Increased 11β-hydroxysteroid dehydrogenase type 1 contributes to barrier dysfunction in aged skin

( Beom Jun Kim ),( Noo Ri Lee ),( Chung Hyeok Lee ),( Young Bin Lee ),( Solam Lee ),( Hyun Jee Hwang ),( Eunjung Kim ),( Eung Ho Choi ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inactive cortisone into cortisol, an active form, and is expressed by several tissues including the skin. Excessive active glucocorticoid (GC) deteriorates skin barrier function. Objectives: To find out if 11β-HSD1 affects on the barrier function in aged skin. Methods: We have performed human and in vivo studies. We measured cortisol in stratum corneum (SC) and oral epithelium of the elderly and young. Hairless mice were used for 11β-HSD1 immunohistochemistry staining of skin and measuring skin barrier function and serum cytokines. 11β-HSD1 knock-out (KO) mice and its wild-type were used for measuring lipid synthesis related enzyme. Results: Cortisol levels were elevated in SC and oral epithelium of the elderly rather than young. The 11β -HSD1 expression was increased in immunohistochemistry stain of aged mice skin. Aged mice showed decreased transepidermal water loss (TEWL) and SC hydration, and increased SC integrity than young. Serum inflammatory cytokines including interleukin-1α, -4, -10, -31 and tumor necrosis factor-α were increased in aged mice than young. The expressions of lipid synthesis related enzymes in epidermis were elevated in KO mice and topical 11β -HSD1 inhibitor applied mice. Conclusion: 11β-HSD1 expression is elevated in aged skin. It increases active GC and then deteriorates skin barrier function.

Insulation Coating of Fe–Si–Cr Soft Magnetic Powder by Selective Oxidation

Jae‑Young Park,Kwangsuk Park,Bosung Seo,Julien O. Fadonougbo,Tae‑Wook Na,Ki Beom Park,Hyeon‑Tae Im,Nong‑Moon Hwang,Hyung‑Ki Park 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7

This study examines the insulation coating technology of Fe–Si–Cr powder via selective oxidation annealing, which oxidizeselements selectively by controlling the oxidation potential. The study calculated the oxidation driving force of Fe, Si, andCr, and conducted a thermodynamic analysis of oxidation and reduction conditions according to temperature and oxidationpotential. Based on the results, a selective oxidation annealing was performed in an atmosphere in which Fe is reduced andonly Si and Cr are selectively oxidized. The oxidation potential was controlled through the partial pressure ratio of hydrogenand water vapor. The XPS analysis results confirmed that a Si and Cr complex oxide layer formed on the powder surfaceafter the selective oxidation annealing. Afterward, withstanding voltages were analyzed to evaluate the insulation property. Then, the withstanding voltage of the powder applying the selective oxidation annealing increased significantly comparedto that of the initial powder. Further analysis showed that the powder annealed in an air atmosphere had a significantly lowersaturation magnetic flux density than the initial powder, while the powder applying the selective oxidation annealing hadonly a slightly reduced saturation magnetic flux density.

