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T.S. Anirudhan,J. Christa,Binusreejayan 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.57 No.-
In the present study, a magnetic protein–polyelectrolyte complex of casein coated iron oxidenanoparticles and folic acid conjugated chitosan-graft-poly(2-dimethylaminoethyl methacrylate) wasprepared for the delivery of an anticancer drug, 5-fluorouracil (5-FU) and characterized using FTIR, XRD,VSM, FESEM, TEM, DLS and zeta potential studies. Sustained and controlled release of 5-FU was observedat acidic pH 5.0. Drug release kinetic studies indicated both swelling and diffusion controlled release. Invitro cytotoxicity studies revealed the low toxicity of the prepared nano drug carrier towards normal cellsand folate receptor targeting efficiency of 5-FU loaded carrier towards cancer cells.