H₂O₂에 의한 Tight Junction Protein Occludin의 변화

정봉수 외 중앙대학교 의과대학 의학연구소 2006 中央醫大誌 Vol.31 No.1·2·3

Cerebral microvessel endothelial cells that form blood-brain barrier (BBB) have tight junction for maintaining brain homeostasis. Occludin, one of tight junction proteins, is crucial for BBB function. H₂O₂-induced occludin changes and its effects on bovine brain BBB endothelial cells were examined in this study. The decrease of transelectrical endothelial resistance (TEER) by H₂O₂ was due to occludin redistribution. Occludin disappeared in a dose dependent manner from intercellular junction in immunofluorescent study. But the total amounts of occludin and cell membrane bound occludin did not changed by H₂O₂. These showed that the loss of function of BBB was not due to the decrease of occludin or the internalization of occludin into cytoplasm. Occludin was limited within cell membrane of endothelial cell and H₂O₂ caused the redistribution of occludin within cell membrane. These data strongly suggest that H₂O₂-mediated loss of BBB function involves the loss of tight junction integrity through occludin redistribution.

동공을 침범한 당뇨병성 동안신경 마비

문지수,김민정,김종국,유봉구 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1

Oculomotor nerve palsy of acute onset with sparing of the pupil in older age is frequently associated with diabetes mellitus. A 73-year-old diabetic woman was admitted because of vertical diplopia and gait disturbance. Neurological examination showed that the left eye had decreased light reflex, dilated pupil, and limited adduction, supraduction and infraduction. Brain MRI and MRA were unremarkable. Two months after onset, movement, pupil size and light reflex of the patient's eyes were normal on examination. It is emphasized that the diabetic ophthalmoplegia can involve the pupil. We report a rare case of diabetic oculomotor nerve palsy with pupil involvement.

진행성 폐 종양 환자에서 종양 내 OK-432 주입술의 효과

정수현,김성빈,박진희,탁희상,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background: Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. We adopted this technique for treating locally advanced lung cancer. The object of this study is to evaluate the local therapeutic efficacy, side effects of injection for treating symptomatic mass. Methods: Twenty lung cancer patients (13 males and 7 females) underwent sonography guided OK-432 injection. We analyzed relationships between response of OK-432 and response of skin test, histology and age. Pain that patients feel was evaluated by VAS (Visual Analog scale). Results: A significant decrease of tumor size was observed. The mean pre-injection diameter of the lesions was 54.7±11.3mm, PR rate were 15.0% (3/20) and minimal change (50%<tumor size decreased.) patients were 35.0% (7/20). The VAS score before injecting OK-432 into the lesion was 5±3, this was decreased to 2.5±1.5 (p=0.04). Object response was significantly correlated with skin response, adenocarcinoma, and age. Conclusion: A significant decrease of tumor size and pain was observed. So OK-432 is a valuable treatment option for patients with symptomatic lesion from advanced lung cancer who are not amenable to further therapy.

뇌경색후 우울증에서 Homocysteine, Vitamin B12 및 Folate 혈청 농도와 관계

문지수,김광수,유봉구,김종국,김민정 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1

Background and purpose : Poststroke depression is common and linked to poor prognosis and higher mortality after stroke. Previous studies suggest that high level of serum homocysteine and low levels of vitamin B12 and folate may cause depression. However previous studies has showed large variation concerning the influencing factors of poststroke depression. The purpose of this study was to evaluated the factor that influencing the poststroke depression including serum levels of homocysteine, vitamin B12 and folate. Methods : Beck depression inventory (BDI) was obtained in 62 patients with cerebral infarction, and the patients were divided into non-depression group (BDI ≤ 13) and depression group (BDI ? 14) according to their BDI scores. Then, we compared serum homocysteine, vitamin B12, folate, age, sex, Barthel index, Scandinavian stroke scale, acute aphasia screening protocol, Korean version of mini-mental state examination and ischemic brain lesion between NDG and DG. And also calculate the correlations between serum homocysteine, vitamin B12 and folate with severity of poststroke depression. Results : The NDG were 41 patients (66.1%) and DG were 21 patients (33.9%). Serum homocysteine, vitamine B12 and folate were not different between the groups, and these levels were not correlated with the severity of BDI. The age, sex, BI, SSS, AASP, K-MMSE and location of ischemic stroke were not different between the groups. Conclusion : Frequency of poststroke depression were high in patients with acute ischemic stroke. In contrast with previous studies, poststroke depression was not influenced by the serum levels of homocysteine, vitamin B12 and folate. And poststroke depression was not influenced by age, sex, physical handicap after stroke, aphasia, cognitive function and location of ischemic stroke.

