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손문방,신극선 大韓成形外科學會 1992 Archives of Plastic Surgery Vol.19 No.5
The congenital giant nevus in neonates not only gives na unsightly appearance, but also has a malignant transformation potential. The incidence of malignant transformation varies from 2 to 32%. Recently, Quaba and Wallace (1986) reported that the giant nevus which covered more than 2% of the total body surface area could become malignant within the first 15years of life with an incidence rate of 8.52%. We treated a neonate with a giant nevus which involved extensively the abdomen, back, buttocks and thighs; the lesion was dermabraded by two times within 5 months age. After 14 months of the follow-up, no signs of recurrence were noted; the result was acceptable in the aesthetic standpoint and for a preventive measure of malignant transformation.
Roles of E-Cadherin (CDH1) Genetic Variations in Cancer Risk: a Meta-analysis
Deng, Qi-Wen,He, Bang-Shun,Pan, Yu-Qin,Sun, Hui-Ling,Xu, Ye-Qiong,Gao, Tian-Yi,Li, Rui,Song, Guo-Qi,Wang, Shu-Kui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
E-Cadherin (CDH1) genetic variations may be involved in invasion and metastasis of various cancers by altering gene transcriptional activity of epithelial cells. However, published studies on the association of CDH1 gene polymorphisms and cancer risk remain contradictory, owing to differences in living habits and genetic backgrounds. To derive a more better and comprehensive conclusion, the present meta-analysis was performed including 57 eligible studies of the association between polymorphisms of CDH1 gene promoter -160 C>A, -347 G>GA and 3'-UTR +54 C>T and cancer risk. Results showed that these three polymorphisms of CDH1 were significantly associated with cancer risk. For -160 C>A polymorphism, -160A allele carriers (CA and CA+AA) had an increased risk of cancer compared with the homozygotes (CC), and the similar result was discovered for the -160A allele in the overall analyses. In the subgroup analyses, obvious elevated risk was found with -160A allele carriers (AA, CA, CA+AA and A allele) for prostate cancer, while a decreased colorectal cancer risk was shown with the AA genotype. For the -347 G>GA polymorphism, the GAGA genotype was associated with increased cancer risk in the overall analysis with homozygous and recessive models. In addition, results of subgroup analysis indicated that the elevated risks were observed in colorectal cancer and Asian descendants. For +54 C>T polymorphism, a decreased risk of cancer was found in heterozygous, dominant and allele models. Moreover, +54T allele carriers (CT, CT+TT genotype and T allele) showed a potential protective factor in gastric cancer and Asian descendants.