http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Amgad I. M. Khedr,Sabrin R. M. Ibrahim,Gamal A. Mohamed,Hany E. A. Ahmed,Amany S. Ahmad,Mahmoud A. Ramadan,Atef E. Abd El-Baky,Koji Yamada,Samir A. Ross 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.7
Phytochemical investigation of Ficus pandurataHance (Moraceae) fruits has led to the isolation of two newtriterpenoids, ficupanduratin A [1b-hydroxy-3b-acetoxy-11a-methoxy-urs-12-ene] (11) and ficupanduratin B [21ahydroxy-3b-acetoxy-11a-methoxy-urs-12-ene] (17), alongwith 20 known compounds: a-amyrin acetate (1), a-amyrin(2), 3b-acetoxy-20-taraxasten-22-one (3), 3b-acetoxy-11amethoxy-olean-12-ene (4), 3b-acetoxy-11a-methoxy-12-ursene (5), 11-oxo-a-amyrin acetate (6), 11-oxo-b-amyrinacetate (7), palmitic acid (8), stigmast-4,22-diene-3,6-dione(9), stigmast-4-ene-3,6-dione (10), stigmasterol (12), b-sitosterol(13), stigmast-22-ene-3,6-dione (14), stigmastane-3,6-dione (15), 3b,21b-dihydroxy-11a-methoxy-olean-12-ene (16), 3b-hydroxy-11a-methoxyurs-12-ene (18), 6-hydroxystigmast-4,22-diene-3-one (19), 6-hydroxystigmast-4-ene-3-one (20), 11a,21a-dihydroxy-3b-acetoxy-urs-12-ene(21), and b-sitosterol-3-O-b-D-glucopyranoside (22). Compound21 is reported for the first time from a natural source. The structures of the 20 compounds were elucidated on thebasis of IR, 1D (1H and 13C), 2D (1H–1H COSY, HSQC,HMBC and NOESY) NMR and MS spectroscopic data, inaddition to comparison with literature data. The isolatedcompounds were evaluated for their anti-microbial, antimalarial,anti-leishmanial, and cytotoxic activities. In addition,their radioligand displacement affinity on opioid andcannabinoid receptors was assessed. Compounds 4, 11, and15 exhibited good affinity towards the CB2 receptor, withdisplacement values of 69.7, 62.5 and 86.5 %, respectively. Furthermore, the binding mode of the active compounds inthe active site of the CB2 cannabinoid receptors was investigatedthrough molecular modelling.
Abd El-Aty, A. M.,Kim, In-Kyung,Kim, Mi-Ra,Lee, ChiHo,Shim, Jae-Han John Wiley Sons, Ltd. 2008 Biomedical chromatography Vol.22 No.5
<P>Ginsenosides are regarded as the main active, non-volatile components of Panax ginseng (C. A. Meyer). However, throughout the long history of ginseng research, there has been virtually no report describing its volatile flavor compounds. A solvent-free procedure for the determination of volatile flavor compounds generated from fresh, white and red Panax ginseng (C. A. Meyer) using solvent-free solid injection (SFSI) coupled with gas chromatography-mass spectrometry (GC-MS) detection is described here. At no point in the SFSI technique were the extraction conditions optimized. Rather, the experimental variables including various sample preparations (fresh, oven-dried and freeze-dried), injector temperatures (100, 150, 200, 250 and 300°C), and preheating times (3, 5, 7, 10 and 15 min), were predicated on the experience of the authors. A total of 47 compounds were identified in various forms of ginseng. Among the compounds identified in the sample, fresh ginseng was characterized by a high proportion of 3-acetyl-1-(3,4-dimethoxyphenyl)-5-ethyl-4,5-dihydro-7,8-dimethoxy-4-methylene-3H-2,3-benzodiazepine (64.24%) and 23,24-dinor-3-oxolean-4,12-dien-28-oic acid (21.42%); 2-furanmethanol (20.26%) and 3-hydroxy-2-methyl-4H-pyran-4-one (17.95%) were detected as the major components in white ginseng while the main components of the red ginseng were found to be 1,2-benzenedicarboxylic acid dibutyl ester (16.27%) and 2-furanmethanol (13.82%). SFSI is a solvent-free, rapid and simple sample preparation technique based on direct vaporization. There is no dilution or contamination with solvent or its impurities and no loss of quickly eluted components was observed in the solvent peak. Copyright © 2008 John Wiley & Sons, Ltd.</P>