왕우렁이(apple snails)의 생리ㆍ생태적 특성에 관한 연구

이상범,고문환,나영은,김진호 한국환경농학회 2002 한국환경농학회지 Vol.21 No.1

왕우렁이가 자연상태에 전파되어 서식되는 경로는 양식장의 배수시, 홍수로 인한 노지 양식장 붕괴 및 제초용 왕우렁이 입식에 의하여 이루어지고 있다. 왕우렁이의 생리적 특성을 보면 알 크기는 2.47 ㎜, 난괴크기는 1.8×4.3×0.94 ㎝, 알무게 12.78 ㎎, 산란수 157∼784개/1마리(평균 321개/마리) 유체크기 1.69×2.15㎜, 유체 무게 3.32㎎ 최저 산란 왕우렁이 크기 2.40×2.26 ㎝ 이상, 1개알 산란소요시간 22.4초 였다. 알의 색변화는 산란직후 우유빛의 연분홍에서 중기에는 선홍색, 부화직전에는 흐린 연보라색으로 변화하면서 부화된다. 왕우렁이 섭식 대상은 벼, 논잡초, 미나리, 토마토, (양)배추, 무, 호박, 콩잎 등 대부분의 농작물을 포함한 식물체 및 동족의 왕우렁이 등 수중동물이었다. 왕우렁이 월동지역은 장항, 장성 및 해남지역으로 양지녘의 식물체 줄기나 벼 그루터기에 산란된 알과 성체 상태로 저수지나 논의 물웅덩이에서 월동고, 5월 중순이후 수로의 벽이나 식물체 줄기에 산란하며 6월과 9월에 번식이 가장 왕성하였다. 서식지 수질특성은 변이 폭이 컸으나 pH가 7.07∼9.50 범위로 알칼리성에서 주로 번성하였다. 왕우렁이에 의한 벼 가해 양상중 바 발아초기에는 왕우렁이 크기에 관계없이 모두 벼싹을 가해하였고, 벼품종과 생육시기에 따라 차이가 있으며 어린묘 일수록 가해율이 높았으며, 이앙후 45일 벼(초장 약 73 ㎝)도 각고 3.3∼3.5 ㎝ 이상의 중형 왕우렁이는 가해하였다. This experiment was carried out to obtain some information about overwintering, physiological and ecological characteristics of apple snails. Another purpose of this experiment was to characterize an appetite for rice plants by apple snails and to elucidate their choice of fresh green ones (vegetables, some other crops, weeds in rice fields). The freshwater snails were found with higher population at sites abundant organic compounds such as plant debris and at regions with high temperature. They also prefer calcium-rich water. This is a naturally occurring process. Apple snails were exceptionally well-adapted to the south regions of Korea, especially Janghang, Jangseong and Haenam, even if the temperature of winter season is cold below 0℃. Apple snails were not very selective in their food choice and eat almost everything available in their environment. A snail have something called a radula in its mouth for grinding up its food. A apple snail also chews on fruits and young succulent plant barks. In case of reproduction, apple snails deposit about 157~784 (average of 321 eggs) milky white to pale orange colored eggs above the waterline. In approximately every 22.4 seconds a new egg appears. The total time needed to deposit a egg mass varies from 58 minutes~4 hours 13 minutes. Apple snails reproduct actively from May to June and from September to October. An appetite of apple snails for rice plants was the different depending on their size and growing stage for rice plants. Apple snails had a great appetite of rice plants as well as dropwort, tomato, cabbage, radish, aquatic plants etc. They preferred to eat young rice plants and drastically quit eating rice plants of over 40 cm in height. Thus considering the food preference of apple snail for various plants including rice, they were thought to be a potentially strong predator in fields, especially, at regions with warmer winter.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

토당귀 종자의 형태적 특성과 발아와 입모율에 대한 저장방법,생장조절제 및 프라이밍 처리 효과

안희정,안복주,·김도현,·안영섭,·김영국,박춘근,이상원,·박충범·차선우,·송범헌, 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.1

This study was conducted to have basic and applied informations to establish the cultivation method and to improve the cultivation techniques of Angelica gigas Nakai through investigating the rates of germination and seedling establishment with treatment of plant growth regulator and seed priming. The germination rates of round shape seed were about 0.3~12% higher than those of parallel shape. The germination rates with different storage durations were increased at the level of 25oC and 4oC with the storage days, while they were clearly higher at -20oC compared to those at 4oC and 25oC without the storage durations. With the results of germination rates with treating of plant growth regulator and seed priming, their rates with the round shape seeds were comparatively higher about 6% than those with parallel shape seed and they were increased with increasing of the storage durations. The germination rates were generally appeared higher with GA3 than did those with seed priming. The highest germination rate was appeared at 50 ppm GA3 of plant growth regulator and at -0.5 MPa PEG6000 of seed priming. The germination rates?ㅤ ?ㅤ of Angelica gigas were different with different temperature, storage durations and the treatments of plant growth regulator and seed priming. These results could be used according to different cultivating conditions.

