S-580 : Vitamin D and carotid subclinical atherosclerosis in SLE

( Chang Bum Bae ),( Ju Yang Jung ),( Bo Ram Go ),( Hyun Ah Kim ),( Chang Hee Suh ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Vitamin D and carotid subclinical atherosclerosis in SLE Chang-Bum Bae, Ju-Yang Jung, Bo-ram Go, Hyun-Ah Kim, Chang-Hee Suh Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea Introduction Atherosclerosis develops earlier in systemic lupus erythematosus (SLE) and is the important cause of mortality. It has been suggested that vitamin D deficiency contributed cardiovascular disease and immune dysregulation in SLE. Methods One-hundred two female patients with SLE and 52 normal controls (NC) were recruited. The carotid artery intima-media thickness (cIMT) and plague were assessed by B-mode ultrasound at the carotid artery level. Vitamin 25(OH)D3 levels were checked by immunoradiometric assay using the Bio-Line 25(OH)D3-Ria CT kit (Bio-Line S.A., Belgium). Disease activity markers were checked at the time of enrollment. Results The cIMT of SLE is 0.41±0.08mm, which is higher than NC (0.37±0.11 mm, p=0.012). Also, carotid artery plague index (PI) of SLE is higher than NC (0.68±1.39 vs 0.26±0.87, p=0.026). The cIMT was correlated with age (r=0.442, p<0.001), body mass index (r=0.246, p=0.013), waist-hip ratio (r=0.245, p=0.013), SLE disease activity index (r=0.239, p=0.016), taking aspirin (r=0.244, p=0.013), and the carotid artery PI was correlated with renal involvement (r=0.224, p=0.023) in patients with SLE. Vitamin 25(OH)D3 was not showed correlation with cIMT and carotid artery PI. Also, it was not correlated with disease activity markers. Conclusion In patients with SLE, the risk of cardiovascular disease measured by cIMT and carotid artery plaque was higher than NC, which may be derived from systemic inflammation. However, vitamin D levels were not showed significant correlations with carotid subclinical atherosclerosis. It may be not suitable to assess vitamin D as marker of disease activity or subclinical atherosclerosis.

정신분열병 환자에서 Risperidone에 의한 Cytokine의 변화

김대진,김원,윤수정,고효진,최보문,전태연 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4

기존의 항정신병약뮬인 haloperidol이나 clozapine과는 약물학적 특성이 다른 대표적인 약물인 risperidone을 사용하여 정신분열병 환자가 치료 전과 4주 치료 후에 어떤 면역학적 차이를 보이는지 6가지 cytokine의 혈장 농도를 측정하여 알아보았다. 방법: 1999년 2월부터 1999년 5월까지 카톨릭대학교 대전성모병원 정신과에 입원한 환자 중 DSM-IV 진단 기준에 의해 정신분열병으로 진단된 환자 25명을 대상으로 하였다. 입원 다음날 아침 8시 risperidone 투여전의 기본적인 cytokine농도를 측정하기 위해 혈액을 채취하였으며 제 2병일에 risperidone 2mg, 제 4병일에 4mg, 제 6병일에 6mg으로 증량하는 방식을 항정신병약물 치료를 하였다. 임상평가는 risperidone 투여 전과 투여 4주 후 정신과 전공의가 각각 PANSS 검사를 시행하였다. 혈장에서 IL-1β,IL-2, IL-6, IL-12, INF-□, TNF-α의 정량 측정은 ELISA kit (Endogen Inc., Woburn, MA, USA)을 사용하여 quantitative ELISA법으로 하였다. 결과: risperidone을 4주간 투여 후 환자 혈장 IL-12 농도가 유의하게 증가되었고 나머지 cytokine 농도는 유의한 변화가 없었다. 결론: 저자들은 연구에서 risperidone 치료 후 IL-12가 증가된 것은 이러한 항정신병약물치료가 면역반응 을 활성화시키는 역할을 한 것으로 시사된다. Objectives: This study was carried out to evaluate immunologic difference between baseline and after 4 weeks drug treatment with atypical antipsychotics(rispreidone) by measurement of serum concentration of 6 cytokines. Methods: The subjets were composed of 25 patients who are admitted at Dajeon St's Marys hospital of psychiatry department and diagnosed as schizophrenia by DSM-IV diagnositc criteria. We measured serum IL-1β, IL-2, IL-6, IL-12, INF-□, TNF-α concenatrations by quantitative ELISA method using ELISA kit(Endogen In., Woburn, MA, USA). The two psyciatrists per-formed PANSS examination between baseline and after 4 weeks risperidone treatments. Results: The serum level of IL-12 was increased significantly after medication of 4 weeks and the serum concentration of IFN-□ showed the tendency of decreasement but not significant. The serum level of the other cytokines showed no significant change. Conclusion: We spectulate that the increasement of IL-12 may contribute to role of activa-tion of immune response by treatment of antipsychotic medication(risperidone). This study is first trial of IL-12 study in neuropsychiatric field and IL-12 which play impor-tant role of immune response becomes interesting subjects in immune research.

