양방 항암치료와 병행하여 산삼약침과 봉약침 치료를 받은 전립선암 환자들의 PSA 수치 변화 관찰 보고

이연희,김채원,이광호,Lee, Yeon-Hee,Kim, Chae-Won,Lee, Kwang-Ho 대한약침학회 2011 Journal of pharmacopuncture Vol.14 No.4

Objectives: The purpose of this report is to find out how Mountain Ginseng Pharmacopuncture(MGP) and Sweet Bee Venom(SBV) treatments are effective on prostate cancer patients by monitoring Prostate specific antigen(PSA) values. Methods: We treated two prostate cancer patients with MGP and SBV from October 2008 to April 2011. One patient had localized prostate cancer, the other was in the terminal stage of prostate cancer with lung and bone metastasis and both had been receiving western anticancer therapy. We had monitored the changes of PSA value. Results: In case 1, MGP and SBV treatments seemed to be helpful in preventing the recurrence of localized prostate cancer. In case 2, PSA value was decreased by MGP treatment. Conclusions: It is conceivable that MGP and SBV are effective treatments for patients with prostate cancer.

특발성 비대경수막염에 동반된 급성 양안 시력 소실

이연희,김정열,남기엽,Yeon-Hee Lee,MD,Jung Yeul Kim,MD,Ki Yup Nam,MD 대한안과학회 2011 대한안과학회지 Vol.52 No.7

Purpose: To report a case of bilateral optic neuropathy related with idiopathic hypertropic pachymeningitis. Case summary: A 66-year old woman presented with acute visual loss that developed 6 days previously in the right eye and 3 days prior in the left eye. During the initial evaluation, her visual acuity was light perception in the right eye and counting fingers at 30 cm in the left eye. A relative afferent papillary defect (RAPD) was noted in the patient’s right eye. On brain MRI, the duramater was thickened and enhanced by contrast. The erythrocyte Sedimentation Rate (ESR) and C-reactive protein (CRP) level were increased and myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) as positive. Other neurological and medical abnormalities were not found. Under the suspicion of bilateral optic neuropathy due to idiopathic hypertrophic pachymeningitis, the patient was treated with methylprednisolone pulse therapy. Two days after the treatment, the visual acuity was hand movements at 20 cm in the right eye and 0.6 in the left eye. Three months after the treatment, the visual acuity was counting fingers at 20 cm in the right eye, and 0.7 in the left eye. The right eye showed optic disc pallor and diffuse retinal nerve fiber layer (RNFL) defect. The left eye showed a suspicious RNFL defect, and was otherwise normal. Conclusions: The authors report a rare case of optic neuropathy related with idiopathic hypertrophic pachymeningitis. Idiopathic hypertrophic pachymeningitis should be considered as one of the various causes of optic neuropathy. J Korean Ophthalmol Soc 2011;52(7):893-896

갑상샘눈병증과 관련된 사시의 자연경과

이연희,황정민,오세열,Yeon Hee Lee,M,D,Jeong Min Hwang,M,D,Sei Yeul Oh,M,D 대한안과학회 2006 대한안과학회지 Vol.47 No.12

Purpose: This study investigated the natural course of strabismus associated with thyroid ophthalmopathy. Methods: A retrospective review was performed on the medical records of 31 patients with strabismus associated with thyroid ophthalmopathy who had been followed up for more than 6 months and had not received surgery. For the purpose of this study, a significant change of deviation angle was defined as more than 10 prism diopters in the primary position. Results: Forty-two percent of patients showed a significant change in deviation angle during the observation period of 23.8±17.7 months. The direction of the change was vertical in 32%, horizontal in 3%, and vertical and horizontal in 6% of patients. A significant change of deviation angle developed in 30% of patients within 6 months from the initial ophthalmologic examination, in 24% between 6 and 12 months, and in 13% of patients between 12 and 18 months from the initial examination. Conclusions: Although the deviation angle of strabismus associated with thyroid ophthalmopathy tended to stabilize with time, it nonetheless was susceptible to change even 12 months after the initial ophthalmologic examination. In addition, a vertical change in the deviation angle was more frequent than a horizontal change

제 1형 신경섬유종증 환자에서 발생한 절반-망막중심정맥폐쇄

이연희,김경남,신경섭,김정열,Yeon Hee Lee,MD,Kyoung Nam Kim,MD,Kyoung Sup Shin,MD,Jung Yeul Kim,MD 대한안과학회 2010 대한안과학회지 Vol.51 No.1

