온두라스 저항운동의 지도자들이 쿠데타에 대항하여 계속 투쟁할 것을 결의하다

베르따 쥬베르 쎄씨(Berta Joubert-Ceci),장진엽(번역자) 노동사회과학연구소 2009 정세와노동 Vol.- No.49

Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain

Berta, Temugin,Lee, Jee Eun,Park, Chul-Kyu Carfax 2017 MEDIATORS OF INFLAMMATION Vol.2017 No.-

<P>Chronic pain affects ~20% of the worldwide population. The clinical management of chronic pain is mostly palliative and results in limited success. Current treatments mostly target the symptoms or neuronal signaling of chronic pain. It has been increasingly recognized that glial cells, such as microglia, and inflammatory signaling play a major role in the pathogenesis of chronic pain. Caspases (CASPs) are a family of protease enzymes involved in apoptosis and inflammation. They are pivotal components in a variety of neurological diseases. However, little is known about the role of CASPs in microglial modulation as to chronic pain. In particular, our recent studies have shown that CASP6 regulates chronic pain via microglial inflammatory signaling. Inhibition of microglia and CASP signaling might provide a new strategy for the prevention and treatment of chronic pain.</P>

Reaction mechanism and kinetic modeling of olefin conversion over phosphorus modified ZSM-5 catalyst

Ashenafi Hailu Berta,황호동,Hagos Birhane Asfha,강나영,김기웅,박용기 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.6

Reaction pathways and kinetics of C2-C6 olefins cracking over ZSM-5 catalyst were investigated based onproduct distribution to develop a model. Experimental tests of the catalytic cracking of olefins were performed in thetemperature range of 450-650 oC, space-time of 0.375-3.5min, and partial pressure of 0.08-0.23 atm. For each feed, apossible reaction pathway was identified and used for the model. Based on the identified reactions a lumped kineticmodel was developed using the power-law method. The developed model included direct olefin cracking, oligomerization,and re-cracking of oligomers. Thirteen reversible reactions were considered as major reactions to represent thiscomplex system. For each forward and backward reaction step, apparent activation energy and pre-exponential factorswere estimated. The model predicts the experimental product components with an R2 value of 0.8735-0.9718. Comparisonof experimental result with the developed model showed the developed model predicted the feed product distributionwith accuracy. Sensitivity analysis was done to identify dominant reaction paths for each feed that affected theyield of ethylene and propylene, the main products that needed to be maximized during industrial catalytic cracking.

Control of Strawberry Anthracnose by Plant Extracts

Jose Ortega Delgado,Berta de los Santos,Fernando Romero 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Distribution of caveolin isoforms in the lemur retina

Aoston Szel,Anes I Berta,Anna L Kiss,Akos Lukats,Arnold Szabo 대한수의학회 2007 Journal of Veterinary Science Vol.8 No.3

The distribution of caveolin isoforms was previously evaluated in the retinas of different species, but has not yet been described in the primate retina. In this study, the distribution of caveolins was assessed via immunochemistry using isoform-specific antibodies in the retina of the blackand- white ruffed lemur. Here, we report the presence of a variety of caveolin isoforms in many layers of the lemur retina. As normal human retinas were not available for research and the retinas of primates are fairly similar to those of humans, the lemur retina can be utilized as a model for caveolin distribution in normal humans.

Astrocyte-targeted Overproduction of IL-10 Reduces Neurodegeneration after TBI

Shanaki-Barvasad Mahsa,Almolda Beatriz,González Berta,Castellano Bernardo 한국뇌신경과학회 2022 Experimental Neurobiology Vol.31 No.3

Traumatic brain injury is the greatest cause of disability and death in young adults in the developed world. The outcome for a TBI patient is determined by the severity of the injury, not only from the initial insult but, especially, as a product of the secondary injury. It is proposed that this secondary injury is directly linked to neuro-inflammation, with the production of pro-inflammatory mediators, activation of resident glial cells and infiltration of peripheral immune cells. In this context, anti-inflammatory treatments are one of the most promising therapies to dampen the inflammatory response associated with TBI and to reduce secondary injury. In this sense, the main objective of the present study is to elucidate the effect of local production of IL-10 in the neurological outcome after TBI. For this purpose, a cryogenic lesion was caused in transgenic animals overproducing IL-10 under the GFAP promoter on astrocytes (GFAP-IL10Tg mice) and the neuro-protection, microglial activation and leukocyte recruitment were evaluated. Our results showed a protective effect of IL-10 on neurons at early time-points after TBI, in correlation with a shift in the microglial activation profile towards a down-regulating phenotype and lower production of pro-inflammatory cytokines. Concomitantly, we observed a reduction in the BBB leakage together with modifications in leukocyte infiltration into the affected area. In conclusion, local IL-10 production modifies the neuro-inflammatory response after TBI, shifting it to anti-inflammatory and neuro-protective conditions. These results point to IL-10 as a promising candidate to improve neuro-inflammation associated with TBI.

