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Bao‑Jian Zhu,Lin Tang,Ying‑Ying Yu,Dao‑Jun Wang,Chao‑Liang Liu 한국유전학회 2017 Genes & Genomics Vol.39 No.6
Ecdysteroids play an important role in the regulation of molting process in crustaceans. The suppression subtractive hybridization (SSH) technique was employed to search for 20-hydroxyecdysone-responsive genes in the hepatopancreas of the crayfish Procambarus clarkii. Ninety-three putative expressed sequence tags were identified by SSH, including three immune response-related genes, two cell cycle and apoptosis genes, four respiration and energy metabolism genes, four transport-related genes, six metabolism-related genes, two stress response genes, and eight transcription and translation regulation genes. The expression levels of the examined genes were regulated by 20-hydroxyecdysone and varied in the hepatopancreas during the molting stages; data were confirmed by real-time PCR. RNAi of the ecdysteroid receptor had significant effects on the expression levels of 20-hydroxyecdysone- responsive genes. These differentially expressed genes identified by SSH will provide insight into the ecdysteroid signaling pathway in P. clarkii.
Vibration Reduction for Offshore Platforms via Delayed Sliding Mode H∞ Control
Bao-Lin Zhang,Xiefu Jiang,Qiuxuan Wu,Gong-You Tang 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.1
This paper deals with delayed sliding mode H∞ control for an offshore steel jacket platform subject tononlinear self-excited wave force and external disturbance. By using both current and delayed states, a delayedsliding mode H∞ controller is designed to attenuate vibration of the offshore platform. It is observed throughsimulation results that the delayed sliding mode H∞ controller is capable of reducing the oscillation amplitudesof the offshore platform significantly. Moreover, compared with the delay-free sliding mode H∞ controller, theoscillation amplitudes of the offshore platform under the controllers are almost the same, while the control forcerequired by the delayed sliding mode H∞ controller is less than that by the delay-free sliding mode H∞ controller.
Controlling chaos for automotive disc brake squeal suppression
Bao-Chau Lin,Shun-Chang Chang,Jui-Feng Hu,Yeou-Feng Lue 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.6
Disc brake squeal is a manifestation of friction-induced, self-excited instability in disc brake systems. This paper investigates the nonsmoothbifurcations and chaotic dynamics associated with braking systems. In most situations, decreasing squealing is a means to suppresschaotic disturbances, which would otherwise compromise the comfort of passengers. The proposed method begins with an estimationof the largest Lyapunov exponent using synchronization to differentiate between periodic and chaotic motions. We then observecomplex nonlinear behaviors associated with a range of parameters and plot them in a bifurcation diagram. Rich dynamics of disc brakesystems are examined using the bifurcation diagram, phase portraits, Poincaré maps, frequency spectra, and Lyapunov exponents. Finally,state feedback control is used to overcome chaotic behaviors and prevent squealing from occurring during braking. Finally, the effectivenessof the proposed control method is examined through numerical simulations.
miR-29 family inhibited the proliferation and migration of lung cancer cells by targeting SREBP-1
Lin Lin,Bao Yongxia,Tian Miao,Ren Qiu,Zhang Wei 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.2
Backgrounds Lipid metabolism dysregulation is an important characteristic of tumor cells. Increased lipid metabolism provides a vital material and energy source for tumor growth, thereby promoting tumor invasion and metastasis. Objectives In the current work, we carried out a series of in vivo and in vitro studies to explore the relationship between miR-29 and lung cancer. Results The results showed that miR-29 was down-regulated in lung cancer, and overexpression of miR-29 inhibited the proliferation and migration of lung cancer cells (in vitro). Anti-lung cancer effect of miR-29 in vivo was evaluated, and results indicated that transfection of miR-29b/c markedly inhibited lung tumor growth (in vivo). We further explored the potential mechanism by which miR-29 could inhibit the cell proliferation of lung cancer. It is well known that lipid metabolism dysregulation is an important characteristic of tumor cells. Increased lipid metabolism provides a vital material and energy source for tumor growth, thereby promoting tumor invasion and metastasis, and sterol regulatory element-binding protein 1 (SREBP) is involved in liposome metabolism. Therefore, we analyzed the interaction between miR-29C and SREBP-1 in lung cancer cells. Bioinformatics analysis showed that the miR-29 has the potential binding site on SCAP and SREBP mRNA, and Luciferase reporter gene assays revealed the interaction between 3′UTR of SREBP-1 mRNA and miR-29c. Further study showed that miR-29 suppressed (SREBP-1) expression by interacting with 3′UTR of SREBP-1. Further work indicated that miR-29 transfection strongly inhibited lung cancer cell proliferation, which was rescued by the overexpression of SREBP-1. Conclusion These fi ndings demonstrate that transfection of miR-29 suppressed lung cancer proliferation via inhibiting SREBP-1 expression. The current study provides a basis for exploring the targeted agents against lung cancer.
Antioxidant Flavone Glycosides from the Root of Pteroxygonum giraldii
Bao-Lin Li,Lin-Ling Jiang,Hui-Chun Wang,Zhan-Jun Yang,Xi-Quan Zhang,Hong-Mei Gu,Xian-Hua Tian 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.7
Two new flavone glycosides, giraldiin A and B, together with three known compounds, annulatin, myricetin 3-O-α-L-rhamnopyranoside and gallic acid, were isolated from the ethanol extract of the root of Pteroxygonum giraldii Damm. et Diels. The structures of giraldiin A and B are designated as 3'-(α-L-arabinopyranosyloxy)-4',5,5',7-tetrahydroxy-3-methoxyflavone and 4'-(β-D-glucopyranosyloxy)-5,5',7-trihydroxy-2',3-dimethoxyflavone, respectively,on the basis of detailed spectroscopic analyses. The free radical scavenging activity of giraldiin A was evaluated by decolouring spectrophotometry of pentamethine cyanine dye (Cy5) with Fe2+-H2O2 Fenton radical generating system. The results indicated the hydroxyl free radical scavenging activity of giraldiin A (ED50 = 23.7 nmol/mL) is higher than that of some known antioxidants such as rutin, puerarin, daidzein and 2,6-di-tertbutyl-4-methylphenol.
Bao-Lin Ye,Shaofeng Niu,Lingxi Li,Weimin Wu 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.9
Efficient trajectory tracking approaches can enable autonomous vehicles not only to get a smooth trajectory but to achieve a lower energy dissipation. Since vehicle model plays an important role in trajectory tracking, this paper investigates and compares the performance of two classical vehicle models for trajectory tracking of autonomous vehicles using model predictive control (MPC). Firstly, a two-degree-of-freedom kinematic model and a three-degree-of-freedom yaw dynamic model are established for autonomous vehicles. Meanwhile, in order to carry out tracking control more effectively and smoothly, the tire slip angle has been taken into account by the dynamic model. Then, we design two MPC controllers for trajectory tracking, which are based on the kinematic model and the dynamic model, respectively. The performances of two MPC controllers are evaluated and compared on the Carsim/Matlab joint simulation platform. Experimental results demonstrated that, under low-speed working conditions, both two MPC controllers can follow the reference trajectory with high accuracy and stability. However, under high-speed working conditions, the tracking error of the kinematic model is too large to be used in the real trajectory tracking problem. On the contrary, the controller based on the dynamic model still performs a good tracking effect. In addition, this study offers guidance on how to select a suitable vehicle model for autonomous vehicles under different speed working conditions.