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Ojas Natarajan,Joseph T. Angeloni,Maxime F. Bilodeau,Kyle E. Russi,Yuqing Dong,Min Cao 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.4
Emerging evidence suggests that aging is associated with the deterioration of immunity, a term known as immunosenescence, which may lead to a higher incidence of infections in the elderly population. Our previous studies reported that supplementation of royal jelly (RJ) extended the lifespan of Caenorhabditis elegans (C. elegans), a nematode model. The aim of this study was to investigate the potential benefits of RJ supplementation on modulation of the innate immunity in C. elegans. Using Staphylococcus aureus (S. aureus; ATCC 25923) as the infection model, we showed that RJ supplementation from the egg hatching stage could protect C. elegans against the infection. Further mechanistic studies demonstrated that RJ coordinated pathways of IIS/DAF-16, p38 MAPK, and Wnt to modulate the innate immunity. In addition, when RJ was administrated to the aged C. elegans, the worms displayed prolonged survival time to a variety of bacterial infections compared with the nontreatment group. This result indicates the RJ may help delay the innate immunosenescence.
ESCAPE OF RESONANTLY SCATTERED LYβ AND Hα FROM HOT AND OPTICALLY THICK MEDIA
장석준,이희원,안상현,이호규,Rodolfo Angeloni,Tali Palma,Francesco Di Mille 한국천문학회 2018 Journal of The Korean Astronomical Society Vol.51 No.1
We investigate the escape of Ly$\beta$ from emission nebulae with a significant population of excited hydrogen atoms in the level $n=2$, rendering them optically thick in H$\alpha$. The transfer of Ly$\beta$ line photons in these optically thick regions is complicated by the presence of another scattering channel leading to re-emission of H$\alpha$, alternating their identities between Ly$\beta$ and H$\alpha$. In this work, we develop a Monte Carlo code to simulate the transfer of Ly$\beta$ line photons incorporating the scattering channel into H$\alpha$. Both H$\alpha$ and Ly$\beta$ lines are formed through diffusion in frequency space, where a line photon enters the wing regime after a fairly large number of resonance scatterings with hydrogen atoms. Various line profiles of H$\alpha$ and Ly$\beta$ emergent from our model nebulae are presented. It is argued that the electron temperature is a critical parameter which controls the flux ratio of emergent Ly$\beta$ and H$\alpha$. Specifically for $T=3 \times 10^4{\rm\ K}$ and H$\alpha$ line center optical depth $\tau_\alpha=10$, the number flux ratio of emergent Ly$\beta$ and H$\alpha$ is $\sim 49$ percent, which is quite significant. We propose that the leaking Ly$\beta$ can be an interesting source for the formation of H$\alpha$ wings observed in many symbiotic stars and active galactic nuclei. Similar broad H$\alpha$ wings are also expected in Ly$\alpha$ emitting halos found in the early universe, which can be potentially probed by the {\it James Webb Telescope} in the future.