자하거 약침의 지표물질 선정 및 분석법 벨리데이션

박상원 ( Sang Won Park ),이재웅 ( Jae Woong Lee ),이진호 ( Jin Ho Lee ),하인혁 ( In Hyuk Ha ),변장훈 ( Jang Hoon Byun ),정범환 ( Bum Hwan Jung ),정화진 ( Hwa Jin Jung ),이인희 ( In Hee Lee ),김민정 ( Min Jeong Kim ),김은지 ( Eun J 한방재활의학과학회 2016 한방재활의학과학회지 Vol.26 No.1

Objectives Despite the increasing use of Ja-ha-guh (Hominis-placenta ) pharmacopuncture in rehabilitative medicine field, its standard compound has yet to be investigated. The purpose of this study is to provide standardization for future studies and increase satisfaction of patients by utilizing standard pharmacopuncture. Methods Alanine and leucine were selected as potential standard compounds. LC/MS was used to devise an analytic method. This analytic method was subject to validation. According to validation guideline of Korea Food and Drug Administration, the specificity, linearity, precision, range, quantitative limits, detection limits and accuracy were measured. With this analysis, 3 lots of Ja-ha-guh pharmacopuncture were analyzed. Results Because the specificity, linearity, precision, range, quantitative limits, detection limits and accuracy meet criteria of the guideline, the analytic method was validated. It was found that Ja-ha-guh pharmacopuncture contained 211.02±7.28 ug/ml of alanine and 372.03±7.58 ug/ml of leucine. Conclusions Both alanine and leucine appear to be suitable standard compounds. These results are likely to contribute to further standardization of Ja-ha-guh for medical use. (J Korean Med Rehab 2016;26(1):33-40)

4 대강 상수원수의 Al (3) 응집제 사용에 따른 수화학적 특성

박상원(Sang Won Park),이태관(Tae Gwan Lee),손무정(Moo Jeong Sohn) 한국수처리학회 1996 한국수처리학회지 Vol.4 No.1

To investigate the effect of alum during the water treatment process on the water quality of the drinking water, some solution characteristics of 4 major rivers (Han River, Nakdong River, Keum River, Youngsan River) in Korea were analyzed before and after addition of the coagulant. Emphasis was given to the dissolved Al(III) concentration which should be kept lower than 0.2ppm in the drinking water. For 4 river waters, the Al(III) concentrations in the treated water were 0.03 ppm at most. Emphasis was also given to the determination of the optimal dosage of the Alum by investigating the surface charge of the suspended particles as a key mechanism of the coagulation process. Behaviors of other solution characteristics as affected by the addition of the Alum were also elucidated.

무시멘트 Multilock 대퇴스템을 이용한 이극성 반치환술의 7년 이상 추시결과

박상원 ( Sang Won Park ),이순혁 ( Soon Hyuck Lee ),한승범 ( Seung Bum Han ),정웅교 ( Woong Kyo Jeong ),김상범 ( Sang Beom Kim ),양재혁 ( Jae Hyuck Yang ),최근석 ( Keun Seok Choi ) 대한고관절학회 2006 Hip and Pelvis Vol.18 No.3