Purpose: We report on a case of hemi-central retinal vein occlusion (Hemi-CRVO) which occurred in a patient with Type 1 neurofibromatosis. Case summary: A 31-year-old woman presented with a chief complaint of a one-month history of decreased visual acuity in the left eye. The patient had Type 1 neurofibromatosis but had no other systemic diseases. The best corrected visual acuity (BCVA) was 0.8 in the right eye and 0.05 in the left eye. Multiple Lisch nodules were present in the irises of both eyes on slit lamp examination. Fundus examination revealed a hemi-central retinal artery occlusion in the left eye. Optical coherence tomograms showed that the central macular thickness was 192 microns in the right eye and 732 microns in the left eye. There was cystoid macular edema in the left eye. A fluorescein angiogram showed delayed filling in the superior branch retinal vein of the left eye. There was an extensive area of non-perfusion of the retinal capillary in the corresponding area, including the perifoveal area. Blood tests for hyper-coagulability, autoimmune disorders, connective tissue disorders and other tests for the brain and carotid artery and coronary artery disease showed no abnormal findings. The clinical course was monitored following an intravitreal injection of bevacizumab (AvastinⓇ). Eight months later, the BCVA had improved to 0.2. Conclusions: Although it is rare, hemi-CRVO occurring in younger patients who have no underlying diseases could be related to neurofibromatosis. J Korean Ophthalmol Soc 2010;51(1):150-154

Ciprofloxacin , HK - 3140 , Norfloxacin , Ofloxacin 에 대한 Escherichia coli 저항균주의 특성

이연희,김경순,편희은,박원봉,박명환,김완주 ( Yeon Hee Lee,Kyung Soon Kim,Hee En Pyun,Woon Boong Park,Myung Hwan Park,Wan Joo Kim ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.2

Resistant strains of Escherichia coli were obtained against ciprofloxacin, ofloxacin, norfloxacin and HK-3140. Each resistant strain showed cross-resistance to other quinolones and peniciline-G. To find out the resistant mechanism, lipid and outer membrane proteins of the cells were separated and analyzed with gas chromatography and SDS denaturing gel electrophoresis. Lipid profiles from sensitive and resistant cells showed no big differences while outer membrane protein profiles showed a large variation. Sensitive cells showed better uptake of quinolone than resistant cells suggesting that the resistance against quinolone was resulted from the change in permeability through the outer membrane proteins.

섬모체망막동맥폐쇄가 첫 임상 증후로 나타난 안매독 환자 1예

이연희,남기엽,김정열,Yeon Hee Lee,Kiyup Nam,Jung Yeul Kim 대한안과학회 2011 대한안과학회지 Vol.52 No.10

Purpose: To report a case of a neurosyphilis patient with cilioretinal artery occlusion as the first manifestation. Case summary: A 58-year old man presented with a visual impairment which developed 5 days earlier in his right eye. During initial evaluation, the visual acuity in the right eye was 0.02. On fundus examination, a whitening adjacent to the macula was observed and fluorescein angiography showed filling delay and late leakage of the cilioretinal arteries. The patient was diagnosed with cilioretinal artery occlusion. Two weeks after his initial visit, visual acuity in the patient’s right eye improved to 0.7 and retinal whitening was decreased on fundus examination. Three months later, a visual decrease in the right eye reoccurred and the visual acuity was 0.01. Anterior chamber cell reaction with hypopyon was observed on slit lamp examination and vitreal opacity was noted during fundus examination. Among the numerous tests performed in order to determine the cause of uveitis, RPR antibody and treponemal antibody were found positive. The patient was diagnosed with neurosyphylis and 2 weeks after intravenous administration of penicillin, visual acuity improved to 0.7 and anterior chamber cell reaction as well as vitreal opacity decreased. Conclusions: The authors reported a case of cilioretinal artery occlusion suspected secondary to neurosyphilis. J Korean Ophthalmol Soc 2011;52(10):1254-1258

갑상샘눈병증에서 심한 사시각변화를 보인 1예

이연희,왕선진,황정민,Yeon-Hee Lee,Seon Jin Wang,Jeong-Min Hwang 대한안과학회 2008 대한안과학회지 Vol.49 No.8

Purpose: We report a patient with strabismus associated with thyroid ophthalmopathy whose condition changed remarkably for 6 years of a natural course. Case summary: A 69-year-old woman with Graves' disease presented with diplopia in April 1999. On examination, she showed left hypotropia of 50 prism diopters (Δ) accompanied by supraduction limitation and lid lag in the left eye. She was diagnosed with strabismus associated with thyroid ophthalmopathy and was observed without any intervention. In October 2000, her left hypotropia decreased to 16Δ, and esotropia of 14Δ developed. Both eyes showed limitation of supraduction, and the left eye showed limitation of abduction. In December 2003, the esotropia increased to 35Δ, and the direction of vertical strabismus changed to 40Δ of right hypotropia. Supraduction limitation of the right eye and abduction restriction of both eyes increased, and infraduction limitation of the left eye developed. In April 2005, esotropia increased to 75Δ, and the amount of right hypotropia was 35Δ. The abduction limitation of both eyes increased. Conclusion: The natural course of strabismus associated with thyroid ophthalmopathy can show continuous and remarkable changes. J Korean Ophthalmol Soc 49(8):1350-1355, 2008

