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      • KCI등재

        Acetalization of glycerol over sulfated UiO-66 under mild condition

        Yuanyuan Jiang,Ruru Zhou,Boyong Ye,Zhaoyin Hou 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.110 No.-

        Sulfated metal–organic framework has attracted much attention as a versatile heterogeneous acid for itsstrong acid strength, large surface area and regular pore channels. In this work, sulfated UiO-66 (UiOSO3H-x) was prepared via the direct oxidation of 2-mercaptobenzoic acid substituted UiO-66. The structureand property of the synthesized UiO-SO3H-x were characterized via XRD, FTIR, static water contactangles, XPS, TG-DTA, N2 adsorption–desorption, SEM and TEM in detail. It was found that sulfonic acidgroups dispersed homogenously in the framework of UiO-SO3H-x. And UiO-SO3H-0.2 exhibited excellentperformance and stability for the synthesis of solketal from surplus glycerol among the tested solid acids(H3PW12O40, Amberlyst-45, HY, HBEA, HZSM-5 and ZrHP). The detected conversion of glycerol reached70.3% with a 99.8% selectivity toward solketal at 60 C, and it could maintain its initial activity in fiverecycles. The highest TOF of each acid site in UiO-SO3H-0.2 reached 676.0 h1. Moreover, it was versatilefor the acetalization of glycerol with other ketones/aldehydes.

      • SCISCIESCOPUS

        <i>Lactobacillus acidophilus</i> NS1 attenuates diet-induced obesity and fatty liver

        Park, Sung-Soo,Lee, Yeon-Joo,Song, Sooyeon,Kim, Boyong,Kang, Hyuno,Oh, Sejong,Kim, Eungseok Journal of Endocrinology, Ltd. [etc.] 2018 The Journal of endocrinology Vol. No.

        <P>Obesity is a major threat to public health, and it is strongly associated with insulin resistance and fatty liver disease. Here, we demonstrated that administration of Lactobacillus acidophilus NS1 (LNS1) significantly reduced obesity and hepatic lipid accumulation, with a concomitant improvement in insulin sensitivity, in high-fat diet (HFD)-fed mice. Furthermore, administration of LNS1 inhibited the effect of HFD feeding on the SREBP-1c and PPAR alpha signaling pathways and reduced lipogenesis with an increase in fatty acid oxidation in ex vivo livers from HFD-fed mice. These LNS1 effects were confirmed in HepG2 cells and ex vivo livers by treatment with LNS1 culture supernatant (LNS1-CS). Interestingly, AMPK phosphorylation and activity in the liver of HFD-fed mice were increased by administration of LNS1. Consistently, chemical inhibition of AMPK with compound C, a specific inhibitor of AMPK, dramatically reduced the effect of LNS1-CS on lipid metabolism in HepG2 cells and ex vivo livers by modulating the SREBP-1c and PPAR alpha signaling pathways. Furthermore, administration of LNS1 to HFD-fed mice significantly improved insulin resistance and increased Akt phosphorylation in the liver, white adipose tissue and skeletal muscle. Together, these data suggest that LNS1 may prevent diet-induced obesity and related metabolic disorders by improving lipid metabolism and insulin sensitivity through an AMPK. SREBP-1c/PPAR alpha signaling pathway.</P>

      • KCI등재후보

        NANOSCALE POROUS SILICON MICROCAVITY BIOSENSOR FOR NOVEL LABEL-FREE TUBERCULOSIS ANTIGEN–ANTIBODY DETECTION

        BAO WU,GUOGUANG RONG,JUNWEI ZHAO,SHULIN ZHANG,YONGXIN ZHU,BOYONG HE 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.6

        One third of the world population is estimated to have Mycobacterium tuberculosis infection. It is urgent to develop a rapid, inexpensive and convenient diagnostic method for detection of tuberculosis. Porous silicon material has taken more and more attention in recent years for biosensing applications and some useful results have been obtained. In this paper, we report the feasibility of applying porous silicon microcavity biosensor in a novel and relatively rapid serodiagnostic approach. Nowadays, most of serodiagnostic tests are based on labeled detection. Applying label-free detection methods can help develop fast and e±cient tuberculosis diagnostic tools, which can meet the current demand. In this study, we use this label-free sensing platform (i.e., porous silicon microcavity) to detect the interaction between 16 kDa antigen and anti-16 kDa antibody. Through a series of experiments, we verify the speci¯city and examine the sensitivity of this new diagnostic technique. The results show that it is feasible to apply porous silicon microcavity in the tests of tuberculosis.