Risperidone 조기 중단군 및 장기 유지군의 임상적 특성 비교

김광수,박원명,전태연,배치운,김대진,백인호,이철,김정수,한상익,최보문,장계호,고효진 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

연구목적 : Risperidone 투여후 조기 중단한 환자들과 장기적으로 계속 risperidone을 복용하고 있는 환자의 임상적 특성을 평가하고 나아가 risperidone장기 유지와 조기 중단의 요인을 분석하고 정신병리가 약물 투여에 미치는 영향을 조사하고자 하였다. 방 법 : 연구 대상자는 1996년 1월부터 1996년 12월까지 가톨릭대학교 의과대학 부속 8개 병원 정신과에서 risperidone을 투여 시작한 환자 580명중 DSM-IV기준에 의해 정신분열병으로 진단받고 투여 기간이 6개월 미만(조기 중단군)이거나 2년 이상(장기 유지군)을 경과하였으며 의무기록의 누락이 없는 210명을 선정하였다. 두 군간 임상적 특성을 조사하기 위하여 인구학적 변인, 정신병리학적 변인, 약물 투여기록 및 부작용 등을 과거 의무기록을 근거로 평가하였다. 결 과 : 대상환자 210명 중 조기 중단군이 67명(31.9%)이었고 장기 유지군은 143명(68.1%)이었으며 두 군간 인구학적 변인과 정신병리학적 변인에 따른 특징에는 두 군간 차이가 없었다. 두 군간 risperidone의 시작 용량과 변인과 정신병리학적 변인에 따른 특징에는 두 군간 차이가 없었다. 두 군간 risperidone의 시작 용량과 최대 용량은 유의한 차이가 없었으나 유지용량은 조기 중단군에서 4.49(±1.44)mg,장기 유지군에서 3.67(±1.50)mg으로 유의한 차이가 있었다(t=3.698, p<0.05). 또한, 이전 항정신병약물의 사용 기왕력 변인에서 조기 중단군은 기왕력이 없는 환자가 39명(58.2%), 고역가 항정신병약물을 사용한 기왕력이 있는 환자는 27명(40.3%), 저역가 항정신병약물을 사용한 기왕력이 있는 환자는 1명(1.5%)이었고, 장기 유지군은 기왕력이 없는 환자가 58명(40.6%), 고역가 항정신병약물을 사용한 기왕력이 있는 환자는 77명(53.8%), 저역가 항정신병약물을 사용한 기왕력이 있는 환자는 8명(5.6%)으로 유의한 차이가 있었다.(x²=6.559, df-=2, p<0.05). 결 론 : 본 연구결과에 의하면 가급적 환자 상태에 따라 낮은 최적 치료 용량을 투여하는 것이 장기잔의 투여를 바람직한 것으로 생각된다. 본 연구와 같은 대규모의 후향적 자연적 연구는 일반 실제 진료에서 risperidone의 효과 및 기타 다른 측면에서의 유용한 정보를 얻을 것으로 기대된다. Objective : This retrospective naturalistic study was designed to compare the clinical characteristics including psychopathology of two groups of patients, long-term maintenance group and short-term drop-out group, who were taking risperidone. Method : Datas were collected for 210 schizophrenic patients with complete medical records among 580 patients who were enrolled with risperidone administration from January 1996 to December 1996 in 8 affiliated hospital of the Catholic University. The short-term drop-out patients group were assigned to whom treatment period was less than 6 month, and the long-term maintained patients group, treatment period was more than 2 years. We assessed demographics, psychopathology, and other variables related with medication based on past medical records. Results : Among subjects of 210, short-term drop-out patients group were 67(31.9%) and long-term maintained patients group were 143(68.1%). Demographics and psychopathology were not significantly different between two groups. The stating and maximal dosage of risperidone was not significantly different between two groups but the maintenance dosage of risperidone was lower in long-term medicated patients group than short-term drop-out patients group(t=3.698, p<0.05). Additionally, the result of this study showed differences in experiences of past antipsychotic use as following. The number of no previous use of antipsychotic was 39(58.2%), the number of high potency amtipsychotic use was 27(40.3%), and the number of no previous use of antipsychotic was 58(40.6%), the number of high potency ntipsychotic use was 77(53.8%), the number of low potency antipsychotic use was8(5.6%) in long-term maintained group.(x²=6.559, df-=2, p<0.05). Conclusions : According to these results, administration of low therapeutic dosage should be recommended for long-term maintenance as if possible. Multi-center based retrospective naturalistic study like this would be useful for getting informations about efficacy and some other aspects of antipsychotic administration in practial field.

