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Boqin Liu 보안공학연구지원센터 2015 International Journal of Database Theory and Appli Vol.8 No.5
Recent years, data mining has become a very popular concept in computer science. Its application has covered many crucial subjects. However, the systemic research based on relevant techniques in the field of chemistry is still non-existent. Here, we present a future possibility of the osmosis of data mining to chemistry under the circumstance of the age of big data, using artificial neural network (ANN) models as a crucial example. By presenting its applications in different research areas, this paper gives a comprehensive understanding to the ANN and its potential to dominate the chemical data mining area.
Study of the Effectiveness of the RVEs for Random Short Fiber Reinforced Elastomer Composites
Lili Chen,Boqin Gu,Jianfeng Zhou,Jiahui Tao 한국섬유공학회 2019 Fibers and polymers Vol.20 No.7
The effectiveness of the representative volume elements (RVEs) established by a modified random sequentialadsorption method for random short fiber reinforced elastomer composites (SFECs) was studied. The RVE is considered tobe effective when the RVE’s fiber orientation is isotropic. And the effectiveness of the RVEs was verified by evaluating themechanical properties in different loading directions based on the finite element method. The results show that the fibernumber N=4000 can be regarded as a steady threshold for the isotropy of the fiber orientation in RVEs with various fiberaspect ratios and dilute volume fraction.
Fatigue Behavior of Aramid Fiber Reinforced Rubber Matrix Sealing Composites
Xiaoming Yu,Bin Zhang,Boqin Gu 한국섬유공학회 2021 Fibers and polymers Vol.22 No.4
This paper presents an experimental and theoretical study of aramid fiber reinforced rubber sealing composites(AFRC). The fatigue performance of AFRC with different stress amplitudes and fiber mass fractions was tested, and theresidual strength of AFRC after different fatigue cycles was conducted. The fracture morphology of AFRC samples withdifferent fiber mass fractions, stress amplitudes and fatigue cycles were observed by scanning electron microscope (SEM),and the fatigue damage modes of AFRC were discussed. The experimental results were analyzed and predicted by fatigue lifemodel, residual stiffness model and residual strength model. It was found that the results predicted by theoretical modelagreed well with that measured by experimental results, which indicated that the proposed model gave an advantage inevaluating the fatigue behavior of AFRC without further morphological experiments.
Creep and Stress Relaxation Performance of Rubber Matrix Sealing Composites after Fatigue Loading
Xiaoming Yu,Bin Zhang,Boqin Gu 한국섬유공학회 2022 Fibers and polymers Vol.23 No.2
The most common working condition in the static seal connection system is load fluctuation. The failuremechanism of sealing material caused by load fluctuation is more complicated than that under static load. This work developsan experimental method to research mechanical property of short fiber reinforced rubber matrix sealing composites (SFRC). The damage behavior of creep and stress relaxation after different fatigue cycles is obtained. The microscopic defects areobserved and analyzed by scanning electron microscope (SEM). The effects of different fatigue cycles on the damage ofmaterials are found, and the damage modes of SFRC are determined. Based on macroscopic phenomena and microscopicmechanism, the parameters of new creep and stress relaxation models of SFRC after different fatigue cycles are determined,respectively. It can be found that the phenomenological model can well characterize fatigue behavior of SFRC.
ShcD interacts with TrkB via its PTB and SH2 domains and regulates BDNF-induced MAPK activation
( Yuangang You ),( Weiqi Li ),( Yanhua Gong ),( Bin Yin ),( Boqin Qiang ),( Jiangang Yuan ),( Xiaozhong Peng ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2010 BMB Reports Vol.43 No.7
Neurotrophins regulate many aspects of neuronal function through activation of the high affinity Trk receptors. Shc family proteins are implicated in the coupling of RTK to the Ras/mitogen- activated protein kinase signaling cascade. Here we report that the fourth Shc family member, ShcD, associates with TrkB receptor and regulates BDNF-induced MAPK activation. Yeast two-hybrid assay and Co-IP experiments demonstrate ShcD interacts with TrkB in a kinase-activity-dependent manner. Confocal analysis shows ShcD cololizes well with TrkB in transfected 293T cells. Subsequent mapping experiments and mutational analysis indicate that both PTB and SH2 domains are capable of binding to TrkB and PTB domain binds to TrkB NPQY motif. Furthermore, ShcD is involved in BDNF-induced MAPK activation. In summary, we demonstrate that ShcD is a substrate of TrkB and mediates TrkB downstream signaling pathway. [BMB reports 2010; 43(7): 485-490]
Wu, Jing,Tan, Xinyu,Peng, Xiaozhong,Yuan, Jiangang,Qiang, Boqin Korean Society for Biochemistry and Molecular Biol 2003 Journal of biochemistry and molecular biology Vol.36 No.4
For better understanding of functions of the Calcyclin Binding Protein (CacyBP) and exploring its possible roles in neuronal differentiation, the subcellular localization of human CacyBP was examined in retinoic acid(RA)-induced and uninduced neuroblastoma SH-SY5Y cells. Immunostaining indicated that CacyBP was present in the cytoplasm of uninduced SH-SY5Y cells, in which the resting $Ca^{2+}$ concentration was relatively lower than that of RA-induced cells. After the RA induction, immunostaining was seen in both the nucleus and cytoplasm. In the RA-induced differentiated SH-SY5Y cells, CacyBP was phosphorylated on serine residue(s), while it existed in a dephosphorylated form in normal (uninduced) cells. Thus, the phosphorylation of CacyBP occurs when it is translocated to the nuclear region. The translocation of CacyBP during the RA-induced differentiation of SH-SY5Y cells suggested that this protein might play a role in neuronal differentiation.