Measurements of B→J/ψ at forward rapidity in p+p collisions at s=510 GeV

Aidala, C.,Ajitanand, N. N.,Akiba, Y.,Akimoto, R.,Alexander, J.,Alfred, M.,Aoki, K.,Apadula, N.,Asano, H.,Atomssa, E. T.,Attila, A.,Awes, T. C.,Ayuso, C.,Azmoun, B.,Babintsev, V.,Bai, M.,Bai, X.,Banni American Physical Society 2017 Physical Review D Vol.95 No.9

<P>We report the first measurement of the fraction of J/psi mesons coming from B-meson decay (F (B -> J/psi)) in p + p collisions at root s = 510 GeV. The measurement is performed using the forward silicon vertex detector and central vertex detector at PHENIX, which provide precise tracking and distance-of-closest-approach determinations, enabling the statistical separation of J=. due to B-meson decays from prompt J/psi. The measured value of F (B -> J/psi) is 8.1% +/- 2.3% (stat) +/- 1.9% (syst) for J/psi with transverse momenta 0 < p(T) < 5 GeV/c and rapidity 1.2 < vertical bar y vertical bar < 2.2. The measured fraction F (B -> J/psi) at PHENIX is compared to values measured by other experiments at higher center of mass energies and to fixed-order-next-toleading- logarithm and color-evaporation-model predictions. The b (b) over bar cross section per unit rapidity [d sigma/dy(pp -> b (b) over bar)] extracted from the obtained F (B -> J/psi) and the PHENIX inclusive J/psi cross section measured at 200 GeV scaled with color-evaporation-model calculations, at the mean B hadron rapidity y = +/- 1.7 in 510 GeV p + p collisions, is 3.63(-1.70)(+1.92) mu b. It is consistent with the fixed-order-next-toleading- logarithm calculations.</P>

Superconducting properties of MgB₂ superconductors in-situ processed using various boron powder mixtures

Kang, M.O.,Joo, J.,Jun, B.H.,Kim, C.J. The Korean Society of Superconductivity and Cryoge 2021 한국초전도저온공학회논문지 Vol.23 No.3

In this study, the effect of the size of B powder on the critical current density (J_c) of MgB₂ prepared by an in situ reaction process was investigated. Various combinations of B powders were made using a micron B, ball-milled B and nano B powders. Micron B powder was reduced by ball milling and the milled B powder was mixed with the micron B or nano B powder. The mixing ratios of the milled B and micron or nano B were 100:0, 50:50 and 0:100. Non-milled micron B powder was also mixed with nano powder in the same ratios. Pellets of (2B+Mg) prepared with various B mixing ratios were heat-treated to form MgB₂. T_c of MgB₂ decreased slightly when the milled B was used, whereas the J_c of MgB₂ increased with increasing amount of the milled B or the nano powder. The used of the milled B and nano B power promoted the formation MgB₂ during heat treatment. In addition to the enhanced formation of MgB₂, the use of the powders reduced the grain size of MgB₂. The use of the milled and nano B powder increased the J_c of MgB₂. The highest J_c was achieved when 100% nano B powder was used. The J_c enhancement is attributed to the high volume fraction of the superconducting phase (MgB₂) and the large grain boundaries, which induces the flux pinning at the magnetic fields.

Adenosine triphosphate-based chemotherapy response assay-guided chemotherapy in unresectable colorectal liver metastasis

Hur, H,Kim, N K,Kim, H G,Min, B S,Lee, K Y,Shin, S J,Cheon, J H,Choi, S H Nature Publishing Group 2012 The British journal of cancer Vol.106 No.1

<P><B>Background:</B></P><P>This study aims to evaluate the effectiveness of adenosine triphosphate-based chemotherapy response assay (ATP-CRA)-guided neoadjuvant chemotherapy for increasing resectability in patients with unresectable colorectal liver metastasis.</P><P><B>Patients and methods:</B></P><P>Patients were randomised into two groups: Group A was treated by conventional chemotherapy regimen and Group B was treated by chemotherapy regimen according to the ATP-CRA. Three chemotherapeutic agents (5-fluorouracil, oxaliplatin and irinotecan) were tested by ATP-CRA and more sensitive agents were selected. Either FOLFOX or FOLFIRI was administered. Between Group A and B, treatment response and resectability were compared.</P><P><B>Results:</B></P><P>Between November 2008 and October 2010, a total 63 patients were randomised to Group A (<I>N</I>=32) or Group B (<I>N</I>=31). FOLFOX was more preferred in Group A than in Group B (26 out of 32 (81.3%) <I>vs</I> 20 out of 31 (64.5%)). Group B showed better treatment response than Group A (48.4% <I>vs</I> 21.9%, <I>P</I>=0.027). The resectability of hepatic lesion was higher in Group B (35.5% <I>vs</I> 12.5%, <I>P</I>=0.032). Mean duration from chemotherapy onset to the time of liver resection was 11 cycles (range 4–12) in Group A and 8 cycles (range 8–16) in Group B.</P><P><B>Conclusion:</B></P><P>This study showed that tailored-chemotherapy based on ATP-CRA could improve the treatment response and resectability in initially unresectable colorectal liver metastasis.</P>