      • KCI등재

        소셜커머스 앱에서 정보구조(IA)의 차이에 따른 사용성 비교연구 -쿠팡, 티몬, 위메프 앱을 중심으로-

        오문석,원종욱,이보용,한규훈,Oh, Moonseok,Won, Jongwook,Lee, Boyong,Han, Gyuhoon 디지털산업정보학회 2015 디지털산업정보학회논문지 Vol.11 No.3

        As the development of new media and smart phone, more and more people are using social commerce application to shop on-line. Comfort and easiness of the UX design of the application directly affect the social commerce user's searching and buying the merchandise. This study analyzes the effect of social commerce application, especially focusing on the lay-out of the GUI, on the consumer's interest and we suggest an attractive application design of the UX. The material of this study is the lay-out of the GUI of 3 major social commerce - Wemakeprice, Coupan and Ticket monster. We asked questions to the university students who are skillful smart phone users to select frequent on-line shoppers and performed in-depth interview with them to draw a conclusion. As a result of study, differences of main screen layout and information architecture of each social commerce applications has confirmed that indicates a significant difference in usability.

      • 食治의 개념 정립 및 적용 이론의 이해

        안상영(Ahn Sangyoung),이민호(Lee Minho),표보영(Pyo Boyong),하정용(Ha Jeongyong),안상우(Ahn Sangwoo) 한국한의학연구원 2008 한국한의학연구원논문집 Vol.14 No.2

        Alimentotherapy refers to the treatment or prevention by means of food. As food is consumed in everyday life and its constituents varies enormously, the practice of alimentotherapy was often misunderstood. By the research on ancient classics we could find 3 prospective about this practice. Firstly, alimentotherapy was used during the recovery and also for prevention. This is a type of Life-nurturing method, which we suggest to be called life-nurturing alimentotherapy. Secondly, it was also used as a dietary prescription made by physicians. Sometimes they made prescriptions combining materials derived from food with herbal medication. This practice was exclusively made by physicians as they had to consider the characteristic of each food as well as the condition of the patient. Thirdly, sometime alimentotherapy was used in cuisine form. They used food components in major part and herbal medicine used as additional ingredients. It was primarily focused on the taste and in some part its functional aspects. The underlying theories in alimentotherapy is exactly the same as used for understanding herbal medicine in TKM. Therefore, except in the case of life-nurturing method, it should be used by expert physicians. Finally, we suggest to differentiate the terms of alimentotherapy in the aspect of life-nurturing, dietary prescriptions and cuisine to prevent confusions.

      • 랜덤워크를 이용한 생태네트워크 변화 모의예측방안 연구(Ⅱ)

        김지영 ( Ji Young Kim ),노태호 ( Tae Ho Ro ),유상덕 ( Sang-duk Yoo ),서보용 ( Boyong Seo ) 한국환경정책평가연구원 2016 기본연구보고서 Vol.2016 No.-

