GUI Reliability Assessment based on Bayesian Network and Structural Profile

Zhi-Fang Yang,Zhong-Xing Yu,Bei-Bei Yin,Cheng-Gang Bai 보안공학연구지원센터(IJSIP) 2015 International Journal of Signal Processing, Image Vol.8 No.1

Graphical User Interfaces (GUI) is becoming increasingly important in the software field as it builds a friendly way between users and software through continuous interactions. A well-developed GUI is therefore an important factor of software quality. In particular, the reliability of GUIs is still on the way of development. Existing software reliability assessment techniques attempt to statistically describe the software testing process and predict the reliability of the system. However, those techniques are not suitable for GUI as quality of GUI is challenged by immense number of event interactions and complex structural profile etc. Furthermore, GUI has a wealth of information about GUI architecture, components, windows and their interactions with each other, which can be adopted to guide the testing process and establish confidence assessment of GUI. In this paper, a Bayesian network model of GUI reliability is introduced to discuss the reliability model topology and its issues encountered in the modeling process. A case is also presented to verify the validity of the model during the GUI reliability assessment process.

Study of Clustered Energy Saving Routing Protocol for Mobile Nodes in Three-dimensional Space

Cheng Huang,Run Zhang,Xiao-bei Wu,Zhi-liang Xu 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.11

Movement of sensor nodes may cause network topology change, communication link fracture and signal propagation delay, while increasing network energy consumption and shortening lifetime of the whole network. This paper proposes an energy-efficient clustering routing algorithm based on mobile wireless sensor networks in three-dimensional space. The algorithm uses multiple-hop routing mechanism, which can effectively balance the node energy consumption in network. The simulation results show that the algorithm has a good effect on node energy saving in the process of moving at different speeds. Thus the network always has more residual energy and longer survival time, which can effectively balance the energy consumption of wireless sensor network and extend the network lifetime.

Elevating Limonene Production in Oleaginous Yeast Yarrowia lipolytica via Genetic Engineering of Limonene Biosynthesis Pathway and Optimization of Medium Composition

Bo-Qian Cheng,Liu-Jing Wei,Yu-Bei Lv,Jun Chen,Qiang Hua 한국생물공학회 2019 Biotechnology and Bioprocess Engineering Vol.24 No.3

As an alternative terpenoid producer, nonconventional oleaginous yeast Yarrowia lipolytica was chosen for limonene production. Y. lipolytica can give high biomass yield and metabolize a broad range of substrates such as glycerol, alkanes, fatty acid, fats, and oils. As previously reported, optimization of limonene synthesis pathway and mevalonate (MVA) pathway leads to the accumulation of 112-fold higher limonene as compared to an initial strain. In this study, we introduced an additional copy of limonene synthesis gene (LS), which resulted in an increase of limonene production. This engineered strain was used to carry out further optimization study. Amongst all the carbon sources tested, the highest level of limonene production was obtained from glycerol, and citrate was selected as an auxiliary carbon source. In fed-batch fermentation with an optimized medium, the engineered strain was found to produce 165.3 mg/L limonene, which corresponds to the highest yield till date for the production of limonene in Y. lipolytica.

The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications

Liu Ziying,Gao Lei,Cheng Long,Lv Gaoyuan,Sun Bei,Wang Gang,Tang Qiushi 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

N6-methyladenosine (m6A) is one of the epigenetic modifications of RNA. The addition of this chemical mark to RNA molecules regulates gene expression by affecting the fate of the RNA molecules. This posttranscriptional RNA modification is reversible and regulated by methyltransferase “writers” and demethylase “erasers”. The fate of m6A-modified RNAs depends on the function of different “readers” that recognize and bind to them. Research on m6A methylation modification has recently increased due to its important role in regulating cancer progression. Noncoding RNAs (ncRNAs) are a class of RNA molecules that are transcribed from the genome but whose roles have been overlooked due to their lack of well-defined potential for translation into proteins or peptides. However, this misconception has now been completely overturned. ncRNAs regulate various diseases, especially tumors, and it has been confirmed that they play either tumor-promoting or tumor-suppressing roles in almost all types of tumors. In this review, we discuss the m6A modification of different types of ncRNA and summarize the mechanisms involved. Finally, we discuss the progress of research on clinical treatment and discuss the important significance of the m6A modification of ncRNAs in the clinical treatment of tumors.

