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Şanlı Beyazıt Abdurrahman,Öztürk Gökçe Zahide Neslihan 한국식물생명공학회 2021 Plant biotechnology reports Vol.15 No.3
Potato (Solanum tuberosum L.) is one of the major tuber crops which is widely grown in the world. Potato growth and development as well as yield is negatively afected by heat and drought stress alone, but combined stress has devastating efect. MicroRNAs are group of small RNAs which play vital role in gene regulation at transcriptional and post-transcriptional level by repressing or inhibiting protein expression of corresponding target. Current study aimed to understand the function of miR160a-5p and its infuence on its target gene ARF16 under applied stresses. Potato cultivars tolerant (Unica) and sensitive (Russet Burbank) were tested under drought, heat, and their combination of stresses. The expression of miR160a- 5p was revealed to be higher along with the suppression of corresponding target gene ARF16 gene. Transgenic plants also showed improved physiological, and biochemical traits, with lower accumulation of H2O2 and higher levels of proline solely under drought stress conditions. It was also observed that overexpression of miR160a-5p could alter mechanisms for auxin response factor pathways which enabled transgenic plants to have higher tolerance to abiotic stress conditions. Based on our fndings, transgenic Unica and Russet Burbank plants showed increased tolerance to drought and heat stress as compared to wild-type plants. This study can be helpful in understanding the role of miR160a-5p in improved tolerance to abiotic stresses.
Abdullah Bolu,Mehmet Sinan Aydın,Abdullah Akgün,Ali Coşkun,Beyazıt Garip,Taner Öznur,Cemil Çelik,Özcan Uzun 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.2
Objective: Findings about inflammatory processes in schizophrenia are increasing day by day. Inflammatory processes in schizophrenia are associated with both its etiology and clinical symptoms. Serum high-sensitivity C-reactive protein (hsCRP) is also one of these inflammatory processes. Particularly, it is thought to be closely related to clinical findings of patients with schizophrenia. Methods: In this study, the relationship between clinical findings of hsCRP levels of patients with drug-naïve first-episode psychosis (FEP) and patients with schizophrenia in acute exacerbation phase is investigated. Clinical findings, psychometric properties (the Scale for the Assessment of Positive Symptoms, the Scale for the Assessment of Negative Symptoms, Brief Psychiatric Rating Scale), and hsCRP levels of patients were compared. Results: Forty-eight patients with FEP, 74 patients with schizophrenia in acute exacerbation phase and 54 healthy controlled volunteers are included in the study. The most substantial finding in the study is that there is a positive correlation between hsCRP levels and severity of positive symptoms of both patient groups, with FEP and with schizophrenia. The second most substantial finding is there is no significant difference between patients with FEP and schizophrenia, in terms of hsCRP. Conclusion: The relationship between hsCRP and positive symptom severity in two groups of patients supports the inflammatory hypothesis in the etiopathogenesis of schizophrenia. This finding is supportive of close relation between inflammatory processes and clinical findings of patient with schizophrenia.