Antioxidant activity of Various Solvent Extract from Stone Cell of Pear Pomace

Bo Yeon Shin,Bo Ram Jung,Jong Go Jung,Mi-Ae Bang 한국식품영양과학회 2015 한국식품영양과학회 학술대회발표집 Vol.2015 No.8

Nutritive Components and Dietary Fiber Content of Stone Cell Resources Extracted from Pear Pomace

Bo Ram Jung,Bo Yeon Shin,Jong Go Jung,Mi-Ae Bang 한국식품영양과학회 2015 한국식품영양과학회 학술대회발표집 Vol.2015 No.8

Can Suboccipital Release Followed by Cranio-Cervical Flexion Exercise Improve Shoulder Range of Motion, Pain, and Muscle Activity of Scapular Upward Rotators in Subjects With Forward Head Posture?

Bo-been Kim,Ji-hyun Lee,Hyo-jung Jeong,Heon-seock Cynn 한국전문물리치료학회 2016 한국전문물리치료학회지 Vol.23 No.2

Background: For the treatment of forward head posture (FHP) and forward shoulder posture, methods for strengthening scapular retractors and deep cervical flexors and stretching pectoralis and upper cervical extensors are generally used. No study has yet assessed whether suboccipital release (SR) followed by cranio-cervical flexion exercise (CCFE) (SR-CCFE) will result in a positive change in the shoulders and neck, showing a “downstream” effect. Objects: The purpose of this study was to investigate the immediate effects of SR-CCFE on craniovertebral angle (CVA), shoulder abduction range of motion (ROM), shoulder pain, and muscle activities of upper trapezius (UT), lower trapezius (LT), and serratus anterior (SA) and LT/UT and SA/UT muscle activity ratios during maximal shoulder abduction in subjects with FHP. Methods: In total, 19 subjects (7 males, 12 females) with FHP were recruited. The subject performed the fifth phase of CCFE immediately after receiving SR. CVA, shoulder abduction ROM, shoulder pain, muscle activities of UT, LT, and SA, and LT/UT and SA/UT muscle activity ratios during maximal shoulder abduction were measured immediately after SR-CCFE. A paired t-test and Wilcoxon signed-rank test were used to determine the significance of differences in scores between pre- and post-intervention in the same group. Results: The CVA (p<.001) and shoulder abduction ROM (p<.001) were increased significantly postversus pre-intervention. Shoulder pain was decreased significantly (p<.001), and LT (p<.05) and SA(p<.05) muscle activities were increased significantly post- versus pre-intervention. The LT/UT muscle activity ratio was increased significantly post- versus pre-intervention (p<.05). However, there was no significant change in UT muscle activity and SA/UT muscle activity ratio between pre- and post-intervention (p˃.05). Conclusion: SR-CCFE was an effective intervention to improve FHP and induce downstream effect from the neck to the trunk and shoulders in subjects with FHP.

