Prevalence of Stress Urinary Incontinence in Women with Multiple Sclerosis

Alana M Murphy,Francois Bethoux,Darlene Stough,Howard B Goldman 대한배뇨장애요실금학회 2012 International Neurourology Journal Vol.16 No.2

Purpose: The purpose of this study was to determine the prevalence of stress urinary incontinence (SUI) in women with multiple sclerosis (MS) and to what degree these women are bothered by their SUI, since there is a paucity of literature regarding the nature of SUI in this unique population of women. Methods: We conducted a prospective Institutional Review Board approved study. Women scheduled for outpatient follow-up appointments at a dedicated MS center were asked to complete a questionnaire regarding urinary incontinence. Urgency urinary incontinence (UUI) and SUI were defined as an answer of slightly, moderately or greatly to the Urogenital Distress Inventory (UDI-6) question #2 and question #3, respectively. Impact of SUI on physical activity was determined by Incontinence Impact Questionnaire (IIQ-7) question #2. Results: A total of 55.9% (80/143) women had SUI, 70.6% (101/143) women had UUI, and 44.8% (64/143) women had mixed urinary incontinence. The mean age was 45.8 years old (range, 20 to 72 years). Women with SUI were significantly older (mean,47.2 vs. 41.9; P=0.023) and there was a trend towards a greater body mass index (mean, 29.3 vs. 26.5; P=0.057). Women with SUI had significantly higher IIQ-7 scores compared to women without SUI (P<0.001). Impact of urinary incontinence on physical activity was also found to be significantly greater in women with SUI (mean IIQ-7 question #2, 0.96 vs. 0.35; P<0.001). Conclusions: The prevalence of SUI in women with MS is 55.9% and the presence of SUI has a significant impact on their quality of life. A comprehensive urologic evaluation of a woman with MS should include assessment of SUI.

Poster Session : PS 0147 ; Neurology : Confusion after “Chasing the Dragon”: A Case of Delayed Toxic Leukoencephalopathy

( Alana Nevares ),( Jorge Morales ),( Nikhil Chadha ),( James Dorman ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Toxic Leukoencephalopathy refers to a spectrum of leukoencephalopathies caused by iatrogenic, drug, hypoxic or infectious insults to the white matter. “Chasing the Dragon” refers to the inhalation of heated heroin fumes. Case presentation: A 31 year old gentleman with no past medical history after loss of consciousness followed by unresponsiveness for 3 hours, after his fi rst time of having “chased the dragon”, was admitted to ICU with respiratory failure requiring mechanical ventilation, recovered and returned to normal functioning within one week. Behavior was at his baseline for 2 weeks after discharge, followed by sudden onset odd behavior. On exam he was alert, but apathetic; he was mute with inappropriate smiling and following simple commands. He had functional urinary-fecal incontinence, symmetric hyperrefl exia in lower extremities and upgoing toes. HIV, syphilis, b12 defi ciency, high sedimentation rate were ruled out. Cerebrospinal fl uid showed elevated protein level. Electroencephalogram showed diffuse slowing. Magnetic resonance imaging (MRI) showed diffuse bilateral cerebral periventricular and deep and subcortical white matter high T2/FLAIR signal intensities. At 5-weeks follow up, he was talkative and coherent, with adequate affect. Cognitive Linguistic Quick Test 8-weeks after discharge, demonstrated mild attention, moderate memory and severe executive functions impairment, normal language and moderate Clock Drawing Severity Rating. Discussion: Post-hypoxic and “Chasing the Dragon” leukoencephalopathies are among the unique causes of delayed-onset toxic leukoencephalopathies. Onset usually occurs 1-3 weeks after the insult as in this patient, who developed the akinetic-mutism form of DPHL and lacked the primarily cerebellar/ataxic syndrome typical of HL. MRI fi ndings were diffuse and lacked the predominantly posterior and cerebellar distribution of HL, supporting the diagnosis of DPHL. As in our patient, most people with DPHL will improve within 3 to 12 months, but impaired attention and executive functions usually persist.

The Use of Cryotherapy in the Gout Pain Control: A Systematic Review

Alana Ludemila de Freitas Tavares,Iranilda Moha Ross,Lilian Araujo Pradal,Morgana Neves,Bárbara Heloise Trombetta Jamilk,Gladson Ricardo Flor Bertolini KEMA학회 2021 근골격계과학기술학회 Vol.5 No.1

Background Gout traditional treatment consists of anti-inflammatory drugs, analgesics and other rheumatic controllers, however, the occurrence of drug interactions occurs with a certain degree of toxicity, requiring that other methods be used to relieve symptoms. An alternative treatment is cryotherapy due to its capacity for analgesia. Purpose The aim of this study was to conduct a systematic review that addressed the literature with production on gouty arthritis and its treatment with cryotherapy. Study design Systematic review Methods This review was described according to the items requested by the PRISMA system. This is a systematic review of publications from the year 2000 to the year 2019 in the following white literature databases PubMed, LILACS, SciELO, Web of Science, Science Direct, Scopus, Cochrane, PEDro and in the gray literature a Google Scholar database. The electronic databases were consulted from November 2019. Results After searching the databases, reading and selection, two studies contemplated the methodological criteria of eligibility, being of the same authorship, both with more than ten years of publication, using similar methods of application of ice. Conclusions It was found that, despite the scarcity of studies that addressed the topic, the articles found show reasonable rigor methodological and homogeneous results, demonstrating that cryotherapy helps in reducing the pain of individuals with gout, however, there is little evidence to support this hypothesis.