Past Millennium Contrasting Hydroclimate Patterns Between Monsoonal Northern China and Arid Central Asia: a Modeling Study

Youbing Peng,Hai Cheng,Caiming Shen,Ying Xu,Naifang Bei 한국기상학회 2018 Asia-Pacific Journal of Atmospheric Sciences Vol.54 No.3

Widely distributed proxy records show that there were out-of-phase behaviors of moisture change between arid central Asia (ACA) and monsoonal northern China during the Little Ice Age (LIA) and Medieval Climate Anomaly (MCA). We examined spatial pattern differences between the MCA and LIA to identify contrasting patterns of summer precipitation variability, and to diagnose explanatory mechanisms through the analysis of a 1000-year global climate model simulation driven by natural and anthropogenic forcing. The results show that the model was able to roughly produce the general features of MCA-LIA hydroclimatic spatial differences between monsoonal northern China and ACA, with a relatively wet MCA found in monsoonal northern China and a relatively dry MCA found in ACA. A further analysis of associated circulations shows that increased summer precipitation in monsoonal northern China was caused by the strengthening of summer monsoon, while the decline in summer precipitation in ACAwas caused by an anomalous northward displacement of the subtropical westerly jet stream. Our analyses suggest that both effective solar forcing and El-Niño Southern Oscillation (ENSO) may produce these contrasting patterns of precipitation between monsoonal northern China and ACA. Due to a change in the probability of ENSO phases at the centennial time scale found in our experiments may be attributed to solar irradiances, higher effective solar irradiances during the MCA relative to those of the LIA may have been the ultimate forcing mechanism for the simulated precipitation differences between the MCA and LIA.

Aminoacyl-tRNA Synthetase-Interacting Multifunctional Protein 1/p43 Controls Endoplasmic Reticulum Retention of Heat Shock Protein gp96 : Its Pathological Implications in Lupus-Like Autoimmune Diseases

Han, Jung Min,Park, Sang Gyu,Liu, Bei,Park, Bum-Joon,Kim, Jin Young,Jin, Cheng He,Song, Yeong Wook,Li, Zihai,Kim, Sunghoon Elsevier 2007 The American journal of pathology Vol.170 No.6

<P>Aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1; previously known as p43) is a multifunctional protein that was initially found in multitRNA synthetase complex. In the present study, screening of the AIMP1-binding proteins revealed that AIMP1 can form a molecular complex with heat shock protein gp96. AIMP1 enhances gp96 dimerization and the interaction between gp96 and KDEL receptor-1 (KDELR-1), which mediates the retrieval of KDEL-containing proteins from Golgi to the endoplasmic reticulum (ER). The interaction between gp96 and KDELR-1 was reduced in AIMP1-deficient cells, and this disturbed ER retention of gp96 and increased its cell surface localization. Moreover, this localization of gp96 at the cell surface was suppressed by its interaction with AIMP1 and enhanced by the depletion of endogenous AIMP1. In addition, AIMP1-deficient mice showed dendritic cell activation attributable to increased gp96 surface presentation and lupus-like autoimmune phenotypes. These results suggest that AIMP1 acts as a regulator of the ER retention of gp96 and provide a new perspective of the regulatory mechanism underlying immune stimulation by gp96.</P>

Physiological and biochemical characterization of sheepgrass (Leymus chinensis) reveals insights into photosynthetic apparatus coping with low-phosphate stress conditions

Lingyu Li,Haomeng Yang,Weibo Ren,Bei Liu,Dongmei Cheng,Xinhong Wu,Jirui Gong,Lianwei Peng,Fang Huang 한국식물학회 2016 Journal of Plant Biology Vol.59 No.4

Sheepgrass [Leymus chinensis (Trin.) Tzvel] is a valuble forage plant highly significant to regional grassland productivity of Euro-Asia steppes. Although effects of environmental stress including drought have been studied, impact of nutrient deficiency in particular phosphate (Pi), one of the essential macronutrient, is not reported. Here, we investigated low-Pi effect on its photosynthetic apparatus via physiological and biochemical analysis. We show that PSII activity was significantly reduced based on chlorophyll fluorescence measurements. We observed decreased amount of core proteins of PSII by immunoblot analysis. Further analysis of thylakoid membranes using 2D-BN/SDS-PAGE and immunoblot detection demonstrated that the amount of PSII complexes was closely correlated with the Pi levels within the range. Together with reduced number of thylakoid grana stackings observed, we suggest that the maintenance of PSII is impaired under Pi-limited condition. Moreover, enzyme activity assays revealed that the activity of several ROS scavenger enzymes was stimulated by low-Pi treatment. Based on these experimental results we conclude that PSII is the component of photosynthetic apparatus most sensitive to Pi supply and the enhanced anti-ROS activity is mainly subjective to protection of PSII against low Pi-induced photo-oxidative stress in the organism.

