review to choose the management most appropriate for an individual patient.</P> <P><B>Conclusions</B></P> <P>Appropriate treatment of AR might improve patients' quality of life and school and work productivity. ARIA recommendations support patients, their caregivers, and health care providers in choosing the optimal treatment.</P>

Improving Reusability of Hazard Analysis Model with Hazard Template for Deriving Safety Properties of Home Network System

Ben Yan,Ken-ichi Matsumoto,Masahide Nakamura,Lydie du Bousquet 보안공학연구지원센터 2009 International Journal of Smart Home Vol.3 No.2

The recent ubiquitous/pervasive technologies allow general household appliances to be connected within the network at home. The home network system (HNS, for short) is comprised of such networked appliances to provide various services and applications for home users. The great advantage of HNS lies in integrating (or orchestrating) features of multiple appliances, which yields more value-added and powerful services. We call such services HNS integrated services. In developing and providing a HNS integrated service, the service provider must guarantee that the service is safe for inhabitants, house properties and their surrounding environment. As for the HNS integrated services, however, we have to consider the safety much more carefully. This paper presents a systematic method that can derive the verifiable safety properties from a given HNS model and hazard contexts. Specifically, we propose the HNS Hazard Analysis Model (HNS-HAM) for deriving safety properties with conducting a goal-oriented analysis. The analysis yields cause-and-effect chains from the abstract hazard contexts to the concrete attributes and operations of HNS objects (appliances, services, and environment). Then the safety properties and their responsible operations are derived from the complete model, which give the strong rationale of the safety of the HNS. On the other hand, to make the proposed method more practical, it is necessary to save the analysis cost while appliances and services in the HNS are added or changed. For this, we have also proposed the notion of the hazard template, which characterizes the generic portion of the HNS-HAM. For every hazard context, the hazard template is supposed to be constructed once by the safety experts. The template can be reused for various kinds of the HNS objects for the common hazard context. The reusable templates make it possible to save the analysis cost and improve the quality of the HNS-HAM.