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David Calderón Guzmán,Ernestina Hernández García,Norma Osnaya Brizuela,Francisca Trujillo Jiménez,Gerardo Barragán Mejía,Daniel Santamaría del Ángel,Elvira Nuñez A,Liliana Carmona Aparicio,Hugo Juárez 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.10
The effect that osteltamivir has on the metabolism of catecholamines and oxidative damage in the brains of young patients remains unclear. The purpose of this study was to measure the effects of oseltamivir, in the presence of oligoelements, on biogenic amines and select oxidative biomarkers in the brains of uninfected, young rats under normal conditions. The study was conducted using male Wistar rats intraperitoneally treated for three days with either a control dose of 0.9 % NaCl, oseltamivir (50 mg/kg), oligoelements (50 μL/rat), or oseltamivir (50 mg/kg) and oligoelements (50 μL/rat). The brain tissue extracted from the treated rats was used to determine the concentrations of adrenaline, noradrenaline, and dopamine, as well as the levels of GSH, lipid peroxidation, and ATPase activity. An increase in the concentration of adrenaline and noradrenaline and in the level of GSH in the group treated with oligoelements (p < 0.001) was observed, while the group treated with oseltamivir and oligoelements, the levels of dopamine increased (p < 0.001), and in the groups treated with oligoelements alone or combination with oseltamivir a decrease in lipid peroxidation was observed (p < 0.001). The results of this study suggest that the consumption of oseltamivir and oligoelements induce biphasic changes in the metabolism of catecholamines; thereby, inducing a protective mechanism against oxidative damage in the brains of young rats.
Performance modelling of single and double absorption heat transformers
Rosa María Barragán Reyes,Víctor Manuel Arellano Gómez,Alfonso García-Gutiérrez 한국물리학회 2010 Current Applied Physics Vol.10 No.2
Absorption heat transformers (heat pump Type II) enable the temperature of a low heat source to be raised to a higher level. This process takes place by means of the absorption of a vaporized working fluid into a substance which has strong affinity for the vapor. The temperature lift and the coefficient of performance (a measure of the efficiency of the process), are important design parameters which depend on the thermodynamic properties of the working pair and also on the configuration of the equipment. In order to investigate the performance of readily available, not expensive and environmentally friendly fluids in heat transformers, the systems H2O/CaCl2 and H2O/LiCl were studied, by using a Fortran program. The theoretical performance of both systems in a single stage absorption heat transformer (SSHT), was derived and compared to results obtained previously for the system H2O/CaCl2 on a double absorption unit (DAHT).
Eder Uzziel Pulido Barragán,Carlos Fernando Castro Guerrero,Ana María Zamudio,Ana Beatriz Morales Cepeda,Thomas Heinze,Andreas Koschella 한국섬유공학회 2019 Fibers and polymers Vol.20 No.6
Cellulose nanocrystals (CNC) were obtained from Typha domingensis (an invasive macrophyte) collected fromlagoons and wetlands in Altamira, Mexico. Cellulose extraction was carried out by a treatment with aqueous NaOH in a batchreactor followed by NaClO-bleaching and subsequent hydrolysis with sulfuric acid. The fibers were characterized by FourierTransform Infrared (FTIR) spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electronmicroscopy (SEM), and atomic force microscopy (AFM). The crystallinity of the cellulose fibers isolated from Typhadomingensis increased from 29 % (not treated fibers) to 73 % and the beginning of thermal degradation increased from 246 oCto 312 oC before and after the bleaching. The CNCs isolated from this plant show average values of 20 nm in diameter and 190 nmin length. Micrographs of the Typha domingensis fibers and the cellulose isolated therefrom as well as bleached celluloseindicate the removal of hemicellulose, lignin, and waxes from the fibers, which corroborates the XRD and FTIR results.