Asmaa M. Arafa,Afaf E. Abdel-Ghany,Samih I. El-Dahmy,Sahar Abdelaziz,Yassin El-Ayouty,Ashraf S. A. El-Sayed 한국미생물·생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.4
Phenylalanine ammonia-lyase (PAL) catalyzes the reversible deamination of phenylalanine to cinnamic acid and ammonia. Algae have been considered as biofactories for PAL production, however, biochemical characterization of PAL and its potency for myristicin biotransformation into MMDA (3-methoxy-4, 5-methylenedioxyamphetamine) has not been studied yet. Thus, PAL from Anabaena flos-aquae and Spirulina platensis has been purified, comparatively characterized and its affinity to transform myristicin was assessed. The specific activity of purified PAL from S. platensis (73.9 μmol/mg/min) and A. flos-aquae (30.5 μmol/mg/min) was increased by about 2.9 and 2.4 folds by gel-filtration comparing to their corresponding crude enzymes. Under denaturing-PAGE, a single proteineous band with a molecular mass of 64 kDa appeared for A. flos-aquae and S. platensis PAL. The biochemical properties of the purified PAL from both algal isolates were determined comparatively. The optimum temperature of S. platensis and A. flos-aquae PAL for forward or reverse activity was reported at 30oC, while the optimum pH for PAL enzyme isolated from A. flos-aquae was 8.9 for forward and reverse activities, and S. platensis PAL had maximum activities at pH 8.9 and 8 for forward and reverse reactions, respectively. Luckily, the purified PALs have the affinity to hydroaminate the myristicin to MMDA successfully in one step. Furthermore, a successful method for synthesis of MMDA from myristicin in two steps was also established. Gas chromatography-mass spectrometry (GC-MS) analysis was conducted to track the product formation.
A Protective Mechanism in Lungs of Rats Experimentally Infected with Aspergillus fumigatus
Yehia A G. Mahmoud,Abdulaziz Yahya Al Ghamdi,Eman H. F. Abd El Zaher The Korean Society of Mycology 2011 Mycobiology Vol.39 No.1
Aspergillus fumigatus is associated with invasive disease aspergillosis in immunocompromised individuals. The major aim of this study was to investigate the biochemical and immunological responses of male Wistar rats against A. fumigatus experimentally-induced pulmonary fungal infection. Nostril experimental exposure of male Wistar rats to a high dose of A. fumigatus freeze-dried preparation for only 24 hr resulted in a significant increase in levels of catalase, nitric oxide and lipid peroxide in lung homogenates, compared to those of the control animals. However, the oxidative status of the lungs of rats challenged with killed fungus did not change significantly, except for the stimulation in the level of lipid peroxide. IgG level was significantly elevated only in rats that received two low doses of fungus, compared to unexposed animals (p < 0.005). Examining the lung of rats exposed to A. fumigatus revealed no abnormal changes, except for pus in bronchial lumen spaces and per bronchial inflammation. Histologically, large numbers of granuloma cells were evident in the lungs of challenged rats, while no granuloma formation was evident in the lungs of rats exposed to killed fungus.
THE STABILITY IN AN INCLINED LAYER OF VISCOELASTIC FLUID FLOW OF HYDROELECTRIC NATURAL CONVECTION
A.A. El-Bary 한국산업응용수학회 2005 Journal of the Korean Society for Industrial and A Vol.9 No.2
The problem of the onset stability in an inclined layer of dielectric viscoelastic fluid(Walter's liquid B') is studied. The analysis is made under the simultaneous action of a normal a.c. electric field and the natural convection flow due to uniformly distributed internal heat sources. The power series method used to obtain the eigen value equation which is then solved numerically to obtain the stable and unstable solutions. Numerical results are given and illustrated graphically.