AKARI-NEP : EFFECTS OF AGN PRESENCE ON SFR ESTIMATES OF GALAXIES

L. Marchetti,A. Feltre,S. Berta,I. Baronchelli,S. Serjeant,M. Vaccari,D. Bulgarella,M.Karouzos,K. Murata,N.Oi,C. Pearson,G. Rodighiero,C. Segdwick,G. J. White 한국천문학회 2017 天文學論叢 Vol.32 No.1

How does the presence of an AGN influence the total SFR estimates of galaxies and change their distribution with respect to the \textit{Galaxy Main Sequence}?To contribute to solving this question, we study a sample of 1133 sources detected in the North Ecliptic Pole field (NEP) by AKARI and Herschel. We create a multi-wavelength dataset for these galaxies and we fit their multi-wavelength Spectral Energy Distribution (SED) using the whole spectral regime (from 0.1 to 500 $\mu$m). We perform the fit using three procedures: \texttt{LePhare} and two optimised codes for identifying AGN tracers from the SED analysis. In this work we present an overview of the comparison between the estimates of the Infrared bolometric luminosities (between 8 and 1000 $\mu$m) and the AGN fractions obtained exploiting these different procedures. In particular, by estimating the AGN contribution in four different wavelength ranges (5-40 $\mu$m, 10-20 $\mu$m, 20-40 $\mu$m and 8-1000 $\mu$m) we show how the presence of an AGN affects the PAH emission by suppressing the ratio $\frac{L_{\rm8~\mu m}}{L_{\rm4.5~\mu m}}$ as a function of the considered wavelength range.

Kinetic modeling of methanol to olefins over phosphorus modified HZSM-5 zeolite catalyst

Hagos Birhane Asfha,강나영,Ashenafi Hailu Berta,황호동,김기웅,박용기 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.10

A lumped kinetic model has been developed for the methanol to olefins (MTO) reaction over phosphorus modified HZSM-5 catalyst. In consideration of mixed feed cracking, a higher reaction temperature than the conventional MTO reaction was chosen. The reaction temperature considered is in range of 500 to 680 oC. The experimental data for the kinetic model were obtained in an isothermal fixed bed reactor over a wide range of operating temperatures and space time of 0.160 to 0.801 g-cat∙h/mole of methanol feed. A reaction mechanism comprising seven lumps was utilized to analyze the kinetic behavior of this catalyst. Based on the mathematical kinetic model for the fixed bed reactor, the kinetic parameters were determined by numerical optimization using a hybrid of genetic algorithm and active set gradient method. The developed kinetic model reasonably predicts the experimental data obtained for the reaction conditions considered. It has been found that increasing space time is favorable to light olefins yield, while a maximum water free basis olefin yield of about 82weight % was obtained at a temperature of 630 oC for a space time of 0.801 g-cat∙h/mole of methanol feed.

The extent of aortic lymphadenectomy in locally advanced cervical cancer impacts on survival

Antoni Llueca,Javier Escrig,Antonio Gil-Moreno,Virginia Benito,Alicia Hernández,Berta Díaz-Feijoo 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.1

Objective: The prognostic impact of surgical paraaortic staging remains unclear in patientswith locally advanced cervical cancer (LACC). The objective of our study was to evaluate theresults of the surgical technique of preoperative aortic lymphadenectomy in LACC related totumor burden and disease spread to assess its influence on survival. Methods: Data of 1,072 patients with cervical cancer were taken from 11 Spanishhospitals (Spain-Gynecologic Oncology Group [GOG] working group). Complete aorticlymphadenectomy surgery (CALS) was considered when the lymph nodes (LNs) were excisedup to the left renal vein. The extent of the disease was performed evaluating the LNs bycalculating the geometric means and quantifying the log odds between positive LNs andnegative LNs. The Kaplan-Meier method was used to estimate the survival distribution. A Coxproportional hazards model was used to account for the influence of multiple variables. Results: A total of 394 patients were included. Pathological analysis revealed positiveaortic LNs in 119 patients (30%). LODDS cut-off value of −2 was established as a prognosticindicator. CALS and LODDS <−2 were associated with better disease free survival and overallsurvival than suboptimal aortic lymphadenectomy surgery and LODDS ≥−2. In a multivariatemodel analysis, CALS is revealed as an independent prognostic factor in LACC. Conclusion: When performing preoperative surgical staging in LACC, it is not advisable totake simple samples from the regional nodes. Radical dissection of the aortic and pelvicregions offers a more reliable staging of the LNs and has a favorable influence on survival.

Potential strategies for prevention of tumor spillage in minimally invasive radical hysterectomy

Vicente Bebia,Sonia Monreal-Clua,Assumpció Pérez-Benavente,Silvia Franco-Camps,Berta Díaz-Feijoo,Antonio Gil-Moreno 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.5

Objective: The publication of a prospective [1] and several retrospective [2,3] studiesdescribing a worse prognosis in patients affected with early-stage cervical cancer whounderwent a minimally invasive radical hysterectomy has raised a high concern in whatmeasures should be undertaken in order to revert these results. Potential strategies [4] toprevent tumor spillage have been previously proposed. Methods: In this video, we describe nine strategies that should be addressed in future trialsregarding this procedure. Results: These strategies are:1. Fallopian tubes should be coagulated prior to start the surgery. 2. All sentinel lymph nodes and lymphadenectomy specimens should be obtained withoutlymph nodes fragmentation. 3. All surgical specimens should be extracted within a containment bag. 4. Uterine manipulators must never be used. 5. Prior to vaginal section, a closed knotted ligature should be placed around the vagina,proximal to the section line, and the remaining vaginal cavity profusely washed. 6. Once the vagina is opened, the surgical specimen should be extracted vaginally within aspecimen retrieval bag. 7. After surgery, the pelvic cavity is profusely washed with physiological serum, and the vaginashould be washed with iodopovidone diluted to 10% [5]. 8. Port-site metastasis prevention measures should be performed. 9. Every action made to prevent tumor spillage should be recorded in the surgical report. Conclusion: As there is a biological rationale in these measures that would prevent tumorspillage and seeding, there is a need of prospectively exploring them within appropriatestudies in order to determine their own oncological outcome.