Enhanced room-temperature HCHO decomposition activity of highly-dispersed Pt/Al2O3 hierarchical microspheres with exposed {110} facets

Xiaofeng Zhu,Jiaguo Yu,Chuanjia Jiang,Bei Cheng 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.45 No.-

Formaldehyde (HCHO) catalytic decomposition at room temperature is an important method for HCHOremoval in indoor environment. Herein,flower-like g-Al2O3 microspheres with high specific surface area,special textural structure, and abundant surface defects were prepared through a one-pot hydrothermalmethod by using aluminum foil as Al source. And it was used as oxide support to prepare highly-dispersed Pt catalyst (Pt/Al2O3). Compared with Pt supported on commercial g-Al2O3, the as-prepared Pt/Al2O3 showed enhanced catalytic activity for HCHO decomposition at room temperature. This workprovides new insights into designing and fabricating highly-dispersed Pt catalysts for efficient indoor airpurification.

Outcomes Based on Risk Assessment of Anastomotic Leakage after Rectal Cancer Surgery

Gong, Jian-Ping,Yang, Liu,Huang, Xin-En,Sun, Bei-Cheng,Zhou, Jian-Nong,Yu, Dong-Sheng,Zhou, Xin,Li, Dong-Zheng,Guan, Xin,Wang, Dong-Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Purpose: Anastomotic leakage (AL) is associated with high morbidity and mortality, high reoperation rates, and increased hospital length of stay. Here we investigated the risk factors for AL after anterior resection for rectal cancer with a double stapling technique. Patients and Methods: Data for 460 patients who underwent primary anterior resection with a double stapling technique for rectal carcinoma at a single institution from 2003 to 2007 were prospectively collected. All patients experienced a total mesorectal excision (TME) operation. Clinical AL was defined as the presence of leakage signs and confirmed by diagnostic work-up according to ICD-9 codes 997.4, 567.22 (abdominopelvic abscess), and 569.81 (fistula of the intestine). Univariate and logistic regression analyses of 20 variables were undertaken to determine risk factors for AL. Survival was analysed using the Cox regression method. Results: AL was noted in 35 (7.6%) of 460 patients with rectal cancer. :Median age of the patients was 65 (50-74) and 161 (35%) were male. The diagnosis of AL was made between the 6th and 12th postoperative day (POD; mean 8th POD). After univariate and multivariate analysis, age (p=0.004), gender (p=0.007), tumor site (p<0.001), preoperative body mass index (EMI) (p<0.001), the reduction of TSGF on 5th POD less than 10U/ml (p=0.044) and the pH value of pelvic dranage less than or equal to 6.978 on 3rd POD (p<0.001) were selected as 6 independent risk factors for AL. It was shown that significant differences in survival of the patients were AL-related (p<0.001), high ASA score related (p=0.036), high-level EMI related (p=0.007) and advanced TNM stage related <p<0.001). Conclusions: AL after anterior resection for rectal carcinoma is related to advanced age, low tumor site, male sex, high preoperative EMI, low pH value of pelvic drainage on POD 3 and a significant reduction of TSGF on POD 5. In addition to their high risk of immediate postoperative morbidity and mortality, AL, worse physical status, severe obesity and advanced TNM stage have similarly negative impact on survival.

Investigation of Cu Interlayer on Joint Formation of Ti/Mg Bimetal Fabricated by Liquid–Solid Compound Casting Process

Fulin Wen,Jianhua Zhao,Kaiqing Feng,Miaowang Yuan,Dengzhi Zheng,Cheng Gu,Bei Xu 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7

In this paper, TC4/AZ91D bimetallic composites has been prepared by liquid–solid compound casting process adaptingvarious thickness of Cu coating. The effects of Cu coating thickness on the evolution of interface microstructures and jointmechanical properties are investigated. The results indicate that metallurgical bonded joints are obtained with Cu coatingthickness ranging from 36.7 to 51.4 μm. With the increase of Cu coating thickness, the interface microstructure evolvesfrom δ-Mg + Mg2Cueutectic structure to Mg–Cu intermetallic compound (IMC) Cu2Mg+ Mg2Cuand Mg–Al–Cu ternaryintermetallic compound. The calculation results of formation enthalpy and chemical potential of Mg–Al–Cu system suggestthat Cu element prefers to react with Mg element and formed Mg–Cu IMC. In particular, when Cu coating thickness reaches36.7 μm, the average shear strength of the bimetal reaches a maximum of 65.3 MPa. Further increasing Cu coating thicknessleads to the generation of thick Mg2CuIMC layer and Mg2Cu+ Cu2Mgmixed IMC layer which are proved to be harmful tothe shear strength of TC4/AZ91D bimetals. All the fracture surfaces of the bimetallic composites exhibite to have a brittlefracture morphology. However, the fracture location is different with each other. For Cu coating thickness of 36.7 μm, theinterface fractures at the δ-Mg + Mg2Cueutectic structure, while the interface fractures at the Cu2Mg+ Mg–Al–Cu ternaryintermetallic layers when Cu coating thickness is 44.2 μm and 51.4 μm.