Middle Eastern Plants with Potent Cytotoxic Effect Against Lung Cancer Cells
Jilan A. Nazeam,Soad Z. EL-Emam 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.2
Cancer is one of the leading causes of increasing global mortality with uprising health concerns and threats. Unfortunately, conventional chemotherapy has substantial side effects, limiting its relevance and prompting a quest for safe andefficient alternatives. For thousands of years, plants have provided a rich reservoir for curing a variety of ailments, includingcancer. According to the World Health Organization, medicinal plants would be the best source of medications. However, only25% of drugs in the present pharmacopoeia are derived from plants. Hence, further research into different plants is required tobetter understand their efficacy. Twenty extracts of widely distributed Middle Eastern plants were screened for the cytotoxiceffect against lung cancer cell lines (A549). Eleven plants showed IC50 below 25 lg/mL, consequently, the bioactive extractswere further fractionated by graded precipitation using absolute ethanol. All fraction A (FA; crude polysaccharides precipitate)showed potent IC50, 0.2–5.5 lg/mL except the FA of Brassica juncea, Silybum marianum, and Phaseolus vulgaris, whereas FBfractions (filtrate) of Anastatica hierochuntica, Plantago ovate, Tussilago farfara, and Cucurbita moschata had lower efficacythan other fractions with IC50 values in the range of 0.1–7.7 lg/mL. The fractions of FA Taraxacum officinale and FB Ziziphusspina possess the most potent cytotoxic activity with IC50, 0.2 and 0.1 lg/mL, respectively. Moreover, cell cycle analysis of bothfractions revealed an arrest at G1/S-phase and activation of apoptosis rather than necrosis as the mode of cell death. Therefore, T. officinale and Z. spina fractions may pave the way to manage lung carcinoma as an alternative and complementary food regimen.
Exchange couplings calculation in Sr2CrNO6 (N = Os, Ir) Double Perovskites: Monte Carlo simulation
O. El Rhazouani,A. Slassi,Y. Ziat,A. Benyoussef 한국물리학회 2017 Current Applied Physics Vol.17 No.7
Exchange couplings in Sr2CrNO6 (N ¼ Os, Ir) Double Perovskites (DPs) have been calculated numerically by using a Monte Carlo Simulation (MCS) in the frame work of Ising model by means of a relation between internal energy per site and magnetization per site. Two model parameters a and a0 have been proposed for Sr2CrOsO6 and Sr2CrIrO6, respectively. The exchange couplings have been computed by varying a and a0 through a MCS to find their values corresponding to the transition temperature 725K specific to Sr2CrOsO6 and 884K specific to Sr2CrIrO6. The exchange couplings JCr『Os ¼ 『35:201meV, JCr『Cr ¼ 5:452 meV and JOs『Os ¼ 14:873 meV have been obtained for Sr2CrOsO6, while JCr『Ir ¼ 『24:464 meV, J0 Cr『Cr ¼ 2:181 meV and JIr『Ir ¼ 16:730 meV have been obtained for Sr2CrIrO6. Magnetization and magnetic susceptibility have been investigated in both compounds. Internal energy per site has been given.
