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Structural studies of serotonin receptor family
Apeksha Parajulee,Kuglae Kim 생화학분자생물학회 2023 BMB Reports Vol.56 No.10
Serotonin receptors, also known as 5-HT receptors, belong tothe G protein-coupled receptors (GPCRs) superfamily. Theymediate the effects of serotonin, a neurotransmitter that plays akey role in a wide range of functions including mood regulation,cognition and appetite. The functions of serotonin aremediated by a family of 5-HT receptors including 12 GPCRsbelonging to six major families: 5-HT1, 5-HT2, 5-HT4, 5-HT5,5-HT6 and 5-HT7. Despite their distinct characteristics and functions,these receptors’ subtypes share common structural featuresand signaling mechanisms. Understanding the structure, functionsand pharmacology of the serotonin receptor family is essentialfor unraveling the complexities of serotonin signalingand developing targeted therapeutics for neuropsychiatric disorders. However, developing drugs that selectively target specificreceptor subtypes is challenging due to the structural similaritiesin their orthosteric binding sites. This review focuses onthe recent advancements in the structural studies of 5-HT receptors,highlighting the key structural features of each subtypeand shedding light on their potential as targets for mentalhealth and neurological disorders (such as depression, anxiety,schizophrenia, and migraine) drugs.
Acceptance of Social Media as a Marketing Tool : A Quantitative Study
Apeksha Hooda,Ankur 한국유통과학회 2018 Asian Journal of Business Environment (AJBE) Vol.8 No.3
Purpose - The purpose of current paper is to identify features of advertisements at social media that generate the ad-click and to further identify if these advertisements lead to purchase. If no purchase is made, then reasons for not making purchase are identified. Users' purchase experience after users clicked at advertisements are also studied. Research design, data, and methodology - Research design followed is exploratory research, where various factors leading to ad-clicks and generating purchase at social media platform were explored. Raw data was gathered by means of survey among a sample of 185 respondents in India using online structured questionnaire. GLM model and multinomial regression were used to analyze the data. Results - Several factors including endorsement by friends, advertisement aesthetics, product reviews, and aggressive pricing played major role in generating ad-clicks. Major impediment to purchase on were product misrepresentation in advertisement, false discounts, and site security. Female users clicked more on social media advertisements and made more purchases compared to their male counterpart. Conclusions - Social media advertisements have significant positive effect on buying behavior of online customers. Transactions culminating from social media ad-click generated significant positive experience for social media users. Thus, social media can be effective marketing tool.
Goodsitt, Mitchell M,Shenoy, Apeksha,Shen, Jincheng,Howard, David,Schipper, Matthew J,Wilderman, Scott,Christodoulou, Emmanuel,Chun, Se Young,Dewaraja, Yuni K The American Association of Physicists in Medicine 2014 Medical physics Vol.41 No.5
<P>To evaluate a three-equation three-unknown dual-energy quantitative CT (DEQCT) technique for determining region specific variations in bone spongiosa composition for improved red marrow dose estimation in radionuclide therapy.</P>
Tandon, Sarthak,Gairola, Munish,Ahlawat, Parveen,Sharma, Kanika,Barik, Soumitra,Sachdeva, Nishtha,Pasricha, Sunil,Shenoy, Apeksha The Korean Society for Radiation Oncology 2018 Radiation Oncology Journal Vol.36 No.4
Surgical excision along with use of postoperative radiotherapy forms an integral management of sinonasal teratocarcinosarcoma (SNTCS). However, given the rarity of the tumor, no standardised guidelines, dose, technique and target delineation exist especially in the era of modern radiation delivery techniques. This is a case of 55-year-old male diagnosed as SNTCS treated with radical ethmoidectomy followed by volumetric modulated radiotherapy, showing good local control and acceptable toxicity profile.
Sarthak Tandon,Munish Gairola,Parveen Ahlawat,Kanika Sharma,Soumitra Barik,Nishtha Sachdeva,Sunil Pasricha,Apeksha Shenoy 대한방사선종양학회 2018 Radiation Oncology Journal Vol.36 No.4
Surgical excision along with use of postoperative radiotherapy forms an integral management of sinonasal teratocarcinosarcoma (SNTCS). However, given the rarity of the tumor, no standardised guidelines, dose, technique and target delineation exist especially in the era of modern radiation delivery techniques. This is a case of 55-year-old male diagnosed as SNTCS treated with radical ethmoidectomy followed by volumetric modulated radiotherapy, showing good local control and acceptable toxicity profile.