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Application of advanced biomaterials in photothermal therapy for malignant bone tumors
Bo Chao,Jianhang Jiao,Lili Yang,Yang Wang,Weibo Jiang,Tong Yu,Linfeng Wang,He Liu,Han Zhang,Zhonghan Wang,Minfei Wu 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Malignant bone tumors are characterized by severe disability rate, mortality rate, and heavy recurrence rate owing to the complex pathogenesis and insidious disease progression, which seriously affect the terminal quality of patients' lives. Photothermal therapy (PTT) has emerged as an attractive adjunctive treatment offering prominent hyperthermal therapeutic effects to enhance the effectiveness of surgical treatment and avoid recurrence. Simultaneously, various advanced biomaterials with photothermal capacity are currently created to address malignant bone tumors, performing distinctive biological functions, including nanomaterials, bioceramics (BC), polymers, and hydrogels et al. Furthermore, PTT-related combination therapeutic strategies can provide more significant curative benefits by reducing drug toxicity, improving tumor-killing efficiency, stimulating anti-cancer immunity, and improving immune sensitivity relative to monotherapy, even in complex tumor microenvironments (TME). This review summarizes the current advanced biomaterials applicable in PTT and relevant combination therapies on malignant bone tumors for the first time. The multiple choices of advanced biomaterials, treatment methods, and new prospects for future research in treating malignant bone tumors with PTT are generalized to provide guidance.
Bo-Chao Zheng,Park, Ju H. IET 2015 IET CONTROL THEORY AND APPLICATIONS Vol.9 No.15
<P>Adaptive integral sliding mode control (ISMC) is investigated for a class of non-linear uncertain systems considering the mismatch relation between quantisation sensitivity parameters. First, by analysing the operation principle of the encoder/decoder, a mismatched relation between the quantisation parameters is established by using a time-varying ratio model, where the boundaries of the time-varying ratio can be unknown, regarding the existing cases as special ones. Second, using linear matrix inequality techniques, the prescribed bounded L-2 gain performance condition is obtained for the sliding dynamics. Sequently, based on the formed boundary unknown time-varying ratio relation, adaptive ISMC laws are designed to ensure the reachability of the sliding manifold, then the establishment of the stability of the closed-loop system. Finally, an example is provided to illustrate the effectiveness of the proposed methods.</P>
A Context Aware Gateway for SIP-based Services in Ubiquitous Smart Homes
Bo-Chao Cheng,Huan Chen,Ryh-Yuh Tseng 보안공학연구지원센터 2008 International Journal of Smart Home Vol.2 No.1
The smart home concept brings innovation and convenience to our every day's life style. Without context awareness, smart home applications can neither offer adaptive services based on users’ dynamic situations nor provide preferential treatments according to users’ various preferences. Such a design paradigm forces human to live in the world of machines rather than a human-centric world. The use of SIP-protocol allows smart home devices and services to be connected compatibly and effectively. In this paper, we propose an adaptive SIP Context Aware Gateway (SIP-CAG) for the ubiquitous SIP-based services. With the SIPCAG solution, the home owner is able to use preferred devices for communication and to post his/her context information to home appliances or to people and civil society communities on an “as needed” basis.
A Sliding Sector Approach to Quantized Feedback Variable Structure Control
Bo-Chao Zheng,Yan-Mei Xue 제어·로봇·시스템학회 2013 International Journal of Control, Automation, and Vol.11 No.6
This paper is concerned with the quantized feedback quadratic stabilization problem for linear time-invariant systems. Sliding sector based quantized state feedback variable structure control schemes are established. The main benefit of the sliding sector technique is that it can avoid chattering caused by the utilization of variable structure control strategy. With the proposed discrete on-line adjustment of the quantization parameter, it is shown that the proposed sliding sector based sliding mode controllers can tackle state quantization and guarantee quadratic stability of the closed-loop system. Simulation results are given to verify the effectiveness of the proposed method.
