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Bala Murali Krishna Vasamsetti,In-sul Hwang,Heasun Lee,Sung-June Byun,Hyeon Yang,Sun A Ock,Hwi-Cheul Lee,Jae-Seok Woo,Keon Bong Oh 한국수정란이식학회 2018 한국수정란이식학회 학술대회 Vol.2018 No.11
In our previous studies, the cardiac xenotransplantation from an alpha-1,3-galactosyltransferase knockout pig (GT-MCP-MCP) to cynomolgus monkeys showed a mean survival of 38 days. The objective of this study is to genetically upgrade the GT-MCP-MCP pig, to further enhance membrane cofactor protein (MCP) expression and to express an endothelial specific thrombomodulin (TBM). MCP is a complement regulatory protein and TBM is a coagulation inhibitor. As the dicistronic cassette for wild-type-based MCP and TBM concurrent expressions does not show any increase of MCP, we optimized the MCP codon usage (mMCP) and substituted mMCP for MCP. When the mMCP-TBM cassette was transfected to HeLa cells, we were able to find an increased expression of MCP and endothelial cell-specific TBM expression. The cassette was then transfected into ear-skin fibroblasts isolated from one-month-old #23-4 of a GT-MCP-MCP pig, and the cell populations expressing MCP were obtained by MACS cell sorting. We performed a single cell culture of the selected cells, and obtained clones over expressing 90% MCP. The cells of a clone were used as a donor for nuclear transfer and generated GT-MCP/-MCP/mMCP/TBM pig. The transgenic pig was confirmed to be carrying the cells expressing MCP and functioning as an inhibitor against the cytotoxic effect of normal monkey serum, comparable with donor cells. Thus, we believe that the GT-MCP/-MCP/mMCP/TBM transgenic pig would be potential for the prolongation of xenograft survival in the recipients.
Building Social Work Education and the Profession in a Transition Country: Case of Nepal
Bala Raju Nikku 한국사회복지학회 2012 Asian Social Work and Policy Review Vol.6 No.3
Drawing on interviews and personal accounts of the author working in Nepal for the last 7 years,this paper discusses the evolution of social work education and challenges for its growth in Nepal,a country that is going through a series of transitions and is emerging from a recent decade-longarmed conflict. Due to a lack of formal recognition and commitment from state and non-stateactors, the future of social work in Nepal is in the hands of university-affiliated colleges and the fewsocial work graduates and educators. Their commitment, strategies, and passion are crucial to thesurvival and growth of social work in conflict-stricken, transition Nepal in South Asia.
VIG-1 is required for maintenance of genome stability in Caenorhabditis elegans
Bala Murali Krishna Vasamsetti,박양서,조남정 한국통합생물학회 2018 Animal cells and systems Vol.22 No.3
To explore the function of VIG-1 in Caenorhabditis elegans, we analyzed the phenotypes of two vig-1 deletion mutants: vig-1(tm3383) and vig-1(ok2536). Both vig-1 mutants exhibited phenotypes associated with genome instability, such as a high incidence of males (Him) and increased embryonic lethality. These phenotypes became more evident in succeeding generations, implying that the germline of vig-1 accumulates DNA damage over generations. To examine whether vig-1 causes a defect in the DNA damage response, we treated worms with UV or camptothecin, a specific topoisomerase I inhibitor. We observed that the embryonic survival of the vig-1 mutants was reduced compared with that of the wild-type worms. Our results thus suggest that VIG-1 is required for maintaining genome stability in response to endogenous and exogenous genotoxic stresses.
Interband optical properties in wide band gap group-III nitride quantum dots
Bala, K. Jaya,Peter, A. John Techno-Press 2015 Advances in nano research Vol.3 No.1
Size dependent emission properties and the interband optical transition energies in group-III nitride based quantum dots are investigated taking into account the geometrical confinement. Exciton binding energy and the optical transition energy in $Ga_{0.9}In_{0.1}N$/GaN and $Al_{0.395}In_{0.605}N$/AlN quantum dots are studied. The largest intersubband transition energies of electron and heavy hole with the consideration of geometrical confinement are brought out. The interband optical transition energies in the quantum dots are studied. The exciton oscillator strength as a function of dot radius in the quantum dots is computed. The interband optical absorption coefficients in GaInN/GaN and AlInN/AlN quantum dots, for the constant radius, are investigated. The result shows that the largest intersubband energy of 41% (10%) enhancement has been observed when the size of the dot radius is reduced from $50{\AA}$ to $25{\AA}$ of $Ga_{0.9}In_{0.1}N$/GaN ($Al_{0.395}In_{0.605}N$/AlN) quantum dot.
Bala Krishna Juluri,Wu Lin,Lennie E N Lim 한국정밀공학회 2007 International Journal of Precision Engineering and Vol.8 No.4
Existing long range piezoelectric motors with friction based transmission mechanisms are limited by the axial load capacity. To overcome this problem. a new linear piezoelectric motor using one piezoelectric actuator combined with a novel stepping mechanism is reported in this paper. To obtain both long range and fine accuracy, dual positioning control strategy consisting of coarse positioning and fine positioning is used. Coarse positioning is used for long travel range by accumulating motion steps obtained by piezoelectric actuator. This is followed by fine positioning where required accuracy is obtained by fine motion displacement of piezoelectric actuator. This prototype is able to provide resolution of 20 nanometers and withstand a maximum axial load of 300N. At maximum load condition, the positioner can move forward to a travel distance of 5mm at a maximum speed of 0.4 mm/sec. This design of nanopositioner can be used in applications for ultra precision positioning and grinding operations where high axial force capacity is required.
Bala Susmita,Reddy P. Soni,Mondal Rahul,Sarkar Partha Pratim,Sarkar Sushanta 한국전자파학회 2022 Journal of Electromagnetic Engineering and Science Vol.22 No.3
A novel design for the planar monopole antenna presented in this article consists of a patch resembling a tree and a modified ground plane resembling a flower vase. The proposed antenna is planned, designed, and made by utilizing FR4 substrate. The proposed antenna contributes to a computer simulation and tested S11 bandwidth of 9.4 GHz (144.62%) and 9.3 GHz (136.76%), respectively. A peak tested gain of 6.5 dBi and peak efficiency of 77.51% have been achieved. The measured results of the fabricated antenna are compared with the simulated results and are found to be in good agreement. The proposed antenna has a low general volume of 38 × 20 × 1.6 mm<sup>3</sup> . The antenna can be used in C-band and X-band application.