뇌성마비 환아의 발달 평가와 유발 전위, 뇌파,뇌 자기 공명 영상의 비교연구

서정수,김태민,채진목,김영경,김봉옥 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.4

流砂運動과 流砂量算定에 關한 硏究

鄭鳳守 진주산업대학교 1983 論文集 Vol.21 No.-

This study culculated a condition for sediment distribution and sedimentation this experment practiced for aquiring correlation in the lower Nam River, Jin yang gun, Jin Sung meon, Ha country, and then obtain a result as follows. 1. Suspention sediment spread and downstream in the total groups as a most of clay materials without the depth of water. 2. The result which required correlation of the amount of flowing and suspension sediment obtained Q_s=0.04524Q as follows. 3. A rate of suspension sediment and tractive sediment on the total of the mount of flowing was to be of almost suspension sediment 99:1. 4. Because of lacking time, materials, instrument and so, it was considered that did not obtain an accurated results, and continue to survey and wish to obtain each kind materials.

窒素施肥量 및 菌株가 稻葉部位에 따른 稻熱病의 稻原力과 病斑型에 미치는 影響

白壽鳳 건국대학교 1980 學術誌 Vol.24 No.2

The effect of nitrogen and Pyricularia oryzae strains on disease index and lesion type of leaf blade at different positions and leaf parts in paddy field was examined and the results were as follows 1)The disease index of the upper 1st leaf to 3rd leaf at 2 times of nitrogen was not different from that of the standard nitrogen. The disease index of the upper 4th leaf at 2 times of nitrogen was higher than that of the standard nitrogen and lesion type was brown spot type, chronicity type and acute type. 2)The disease index of the upper part at the standard nitrogen was higher than that of the lower part. The disease index of the middle part at the 2 times nitrogen was highest and that of the lower part was lowest. In the standard nitrogen the upper part showed chronicity type and acute type and the lower part showed few spots of both type. In 2 times nitrogen chronicity type was appeared at the upper and the lower part but few at the middle part, and acute type was appeared at the middle part, but few at the lower part. 3)The disease index of Pyricularia oryzae strains was in order of the first, second, third and fourth leaf from highest to lowest. This tendency was shown only in acute type not in brown spot type and chronicity type. 4)The disease index and lesion type of blade leaf of Pyricularia oryzae strains did not have consistent along the leaf position.

朝鮮時代 地方行政區域의 整備에 관한 硏究 : 州·府·郡·縣을 中心으로

崔鳳秀 단국대학교 정책과학연구소 1993 정책과학연구 Vol.5 No.-

How can we fitly readjust the local government areas and reasonably establish the tier system to maximize the administrative efficiencies in democratic local bodies? This is one of the issues to which we are faced today. It is necessary, to solve the problems, for us to review the historical and traditional backgrounds of the existing local government area as well as to find new administrative techniques. For almost of the existing local government areas originated from those of the Chosun dynasty, the careful study of the formation and management of the local administration system of Chosun dynasty give us the possibility to measure the importance of the problems to which we are faced and to determine the way how we effectively solve them. This paper, however, is focused on the limited perspectives in local administration of Chosun dynasty (1) the purposes and the process of the adjustment of local administration areas and their suborganizations. (2) the structures of local administration bodies and the problems appeared in their operations. The conclusion of the study could be summarized as follow ; Chosun had the highly centralized bureaucratic political system based on the confucian ideology. The political power was centred on the king, who exercised his power through the Yangban bureaucrats. The local administration system therefore, was set up to protect the interest of the king and yangban class. Especially the chu. Bu·Kun·Hyun areas which are now the bases of local government bodies, were demarcated for the purpose of strengthening the power of the king and the Sooryung, the head executive and King's delegate in the Chu·Bu·Kun and extending the efficiencies of central control. This is the reason why the existing local government areas are inadequately larger than those of foreign democratic countries. And we, therfore, have to reorganize the existing local government areas adequately in order to practice the local self governing system.