Jose Luis Lozano Villanueva,Javier Francisco Torres Zafra,Fabián Cortés Muñoz,Fernán del Cristo Mendoza Beltrán,Jenny Carolina Sánchez Casas,Luis Alfonso Barragán Pedraza 대한신경과학회 2021 Journal of Clinical Neurology Vol.17 No.2
Background and Purpose Ischemic stroke is a common cause of death worldwide. In clinical practice it is observed that many individuals who have experienced an ischemic stroke also suffer from simultaneous comorbidities such as heart failure, which could be directly associated with a worse clinical prognosis. Therefore, this study analyzed outcomes in terms of the severity of the event, inhospital mortality, duration of hospital stay, and inhospital recurrence of the episode, in order to determine the implications resulting from the presentation of both pathologies. Methods This was a retrospective-cohort, hospital-based study. Results The study included 110 subjects with heart failure (exposed) and 109 subjects without heart failure (nonexposed). The incidence of inhospital mortality was 27.27% in exposed patients and 9.17% in nonexposed patients (p<0.001), and the presence of heart failure increased the risk of death by 92% (p=0.027). According to scores on the National Institutes of Health Stroke Scale, the median severity was worse in exposed than nonexposed patients (16.1 vs. 9.2, p=0.001). The median hospital stay was 9 days in subjects with heart failure and 7 days in nonexposed patients (p=0.011). The rate of inhospital stroke did not differ significantly between exposed and nonexposed patients (1.82% vs. 0.92%, p=0.566). Conclusions Individuals with heart failure who suffer from an acute ischemic stroke show worse clinical outcomes in terms of mortality, event severity, and duration of hospital stay.
Anti-inflammatory and utero-relaxant effect of α-bisabolol on the pregnant human uterus
Victor Manuel Muñoz-Pérez,Mario I. Ortiz,Héctor A. Ponce-Monter,Vicente Monter-Pérez,Guillermo Barragán-Ramírez 대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.4
The aim of this study was to evaluate the in vitro anti-inflammatory and utero-relaxant effect of α-bisabolol on the pregnant human myometrium. Samples from the pregnant human myometrium were used in functional tests to evaluate the inhibitory effect of α-bisabolol (560, 860, 1,200 and 1,860 µM) on spontaneous myometrial contractions. The intracellular cyclic adenosine monophosphate (cAMP) levels generated in response to α-bisabolol in human myometrial homogenates were measured by ELISA. The anti-inflammatory effect of α-bisabolol was determined through the measurement of two pro-inflammatory cytokines, tumor necrosis factor-α (TNFα) and interleukin (IL)-1β, and the anti-inflammatory cytokine IL-10, in pregnant human myometrial explants stimulated with lipopolysaccharide (LPS). Forskolin was used as a positive control to evaluate the cAMP and cytokine levels. α-Bisabolol was found to induce a significant inhibition of spontaneous myometrial contractions at the highest concentration level (p<0.05). α-Bisabolol caused a concentration-dependent decrease in myometrial cAMP levels (p<0.05) and a concentration-dependent decrease in LPS-induced TNFα and IL-1β production, while IL-10 production did not increase significantly (p>0.05). The anti-inflammatory and utero-relaxant effects induced by α-bisabolol were not associated with an increase in cAMP levels in pregnant human myometrial samples. These properties place α-bisabolol as a potentially safe and effective adjuvant agent in cases of preterm birth, an area of pharmacological treatment that requires urgent improvement.
First report of splenic myelolipoma in a Schnauzer in Colombia: case report
Valentina Rueda-García,Nicolas Carrillo-Godoy,Carlos Alberto Bonilla-Gutiérrez,Alejandra Valdivieso-Valencia,Iang Schroniltgen Rondón-Barragán 대한수의학회 2022 大韓獸醫學會誌 Vol.62 No.4
Splenic myelolipoma is a rare tumor in dogs with an unclear origin. A male 13-year-old Schnauzer dog was presented because of a bump on the left side of the abdomen. Clinical examination and abdominal ultrasound revealed a mass in the spleen. A total splenectomy was carried out, and histopathology revealed a splenic myelolipoma. Before surgery, the patient showed high serum alanine aminotransferase levels, which returned to normal eight months after the resection. Unfortunately, the postoperative follow-up showed increased serum cholesterol and triglyceride levels, suggesting liver compromise. This is the first report of a splenic myelolipoma in Colombia.