목적:무시멘트형 환형성 대퇴스템인 Multilock 대퇴스템과 biarticular 비구컵을 이용한 일차적 이극성 반치환술의 평균 9.8년 추시 결과를 임상적 및 방사선학적으로 분석 하고자 하였다. 대상 및 방법: 1992년 1월부터 1999년 3월 사이에 Multilock 대퇴스템과 biarticular cup을 이용하여 이극성 반치환술을 시행하고 7년 이상 추시가 가능하였던 24명(29예)를 대상으로 하였다. 임상적으로는 Harris 고관절 점수를 측정하였고, 대퇴부 동통 및 서혜부 동통을 관찰하였다. 대퇴스템 주위의 방사선 평가는 골용해, 방사선 경화선을 동반한 방사선 투과선, 피질골 비후, 대퇴거 흡수, 대퇴스템 끝의 plug 형성, 대퇴스템의 안정도 등을 관찰 하였다. 비구 주위의 방사선 평가는 비구 연골의 마모, 골용해, 비구컵의 이동 등을 관찰하였다. 결과: Harris 고관절 점수는 평균 57.4점에서 평균 91.6점으로 향상되었고, 서혜부 동통은 3예(10.3%), 대퇴부 동통은 4예(13.8%)에서 관찰되었다. 대퇴스템 주위의 방사선 투과선은 4예(13.8%) 대퇴스템 주위의 골용해는 6예(20.6%)에서 관찰되었고, 대퇴스템의 안정도는 골성 고정 26예(89.7%), 섬유성 안정고정 3예(10.3%)였다. 비구 주위의 골용해는 5예(17.2%), bipolarcup의 근위부 이동은 2예(6.9%)에서 관찰되었고, 비구 연골 마모는 10예(34.5%)였다. Bipolar cup의 재치환술은 3예(10.3%)에서 시행하였고 대퇴스템의 재치환술은 없었고, 전체적인 실패율은 10.3%였다. 결론: 환형성 미세포말형 Multilock 대퇴스템을 이용한 이극성 반치환술의 평균 9.8년 추시시 임상적 결과는 만족스러웠으나 전치환술과 마찬가지로 골용해가 문제점으로 대두되었으며 특히 시간이 경과할수록 비구골 주위의 골용해가 증가되어 비구컵 재치환술의 주요원인으로 작용할 것으로 사료된다. Purpose: To evaluate the clinical and radiographic results of primary bipolar arthroplasty during average 9.8-year period, using a non-cemented Multilock femoral stem and a biarticular acetabular cup. Materials and Methods: This study included 24 patients (29 hips) who underwent primary bipolar hemiarthroplasties with Multilock femoral stems and biarticular cups and who could be followed for more than seven years. Clinically, we evaluated the Harris Hip scores and patient complaints of thigh and inguinal pain. We also evaluated the radiographic measurements around the femoral stems and the bipolar cups. Results: The average Harris Hip score improved from 57.4 points to 91.6 points; and 3 (10.3%) hips were associated with thigh pain and 4 (13.8%) hips with inguinal pain. Around the femoral stem there was a non-progressive radiolucent line less than 1 mm in length in 4 (13.8%) hips and osteolysis was present in 6 (20.6%) hips. With respect to the stability of the fixations, there was osseous ingrowth in 26 (89.7%) hips and fibrous ingrowth in 3 (10.3%) hips. Around the acetabulum there was osteolysis in 5 (17.2%) hips, proximal migration of the cup in 2 (6.9%) hips, and erosion of the acetabular cartilage in 10 (34.5%) hips. There were 3 (10.3%) biarticular cups, which were converted to total hip arthroplasties, but no femoral stems were revised. The overall failure rate of the primary operations was 10.3%. Conclusion: The current study demonstrated favorable results after bipolar hemiarthroplasties with Multilock femoral stems. However, the osteolysis that occurred around the femoral stems and the acetabula emerged as a problem after the total hip arthroplasties. In particular, it is expected that the osteolysis would increase over time and become the main cause for the need for surgical revision.

포스터 전시 : 상부위장관 ; Presentation of symptoms in endoscopic GERD (130 cases)

박상원 ( Park Sang Won ),박재범 ( Park Jae Beom ),김정훈 ( Kim Jeong Hun ),양윤석 ( Yang Yun Seog ),이호섭 ( Lee Ho Seob ),이창구 ( Lee Chang Gu ),이진관 ( Lee Jin Gwan ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-

<목적> 내시경적 GERD와 임상증상이 일치하지 않는 것을 경험하는 경우가 흔하다. 이에 연구자들은 내시경적 GERD에서 증상발현의 빈도를 알아보기 위해 이 조사를 하였다. <방법> 2002년 10월부터 2003년 9월까지 울산동강병원에서 종합검사를 받은 대상자 중 내시경상 전형적인 역류성 식도염이 있는 130예에 대해서 임상증상을 설문 조사하였다. 객관성을 기하기 위해 위십이지장에 급성 병변이 있는 경우와 최근 소화기질환으로 치료중인 환자는 제외하였으

Risk Assessment of As, Cd, Cu and Pb in Different Rice Varieties Grown on the Contaminated Paddy Soil

Won-Il Kim(김원일),Jin-Kyoung Kim(김진경),Ji-Hyock Yoo(류지혁),Min-Kyoung Paik(백민경),Sang-Won Park(박상원),Oh-Kyung Kwon(권오경),Moo-Ki Hong(홍무기),Jay-E Yang(양재의),Jeong-Gyu Kim(김정규) 한국토양비료학회 2009 한국토양비료학회지 Vol.42 No.1

