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Acebedo, Alvin Resultay,Amor, Evangeline Cancio,Jacinto, Sonia Donaldo Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Voacanga globosa (Blanco), a plant endemic to the Philippines, is traditionally used especially by indigenous people of Bataan in the treatment of ulcers, wounds and tumorous growths. This study aimed to provide scientific evidence to therapeutic properties by determining cytotoxic and pro-apoptotic activity of HPLC fractions from leaves on HCT116 human colon carcinoma and A549 human lung carcinoma cell lines. Ethanolic extraction was performed on V globosa leaves followed by hexane and ethyl acetate partitioning. Silica gel column chromatography and high performance liquid chromatography (HPLC) produced MP1, MP2 and MP3 fractions. Cytotoxic activity of the fractions was determined through MTT assay against the cancer cell lines HCT116 and A549 and the non-cancer AA8 Chinese hamster ovarian cell line. Pro-apoptotic activities of the most active fractions were further assessed through DAPI staining, TUNEL assay and JC-1 mitochondrial membrane potential assay with HCT116 cells. While the MPI fraction exerted no significant activity against all cell lines tested, MP2 and MP3 fractions demonstrated high toxicity against HCT116 and A549 cells. The MP3 fraction induced formation of apoptotic bodies, condensed DNA and other morphological changes consistent with apoptosis of HCT116 cells and TUNEL assay showed significant increase in DNA fragmentation over time. In these cells, the MP3 fraction also induced mitochondrial membrane destabilization, which is generally associated with the beginning of apoptosis. Phytochemical analysis demonstrated the presence only of saponins and terpenoids in the MP3 fraction. The results indicate that the MP3 fraction exerts cytotoxic activity on HCT116 cells via induction of apoptosis triggered by loss of mitochondrial membrane potential crucial for cell survival.
Alberto S. Banacia,Joseph C. Acebedo,Johari C. Villegas,Arvin Tate N. Yu 대한전자공학회 2017 대한전자공학회 학술대회 Vol.2017 No.1
The recent adoption by the Philippine government of Japan’s Integrated Services Digital Broadcasting- Terrestrial (ISDB-T) standard as the digital TV standard to be used in the country prompts the need for a platform that will facilitate understanding of its concept and provide a framework for evaluating algorithms that will improve ISDB-T receiver’s performance. This research work develops and implements an ISDB-T decoder in a Software-Defined Radio (SDR) platform. The study covers two parts. First, a recorded raw baseband ISDB-T signal in .dat file format was simulated through the configuration of signal processing blocks in GNU Radio Companion (GRC). The successful simulation produced a transport stream .ts H264- MPEG-4 AVC file and resulted to the display of the signal in a 6MHz bandwidth with a 64QAM constellation plot, a 34.22 dB Modulation Error Rate (MER), 8.95 dB and 18.00 dB Bit Error Rate (BER) for the Viterbi and Reed Solomon decoders, respectively. The simulation measurements served as indicators for the quality of the decoded signal as the output transport stream file was played simultaneously in VLC media player. Second, an actual reception of a private Philippine ABS-CBN Digital Television Terrestrial (DTT) signal located in UHF Channel 43 was performed in real-time through the system integration of the USRP1 with the GRC Signal flow graph. A Log Periodic LP0410 PCB antenna that can operate within 400MHz to 1GHz is also integrated to the SDR platform to receive the digital broadcast. Due to proprietary DTV issues, the system was only able to display ABS-CBN’s frequency spectrum centered at its assigned frequency of 611.143MHz at a 6MHz bandwidth.