A case of pregnant women with psoriasis exposed to acitretin: teratogenic risk of acitretin treatment

( Bo Young Kim ),( Go Eun Kim ),( Tae Jun Park ),( Ji Hyun Park ),( Il-hwan Kim ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Acitretin is a synthetic retinoid specifically used in severe psoriasis and disorders of keratinization. Teratogenicity is the most important safety issue of acitretin. Strict pregnancy prevention is required in women of childbearing potential who use acitretin. We report a 30-year-old female with pustular psoriasis who had been taking acitretin at 20mg/day before contraception and during pregnancy until 7 completed weeks after the last menstrual period. We normally avoid prescribing acitretin to women of childbearing potential, but she wanted to receive acitretin because of its effectiveness. She has two induced abortion history. We explained to the patient about teratogenicity of actiretin, and recommended contraception. Once her pregnancy was confirmed, we stopped using acitretin, and explained the possibility of teratogenicity. Also, the obstetrics service was consulted. Acitretin is one of the drug had Pregnancy prevention plan(PPP) in the European union. Pregnancy test and contraception should be performed before, during, and after the treatment for 36 months. However, there is no legal risk minimization measure such as PPP in Korea. Therefore, additional supports should be provided for the special policies for teratogenic drug. Physicians and pharmacists must rigorously apply the acitretin PPP recommendations, and patients must be fully informed about acitretin’s risk of teratogenicity.

3,3′-Diindolylmethane Suppressed Cyprodinil-Induced Epithelial-Mesenchymal Transition and Metastatic-Related Behaviors of Human Endometrial Ishikawa Cells via an Estrogen Receptor-Dependent Pathway

Kim, Bo-Gyoung,Kim, Jin-Wook,Kim, Soo-Min,Go, Ryeo-Eun,Hwang, Kyung-A,Choi, Kyung-Chul MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.1

<P>Cyprodinil (CYP) is a pyrimidine amine fungicide that has been extensively used in agricultural areas. 3,3′-Diindolylmethane (DIM) is a derivative of the dietary phytoestrogen, indole-3-carbinol (I3C), which is derived from cruciferous vegetables and considered to be a cancer-preventive phytonutrient agent. In this study, the effects of CYP and DIM were examined on the cell viability, invasion, and metastasis of human endometrial cancer cells, Ishikawa, via epithelial mesenchymal transition (EMT). CYP increased the level of cell viability of Ishikawa cells compared to DMSO as a control, as did E2. Ishikawa cells lost cell-to-cell contact and obtained a spindle-shaped or fibroblast-like morphology in response to the application of E2 or CYP by the cell morphology assay. In the cell migration and invasion assay, CYP enhanced the ability of migration and invasion of Ishikawa cells, as did E2. E2 and CYP increased the expressions of N-cadherin and Snail proteins, while decreasing the expression of E-cadherin protein as EMT-related markers. In addition, E2 and CYP increased the protein expressions of cathepsin D and MMP-9, metastasis-related markers. Conversely, CYP-induced EMT, cell migration, and invasion were reversed by fulvestrant (ICI 182,780) as an estrogen receptor (ER) antagonist, indicating that CYP exerts estrogenic activity by mediating these processes via an ER-dependent pathway. Similar to ICI 182,780, DIM significantly suppressed E2 and CYP-induced proliferation, EMT, migration, and invasion of Ishikawa cancer cells. Overall, the present study revealed that DIM has an antiestrogenic chemopreventive effect to withdraw the cancer-enhancing effect of E2 and CYP, while CYP has the capacity to enhance the metastatic potential of estrogen-responsive endometrial cancer.</P>