OFPT: OpenFlow based Parallel Transport in Datacenters
( Bo Liu ),( Bo Xu ),( Chao Hu ),( Hui Hu ),( Ming Chen ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.10
Although the dense interconnection datacenter networks (DCNs) (e.g. FatTree) provide multiple paths and high bisection bandwidth for each server pair, the single-path TCP (SPT) and ECMP which are widely used currently neither achieve high bandwidth utilization nor have good load balancing. Due to only one available transmission path, SPT cannot make full use of all available bandwidth, while ECMP`s random hashing results in many collisions. In this paper, we present OFPT, an OpenFlow based Parallel Transport framework, which integrates precise routing and scheduling for better load balancing and higher network throughput. By adopting OpenFlow based centralized control mechanism, OFPT computes the optimal path and bandwidth provision for each flow according to the global network view. To guarantee high throughput, OFPT dynamically schedules flows with Seamless Flow Migration Mechanism (SFMM), which can avoid packet loss in flow rerouting. Finally, we test OFPT on Mininet and implement it in a real testbed. The experimental results show that the average network throughput in OFPT is up to 97.5% of bisection bandwidth, which is higher than ECMP by 36%. Besides, OFPT decreases the average flow completion time (AFCT) and achieves better scalability.
Bo-Chao Zheng,Lina Guo,Yangyang Zhao,Xiaoguang Liu,Zhou Gu 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.12
Robust security problem for uncertain cyber-physical systems (CPSs) subject to periodic denial-ofservice (DoS) jamming attacks is investigated based on event-triggered (ET) sliding-mode control (SMC) approach in this paper. First, a new type of SMC approach driven by ET mechanism is constructed using the property of the period DoS jamming attacks. Then, sufficient conditions for robust stabilization of dynamical systems constrained by system parameters and attacks period are proposed. Further, it is proved that the execution time interval of the proposed ET-based SMC strategy has a positive lower bound, and thus Zeno-free behavior occurs during system evolution. Finally, comparisons results show the effectiveness and superiority of this methodology.
Bo-Chao Zheng,Lina Guo,Kun Li 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.8
This paper concerns with the robust sliding mode fault-tolerant consensus problem for a class of undertain second-order leader-follower multi-agent systems based on event-triggering strategies. First, a sliding mode faulttolerant controller which uses the bound information of actuator failure rate and the event-triggering threshold is designed to ensure the robust consensus of the multi-agent systems, and the range of the sliding mode band is also shown. Second, by constructing an equivalent relationship, the upper bound of robust consensus error is alsogiven. Third, the minimum event-triggered execution time for the second-order leader-follower multi-agent systems is calculated. Finally, the simulation results verify the effectiveness of the proposed event-triggered sliding mode fault-tolerant consensus algorithm.
Laparoscopic hepatectomy for the treatment of Caroli’s disease: a case report
Chao-bo Chen,Wei-dong Hu,Wan-wen Zhao,Yan-yan Gu,Hong-wei Hou,Zheng Pan 대한외과학회 2018 Annals of Surgical Treatment and Research(ASRT) Vol.94 No.3
Caroli disease is a rare congenital disorder characterized by nonobstructive dilatation of intrahepatic ducts. In cases with symptomatic intrahepatic manifestations, treatment should correspond to the type with hepatic resection for localized disease and transplantation for diffuse forms. If possible, complete resection of the cysts can cure the symptoms and avoid the risk of malignancy. A 66-year-old woman presented to Wuxi Xishan People's Hospital with recurrent intermittent upper quadrant abdominal pain. Further examinations suggested the diagnosis of Caroli disease limited to the left hepatic lobe. She underwent laparoscopic hepatectomy. Pathological examination confirmed the diagnosis of Caroli disease, and no malignancy was found. There were no immediate complications and no long-term complications after one and one-half years of follow-up. Laparoscopic hepatectomy could be a feasible, safe treatment option for localized Caroli disease