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Epidermal Growth Factor가 흰 생쥐 표피 및 모발 성장에 미치는 영향에 관한 연구
이유신(Yoo Shin Lee),최지호(Jee Ho Choi) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.6
Epiclerrnal growth factor(EGF), a low-molecular-weight polypeptide chain consisting of 53 amino acids, stimulates the growth and keratinization of epidermal cells. Recently, some authors reported that hair growth rate and follicular bulb growth were inhibited by EGF in neonatal mice. Since the hair and follicular cells are of epidermal origin, the effect of EGF would appear to be inconsistent with its role promoting the proliferation and differentiation of epidermal cells in vivo and in vitro. We have investigated the effects of EGF on the hair and epidermis in adult male mouse. The results are summarized as follows: l. 1'he hair length and maximum diameter were significantly reduced in EGF- treated regions compared with control group, and inhibition of hair growth was correlated with EGF dose. Thickness of the epidermis was significantly increased in EGF-treated regions compared with control group, and proliferation of the epidermis was correlated with EGF dose. 3 There were no significant differences in the hair length, maximum diameter, and egidermal thickness between untreated contralateral right mid-side regions of EGF-treated groups and control group.
이유신(Yoo Shin Lee),조광현(Kwang Hyun Cho),김선훈(Seon Hoon Kim),김철우(Chul Woo Kim) 대한피부과학회 1987 大韓皮膚科學會誌 Vol.25 No.4
Immunohistochemial staining was performed in metastatic skin cancer using a variety of antistera. Both carcinoembrytonic antigen(CEA) and epithelial membrane antigen(EMA) were demonstrated in large cell carcinoma of the lung, adenocarcinoma of the stomach and skin adnexal cancer with eccrine differentiation. Although papillary carcinoma of the thyroid, squamous cell carcinoma of the skin and squamous cell carcinoma of the lung showed positive staining for CEA and EMA, these were weak or focal reactions in the keratinizing area. In rectal adenocarcinoma, staining for CEA was significantly positive, but staining for EMA was negative. Epiderrnal cytokeratin was observed in squamous cell carcinoma of the lung, squamous cell carcinoma of the skin and skin adnexal cancer with eccrine differentiation. Epidermal cytokeratin was also demonstrated in well differentiated adenocarcinoma of the gastrointestinal tract. By using a variety of tumor markers, the authors tried to locate possible primary sites in six metastatic skin cancers of unknown origin.
태양전지를 이용한 리튬이온 배터리의 충전회로에 관한 연구
이유신(Yoo-Shin Lee),오덕진(Duk-Jin Oh),김희준(Hee-Jun Kim) 전력전자학회 2000 전력전자학술대회 논문집 Vol.2000 No.11
A charging characteristics of Li-ion battery using solar cell is discussed. Firstly studying the conventional charging method by only using diode, it is known that the battery is always charged by the lower power than the peak power of solar cell.<br/> In order to boost the charging power of the battery, the peak power output circuit of solar cell using the feedforward controlled DC-DC converter is proposed,<br/> And applying it to the Li-ion battery charging circuit, the possibility of the improved charging characteristics is shown
이애영,이유신 ( Ai Young Lee,Yoo Shin Lee ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.4
N/A Ultrastructurai Study of Fixed Drug Eruption Ai Young Lee, M.D., Yoo Shin Lee, M.D. Department of Dermatology, College of Medicine, Seoul National University Hospital Seoul, Korea Although patch test responses and histopathology of fixed drug eruption and allergic contact dermatitis are similar, the former recurrs persistently at the same site. The pathogenesis of this site predilection remains to be clarified. The purpose of this study was to examine ultrastructurally healed and active sites of fixed drug eruption. Degenerative changes of keratinocytes, which showed aggregation of tonofilaments, increment of electron density, decrement of nuclear size and irregular condensation of chromatin, were observed in asymptomatic lesions above 1 month after attacks as well as in active lesions. The changed keratinocytes usually attached to lymphocytes and Langerhans cells in both active and healed lesions. The ultrastructrual difference between active and healed lesions lay mainly in the extent and degree to be changed. In the provocation, changed keratinocytes with lymphocytes and Langerhans cells appeared earlier than macrophages. Langerhans cells and lymphocytes seemed to be pulled from dermis to epidermis in active and provoked lesions, and to play a role in the pathogenesis. (Kor J Dermatol 29(4) : 466-470, 1991)
여운철,조광현,이유신,허대석,이승철 ( Un Cheol Yeo,Kwang Hyun Cho,Yoo Shin Lee,Dae Seog Heo,Seung Chul Lee ) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.5
A Case of Erythema Multiforme A ssociated with Malignant Lymphoma Un Cheol Yeo, M.D., Kwang Hyun Cho, M.D., Yoo Shin Lee, M.D., Dae Seog Heo*, M.D., Seoung Chul Lee**, M.D Department of Dermatology and Internal Medicine*, College of Medicine, Seoul National University, Seoul, Korea, Department of Dermatology**, College of Medicine, Inha University, Kyung Gi Do, Korea We report a case of erythema multiforme associated with malignant lymphoma. Fifty-six-year-old male patient visited our clinic complaining generalized skin lesions which were compatible with erythema multiforme clinically and histopathologically. The skin lesions were treatment-resistant, recurrent and persistent for 3 years. In consideration of old age, atypical features of erythema multiforme and no other demonstrable etiology of erythema multiforme, we studied for internal malignancy. Malignant lymphoma at the duodenum was revealed by UGI series, abdominal CT, and endoscopic biopsy. After chemotherapy, the tumor mass and active skin lesions were cleared simultaneously. Erythema multiforme may be regarded as one of the paraneoplastic syndromes.