한국의 HIV-1 감염의 분자역학

이주실,김은영,남정구,기미경,최병선,김성순,강춘,구본기,신영오 국립보건연구원 1998 국립보건원보 Vol.35 No.-

Development of an antibody-based diagnostic method for the identification of Bemisia tabaci biotype B

Baek, J.H.,Lee, H.J.,Kim, Y.H.,Lim, K.J.,Lee, S.H.,Kim, B.J. Academic Press 2016 Pesticide biochemistry and physiology Vol.131 No.-

<P>The whitefly Bemisia tabaci is a very destructive pest. B. tabaci is composed of various morphologically undistinguishable biotypes, among which biotypes B and Q, in particular, draw attention because of their wide distribution in Korea and differential potentials for insecticide resistance development. To develop a biotypespecific protein marker that can readily distinguishes biotypes B from other biotypes in the field, we established an ELISA protocol based on carboxylesterase 2 (COE2), which is more abundantly expressed in biotypes B compared with Q. Recombinant COE2 was expressed, purified and used for antibody construction. Polydonal antibodies specific to B. tabaci COE2 [anti-COE2 pAb and deglycosylated anti-COE2 pAb (DG anti-COE2 pAb)] revealed a 3-9-fold higher reactivity to biotype B COE2 than biotype Q COE2 by Western blot and ELISA analyses. DG anti-COE2 pAb exhibited low non-specific activity, demonstrating its compatibility in diagnosing biotypes. Western blot and ELISA analyses determined that one of the 11 field populations examined was biotype B and the others were biotype Q suggesting the saturation of biotype Q in Korea. DG anti-COE2 pAb discriminates B. tabaci biotypes B and Q with high specificity and accuracy and could be useful for the development of a B. tabaci biotype diagnosis kit for on-site field applications. (C) 2016 Elsevier Inc. All rights reserved.</P>

反芻胃 Celluloytic Bacteria에 의한 섬유소 분해 및 비구조 탄수화물의 이용성에 관한 硏究

민병렬,김범석,맹원재 건국대학교 동물자원연구센터 1991 動物資源硏究誌 Vol.16 No.-

본 실험은 반추위내에 존재하는 주요한 cellulolytic bacteria를 選擇 및 非選擇培地를 사용하여 면양의 rumen내에 존재하는 celluloytic bacteria를 사용하여 纖維素 分解菌 각각의 纖維素源의 分解度, 비구조 탄수화물의 이용성 및 휘발성 지방산의 생성량을 측정하였다. 본 실험결과를 요약해 보면 다음과 같다. 1) In vitro상에서 Corn stover, alfalfa, rice straw 및 filterpaper No.1등의 섬유소원에 대한 R.flavefaciens의 평균 DM 소화율은 10.75%로 가장 높은 소화율을 나타내었으며, B.succinogenes, Buty. fibrisolvens 및 B. ruminicola subsp. 등은 각각 8.20%, 5.66% 및 2.5%의 DM소화율을 나타내었다.(p<0.05). 2) 섬유소원에서의 평균 microbial dry cell生成量은 R.flavefaciens. B.succinogenes, Buty.fibrisolvens 및 B.rumminicola subsp. 등이 각각 11.4, 4.47, 6.38 및 1.13mg/100ml를 가장 높은 미생물 cell의 생성량을 나타내었다. 3) ADF 및 NDF 평균 소화율은 R.flavefaciens가 가장 높았으며(23.61% 및 39.87%), B.succinogenses는 각각 11.16% 및 35.91%의 분해도를 나타내었다. Buty. fibrisolvens는 16.82% 및 24.34%로서 가장 낮은 분해도를 나타내었다. CEllulose消化率은 B.succinogenes가 14.43%로 R.flavefaciens(11.11%)보다 높은 분해율을 나타내었다. 4) 비구조 炭水化物 利用率은 (OD=670nm)R.flavefaciens가 mannose, arabinose 및 xylose 등을 가장 잘 이용하며, B. ruminicola subsp.은 galactose, mannose, arabinose 및 xylose등을 가장 잘 이용하는 것으로 나타났다. B.succinogenes는 glucose 및 rffainose를 가장 잘 이용하며, B.fibrisolvens는 glucose, galactose, arabinose, xylose 및 maltose등을 가장 잘 이용하는 것으로 나타났다. (P<0.05). 5) PYG basal medium에 炭水化物源을 각각 1g씩 첨가한 培養區에서 VFA 생성량은 R.flavefaciens는 주로 acetate, propionate, n-butyrate 및 succinate를 생산하는 것으로 나타났으며, 이것들의 생산량은 각각 81.65, 26.36, 20.16 및 108.91mM/100ml를 생산하여 succinate를 가장 많이 생산하는 것으로 나타났다. B.ruminicola subsp은 주로 acetate, propionate 및 n-butyrate를 생산하는 것으로 나타났으며, 이 균의 생산량은 각각 104.72, 31.32 및 26.12mM/100ml를 생산하였으며, B. succinogenes는 주로 acetate, propionate, n-butyrate 및 succinate를 생산하며, 이 균들의 생산량은 각각 87.66, 27.70 및 56.07mM/100ml 생산하였다. Buty.fibrisolvens는 주로 acetate, propionate 및 n-butyrate를 생산하는 것으로 나타났다. Fiber degradation of corn stover, rice straw, alfalfa or filter paper No.1 was evaluated using microscopy and in vitro analyses after incubation with pure culture of cellulolytic ruminal bacteria. 1) Analyses of the initial substrate and the recovered residue after 24h of static incubation showed that R.flavefaciens degraded a mean dry matter(10.75% versus 5.66%) more effectively than B. succinogenes. However, B, succinogenes demonstrated a qualitative advantage in degrading cellulose of particular substrates. DM digestibilities for alfalfa and rice straw. Treatment for 24h were 13.96% and 9.46% for R.lflavefaciens, 10.27% and 4.32% for B.succinogenes, and 7.74% and 2.31% for Buty. fibrisolvens(p<0.05). Bacteriodes ruminitola subsp. was unable to degrade plant cell wall components, while it degraded non-structural carbohydrates more actively than any other bacteria. Microbial cell DM yield(avg, 11.44mg/dl) was the highest for R. flavefaciens cultured with alfalfa substrate(p<0.05). 2) Ruminococcu flavefaciens degraded a mean 23.61% of the ADF and 39.87% of the NDF in the various substrates. whereas, B. succinogenes degraded a mean 11.6% and 35.91% of these fractions, respectively. 3) The utilization of carbodydrates was the highest for R.flavefaciens cultured with mannose and xylcse substrate, and for B. ruminicola subsp. with arabinose, xylose, raffinose and galactose respectively. B. succinogenes utilized glucose and raffinose, as major substrates fermentd(p<0.05) and Buty. fibrisolvens utilized glucose, galactose, arabinose, xylose and maltose. 4) Ruminococcus flavefaciens produced acetate, succinate and propionate, and B.ruminicola subsp. produced acetate, propionate and n-butyrate as major VFA. B.succinogenes produced acetate, propionate, n-butyrate and succinate, and Buty.fibrisolvens produced n-butyrate and acetate as major VFA.

