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Anca Hermenean,Aurel Ardelean,Miruna Stan,Nicoleta Hadaruga,Ciprian-Valentin Mihali,Marieta Costache,Anca Dinischiotu 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.6
The present study evaluated the antioxidant and hepatoprotective effects of the flavonoid naringenin (NGN) and its b-cyclodextrin formulation at a dose of 50 mg/kg b.w. The assessment was done by the investigation of serumenzymatic and liver antioxidant activity, histopathological and ultrastructural changes in male Swiss mice, which were subjected to acute experimental intoxication with CCl4. Formulated and free flavonoid were orally given to mice for 7 days and then were intraperitoneally injected with 1.0 mL/kg CCl4 on the 8th day. After 24 h of CCl4 administration, an increase in the levels of transaminases aspartate aminotransferase and alanine aminotransferase activities and malondialdehyde concentration occurred and a significant decrease in superoxide dismutase, catalase glutathione-peroxidase activities, and glutathione levels was detected as well. These were accompanied by extended centrilobular necrosis, steatosis, fibrosis, and an altered ultrastructure of hepatocytes. Pretreatment with formulated or free flavonoid retained the biochemical markers to control values. Histopathological and electron-microscopic examination confirmed the biochemical results. In conclusion, both NGN and NGN/b-cyclodextrin complex showed antioxidant and hepatoprotective effects against injuries induced by CCl4.
Effect of bed configuration of immobilized biocatalysts on penicillin G hydrolysis efficiency
Anca-Irina Galaction,Alexandra Cristina Blaga,Ramona Mihaela Matran,Dan Caşcaval 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.2
The external and internal mass transfer of Penicillin G in the process of its enzymatic hydrolysis to 6-Aminopenicillanicacid under competitive and non-competitive inhibitions have been comparatively analyzed for a bioreactorwith mobile bed vs. a stationary basket bioreactor, both with Penicillin amidase immobilized in Eupergit C. ThePenicillin G mass transfer and hydrolysis enzymatic rates have been analyzed by means of the ratios’ values betweenthe oxygen mass transfer coefficients, effectiveness factors, external mass flows and Penicillin G concentrations at thebiocatalyst particle surface for the considered bioreactors. The results indicated that the bioreactor with mobile bed ismore efficient especially for biocatalyst particles with diameter under 1.5 mm. For larger particles the performances ofthe two bioreactors become similar. Moreover, taking into consideration the external mass flow of Penicillin G and thenumber of enzymatic hydrolysis cycles, the basket bioreactor is recommended. The mathematical equations proposedare in good concordance with the experimental results, the average deviations varying from ±4.11% for the bioreactorwith mobile bed of immobilized Penicillin amidase to ±5.03% for the basket bioreactor.
Anca Roxana Costan,Carmen Vulpoi,Veronica Mocanu 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.5
Nursing home residents have severe vitamin D deficiency and increased risk of falls and fractures. These individuals may need 125 lg of vitamin D3 to achieve desirable 25-hydroxyvitamin D [25(OH)D] concentrations to improve overall health. We evaluated health-related quality of life (HRQoL) in 45 nursing home residents (28 women and 17 men, aged 58–89 years) with 25(OH)D concentrations < 50nM who consumed daily one bun that had been fortified with 125 lg vitamin D3. The Romanian version of Questionnaire of the European Foundation for Osteoporosis (QUALEFFO-41) was applied at baseline and after 12 months. Data were analyzed using repeated measures analyses of variance (ANOVA). After one year supplementation, serum 25(OH)D reached optimal status ( > 75 nM) and bone health has improved significantly. Nursing home residents who consumed daily bread fortified with 125 lg vitamin D3 reported significant (P = .02 for the effect of time) improvement in HRQoL (total score of QUALEFFO-41). The interaction time x treatment was also statistically significant on pain (P = .04), daily activities (P = .02), and locomotion (P = .04). To ensure the serum concentrations of 25(OH)D recommended by medical groups for bone- and general-health in the older nursing residents, the practical experience shows that much higher amounts of vitamin D3 are required. Fortification of bread and cereals is a feasible way to improve vitamin D nutrition.