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돼지 H-FABP 유전자의 다형성 및 경제 형질과의 연관성 구명
최봉환,김태헌,이지웅,조용민,이혜영,조병욱,정일정 한국동물자원과학회 2003 한국축산학회지 Vol.45 No.5
The purpose of this study was to detect association between genetic variation and economic trait in the porcine heart type fatty acid-binding protein gene as a candidate gene for the traits related with growth and meat quality in pigs. The H-FABP is a 15-kDa protein expressed in several tissues with high demand for fat metabolism such as cardiac and skeletal muscle and lactating mammary gland. H-FABP is small intracellular protein involved in fatty acid transport from the plasma membrane to the site of β-oxidation and/or triacylglycerol or phospholipid synthesis. In this study, H-FABP PCR-RFLP was performed in F_(2) population composed of 214 individuals form an intercross between Korean Native Boars and Landrace sows. PCR products form tow primer sets within H-FABP gene were amplified in 850bp and 700bp. Digestion of PCR products with the restriction digestion enzymes HaeⅢ and Hinf Ⅰ, revealed fragment length polymorphisms(RFL. Ps). The genotype frequencies from H-FABP/HaeⅢ was .29 for genotype DD, .53 for genotype Dd, and .15 for genotype dd, respectively. The genotype frequencies of HH, Hh, and hh from H-FABP(hinf Ⅰ was .38, .41, and .20, respectively, in the population.Relationships between their genotypes and economic traits were estimated. In H-FABP/HaeⅢ locus, there were specific genotypes(Dd and dd) associated with economic traits such as body weight. In H-FABP/Hinf Ⅰ Iocus, Genotypes of HH and Hh associated with growth traits such as body weights at 5, 12, and 30 week of age (p<.05 or p<.001) and back fat thickness, body fat including abdominal and trimmed fat (p<.001) and intramuscular fat(p<.05). The 'H'allele was positivecly associated with gaining of body weight and fatness deposition. In conclusion, a significant association of the H-FABP gene from its genetic variation was found on body weight, intramuscular fat and backfat thickness.
Park, S R,Kong, S-Y,Nam, B-H,Choi, I J,Kim, C G,Lee, J Y,Cho, S J,Kim, Y W,Ryu, K W,Lee, J H,Rhee, J,Park, Y-I,Kim, N K Nature Publishing Group 2011 The British journal of cancer Vol.104 No.7
<P><B>Background:</B></P><P>We evaluated the association between polymorphisms of cytochrome P450 2A6 (<I>CYP2A6</I>)/excision repair cross-complementation group 1 (<I>ERCC1</I>)/X-ray repair cross-complementing group 1(<I>XRCC1</I>) and treatment outcomes of metastatic gastric cancer (MGC) patients treated with S-1/cisplatin.</P><P><B>Methods:</B></P><P>Among MGC patients (<I>n</I>=108), who received S-1 (40 mg m<SUP>−2</SUP> b.i.d., days 1–14) and cisplatin (60 mg m<SUP>−2</SUP>, day 1) every 3 weeks, we analysed the wild-type allele (<I>W</I>) and variants (<I>V</I>) of <I>CYP2A6</I> (<I>*4</I>, <I>*7, *9, *10</I>), and the polymorphisms of <I>ERCC1</I> (rs11615, rs3212986) and <I>XRCC1</I> (rs25487).</P><P><B>Results:</B></P><P>Patients having fewer <I>CYP2A6</I> variants had better response rates (<I>W</I>/<I>W vs W</I>/<I>V</I> other than <I>*1/*4 vs V</I>/<I>V</I> or <I>*1/*4</I>=66.7 <I>vs</I> 58.3 <I>vs</I> 32.3% <I>P</I>=0.008), time to progression (TTP) (7.2 <I>vs</I> 6.1 <I>vs</I> 3.5 months, <I>P</I>=0.021), and overall survival (23.2 <I>vs</I> 15.4 <I>vs</I> 12.0 months, <I>P</I>=0.004). <I>ERCC1 19442C</I>><I>A</I> (rs3212986) was also associated with response rate (<I>C/C</I>, 46.7% <I>vs C/A</I>, 55.3% <I>vs A/A</I>, 87.5%) (<I>P</I>=0.048) and TTP (4.4 <I>vs</I> 7.6 <I>vs</I> 7.9 months) (<I>P</I>=0.012). Patients carrying both risk genotypes of <I>CYP2A6</I> (<I>V</I>/<I>V</I> or <I>1/*4</I>) and <I>ERCC1 19442C</I>><I>A</I> (<I>C/C</I>) <I>vs</I> those carrying none showed an adjusted odds ratio of 0.113 (<I>P</I>=0.004) for response, and adjusted hazard ratios of 3.748 (<I>P</I>=0.0001) for TTP and 2.961 (<I>P</I>=0.006) for death.</P><P><B>Conclusion:</B></P><P>Polymorphisms of <I>CYP2A6</I> and <I>ERCC1 19442C</I>><I>A</I> correlated with the efficacy of S-1/cisplatin.</P>