Ragaa Hosny Mohamad,Zekry Khalid Zekry,Hussain A. Al-Mehdar,Omar Salama,Siad Ebrahim El-Shaieb,Amany A. El-Basmy,Mohamad Gamil Abdel Monem Al-said,Sabry Mohamed Sharawy 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.2
There is a traditional belief in the Middle East that regular consumption of camel milk may aid in prevention and control of diabetes. The aim of this work was to evaluate the efficacy of camel milk as an adjuvant therapy in young type 1 diabetics. This 16-week randomized study enrolled 54 type 1 diabetic patients (average age 20 years) selected from those attending the outpatient diabetes clinic of the Menofia University Hospital, affiliated with Egypt's National Cancer Institute. Subjects were randomly divided into two groups of 27 patients: one received usual management (diet, exercise, and insulin), whereas the other received 500 mL of camel milk daily in addition to standard management. A control group of 10 healthy subjects was also assessed. The following parameters were evaluated at baseline and at 4 and 16 weeks: hemoglobin A1c (HbA1c), human C-peptide, lipid profile, serum insulin, anti-insulin antibodies, creatinine clearance, albumin in 24-hour urine, body mass index, and Diabetes Quality of Life score. The following parameters were significantly different between the usual-management group versus the camel milk group after 16 weeks: fasting blood sugar (227.2 ± 17.7 vs. 98.9 ± 16.2 mg/dL), HbA1c (9.59 ± 2.05[%] vs. 7.16 ± 1.84[%]), serum anti-insulin antibodies (26.20 ± 7.69 vs. 20.92 ± 5.45 μU/mL), urinary albumin excretion (25.17 ± 5.43 vs. 14.54 ± 5.62 mg/dL/24 hours), daily insulin dose (48.1 ± 6.95 vs. 23 ± 4.05 units), and body mass index (18.43 ± 3.59 vs. 24.3 ± 2.95 kg/m2). Most notably, C-peptide levels were markedly higher in the camel milk group (0.28 ± 0.6 vs. 2.30 ± 0.51 pmol/mL). These results suggest that, as an adjunct to standard management, daily ingestion of camel milk can aid metabolic control in young type 1 diabetics, at least in part by boosting endogenous insulin secretion.
Al-Tahtawy, Ragaa Hosny Mohamad,Zekry, Zekry Khalid,Al-Mehdar, Hussain A.,Salama, Omar,El-Shaieb, Siad Ebrahim,El-Basmy, Amany A.,Al-said, Mohamad Gamil Abdel Monem,Sharawy, Sabry Mohamed The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.2
There is a traditional belief in the Middle East that regular consumption of camel milk may aid in prevention and control of diabetes. The aim of this work was to evaluate the efficacy of camel milk as an adjuvant therapy in young type 1 diabetics. This 16-week randomized study enrolled 54 type 1 diabetic patients (average age 20 years) selected from those attending the outpatient diabetes clinic of the Menofia University Hospital, affiliated with Egypt's National Cancer Institute. Subjects were randomly divided into two groups of 27 patients: one received usual management (diet, exercise, and insulin), whereas the other received 500 mL of camel milk daily in addition to standard management. A control group of 10 healthy subjects was also assessed. The following parameters were evaluated at baseline and at 4 and 16 weeks: hemoglobin A1c (HbA1c), human C-peptide, lipid profile, serum insulin, anti-insulin antibodies, creatinine clearance, albumin in 24-hour urine, body mass index, and Diabetes Quality of Life score. The following parameters were significantly different between the usual-management group versus the camel milk group after 16 weeks: fasting blood sugar ($227.2\;{\pm}\;17.7$ vs. $98.9\;{\pm}\;16.2\;mg/dL$), HbA1c ($9.59\;{\pm}\;2.05$[%] vs. $7.16\;{\pm}\;1.84$[%]), serum anti-insulin antibodies ($26.20\;{\pm}\;7.69$ vs. $20.92\;{\pm}\;5.45\;{\mu}U/mL$), urinary albumin excretion ($25.17\;{\pm}\;5.43$ vs. $14.54\;{\pm}\;5.62\;mg/dL$/24 hours), daily insulin dose ($48.1\;{\pm}\;6.95$ vs. $23\;{\pm}\;4.05$ units), and body mass index ($18.43\;{\pm}\;3.59$ vs. $24.3\;{\pm}\;2.95\;kg/m^2$). Most notably, C-peptide levels were markedly higher in the camel milk group ($0.28\;{\pm}\;0.6$ vs. $2.30\;{\pm}\;0.51\;pmol/mL$). These results suggest that, as an adjunct to standard management, daily ingestion of camel milk can aid metabolic control in young type 1 diabetics, at least in part by boosting endogenous insulin secretion.