휴폐광산 인근 주민에 대한 위해영향을 평가하는데 있어서 벼 품종에 따른 변이를 파악하기 위하여 농경지 토양 및 쌀의 비소, 카드뮴, 구리 및 납의 함량을 분석하였다. 중금속 오염농경지에서 조사된 잠재적인 인체노출경로로서 오염된 농경지 및 쌀을 통한 경구섭취 및 피부접촉을 통한 품종간 일일평균 인체노출량(ADD)을 산정하였다. 비발암성 위해도 평가로 노출경로별 중금속의 위험비율인 HQ 지수와 모든 노출경로를 총합한 중금속의 위험지수인 HI 값을 US-EPA D/B를 활용하였다. 벼 품종간 HI 지수는 23.6∼34.3으로 전품종에서 높은 잠재적 위해성으로 평가되었는데 DA 품종이 가장 낮은 반면 TB 품종이 가장 높은 HI 값을 보였다. 쌀 소비에따른 비소의 발암성 위해도 평가는 품종간 2.0E-03∼3.5E-03을 보여 미국 EPA에서 정한 위해성 기준인 만명중 한명 이상으로 높게 나타났다. 발암성 위해도에 대한 품종간 비교에서 DA 품종이 가장 낮은 반면 TB 품종이 가장 높은 HI 값을 보였다. 이러한 결과는 위해성 평가가 중금속 오염에 안전한 품종을 선발하는데 유용한 도구로서 활용할 수 있음을 보여준다. Heavy metal pollution may be one of the most serious challenges confront crop production and human health. Therefore, the selection of heavy metal tolerance cultivars which adapted to the contaminated fields will introduced a suitable solution for management this critical environmental risk. The objectives of this research is to assess human health risk using geochemical analyses and exposure assessment of heavy metals in rice cultivars. Risk for inhabitants in the closed mine area was comparatively assessed for As, Cd, Cu and Pb in 10 rice varieties as a major exposure pathway. The average daily dose (ADD) of each heavy metal was estimated by analyzing the exposure pathways to rice and soil. For the non-carcinogenic risk characterization, Hazard Quotient (HQ) and Hazard Index (HI) were calculated using toxicity indices provided by US-EPA IRIS. The different rice varieties revealed a wide range of HI values from 23.6 to 34.3, indicating that all rice varieties have a high potential toxic risk. The DA rice variety showed the lowest HI value while the TB rice variety the highest. The probabilities of cancer risk for As via rice consumption were varied with rice varieties ranging from 2.0E-03 to 3.5E-03 which exceeded the regulatory acceptable risk of 1 in 10,000 set by US-EPA. The DA rice variety also showed the lowest value while the TB rice variety gave the highest value. Our results indicate that risk assessment can be contribute to screen the pollution safe rice cultivars in paddy fields affected by the mining activity.

Bcl-2 유전자 발현이 apolipoprotein E knockout mouse의 동맥경화병변에 미치는 영향

박상원 ( Park Sang Won ),서홍석 ( Seo Hong Seog ),신성희 ( Sin Seong Hui ),안정천 ( An Jeong Cheon ),박창규 ( Park Chang Gyu ),심완주 ( Sim Wan Ju ),오동주 ( O Dong Ju ),노영무 ( No Yeong Mu ) 한국지질동맥경화학회 ( 구 한국지질학회 ) 2003 춘계학술대회 Vol.- No.-

메틸비닐케톤 . 스티렌의 유화공중합에 의한 반응성 마이크로겔의 합성과 입자의 반응성

김정수(Jeong Soo Kim),박상원(Sang Won Park) 한국고분자학회 1998 폴리머 Vol.22 No.1

상완골 간부 골절과 동반된 외상성 회전근 개 전층 파열 - 증례 보고 -

정웅교,박상원,이순혁,최근석,Jeong, Woong-Kyo,Park, Sang-Won,Lee, Soon-Hyuck,Choi, Keun-Seok 대한견주관절학회 2006 대한견주관절의학회지 Vol.9 No.2

Full-thickness rotator cuff tears are relatively uncommon in the young adults. One of the pathogenesis of such tear is thought to be closely related to the specific trauma event. Favorable outcome is expected in young patient rotator cuff tears when it is diagnosed early following prompt surgical repair. However, early detection is sometimes difficult when the acute rotator cuff tear is combined with other injuries especially around the shoulder joints such as ipsilateral humerus fractures. Authors report an uncommon case of acute traumatic rotator cuff tear accompanied by the midhumerus shaft fracture in young adult.

사염화규소 노출에 따른 주변환경 영향 범위 산정

최정민 ( Jeong-min Choi ),최서영 ( Seo-young Choi ),박상원 ( Sang-won Park ),최종우 ( Jong-woo Choi ) 한국환경농학회 2021 한국환경농학회 학술대회집 Vol.2021 No.-

