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Vahid Alimardani,Samira Sadat Abolmaali,Gholamhossein Yousefi,Mohammad Hossein Nowroozzadeh,Ali Mohammad Tamaddon 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.119 No.-
Dissolving microneedles (dMNs) are proving to be attractive minimally invasive ophthalmic delivery systemsowing to their superior ability to deliver a variety of therapeutic agents through the cornea or sclera. Nevertheless, dMN formulation is most often complicated when poorly water-soluble drugs are used,because dMNs usually contain water-soluble polymers that dissolve quickly in ocular tissues. Here, wesynthesized the thermosensitive in-situ micelle-forming poly (N-isopropyl acrylamide)-b-poly (lglutamicacid) (PNIPAAm-b-PGA) copolymer which was soluble in organic and aqueous solvents, makingit possible to prepare MNs containing hydrophilic drugs. After full characterization of the copolymer, itwas successfully used to fabricate dMNs using the micro-molding technique. Remarkably, they generatedin-situ nanomicelles (NMCs) with sizes below 100 nm allowing for efficient dexamethasone (DEX) encapsulation. In this regard, the concentration of PNIPAAm-b-PGA copolymer was optimized to producemicroneedles with acceptable properties. A series of characteristics were assessed for microneedles,including mechanical and insertion properties, drug loading, in vitro release behavior, and in vitro permeation. Overall, the findings indicated that poly PNIPAAm-b-PGA copolymer is capable of self-assemblinginto NMCs and can significantly incorporate DEX as a hydrophobic drug, improving the trans-scleral DEX)permeation across the sclera, making it a promising system for treating posterior ocular diseases.
Effect of stiffeners on steel plate shear wall systems
Ahmad Rahmzadeh,Mehdi Ghassemieh,Yeonho Park,Ali Abolmaali 국제구조공학회 2016 Steel and Composite Structures, An International J Vol.20 No.3
Stiffeners have widely been used in lateral load resisting systems to improve the buckling stability of shear panels in steel frames. However, due to major differences between plate girders and steel plate shear walls (SPSWs), use of plate girder equations often leads to uneconomical and, in some cases, incorrect design of stiffeners. Hence, this paper uses finite element analysis (FEA) to describe the effect of the rigidity and arrangement of stiffeners on the buckling behavior of plates. The procedures consider transverse and/or longitudinal stiffeners in various practical configurations. Subsequently, curves and formulas for the design of stiffeners are presented. In addition, the influence of stiffeners on the inward forces subjected to the boundary elements and the tension field angle is investigated as well. The results indicate that the effective application of stiffeners in SPSW systems not only improves the structural behavior, such as stiffness, overall strength and energy absorption, but also leads to a reduction of the forces that are exerted on the boundary elements.
Haniye Najafi,Ali Mohammad Tamaddon,Samira Sadat Abolmaali,Bahareh Owrangi,Younes Ghasemi 한국고분자학회 2015 Macromolecular Research Vol.23 No.7
To improve transfection of plasmid DNA as well as serum protein stability of polyionic complex nanoparticles of branched polyethyleneimine (bPEI), poly(ethylene glycol) (PEG)-stabilized nanoparticles were made from L-histidine substituted bPEI (PEI-Histidine) synthesized by Fmoc chemistry. The polymer was characterized by TNBS assay, 1H NMR, GFC, potentiometric titration and elemental analysis of carbon and nitrogen, DNA condensation, and the stability against extracellular matrix (heparin sulfate) was investigated by dye exclusion and agarose gel retardation assays. The nanoparticles were characterized by dynamic light scattering-zeta potential analyzer. Cytotoxicity and expression of enhanced green fluorescent protein (EGFP) were determined in hepatocellular carcinoma by MTT assay and fluorescent techniques. PEI-Histidine showed a reduced pKa without any significant loss of total primary amines. Plasmid DNA was condensed almost thoroughly with PEGylated polymers, either bPEI or PEI-Histidine, at lower critical N/P ratios. PEGylated PEI-Histidine showed the better resistance to heparin induced displacement and the lower cytotoxicity when it was compared to bPEI. Interestingly unlike bPEI, smaller and less positively charged nanoparticles were obtained from PEGylated PEI-Histidine at N/P ratio=2 that resulted in about 4 folds higher EGFP expression than bPEI without any significant cytotoxicity. These properties are consistent with the higher serum protein resistance and buffer capacity of PEGylated PEI-Histidine at endosomal acidic pH.
탄소섬유 강화플라스틱을 활용한 콘크리트파이프 접합부 성능평가에 관한 연구
이수규 ( Lee Sugyu ),홍기남 ( Hong Ki Nam ),아보말리알리 ( Abolmaali Ali ) 한국구조물진단유지관리공학회 2017 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.21 No.2
The purpose of this research is to develop a joint system for two concrete pipes with reduced wall thickness by a carbon fiber reinforced polymer (CFRP) fabric. As compared to conventional concrete pipe, the concrete pipe with the reduced wall thickness has more flexibility. However, the reduced wall thickness makes the conventional joint system not feasible. As an alternative joint, externally wrapping system with the CFRP fabric was proposed. The two CFRP widths (75mm and 150mm) were accounted for as a variable under joint shear test from ASTM C497M specification. The externally wrapping system showed 81.07% higher shear strength, as compared to the required shear strength by ASTM C497M.