그린뉴딜 시대 비건 텍스타일 사례 연구

고보경 ( Go Bo Kyung ),한선주 ( Han Sun Ju ) 한국기초조형학회 2021 기초조형학연구 Vol.22 No.3

코로나19(COVID-19) 팬데믹(Pandemic)으로 기후변화와 저성장이라는 환경·경제적 이슈는 지속가능 사회 실현을 위한 어젠다(Agenda)로 그린뉴딜을 한 축으로 하는 ‘한국판 뉴딜 종합계획’에 이어 2020년 11월 산업통상자원부는 ‘섬유·패션산업 한국판 뉴딜 실행전략’을 발표하였다. 이러한 패러다임의 전환에 섬유·패션산업은 자연·생태계 보전, 자원순환 등에 기초한 환경친화적 경제안정정책의 필요성이 요구된다. 본 연구의 목적은 2020년 7월 정부가 발표한 그린뉴딜(Green New Deal) 정책을 토대로 섬유산업의 나아갈 방향을 이해하고, 지속가능한 비건 텍스타일(Vegan Textile) 사례를 분석하여 그린뉴딜 시대에 비건 텍스타일 소재 개발의 중요성과 가능성, 방향성을 제시하고자 한다. 연구 방법으로는 정부와 섬유·패션산업에서 발표한 그린전략과 행동양식을 분석하여 환경에 유해한 소재 대체를 위한 신소재 R&D 강화의 중요성과 신종감염병 상황에 친환경 기업에 적극적인 소비 행동을 보이는 비건 지향적인 소비 행태, 그리고 비건 텍스타일 연구를 통해 생분해성 섬유, 리사이클 섬유 등을 포함한 비건 텍스타일의 범주가 확장되고 있음을 확인하였다. 따라서 비건이 지속가능, 환경, 사회문제 등과 관련하여 그린뉴딜 추진 전략과 방향을 같이 한다고 볼 수 있으며 그린뉴딜 시대에 섬유·패션산업의 지속가능을 위해서는 생태계 보호와 사회복지를 아우르는 ESG를 고려한 글로벌 가치사슬 구조(GVC)의 진정성 있는 친환경 전략과 실행 체계 등의 구축이 필요한 상황이며 소비자 욕구와 사회적 가치가 맞물리는 공동의 목표 실현을 위해서는 정부의 적극적인 정책 및 지원이 필요하다. Due to the Covid-19 pandemic, environmental and economic issues such as climate change and low growth have become an agenda for realizing a sustainable society, and as a resolution to this agenda, South Korean Ministry of Trade, Industry and Energy announced the ‘Korean New Deal Implementation Strategy for Textile and Fashion Industry’ after ‘the Korean New Deal Comprehensive Plan’. In this paradigm shift, the textile and fashion industries require the need for eco-friendly economic stabilization policies based on nature and ecosystem conservation and resource circulation. The purpose of this study is to understand the direction of the textile industry based on the Green New Deal policy that was announced by the government in July 2020, and analyze the case of sustainable vegan textiles and present the importance, possibility and direction of developing vegan textile material in the Green New Deal. By analyzing green strategies and behavior patterns announced by the government and the textile and fashion industries, the importance of strengthening R&D for new materials to replace materials harmful to the environment, vegan-oriented consumption showing active consumption behavior for eco-friendly companies in the face of new infectious diseases, and the expansion of categories of vegan textiles that include biodegradable fibers and recycled fibers through research on vegan textiles were confirmed as research methods. Therefore, it can be said that veganism is in the same direction as the strategy for promoting the Green New Deal in relation to sustainability, environment, and social issues. For the sustainability of the textile and fashion industries in the era of the Green New Deal, it is necessary to establish a genuine eco-friendly strategy and implementation system of the global value chain structure (GVC) considering ESG that encompasses ecosystem protection and social welfare. The government's active policies and support are needed to realize the common goal that meets both consumer needs and social values.

감귤가격 신축성함수 분석 및 시사점

고성보 ( Go Seong Bo ) 한국축산경영학회 2004 농업경영정책연구 Vol.31 No.1