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The Expression of Estrogen Receptors in Hepatocellular Carcinoma in Korean Patients
Ai Guo Wang,이기영,김성용,최종영,이기호,김욱환,왕희정,김진만,박문기,염영일,김남순,유대열,이동석 연세대학교의과대학 2006 Yonsei medical journal Vol.47 No.6
Expression of estrogen receptors (ER)- and - , as well as androgen receptor (AR), in hepatocellular carcinoma (HCC) is thought to be correlated with prognosis, survival, and male prevalence of HCC. These hypotheses are based on investigations of European patients; however the expression patterns of these receptors in Asian patients are largely unknown. In this study, we collected liver carcinoma and peritumor tissues from 32 patients (9 females and 23 males) in South Korea. The expression of ERs and ARs was studied using RT-PCR. Wild-type ER- and AR were expressed in all of the samples investigated, and their expression was independent of the causal virus or patient sex. Expression of the ER- variant was independent of sex (100% female vs. 91.3% male) and HCV and HBV status (91.3% vs. 100%). Wild-type ER- was expressed more often in HCV patients than in HBV patients (95.7% vs. 44.4%; p 0.05). In conclusion, the stronger ER- variant expression in HCC tissues implies that this variant has an important role in HCC development. However, at least in Korean patients, expression of the ER- variant (vER- ) is not related to male HCC prevalence. In addition, the predominant expression of ER- in HCV patients suggests that it plays an important role in HCV-induced liver disease.
Design of PD Observers in Descriptor Linear Systems
Ai-Guo Wu,Guang-Ren Duan 대한전기학회 2007 International Journal of Control, Automation, and Vol.5 No.1
A class of new observers in descriptor linear systems, proportional-derivative (PD) observers, are proposed. A parametric design approach for such observers is proposed based on a complete parametric solution to the generalized Sylvester matrix equation. The approach provides complete parameterizations for all the observer gains, gives the parametric expression for the corresponding left eigenvector matrix of the observer system matrix, realizes elimination of impulsive behaviors, and guarantees the regularity of the observer system.
Expression of hepatitis C virus nonstructural 4B in transgenic mice
Ai-Guo Wang,문형배,김진만,황순봉,유대열,이동석 생화학분자생물학회 2006 Experimental and molecular medicine Vol.38 No.3
Hepatitis C virus (HCV) is a pathogen that is of great cirrhosis, and hepatocellular carcinoma worldwide. Although the HCV proteins have been intensively investigated over the past decade, the biochemical functions of the NS4B protein are still largely unknown. To investigate NS4B as a potential cau-sative agent of liver disease, transgenic mice expressing the NS4B protein in liver tissue were produced. The transgenic animals were phenoty-pically similar to their normal littermates for up to 18 months of age. Our results suggest that the HCV NS4B protein is not directly cytopathic or oncogenic in our transgenic mice model.
Robust H-infinity Estimation for Linear Time-Delay Systems: An Improved LMI Approach
Ai-Guo Wu,Jin Dong,Guang-Ren Duan 제어·로봇·시스템학회 2009 International Journal of Control, Automation, and Vol.7 No.4
The problem of robust H∞ estimation for the polytopic uncertain linear system with state delay is considered. Firstly, by introducing two auxiliary matrices a new LMI representation of H∞ performance is presented for the linear systems with a single time-varying state delay. The proposed criterion exhibits a kind of separation between the system matrices and the positive definite Lyapunov matrices. So the vertex-dependent Lyapunov functions can be adopted, and thus a less conservative re-sult is expected to be obtained.
Reactive Oxygen Species Co-Operated with Sex Hormones Inhibit Proliferation of Hepal-6 Cells
Wang Ai-Guo,Kim Nam-Soon,Lee Dong-Seok The Korean Society for Biomedical Laboratory Scien 2005 Journal of biomedical laboratory sciences Vol.11 No.3
Reactive oxygen species (ROS) and sex hormones affect the proliferation of cells and are believed to play important roles in tumorigenesis. However, little is known regarding how these two factors interact to affect cell proliferation. In this study, hepal-6 cells were treated with ROS and sex hormones (testosterone and steroidal) either separately or in combination. The sex hormones had no significant influence the cell proliferation up to a concentration of $1{\mu}M$. However, cell proliferation was inhibited when the cells were treated simultaneously with $H_2O_2$, which alone was found to promote cell proliferation at the concentrations of $15{\mu}M$. In conclusion, this study indicates that instead of promoting the cell proliferation, ROS interact with sex hormones to inhibit the Hepa 1-6 cell proliferation.
( Le Ai-guo ) 성균관대학교 유교문화연구소 2011 儒敎文化硏究(中文版) Vol.0 No.16
《中庸》論“誠”, 又講“三達德”、“五達道”;在《中庸章句》中, 朱子對“誠”作了界定, 提出“誠者, 眞實无妄之謂”, 而且進一步從天道與人道統一的層面對“誠”的內涵作了詮釋, 認爲誠旣是天之道, 也是人之道;同時還對“誠”與“三達德”、“五達道”的關系作了新的闡述, 認爲“誠”是“三達德”、“五達道”之本, 從而爲儒家倫理找尋到形上學的根据。這旣是朱子解讀儒家經典的特点, 也是朱子對于儒家思想的發展和貢獻。 In the Doctrine of the Mean, Sincerity and Three great Virtues and Five great Ways are discussed. Chu His wrote The Textual Study of the Doctrine of the Mean, and defined Sincerity and said “Sincerity is genuine without pretended.” Further more, He explained the meaning of Sincerity at the level of the unification of the way of Heaven(天道) and the way of Human(人道), thought Sincerity is the way of Heaven, also the way of Human. He also interpreted the connections between Sincerity and Three great Virtues and Five great Ways, considered that Sincerity is root of Three great Virtues and Five great Ways. In this way, Chu His established the metaphysics foundation for Confucian ethic. This is Chu His’s characteristic unscrambling Confucian classics and developing and contributing to Confucian thought. [Article in Chinese]
Non-structural 5A protein of hepatitis C virus induces a range of liver pathology in transgenic mice
Wang, Ai-Guo,Lee, Dong-Seok,Moon, Hyung-Bae,Kim, Jin-Man,Cho, Kyung-Hyun,Choi, Soo-Ho,Ha, Hye-Lin,Han, Ying-Hao,Kim, Dae-Ghon,Hwang, Soon B.,Yu, Dae-Yeul John Wiley Sons, Ltd. 2009 The Journal of pathology Vol.219 No.2
<P>Hepatitis C virus (HCV) is a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma (HCC). However, the mechanism of HCV pathogenesis is not well understood. Our previous in vitro studies suggested that non-structural 5A (NS5A) protein may play an important role in liver pathogenesis. To elucidate the mechanism of HCV-induced liver pathogenesis, we investigated the histopathological changes of liver in transgenic mice harbouring the NS5A gene. We generated transgenic mice harbouring HCV NS5A gene under the control of hepatitis B virus (HBV) enhancer. Pathological changes were analysed by immunohistochemical staining and western blot analysis. Lipid composition and reactive oxygen species (ROS) production in NS5A transgenic mice were analysed. HCV NS5A transgenic mice developed extraordinary steatosis over 6 months old and induced HCC in some mice. NS5A was co-localized with apolipoprotein A-I in fatty hepatocytes. In addition, the extraordinarily high levels of ROS, NF-κB and STAT3 were detected in hepatocytes of NS5A transgenic mice. These data suggest that NS5A, independent of other HCV viral proteins, may play an important role in the development of hepatic pathologies, including steatosis and hepatoceullular carcinoma in transgenic mice. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</P>