흰쥐의 원위콩팥단위내 칼슘결합단백질 (calbindin-D28k)에 관한 면역세포화학적 연구

김영희,김완영,김인범,한승호,오수자,차정호,김진 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.6

품질경영에 있어서의 다꾸지 방법과 VTA 방법에 관한 연구

金容範 忠州大學校 1998 한국교통대학교 논문집 Vol.33 No.1

As new methods for off-line quality control, Taguchi and VTA methods are presented. Taguchi methods using experimental design and VTA methods using regression analysis are studied and compared with each other in terms of parameter design and tolerance design. Also, an example of calculating tolerance interval for the given defect rate in ppm are introduced in this study.

상속성과 병행성 통합에서 오는 상속 변칙 분석에 관한 연구

박영옥,송기범,이준 조선대학교 전자정보통신연구소 2001 電子情報通信硏究所論文誌 Vol.4 No.2

The integration of concurrent and object-oriented programming paradigm hae been a goal of researchers for over a decade. The concurrent object-oriented programming languages used for development of various concurrent applications. However, concurrency and inheritance have conflicting characteristics, thereby inhibiting their simultaneous use without heavy breakage of encapsulation. This conflicting phenomenon is known as inheritance anomalies, have been limited in applicability and have not addressed all the issues that synchronization raises. In this paper, we introduce the behavior description equation is introduced for the solution for the conflicting phenomenon between inheritance and object-based concurrency. As a result, we can solve the several inheritance anomalies without redefining object methods. Therefore this paper offers flexible concurrency model with an emphasis on the reuse of both synchronization and function code.

아토피 환자의 축색성 발한 기능

이정범,민영기,양훈모 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

To examine the sweating function in atopic dermatitis, we investigated the sweating response of the lesional and nonlesional skin of adult patients with atopic dermatitis by a quantitative sudomotor axon reflex test (QSART) in which the axon reflex is stimulated by acetylcholine (ACh) iontophoresis. Directly activated(DIR) and axon reflex (AXR)-mediated sweating during ACh10% iontophoresis (2 mA × 5 min) were measured by capacitance hygrometer QSART. Sweat volume on the volar aspect of the orearm was measured in 23 adult patients with atopic dermatitis and in 65 nonatopic healthy controls. In the atopic patients, all measurements were performed on both lesional and nonlesional skin. Onset-time time, directs of muscarine receptor (DIR) sweat volume, and axon reflex-mediated indirect of nicotine receptor (AXR(1) and AXR(2)) sweat volume were the variables studied. The results showed that onset- time of axon reflex in atopic dermatitis patients was significantly prolonged and AXR(1) and AXR(2) significantly reduced compared with those in nonatopic healthy contrl subjects. The onset-time and AXR(1) and AXR(2) sweat volume of the atopic dermatitis lesional skin were signficsantly more prolonged and reduced, respectively, than shose of the nonlesional skin. Also, the DIR sweat volume of the lesional or nonlesional atopic dermatitis skin induced by direct stimulation with ACh was reduced when compared with that in nonatopic healthy controls.

객체지향 기법을 이용한 다중 스레드 프로그램 기법에 관한 연구

송기범,박영옥,이준 조선대학교 동력자원연구소 1995 動力資源硏究所誌 Vol.17 No.2

The Software which uses object-oriented method has the advantage of extensibility, independence and easy maintenance, but has the disadvantage of decrease of system performance. Object-oriented software provides parallel process of objects, and then to improve of system performance we categorize objects into active and passive ones and then use active one. Therefore we implement active and passive objects with object-oriented language, propose multi threaded programming method using thread library for real time process.