Cho H.J.,Kwon H.T.,Ryu H.H.,Sohn K.Y.,You B.S.,Park W.W. The Korean Powder Metallurgy Institute 2006 한국분말재료학회지 (KPMI) Vol.13 No.4
Co-Fe-Ni-B-Si-Cr based amorphous strips containing nitrogen were manufactured via melt spinning, and then devitrified by crystallization treatment at the various annealing temperatures of $300^{\circ}C{\sim}540^{\circ}C$ for up to 30 minutes in an inert gas $(N_2)$ atmosphere. The microstructures were examined by using XRD and TEM and the magnetic properties were measured by using VSM and B-H meter. Among the alloys, the amorphous ribbons of $Co_{72.6}Fe_{9.8}Ni_{5.5}B_{2.4}Si_{7.1}Cr_{2.6}$ containing 121 ppm of nitrogen showed relatively high saturation magnetization. The alloy ribbons crystallized at $540^{\circ}C$ showed that the grain size of $Co_{72.6}Fe_{9.8}Ni_{5.5}B_{2.4}Si_{7.1}Cr_{2.6}$ alloy containing 121 ppm of nitrogen was about f nm, which exhibited paramagnetic behavior. The formation of nano-grain structure was attributed to the finely dispersed Fe4N particles and the solid-solutionized nitrogen atoms in the matrix. Accordingly, it can be concluded that the nano-grain structure of 5nm in size could reduce the core loss within the normally applied magnetic field of 300A/m at 10kHz.
Gas-sensing properties of In<sub>2</sub>O<sub>3</sub> films modified with gold nanoparticles
Korotcenkov, G.,Brinzari, V.,Han, S.H.,Cho, B.K. Elsevier 2016 Materials chemistry and physics Vol.175 No.-
<P><B>Abstract</B></P> <P>A study of the surface and gas–sensitive properties of In<SUB>2</SUB>O<SUB>3</SUB> films modified with gold nanoparticles and synthesized by the successive ionic layer deposition (SILD) method was conducted. In<SUB>2</SUB>O<SUB>3</SUB> films were prepared using the spray pyrolysis method. The gas-sensing characteristics were tested using CO, H<SUB>2</SUB>, and O<SUB>3</SUB> as target gases. It has been shown that the surface modification with gold nanoparticles gives the opportunity to optimize the response of In<SUB>2</SUB>O<SUB>3</SUB>-based gas sensors to both reducing (CO, H<SUB>2</SUB>) and oxidizing (O<SUB>3</SUB>) gases. It has been found that the sensitizing effect during ozone detection was significantly higher than the effect during CO and H<SUB>2</SUB> detection. It has been demonstrated that the sensitizing effect depended on the number of SILD cycles used for gold nanoparticle deposition and was maximal for the In<SUB>2</SUB>O<SUB>3</SUB> surface decorated with gold nanoparticles with the smallest size. The mechanism of the gold nanoparticles' influence on the gas-sensing properties of the In<SUB>2</SUB>O<SUB>3</SUB> films is also discussed. It is suggested that to explain the observed effects, we have to consider both the “electronic” and “chemical” mechanisms of sensitization. Suggestions for studies to be carried out to further improve both the understanding of the nature of the gas-sensitive effects and the parameters of In<SUB>2</SUB>O<SUB>3</SUB>:Au-based gas sensors are also formulated.</P> <P><B>Highlights</B></P> <P> <UL> <LI> •In<SUB>2</SUB>O<SUB>3</SUB> gas sensors modified with gold nanoparticles using SILD method are studied. </LI> <LI> •AuNPs exhibit activity during interaction with either reducing or oxidizing gases. </LI> <LI> •Maximal effect of optimization is observed during ozone detection. </LI> <LI> •Sensitizing effect depends on the number of SILD cycles. </LI> <LI> •Proposed mechanisms explain effects observed in the In<SUB>2</SUB>O<SUB>3</SUB>:Au based gas sensors. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Oh, B.T.,Seo, Y.S.,Sudhakar, D.,Choe, J.H.,Lee, S.M.,Park, Y.J.,Cho, M. Elsevier Scientific Pub. Co 2014 Journal of hazardous materials Vol.279 No.-