이유나 ( Lee Yoo Na ),신소라 ( Shin So Ra ) 한국경찰학회 2016 한국경찰학회보 Vol.18 No.5
이 연구는 아동의 자살생각에 실질적으로 영향을 미치는 위험요인을 알아보고자 하였다. 위험요인은 최근 아동자살사건의 원인으로 제기되고 있는 `학교폭력 피해, 부모폭력, 학업스트레스`로 보았으며, 그동안 보호요인으로 제시되던 ‘자아존중감`의 매개효과를 살펴보았다. 연구의 자료는 제 10차 (2015년) 한국복지패널(KOWEPS)데이터의 부가조사자료를 2차 자료로써 활용하였고, 연구대상은 2014년 기준 초등학교 4-6학년 아동 458명이다. 분석방법은 AMOS 프로그램의 구조방정식 모형을 활용한 분석을 실시하였다. 분석결과, 학교폭력과 학업스트레스는 아동의 자아존중감에 부(-)적인 영향을 미치는 것으로 나타났다. 반면 학교폭력은 자살생각에 직접적으로 정(+)적인 영향을 미치는 유일한 변인인 것으로 나타났다. 선행연구들의 주장과는 다르게 부모폭력 및 스트레스변인은 자살생각에 직접적인 영향을 미치지 않았으며, 자아존중감의 매개효과도 나타나지 않았다. The purpose of study is to examine the influence of factors on children`s suicidal ideation. Risk factors influenced on suicidal ideation are composed of school violence victimization, parental violence, and academic stress. This study investigates the effect of risk factors on children`s suicidal ideation and the mediating effect of the self-esteem. The data from 10thwave Korea Welfare Panel Study(KOWEPS) was used. The analyses were conducted on 458 elementary school students(4th-6th grades). Structural equation modeling by using AMOS was used for this study. As results of the study, first it is shown that school violence and academic stress have negative impact on self-esteem. Second, school violence is the only factor that has significant effect on suicidal ideation. In addition, parental violence and academic stress do not have a direct impact on suicidal ideation, unlike the results of previous researches. Also, there is no mediating effect of self-esteem. Based on these research results, this study suggests that there is a necessity for intervention for the purpose of prevention of suicidal ideation among children.
흡입에 의하여 분리된 백반증 환자 수포 표피의 광학 및 전자 현미경 관찰
이애영,이유신 ( Ai Young Lee,Yoo Shin Lee ) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.5
Suction is a useful tool for separation of epidermis from dermis in vivo. With appropriate suction pressures and durations applied, cellular damage of the separated epidermis can reduce, This study was performed to examine the appropriste suction pressures and durations in the lhsional and normal skin of four vitiligo patients who wanted to take epidermal autograft. The suction pressures and durations for making the blisters of similar morphology were different according to person. Microscopic changes in the blisters of similar morphology were not very different, and suction of 200 to 250 mmHg for 2 to 3 hours with a 2cm diametered suction cup was considered to be acceptable. Obvious damage to keratinocytes and diminish of melanacyte number were observed with much more powerful and longer suction such as suction of 350 to 400 mmHg for 3 to 4 hours. The level of dermo-epidermal separation was between basal cell membrane.