Aggravation of post-ischemic liver injury by overexpression of A20, an NF-κB suppressor

Yu, J.,Lee, H.S.,Lee, S.M.,Yu, H.C.,Moon, W.S.,Chung, M.J.,Park, J.W.,Park, B.H. Elsevier Science Publishers 2011 Journal of hepatology Vol.55 No.2

Backgroud & Aims: A20 is an intracellular ubiquitin-editing enzyme that plays an important role in the negative feedback regulation of NF-κB activation in response to a diverse range of stimuli. Liver ischemia/reperfusion injury is associated with rapid activation of NF-κB signaling, but the role of NF-κB in hepatic ischemia/reperfusion injury remains controversial. The NF-κB signaling pathway mediates both protective and deleterious effects in the liver. Here, we examined whether A20 inhibited or aggravated hepatic ischemia/reperfusion injury. Methods: We used IκBα super-repressor as a positive control and overexpressed A20 and IκBα super-repressor in the liver of C57BL/6 mice. Mice underwent 45min of partial hepatic ischemia and were then reperfused. Results: Protein level of A20 was increased after reperfusion. Mice subjected to ischemia/reperfusion injury showed increased NF-κB activation, as evidenced by phosphorylation of IκBα and nuclear translocation of NF-κB. Prior transfection with Ad-A20 or Ad-IκBα super-repressor attenuated NF-κB activation and aggravated liver injury. Serum aminotransferases and proinflammatory cytokines, hepatocellular necrosis, and hepatic neutrophil infiltration were markedly increased compared to those of uninfected or control virus infected mice. In addition, A20 abolished the beneficial effect of ischemic preconditioning. Conclusions: Our results suggest that inhibition of NF-κB activation by A20 aggravated partial hepatic ischemia/reperfusion injury. Understanding how the NF-κB pathway plays a role in directing a clinical outcome may lead to better prospects of more rational approaches to reduce post-ischemic liver injury.

국내 감염성질환 병원체의 성상분석을 통한 표준실험실 체계 구축(Ⅱ) : 장내바이러스와 B형간염바이러스 국내 분리주의 성상분석(1)

윤재득,지영미,김기순,천두성,안정배,정윤석,신수연,이선화,이지원,조해월 국립보건연구원 2000 국립보건원보 Vol.37 No.-

반추위내 (反芻胃內) Cellulolytic bacteria 의 분리 동정 (同定) 및 Activity 에 관한 연구 (2) 반추위내 Cellulolytic bacteria 의 Activity 에 관한 연구

민병렬(B . R . Min),맹원재(W . J . Maeng),조남기(N . K . Cho) 한국영양사료학회 1991 韓國營養飼料學會誌 Vol.15 No.3

1998년 분리된 이질균의 역학적 특성

이복권,강연호,김성한,유재연,전정훈 국립보건연구원 1998 국립보건원보 Vol.35 No.-