Fractional Integration in the Context of Deterministic Trends

Gil-Alana, L.A. The Korean Statistical Society 2004 Communications for statistical applications and me Vol.11 No.2

In this article we show that the tests of Robinson (1994) may have serious problems in distinguishing between fractionally integrated processes in the context of deterministic trends. The results are obtained via Monte Carlo experiments. A simple procedure, based on the t-values of the coefficients from the differenced regression, is presented to correctly specify the time series of interest and, an empirical application, using data of the US GNP is also carried out at the end of the article.

A Historical Perspective of Inflation in Latin America. A New Approach Based on Fractional Integration with a Structural Break

Gil-Alana,Carlos Pestana Barros 한국국제경제학회 2009 International Economic Journal Vol.23 No.2

This paper deals with the analysis of inflation in Latin America across the 20th century. We use annual data from 18 countries using a methodology based on fractional integration. However, given the structure of the inflation rates in these countries, we allow for the possibility of a structural break that is endogenously determined by the model. The results show that for most of the countries the break-date takes place in the late 1980s or early 1990s, and the orders of integration are in all cases higher than 0.5 and, in many cases, smaller than 1, implying non-stationary mean reverting behaviour.

Testing of Stochastic Trends, Seasonal and Cyclical Components in Macroeconomil Time Series

Gil-Alana Luis A. The Korean Statistical Society 2005 Communications for statistical applications and me Vol.12 No.1

We propose in this article a procedure for testing unit and fractional orders of integration, with the roots simultaneously occurring in the trend, the seasonal and the cyclical component of the time series. The tests have standard null and local limit distributions. However, finite sample critical values are computed, and several Monte Carlo experiments conducted across the paper show that the rejection frequencies against unit (and fractional) orders of integration are relatively high in all cases. The tests are applied to the UK consumption and income series, the results showing the importance of the roots corresponding to the trend and the seasonal components and, though the unit roots are found to be fairly suitable models, we show that fractional processes (including one for the cyclical component) may also be plausible alternatives in some cases.

노동교육 : 세계화에 대한 대응; 국제스터디서클(ISC)

알라나데이브 ( Alana Dave ) 한국노동사회연구소 1998 노동사회 Vol.28 No.-

Fractional Integration in the Context of Periodicity: A Monte Carlo Experiment and an Empirical Study

Gil-Alana Luis A. The Korean Statistical Society 2006 Communications for statistical applications and me Vol.13 No.3

Recent results in applied statistics have shown that the presence of periodicities in time series may influence the estimation and testing of the fractional differencing parameter. In this article, we provide further evidence on the issue by using several procedures of fractional integration. The results show that in the presence of periodicities, the order of integration can be erroneously detected. An empirical application in the context of seasonal data is also carried out at the end of the article.

An Impedance-Transduced Chemiresistor with a Porous Carbon Channel for Rapid, Nonenzymatic, Glucose Sensing

Ogata, Alana F.,Song, Seok-Won,Cho, Su-Ho,Koo, Won-Tae,Jang, Ji-Soo,Jeong, Yong Jin,Kim, Min-Hyeok,Cheong, Jun Young,Penner, Reginald M.,Kim, Il-Doo American Chemical Society 2018 ANALYTICAL CHEMISTRY - Vol.90 No.15

<P>A new type of chemiresistor, the impedance-transduced chemiresistor (ITCR), is described for the rapid analysis of glucose. The ITCR exploits porous, high surface area, fluorine-doped carbon nanofibers prepared by electrospinning of fluorinated polymer nanofibers followed by pyrolysis. These nanofibers are functionalized with a boronic acid receptor and stabilized by Nafion to form the ITCR channel for glucose detection. The recognition and binding of glucose by the ITCR is detected by measuring its electrical impedance at a single frequency. The analysis frequency is selected by measuring the signal-to-noise (<I>S</I>/<I>N</I>) for glucose detection across 5 orders of magnitude, evaluating both the imaginary and real components of the complex impedance. On the basis of this analysis, an optimal frequency of 13 kHz is selected for glucose detection, yielding an <I>S</I>/<I>N</I> ratio of 60-100 for [glucose] = 5 mM using the change in the total impedance, Δ<I>Z</I>. The resulting ITCR glucose sensor shows a rapid analysis time (<8 s), low coefficient of variation for a series of sensors (<10%), an analysis range of 50 μM to 5 mM, and excellent specificity versus fructose, ascorbic acid, and uric acid. These metrics for the ITCR are obtained using a sample size as small as 5 μL.</P> [FIG OMISSION]</BR>

Correlations between lignin content and related genes, weathering deterioration, and soybean seed quality at pre-harvest

Madureira Alana,Molinari Mayla D. C.,Marin Silvana R. R.,Pagliarini Renata Fuganti,Henning Fernando A.,Nepomuceno Alexandre L.,Finatto Taciane,Mertz-Henning Liliane M. 한국작물학회 2023 Journal of crop science and biotechnology Vol.26 No.4

The present study aimed to identify the relationship between lignin content in soybean pods, pod dehiscence rate, gene expression from phenylpropanoid pathway, cell wall lignifcation, and deterioration of seed due to weather. To evaluate the weathering deterioration, an experiment simulating 150 mm of rainfall was performed in greenhouse conditions. Gene expression was assessed by RT-qPCR. Results showed that soybean cultivars BRS Jiripoca and BRS 388 RR considered tolerant to weathering deterioration, presented higher levels of lignin content in pods. The data showed that dehiscence rate was neither a trait involved in weathering deterioration tolerance nor in lignin content in soybean pods. Lignin content and weathering deterioration were highly negatively correlated, probably due to changes in cell wall permeability to water accordingly to lignin level. Higher expression levels of genes involved in lignin biosynthesis and cell wall lignifcation were identifed in both tolerant cultivars, however, with opposite expression profles and in diferent developmental phases, suggesting a possible temporal strategy to cope with environmental adverse conditions.