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Kentaro Atsukawa,Shuntaro Amari,Hiroshi Takiyama 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.101 No.-
From the designs of product and industrial process perspectives, the solubility of a target material is oneof the most valuable qualities. We proposed the ‘solid dispersion melt crystallization (SDMC) concept’ asa original strategy for dispersing a target material in a matrix one, in which the target material is naturallydispersed between the crevices formed by the matrix material precipitatedfirst. Furthermore, the effectsof introducing some operations, such as cooling, agitation and aeration, to the SDMC concept on thedissolution rate were investigated by a binary eutectic system. According to the experimental results, thedissolution rate was enhanced by the operations (cooling, agitation and aeration). This improvement inthe dissolution rate was attributed to the SDMC concept-based enhancement of the nucleation rate. Therefore, it was revealed that an increase in the nucleation rate due to the SDMC concept had effectivelyimproved the dissolution rate.
Kentaro Atsukawa,Shuntaro Amari,Hiroshi Takiyama 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.106 No.-
Quality control of the crystalline materials obtained from melts with the difficulty of nucleation is challenging. When nucleation is enhanced in such melts, the quality distribution is improved. Herein, the aerationmethod, which enhances nucleation in solution systems, was employed in a melt to investigate theaeration effect on nucleation in a melt and the effect of the crystallization conditions with aeration on theinduction time sind. Experimental results show that aeration enabled nucleation in a melt under supercoolingconditions, where nucleation could not occur without aeration. Furthermore, sind depended onthe operating conditions with aeration (initial supercooling, aeration period, and atmospheric temperature). The crystal size in the obtained solid phase decreased as the atmospheric temperature decreased. These results suggest that the desired nucleation timing and crystal size can be obtained by manipulatingthe crystallizer and aeration conditions. Thus, aeration is promising for improving the quality distributionsin crystalline materials.
Takashi Nonaka,Takaomi Kessoku,Yuji Ogawa,Shogo Yanagisawa,Tadahiko Shiba,Takashi Sakaguchi,Kazuhiro Atsukawa,Hisao Takahashi,Yusuke Sekino,Hiroshi Iida,Hiroki Endo,Yasunari Sakamoto,Tomoko Koide,Hiro 대한소화기 기능성질환∙운동학회 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.1
Background/Aims The aim of this study was to examine the convenience of the quality of life and utility evaluation survey technology (QUEST) questionnaire and the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) questionnaire as self-assessment diagnostic instrument. Methods This was a two-way crossover study conducted over 6 weeks from September 2010 to November 2010. The subjects were 60 consecutive patients admitted to the Hiratsuka city hospital with a gastrointestinal condition, regardless of the coexistence of heartburn. They were assigned to fill in both the QUEST and FSSG questionnaires in random order. We analyzed the time taken to complete the questionnaires, whether subjects asked any questions as they filled in the questionnaire, and the questionnaire scores. Results Comparison of the QUEST and the FSSG revealed significant differences in the completion time (196.5 vs. 97.5 seconds, respectively; P < 0.0001) and in whether subjects asked any questions (37 vs. 15 subjects, respectively; P < 0.0001). Completion time in QUEST scores of ≥ 4 was lower than < 4 (170.5 vs. 214.0 seconds, respectively; P = 0.022), and the QUEST score was significantly higher without questions than with question (3 vs. 1 points, respectively; P = 0.025). Conclusions This study revealed that the FSSG questionnaire may be easier for Japanese subjects to complete than the QUEST questionnaire.
( Takashi Nonaka ),( Takaomi Kessoku ),( Yuji Ogawa ),( Shogo Yanagisawa ),( Tadahiko Shiba ),( Takashi Sakaguchi ),( Kazuhiro Atsukawa ),( Hisao Takahashi ),( Yusuke Sekino ),( Hiroshi Iida ),( Hirok 대한소화기기능성질환·운동학회 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.1
Background/Aims The aim of this study was to examine the convenience of the quality of life and utility evaluation survey technology (QUEST) questionnaire and the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) questionnaire as self-assessment diagnostic instrument. Methods This was a two-way crossover study conducted over 6 weeks from September 2010 to November 2010. The subjects were 60 consecutive patients admitted to the Hiratsuka city hospital with a gastrointestinal condition, regardless of the coexistence of heartburn. They were assigned to fill in both the QUEST and FSSG questionnaires in random order. We analyzed the time taken to complete the questionnaires, whether subjects asked any questions as they filled in the questionnaire, and the questionnaire scores. Results Comparison of the QUEST and the FSSG revealed significant differences in the completion time (196.5 vs. 97.5 seconds, respectively; P < 0.0001) and in whether subjects asked any questions (37 vs. 15 subjects, respectively; P < 0.0001). Completion time in QUEST scores of ≥ 4 was lower than < 4 (170.5 vs. 214.0 seconds, respectively; P = 0.022), and the QUEST score was significantly higher without questions than with question (3 vs. 1 points, respectively; P = 0.025). Conclusions This study revealed that the FSSG questionnaire may be easier for Japanese subjects to complete than the QUEST questionnaire. (J Neurogastroenterol Motil 2013; 19:54-60)
( Takashi Nonaka ),( Takaomi Kessoku ),( Yuji Ogawa ),( Kento Imajyo ),( Shogo Yanagisawa ),( Tadahiko Shiba ),( Takashi Sakaguchi ),( Kazuhiro Atsukawa ),( Hisao Takahashi ),( Yusuke Sekino ),( Eiji 대한소화기기능성질환·운동학회 2011 Journal of Neurogastroenterology and Motility (JNM Vol.17 No.3
Background/Aims The effects of Histamine-2 receptor antagonists and proton pump inhibitors on the gastrointestinal motility have not yet been sufficiently investigated. The aim of this study was to determine the effects of intravenous bolus administration of famotidine and omeprazole on the rate of gastric emptying using the continuous 13C breath test (BreathID system, Exalenz Bioscience Ltd, Israel). Methods Twelve healthy male volunteers participated in this randomized, 3-way crossover study. After fasting overnight, the subjects were randomly assigned to receive 20 mg of famotidine, 20 mg of omeprazole or 20 mL of saline alone by intravenous bolus injection before a test meal (200 kcal per 200 mL, containing 100 mg of 13C-acetate). Gastric emptying was monitored for 4 hours after the ingestion of test meal by the 13C-acetic acid breath test performed using the BreathID system. Results No significant differences in the calculated parameters, namely, the T1/2, Tlag, GEC, β and κ, were observed among the 3 test conditions. Conclusions The study revealed that intravenous administration of gastric acid suppressant drugs had no significant influence on the rate of gastric emptying in comparison with that of saline alone as a placebo. Our results indicating the absence of any effect of either famotidine or omeprazole on accelerating the rate of gastric emptying suggest that both medications can be administered safely to patients suffering from hemorrhagic peptic ulcers who need to be kept nil by mouth from the viewpoint of possible acceleration of gastrointestinal motility in the clinical setting.