        어느 지역에 개발사업이 시행되면 이로 인해 자연상태에 인공적인 지형 장애요소들이 추가되고 이것들이 동물의 이동을 방해하여 사업 시행 전보다 이동 가능 통로가 감소해 동물들은 다른 이동경로를 선택하게 될 것이다. 이 연구는 개발사업이 생태계 네트워크에 미치는 영향을 예측하는 시뮬레이션 프로그램을 개발하고 이 프로그램을 이용하여 동물의 이동에 변화가 발생하는 것을 분석하는 방법을 제시한다. 이에 주어진 조건에서의 가능한 생태네트워크의 형성과 지형 장애요소가 추가되었을 때의 네트워크의 변화와 영향 정도를 모의 실험할 수 있는 Ecological Network Simulator(EN Simulator)를 개발하였다. EN Simulator의 분석조건을 설정하기 위한 초기 테스트(Background Test)와 이동선호 분석법(Basic Method)을 기본 방법으로 제시하였다. 이동선호 분석법은 동물이 어떤 한 지점에서 주변으로 이동할 때 가장 선호하리라 예상되는 방향을 랜덤워커의 이동 결과를 통해서 결정하는 방법으로, EN Simulator에서 사용하는 기본 분석방법이다. 이 기본 방법을 반복적으로 수행하면서 동물 이동을 모사해 동물의 이동가능성 변화를 공간적으로 분석하는 방법으로 주 이동방향 분석법(Major Movement Direction Analysis), 이동가능성 분석법(Permeability Analysis) 및 이동 추적법(Trekker)을 제시하였다. 시뮬레이션 결과와 실제 동물의 이동이 유사한지를 검토하기 위해서 EN Simulator에 의한 이동패턴과 고라니 이동 원격추적 결과 및 삵의 흔적 조사결과를 비교하였다. 시뮬레이션 결과와 실제 장애요소 간의 관계를 검토하기 위해 경사도에 따른 이동확률을 비교하였고 이를 토대로 최적의 이동확률을 설정하였다. 랜덤워커의 위치에 따라 시뮬레이션 결과에 얼마나 영향이 있을지를 검토하기 위해서 출발점에 따른 결과를 비교하여 제시하였고, 이를 Simulator에 반영하였다. EN Simulator를 이용하여 사업 시행 전과 사업 시행 후의 이동가능성이 어떻게 변하는지를 분석 제시하였다. 사업부지의 형태를 바꿀 경우 이동가능성에 발생되는 변화를 분석하였고 이를 이용하여 최적의 부지형태를 선정하기 위한 활용가능성을 제시하였다. EN Simulator의 사용방법을 정리한 매뉴얼은 부록에 수록하였다. As a development project is implemented in a certain area, addition of artificial obstacles may hider movements of animals, losing some available paths that they had been used without any interruptions. This kind of impacts results in that they find the other routes to pass around. This study is about developing simulation program for estimating impacts of development project on ecological network and analysing methods of change in animal movement paths are proposed. Ecological Network Simulator (EN Simulator) is developed to simulate possible ecological network changes and relative influences on the network when obstacles are added from disturbances by development project. Random walker is used as an imaginary animal in the EN Simulator and moves by choosing next position based on their probabilities. Each random walker determines its next position by probabilistic choice from adjacent points that have their own properties, which reflects existence of obstacles, inclination and surface condition. Suggested elementary methods are composed of `Background test` and `Basic method`. The Background test is to ensure the simulator works properly in a designated settings, and the Basic method is a fundamental operating method of the EN Simulator. In the Basic Method - analysis of moving preferences - the preferable direction is determined by analysing movement results of many random walkers starting from a point to other points located within a given distance. In addition, 3 spatial analysis methods - Major Movement Direction Analysis, Permeability Analysis and Trekker - are suggested to assess changes of movement patterns. These 3 assessment methods use iterations of the Basic method. Telemetry track records of water deer (Hydropotes inermis) and field traces of Leopart Cat (Prionailurus bengalensis euptilura) are used to validate the simulation results between imaginary movements of random walkers and real traces of animals. Various sets of probability values to define difficulties of movement due to inclination degree of geographical surfaces are applied to find an optimum setting parameters for EN Simulator. Results are compared to check stability of simulation results when starting points are selected by operators who may produce slight deviations inadvertently. Simulation analysis cases are presented to see change in moving probabilities before and after project implementation. Analyses are also accomplished to see changes in animal movement probabilities when shape of a site is modified. The results suggest that the simulator can be applied to find optimum site shape to minimize impacts on ecological networks. Manual is attached as an appendix.

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