경력개발활동 유형이 성과에 미치는 영향

김경수,최광신,김봉광 全南大學校 企業經營硏究所 1997 産業經濟硏究 Vol.21 No.1

초록 본 연구의 목적은 조직 뿐만 아니라 개인 종업원들이 경력개발에 대한 책임을 느끼고 노력 을 하는 것이 그렇지 않을 때보다 효과적인지를 검증하는데 있다. 이를 위하여 길레이 (Gilley)가 주장한 경력개발활동을 기초로 개인개발활동과 조직의 경력개발활동의 시행여부, 활용정도, 파급효과 등에 대해 종업원이 지각하는 형태에 따라 경력개발유형을 부진 미흡형, 개별 분리형, 상호 보완형으로 분류하였으며, 이들 유형이 조직몰입과 이직의도, 주관적인 성과 등에 달리 영향을 미칠 것으로 보았다. 즉, 개인의 경력개발활동과 조직의 지원활동이 활발한 상호보완형의 경우 조직몰입도나 성과가 높게 나타날 것이고, 이직의도는 낮게 나타날 것이며, 이와 반대로 개인의 경력개발활동도 부진하고 조직의 지원활동도 미흡한 부진미 흡형의 경우 조직몰입과 성과는 낮게 나타날 것이고, 이직의도는 높게 나타날 것이란 가설 을 설정하였다. 12개의 금융회사의 직원들로부터 수집한 자료를 분석한 결과 경력개발활동 유형중 상호보완형에 속한 직원들은 높은 조직몰입과 주관적인 성과를 보였으며, 이직의도 는 낮은 것으로 나타났다. 반대로 부진미흡형에 속한 직원들은 낮은 조직몰입과 주관적인 성과를 보였으며, 높은 이직의도를 가지는 것으로 나타났다. 또한 개별분리형에 속한 직원들 은 중간 정도의 조직몰입과 성과를 보였으며, 이직의도 역시 중간 정도로 나타났다. 이러한 결과 결론부분에서 개인과 조직목표의 조화측면에서 논의되었다. <Abstract> The purpose of this study is to investigate the effects of Career Development Activites(CDA), which improves QWL and expedites the attainment of organizatonal goal, on performance. To accomplish this purpose, we classified CDA types into three dimentions(stagnation type, separation type, integration type) according to the employees perception regarding personal and organizational activities and analyzed the effects of CDA on performance such as organizational commitment, subjective outcome, and turnover intention. The results from 12 financial company showed that1) with regard to the level of organizational commitment and subjective outcome, employees in the separation type among CDA significantly and lowly differd from those in the stagnation type, 2) as for the level of turnover intention, employees in the separation type significantly and highly differed from thise in the integration type and significantly and lowly differed from those in the stagnation type. These results were discussed in terms of the fit between person and organizational goals.

廢棄物의 好氣性 堆肥化에 관한 硏究

鄭鳳守,黃光性 진주산업대학교 2000 산업과학기술연구소보 Vol.- No.7

This paper has compared experimenta1 values with the theoretical values of composting model to examine the possibility of putting the theoretical calues to actual use in the aerobic composting of the sewage sludge and hog manure. The results of the experiments are as follows : 1. In the ranges of 54∼60 % of moisture content of initial material, 7.3∼7.6 of pH, 27.3∼29.7 of C/N ratio and 0.35~0.37 gr / ㎤ of bulk weight, the experimental values of the periodical changes of moisture content, fermantation temperature and organic matter were approximately identical with the theoretical values of those. So those ranges were considered to be the optimum ranges. And it can be concluded that it is possible to plan an aerobic composting accdording to the theoretical formula. 2. When the ventilation volume was larger than 0.22 ㎥/hr·㎏, the evaporation loss of moisture content was great. When the ventilation volume was 0.0028 ㎥/hr·㎏, the anaerobic condition appeared. Thus we can judge the optimum range of venti1ation volume to be 0.02 - 0.06 ㎥/hr·㎏. 3. The CO^2 generation showed its maximum point of 0.85 mmole/day. g (VM) per organic matter between the temperature range of 58~66℃.