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      • KCI등재

        Hemoglobin F level in different hemoglobin variants

        Akanni E. Olufemi,Oseni B. Sola,Bamisaye E. Oluwaseyi,Raji A. Ajani,Mewoyeka O. Olusoji,Hassan R. Olubunmi 대한혈액학회 2011 Blood Research Vol.46 No.2

        Background :Fetal hemoglobin (HbF) levels in different hemoglobin variants in Osogbo, Nigeria, were estimated using two principal methods of estimation using existing information for HbF concentration and distribution of various hemoglobin variants in the area, as well as diagnosed cases of thalassemia. Two hundred and sixty samples collected from HbSS, HbSC, HbAA, HbAS, and HbAC subjects were analyzed. HbF level and hemoglobin type were determined in this study. Methods :The hemoglobin type was determined using cellulose acetate electrophoresis at an alkaline pH, and HbF was determined by the acid elution and alkaline denaturation methods. Results :The mean±SD of HbF in the respective hemoglobin variants was as follows: HbSS, 2.09±1.94%; HbSC, 0.85±0.54%; HbAA, 0.69±0.46%; HbAS, 0.52±0.31%; and HbAC, 0.57±0.26%. The mean HbF level across the hemoglobin variants was statistically significant (P<0.05). Investigating the sex distribution of the HbF level in the studied population revealed a slightly higher mean HbF level in females than in their male counterparts. Conclusion :Within the study population, the HbF level was found to be highest in HbSS and lowest in HbAS. The two methods of estimating HbF are equally reliable, since there was no significant difference between the results obtained from the two methods.

      • KCI등재

        Anti-leukemic and immunomodulatory effects of fungal metabolites of Pleurotus pulmonarius and Pleurotus ostreatus on benzene-induced leukemia in Wister rats

        Akanni E. Olufemi,Alli O.A. Terry,Oloke J. Kola 대한혈액학회 2012 Blood Research Vol.47 No.1

        Background The use of natural bioactive compounds in conventional chemotherapy is a new direction in cancer treatment that is gaining more research attention recently. Bioactive polysaccharides and polysaccharide-protein complexes from some fungi (edible mushrooms) have been identified as sources of effective and non-toxic antineoplastic agents. Selected oyster mushrooms (Pleurotus pulmonarius and P. ostreatus being local [Nigeria] and exotic strains, respectively) were cultured on a novel medium of yeast extract supplemented with an ethanolic extract of Annona senegalensis, and the antileukemic potential of their metabolites was studied. Methods Leukemia was successfully induced in Wister rats by intravenous injection (0.2 mL) of a benzene solution every 2 days for 3 consecutive weeks. The aqueous solution of fungal metabolites (20 mg/mL) produced by submerged fermentation was orally administered (0.2 mL) before, during, and after leukemia induction. Leukemia burden was assessed by comparing the hematological parameters at baseline and after leukemia induction. The immunomodulatory potential of the metabolites was assessed by using a phagocytic assay (carbon clearance method). The ability to enhance leukopoiesis was assessed by using the total leukocyte count. Results Leukemia induction resulted in significant anemia indices and leukocytosis (P<0.05) in the experimental rats. Both metabolites equally enhanced leukopoiesis and demonstrated phagocytic actions; P. ostreatus activity was significantly higher than that of P. pulmonarius (P<0.05). Conclusion The metabolites exhibited profound antileukemic potential by suppressing leukemia and demonstrating immunotherapeutic activities on animals after oral administration in various experimental groups.

      • KCI등재

        The Moderating Effect of Operations Efficiency on the Links between Environmental Performance and Financial Performance: The UK Evidence

        Ramanathan, Ramakrishnan,Akanni, Adewole Oluwatomi Asian Society for Innovation and Policy 2015 Asian Journal of Innovation and Policy Vol.4 No.1

        Drawing upon the resource-based-view of a firm, we investigate the moderating role of operations efficiency on the link between environmental and financial performance. Extant literature has highlighted that operations efficiency is closely associated with the environmental/financial performance of firms, but no empirical study has investigated how operations efficiency affects the link between environmental and financial performance. We argue that operations efficiency could act as a moderator of this relationship. To test the hypothesized relationships, we have used available secondary quantitative UK data, namely data on the environmental/financial performance of Britain's most admired companies. By employing moderated regression analysis, we have found strong evidence for the moderating impact of operations efficiency. Our results are useful to managers in that they show that improvements in operations efficiency in a company can also help improve environmental/financial performance and vice versa.

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        Color and fastness properties of mordanted Bridelia ferruginea B dyed cellulosic fabric

        Jamiu Mosebolatan Jabar,Ademola Israel Ogunmokun,Tella Adewale Akanni Taleat 한국의류학회 2020 Fashion and Textiles Vol.7 No.1

        Bridelia ferruginea B dye was extracted from the bark of the tree using aqueous extraction method. Extracted dye was used to dye cellulosic (cotton) fabric in presence of 5% calcium chloride ( CaCl2) or 5% alum (KAl(SO4)2·12H2O) of weight of fabric (o.w.f ) as mordant. Fabric dyed without mordant was lighter in hue than metal ion mordanted dyed fabrics. The fabrics dyed in presence of calcium chloride as mordant are of deeper hue than those dyed with alum as mordant. Hence, their dye-uptake and color strength (K/S) are in the same order. K/S value of fabric dyed with alum is 43.71% higher than that without mordant and fabric dyed with calcium chloride has K/S value 51.09% higher than dyed with alum as mordant. CIEL*a*b* coordinate indicator and color space quadrant showed that those dyed fabrics without mordant and with alum as mordant are closer to yellow than red color. Those cellulosic fabrics dyed with calcium chloride as mordant are closer to red than yellow color as confirmed in colour space quadrant. Pre-mordanted dyed fabrics are of deeper color than post-mordanted dyed fabrics than meta-mordanted dyed fabrics than unmordant dyed fabric. Fastness properties of B. ferruginea B dyed cellulosic fabrics ranged from good (3) to excellent (5).

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