The presence of endotoxin in water environments may pose a serious public health hazard. We investigated the effectiveness of advanced oxidative processes (AOP: O<SUB>3</SUB>/H<SUB>2</SUB>O<SUB>2</SUB> and UV/H<SUB>2</SUB>O<SUB>2</SUB>) in the oxidative degradation of endotoxin. In addition, we measured the release of endotoxin from Escherichia coli following typical disinfection methods, such as chlorine, ozone alone and UV, and compared it with the use of AOPs. Finally, we tested the AOP-treated samples in their ability to induce tumor necrosis factor alpha (TNF-α) in mouse peritoneal macrophages. The production of hydroxyl radical in AOPs showed superior ability to degrade endotoxin in buffered solution, as well as water samples from Korean water treatment facilities, with the ozone/H<SUB>2</SUB>O<SUB>2</SUB> being more efficient compared to UV/H<SUB>2</SUB>O<SUB>2</SUB>. In addition, the AOPs proved effective not only in eliminating E. coli in the samples, but also in endotoxin degradation, while the standard disinfection methods lead to the release of endotoxin following the bacteria destruction. Furthermore, in the experiments with macrophages, the AOPs-deactivated endotoxin lead to the smallest induction of TNF-α, which shows the loss of inflammation activity, compared to ozone treatment alone. In conclusion, these results suggest that AOPs offer an effective and mild method for endotoxin degradation in the water systems.
An, H-J,Kwon, K-B,Cho, H-I,Seo, E-A,Ryu, D-G,Hwang, W-J,Yoo, S-J,Kim, Y-K,Hong, S-H,Kim, H-M Lippincott Williams Wilkins, Inc. 2005 EUROPEAN JOURNAL OF CANCER PREVENTION Vol.14 No.4
Nitric oxide (NO) is an antitumour molecule produced in activated macrophages and Solanum nigrum is a plant used in oriental medicine to treat tumours. In this study using mouse peritoneal macrophages, we have examined the mechanism by which Solanum nigrum regulates NO production. When Solanum nigrum was used in combination with 20 U/ml of recombinant interferon-&ggr; (rIFN-&ggr;), there was a marked cooperative induction of NO production. The increase in NO synthesis was reflected as an increased amount of inducible NO synthase (iNOS) protein. The production of NO from rIFN-&ggr; plus Solanum nigrum-stimulated peritoneal macrophages was decreased by treatment with N-monomethyl-L-arginine or N-tosyl-Phe chloromethyl ketone, an iNOS inhibitor. Additionally, the increased production of NO from rIFN-&ggr; plus Solanum nigrum-stimulated cells was almost completely inhibited by pretreatment with 100 μmol/l of pyrrolidine dithiocarbamate, an inhibitor of nuclear factor &kgr;B (NF-&kgr;B). Furthermore, Solanum nigrum increased activation of NF-&kgr;B. These findings suggest that Solanum nigrum increases the production of NO by rIFN-&ggr;-primed macrophages and NF-&kgr;B plays a critical role in mediating these effects.
Jin, H.S.,Cho, Y.J.,Lee, S.M.,Kim, D.H.,Kim, D.W.,Lee, D.,Park, J.B.,Won, J.Y.,Lee, M.J.,Cho, S.H.,Hwang, C.S.,Park, T.J. New York] ; North-Holland 2014 APPLIED SURFACE SCIENCE - Vol.315 No.-
Atomic-layer-deposited Al<SUB>2</SUB>O<SUB>3</SUB> films were grown on ultrathin-body In<SUB>0.53</SUB>Ga<SUB>0.47</SUB>As substrates for III-V compound-semiconductor-based devices. Interface sulfur (S) passivation was performed with wet processing using ammonium sulfide ((NH<SUB>4</SUB>)<SUB>2</SUB>S) solution, and dry processing using post-deposition annealing (PDA) under a H<SUB>2</SUB>S atmosphere. The PDA under the H<SUB>2</SUB>S atmosphere resulted in a lower S concentration at the interface and a thicker interfacial layer than the case with (NH<SUB>4</SUB>)<SUB>2</SUB>S wet-treatment. The electrical properties of the device, including the interface property estimated through frequency dispersion in capacitance, were better for (NH<SUB>4</SUB>)<SUB>2</SUB>S wet-treatment than the PDA under a H<SUB>2</SUB>S atmosphere. They might be improved, however, by optimizing the process conditions of PDA. The PDA under a H<SUB>2</SUB>S atmosphere following (NH<SUB>4</SUB>)<SUB>2</SUB>S wet-treatment resulted in an increased S concentration at the interface, which improved the electrical properties of the devices.