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      • Burden of Smoked and Smokeless Tobacco Consumption in India - Results from the Global adult Tobacco Survey India (GATS-India)- 2009-2010

        Bhawna, Gupta Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

        Background: The Global Adult Tobacco Survey (GATS) was carried out for systematically monitoring tobacco use and for tracking key tobacco control indicators. Materials and Methods: A total of 70,802 households, including 42,647 in rural areas and 28,155 in urban areas, were covered with a three stage sampling design. Data were collected on sociodemographic characteristics, knowledge, attitude and practices of tobacco consumption.Results: GATS-India highlighted that total tobacco use among its residents is overall 34.6%, varying for males (47.9%) and females (20.7%). The rural areas of the country exhibit comparatively higher prevalence rates (38.4%) in comparison to urban areas (25.3%). Overall, Khaini, a smokeless tobacco product (12.0%), is the most popular form of tobacco use among males and females, followed by bidi smoking (9.0%). Conclusion: Results of GATS data can be used as baseline for evaluation of new tobacco control approaches in India integrating culturally acceptable and cost effective measures.

      • KCI등재

        Assessment of Genetic Diversity in Cabbage Cultivars Using RAPD and SSR Markers

        Bhawna Saxena,Rajinder Kaur,Satya Vrat Bhardwaj 한국작물학회 2011 Journal of crop science and biotechnology Vol.14 No.3

        Genetic relationship and diversity among seven cabbage cultivars were analyzed using RAPD and SSR markers. These cultivars are of great commercial value in India and are confirmed for their reaction to black rot caused by Xanthomonas campestris pv. campestris. However, so far the extent of genetic diversity and relatedness has not been studied in these cultivars. A total of 17selected RAPD primers generated 90 bands, 76 of which were polymorphic (84.44%). In addition, 27 selected SSR primers generated 67 amplified bands with 59 of which were polymorphic (87.6%). Though both the marker techniques were able to discriminate the cultivars effectively, analysis of combined data of markers (RAPD and SSR) resulted in better distinction of cultivars. By combining both the markers, a total of 157 bands were detected of which 135 bands (85.98%) were polymorphic, i.e. an average of 5.95 bands per primer. High level of polymorphism (> 85%) recorded with two different marker systems indicated a high level of genetic variation existing among the cultivars. Genetic relationship estimated using similarity co-efficient (Jaccard’s) values between different pairs of cultivars varied from 0.21 to 0.77 in RAPD, 0.42 to 0.82 in SSR, and 0.43 to 0.89 with combined markers. A high correspondence had been recorded between the values of genetic variations generated by UPGMA, clustering, and scatter plot diagrams. The cultivars ‘January King Sel. Improved’ and ‘Golden Acre’ are highly divergent cultivars as demonstrated by both the marker systems.

      • KCI등재

        Nutritional components as mitigators of cellular senescence in organismal aging: a comprehensive review

        Bhawna Diwan,Rohit Sharma 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.9

        The process of cellular senescence is rapidly emerging as a modulator of organismal aging and disease. Targeting the development and removal of senescent cells is considered a viable approach to achieving improved organismal healthspan and lifespan. Nutrition and health are intimately linked and an appropriate dietary regimen can greatly impact organismal response to stress and diseases including during aging. With a renewed focus on cellular senescence, emerging studies demonstrate that both primary and secondary nutritional elements such as carbohydrates, proteins, fatty acids, vitamins, minerals, polyphenols, and probiotics can influence multiple aspects of cellular senescence. The present review describes the recent molecular aspects of cellular senescence-mediated understanding of aging and then studies available evidence of the cellular senescence modulatory attributes of major and minor dietary elements. Underlying pathways and future research directions are deliberated to promote a nutrition-centric approach for targeting cellular senescence and thus improving human health and longevity.

      • KCI등재

        Inter-operator Variability of Electrodermal Measure at Jing Well Points using AcuGraph 3

        Bhawna Sharma,Alex Hankey,Hongasandra Ramarao Nagendra,Kaniyamparambil Baburajan Meenakshy 사단법인약침학회 2014 Journal of Acupuncture & Meridian Studies Vol.7 No.1

        Recent studies have found that many factors, both biological and operator induced, influ- ence electrodermal measurements. Here, we report on operator variability for a series of measurements made by four operators at Jing-Well points on 132 individuals of both sexes (68 males and 64 females) by using the AcuGraph 3 ‘Digital Meridian Imaging Tool’: Opera- tor 1 (16 males, 12 females), Operator 2 (18 males, 13 females), Operator 3 (15 males, 21 females), and Operator 4 (19 males, 18 females). The individuals studied were attending a yoga therapy program for type 2 diabetes mellitus and were assessed on the 1st day of treatment. Large inter-operator variations in overall acumeridian energy readings were observed. For individual meridians, the AcuGraph 3 measure differed by up to 42 points for minimum values and 67 points for maximum values. After normalization, the data showed similar patterns between different acumeridians. This suggested that variations were caused by operators applying different pressures when making measurements. Thus, inter-operator variability should be considered when interpreting electrodermal measurements made by several different operators. Unless inter-operator variability is taken into account, actual values may not have meaning; only then can readings for the same population taken by different operators be evaluated correctly.