사염화규소를 다루는 공장에서 배관 크랙 보수작업 중 사염화규소 가스누출 사고가 발생하여 인근 지역의 논과 밭에 염화수소의 피해가 발생하였다. 사염화규소가 대기로 누출되면 공기 중의 수분과 접촉하여 염화수소가 생성되고 풍하 방향으로 이동하면서 농작물과 식물에 염화수소 피해를 야기 시킨다. 본 조사에서는 염화수소 영향 범위를 산정하고자 인근지역 작물과 식생 총 17종 114개 시료를 채취하여 pH와 염소함량을 조사하였다. 수거한 작물과 식생 시료는 액화질소로 동결처리한 후, 막자사발로 분쇄하여 분말시료로 조제하였으며, 분말시료는 증류수 추출과 cellulose acetate 필터를 통과한 추출액을 사용하였고, pH 미터(메틀러, S220)와 이온크로마토그래프(다이오넥스, ICS 3000)를 이용하여 pH와 염소이온 농도를 분석하였다. 농작물 시료의 염소이온 농도, pH 그리고 염소이온 농도와 pH의 상관관계를 이용하여 영향범위를 산정한 결과, 염소이온 농도 2,000 mg/kg 이상이면서 pH와의 상관성이 인정되는 지점은 총 59개 대상 시료 중 16개 이었으며, 대부분 사고지점에서 남동쪽으로 약 800 m 범위에 분포하였다. 주변 식생 및 유실수 총 8종 31개 시료의 염소이온 농도와 pH를 조사한 결과, 5종 8개 시료가 염화수소의 영향을 받은 것으로 추정되며, 대부분 사고지점 동남쪽 인근 도로변과 350 m 내에 분포하였다. 인근마을 농작물 및 식생 중 염소이온(Cl^-) 농도분석 및 pH 측정결과, 5개 마을 농작물 및 식생 8종 36시료 모두 대조군과 유사한 수준으로 염화수소에 의한 영향은 찾아 볼 수 없었다. 이상의 결과는 사염화규소 누출에 따른 인근지역의 영향범위를 산정하는데 농작물과 식생이 지표로 활용될 수 있으며, 오염물질의 환경노출에 따른 피해보상을 결정하는데 법원 판단의 기초자료로 이용되고, 향후 유사한 사고 발생시 하나의 대응기법으로 활용될 수 있다.

타이타늄 표면 코팅 처리에 따른 타이타늄도재관의 파절강도 비교

김지혜,박상원,방몽숙,양홍서,박하옥,임현필,오계정,김현승,이광민,이경구,Kim, Ji-Hye,Park, Sang-Won,Vang, Mong-Sook,Yang, Hong-So,Park, Ha-Ok,Lim, Hyun-Pil,Oh, Gye-Jeong,Kim, Hyun-Seung,Lee, Kwang-Min,Lee, Kyung-Ku 대한치과보철학회 2007 대한치과보철학회지 Vol.45 No.2

Statement of problem: Titanium and its alloy, with their excellent bio-compatibility and above average resistance to corrosion, have been widely used in the field of dentistry. However, the excessive oxidization of titanium which occurs during the process of firing on porcelain makes the bonding of titanium and porcelain more difficult than that of the conventional metal-porcelain bonding. To solve this problem related to titanium-porcelain bonding, several methods which modify the surfaces, coat the surfaces of titanium with various pure metals and ceramics, to enable the porcelain adhesive by limiting the diffusion of oxygen and forming the adhesive oxides surfaces, have been investigated. Purpose: The purpose of this study was to know whether the titanium-porcelain bonding strength could be enhanced by treating the titanium surface with gold and TiN followed by fabrication of clinically applicable porcelain-fused-to-titanium crown Material and method: The porcelain-fused-to-titanium crown was fabricated after sandblasting the surface of the casting titanium coping with $Al_2O_3$ and treating the surface with gold and TiN coating followed by condensation and firing of ultra-low fusing porcelain. To compare with porcelain-fused-to-titanium crowns, porcelain-fused-to-gold crowns were fabricated and used as control groups. The bonding strengths of porcelain-fused-to-gold crowns and porcelain-fused-totitanium crowns were set for comparison when the porcelain was fractured on purpose to get the experimental value of fracture strength. Then, the surface were examined by SEM and each fracturing pattern were compared with each other Result:Those results are as follows. 1. The highest value of fracture strength of porcelain-fused-to-titanium crowns was in the order of group with gold coating, group with TiN coating, group with $Al_2O_3$ sandblasting. No statistically significant difference was found among the three (P>.05). 2. The porcelain-fused-to-gold crowns showed the highest value in bonding strength. The bonding strength of crowns porcelain-fused-to-titanium crowns of rest groups showed bonding strength reaching only 85%-94% of that of PFG, though simple comparision seemed unacceptable due to the difference in materials used. 3. The fracturing patterns between metal and porcelain showed mixed type of failure behavior including cohesive failure and adhesive failure as a similar patterns by examination with the naked eye and SEM. But porcelain-fused-to-gold crowns showed high incidence of adhesive failure and porcelain-fused-to-titanium crowns showed high incidence of cohesive failure. Conclusion: Above results proved that when fabricating porcelain-fused-to-titanium crowns, treating casting titanium surface with gold or TiN was able to enhance the bonding strength between titanium and porcelain. Mean value of masticatory force was found to showed clinically acceptable values in porcelain bonding strength in all three groups. However, more experimental studies and evaluations should be done in order to get better porcelain bonding strength and various surface coating methods that can be applied on titanium surface with ease.