개방성 안구손상 환자의 시력 예후 인자와 안외상점수의 예측도

이연희,곽주영,이성복,Yeon Hee Lee,MD,Joo Young Kwag,MD,Sung Bok Lee,MD,PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.6

Purpose: To determine the prognostic factors of visual outcome in open globe injury and to assess the possibility of an ocular trauma score (OTS) model of predictive value in open globe injuries in Koreans. Methods: The medical records of 242 patients with open globe injury from 2000 to 2010 were retrospectively reviewed. Prognostic factors of visual outcome, positive predictive rate, and negative predictive rate were surveyed. Results: In the multivariate analysis, old age, relative afferent pupillary defect, impaired initial visual acuity and retinal detachment were the worst predictive factors of vision survival. In OTS categories 1 and 2, worse final visual acuity was acquired, and positive predictive rate and negative predictive rate for assessment of final visual acuity less than 0.02 were 70.1% and 89.8%, respectively. Conclusions: The prognostic factors of open globe injury associated with impaired final visual acuity were old age, relative afferent pupillary defect, worse initial visual acuity, retinal detachment and OTS categories 1 and 2. The OTS may have prognostic value in open globe injuries in Korean patients. However, identified prognostic factors of the present study did not entirely coincide with those of other Koreans or previous studies. Therefore, additional studies on the modified open globe injury as a prognostic model in Korean patients are needed. J Korean Ophthalmol Soc 2012;53(6):825-832

망막분지정맥폐쇄에서 발생한 전층황반원공 1예

이연희(Yeon Hee Lee),왕선진(Seon Jin Wang),김정열(Jung Yeul Kim) 대한검안학회 2010 Annals of optometry and contact lens Vol.9 No.1

목적: 망막분지정맥폐쇄 환자에서 경과 관찰 중 전층황반원공이 발생한 예를 경험하였기에 보고하고자 한다. 대상과 방법: 황반부종을 동반한 망막분지정맥폐쇄로 진단받고 경과 관찰하던 중 전층의 황반원공이 발생한 1예를 대상으로 빛간섭단층촬영을 포함한 전반적인 안검사를 시행하였다. 결과: 78세 여자환자가 2달간의 우안 시력저하를 주소로 내원하였다. 안저검사에서 하이측 망막분지정맥을 따라 불꽃모양의 망막출혈이 있었고, 황반부종이 동반되어 있었다. 망막분지정맥폐쇄로 진단하고 경과 관찰하던 중 내원 10개월째 안저검사 및 빛간섭단층촬영에서 낭포성 변화를 동반한 전층황반원공이 관찰되었다. 결론: 망막분지정맥폐쇄에서 드물지만 합병증으로 전층의 황반원공이 발생할 수 있음을 알 수 있었다. Purpose: To report one case of full thickness macular hole associated with branch retinal vein occlusion. Methods: One patient with branch retinal vein occlusion were followed up and developed full thickness macular hole. They carried out ophthalmic examination including optical coherence tomography (OCT). Results: A 78-year-old female presented with decreased vision of the right eye. There was flame shape hemorrhage along to branch retinal vein and macular edema on fundus examination. She was followed under the diagnosis of branch retinal vein occlusion. At 10 months after initial visit, fundus examination and OCT showed full thickness macular hole with cystic change. Conclusions: Full thickness macular hole may develop as a rare complication of branch retinal vein occlusion.

스톤테라피와 매뉴얼 마사지가 피부에 미치는 영향

이연희(Yeon-Hee Lee) 한국의료정보교육협회 2017 보건의료생명과학논문지 Vol.5 No.2

본 연구는 매뉴얼 마사지와 스톤테라피의 효과를 알아보자 20대의 대학생 남녀 32명을 대상으로 두 그룹으로 나누어 주 2회 총 10회의 피부관리 프로그램을 적용하였다. 마사지군은 클렌징, 마사지, 팩을 적용하였고, 스톤테라피군은 클렌징, 마사지, 스톤테라피, 팩을 적용한 후 aramo TS 기기를 통해 피부를 측정하였다. 그 결과 수분, 탄력, U존과 T존의 유분과 수분, 거칠기에는 마사지 그룹과 스톤테라피그룹 모두에서 피부상태에 변화가 있었으나, 모공, 투명도에는 차이가 없었다. The purpose of this study was to investigate the effects of manual massage and stone therapy. A total of 10 skin care programs were applied twice a week to 32 male and female college students in their 20s divided into two groups. Massage group was used for cleansing, massage and pack. Stone therapy group was applied for cleansing, massage, stone therapy, and pack. The skin was then measured via an aramo TS instrument. As a result, hydration, elasticity, sebum and hydration of U zone and T zone, roughness showed changes in skin condition in both massage group and stone therapy group, but there was no difference in pores and transparency.