      • Emerging and Established Global Life-Style Risk Factors for Cancer of the Upper Aero-Digestive Tract

        Gupta, Bhawna,Johnson, Newell W. Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

        Introduction: Upper aero-digestive tract cancer is a multidimensional problem, international trends showing complex rises and falls in incidence and mortality across the globe, with variation across different cultural and socio-economic groups. This paper seeks some explanations and identifies some research and policy needs. Methodological Approach: The literature illustrates the multifactorial nature of carcinogenesis. At the cellular level, it is viewed as a multistep process involving multiple mutations and selection for cells with progressively increasing capacity for proliferation, survival, invasion, and metastasis. Established and emerging risk factors, in addition to changes in incidence and prevalence of cancers of the upper aero-digestive tract, were identified. Risk Factors: Exposure to tobacco and alcohol, as well as diets inadequate in fresh fruits and vegetables, remain the major risk factors, with persistent infection by particular so-called "high risk" genotypes of human papillomavirus increasingly recognised as also playing an important role in a subset of cases, particularly for the oropharynx. Chronic trauma to oral mucosa from poor restorations and prostheses, in addition to poor oral hygiene with a consequent heavy microbial load in the mouth, are also emerging as significant risk factors. Conclusions: Understanding and quantifying the impact of individual risk factors for these cancers is vital for health decision-making, planning and prevention. National policies and programmes should be designed and implemented to control exposure to environmental risks, by legislation if necessary, and to raise awareness so that people are provided with the information and support they need to adopt healthy lifestyles.

      • KCI등재

        Assessment of Genetic Diversity in Cabbage Cultivars Using RAPD and SSR Markers

        Saxena, Bhawna,Kaur, Rajinder,Bhardwaj, Satya Vrat 한국작물학회 2011 Journal of crop science and biotechnology Vol.14 No.3

        Genetic relationship and diversity among seven cabbage cultivars were analyzed using RAPD and SSR markers. These cultivars are of great commercial value in India and are confirmed for their reaction to black rot caused by Xanthomonas campestris pv. campestris. However, so far the extent of genetic diversity and relatedness has not been studied in these cultivars. A total of 17 selected RAPD primers generated 90 bands, 76 of which were polymorphic (84.44%). In addition, 27 selected SSR primers generated 67 amplified bands with 59 of which were polymorphic (87.6%). Though both the marker techniques were able to discriminate the cultivars effectively, analysis of combined data of markers (RAPD and SSR) resulted in better distinction of cultivars. By combining both the markers, a total of 157 bands were detected of which 135 bands (85.98%) were polymorphic, i.e. an average of 5.95 bands per primer. High level of polymorphism (> 85%) recorded with two different marker systems indicated a high level of genetic variation existing among the cultivars. Genetic relationship estimated using similarity co-efficient (Jaccard's) values between different pairs of cultivars varied from 0.21 to 0.77 in RAPD, 0.42 to 0.82 in SSR, and 0.43 to 0.89 with combined markers. A high correspondence had been recorded between the values of genetic variations generated by UPGMA, clustering, and scatter plot diagrams. The cultivars 'January King Sel. Improved' and 'Golden Acre' are highly divergent cultivars as demonstrated by both the marker systems.

      • A Cross-Country Comparison of Knowledge, Attitudes and Practices about Tobacco Use: Findings from the Global Adult Tobacco Survey

        Gupta, Bhawna,Kumar, Narinder Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12

        Background: Knowledge and individual perceptions about adverse effects of all forms of tobacco exert direct influence on the level of tobacco consumption in various socio-demographic groups. The objective of this study was to determine the nature, extent and demographic correlates of knowledge, attitudes and perceptions of use of tobacco among adults in low and middle income countries. Materials and Methods: The Global Adult Tobacco Survey, conducted in fourteen different countries from 2008-2010, was sourced for the data analyzed in this study. Descriptive statistical analyses were conducted to determine the prevalent knowledge and individual perceptions amongst adults about all forms of tobacco consumption. Results: There was relatively high awareness about the harmful effects of smoking tobacco with main awareness being about its relationship with lung cancer (>90% in most countries). In contrast, there was relatively low awareness about harmful effects of smokeless tobacco (< 90% in all countries except India and Bangladesh), and observed correlation of smoking tobacco with heart attack (40.6% in China, 65.1% in India) and stroke (28.2% in China, 50.5% in India). Conclusions: A large proportion of adults living in low and middle income countries possess adequate knowledge about smoking tobacco but have inadequate awareness as well as false perceptions about smokeless forms of tobacco. Popular beliefs of inverse relationships of tobacco consumption with knowledge, attitudes and perception of populations towards tobacco are challenged by the findings of this study.

      • KCI등재

        Generalized $(C,r)$-Hankel operator and $(R,r)$-Hankel operator on general Hilbert spaces

        Jyoti Bhola,Bhawna Gupta 대한수학회 2023 대한수학회논문집 Vol.38 No.3

        Hankel operators and their variants have abundant applications in numerous fields. For a non-zero complex number $r$, the $r$-Hankel operators on a Hilbert space $\mathcal{H}$ define a class of one such variant. This article introduces and explores some properties of two other variants of Hankel operators namely $k^{th}$-order $(C,r)$-Hankel operators and $k^{th}$-order $(R,r)$-Hankel operators $(k \geq 2)$ which are closely related to $r$-Hankel operators in such a way that a $k^{th}$-order $(C,r)$-Hankel matrix is formed from $r^k$-Hankel matrix on deleting every consecutive $(k-1)$ columns after the first column and a $k^{th}$-order $(R, r^k)$-Hankel matrix is formed from $r$-Hankel matrix if after the first column, every consecutive $(k-1)$ columns are deleted. For $|r| \neq 1$, the characterizations for the boundedness of these operators are also completely investigated. Finally, an appropriate approach is also presented to extend these matrices to two-way infinite matrices.

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