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전이성 거세 저항 전립선암에서 Docetaxel 전신 화학요법의 최적의 횟수
안성훈(Sung Hoon Ahn),박승철(Seung Chol Park) 대한비뇨기종양학회 2013 대한비뇨기종양학회지 Vol.11 No.2
Metastatic prostate cancer is initially treated with androgen deprivation therapy, which induces rapid decrease in bone pain and decrease in serum prostate specific antigen level. However, most of cases with prostate cancer eventually progress to castration-resistant prostate cancer within a median of 18-24 months. Docetaxel-based systemic chemotherapy is now the standard treatment for CRPC, based on the results of 2 phase III studies. However, the optimal cycles of docetaxel-based systemic chemotherapy for CRPC has not been defined. Herein, we present two cases of castration-resistant prostate cancer treated by docetaxel-based systemic chemotherapy and reviewed recent literatures.
안성훈(Ahn, Sung Hoon),고주환(Koh, Joo Hwan),박정태(Park, Jung Tae),김종학(Kim, Jong Hak) 한국신재생에너지학회 2010 한국신재생에너지학회 학술대회논문집 Vol.2010 No.06
The morphology of mesoporous TiO₂ films plays an important role in the operation of a DSSC. For example, the energy conversion efficiency of DSSCs with well-organized mesoporous TiO₂ films is much higher than those with traditional films possessing a random morphology. In previous research, well-organized mesoporous TiO₂ films have mainly been synthesized using an amphiphilic block copolymer, e.g., a poly(ethylene oxide) (PEO)-based template. A graft copolymer is more attractive than a block copolymer due to its low cost and the ease with which it can be synthesized. In this work, we provide the first report on the successful synthesis of well-organized mesoporous TiO₂ films templated by an organized graft copolymer as a structure directing agent. Well-organized mesoporous TiO₂ films with excellent channel connectivities were developed via the sol gel processusing an organized PVC-g-POEM graft copolymer synthesized by one-pot ATRP. The careful adjustment of copolymer composition and solvent affinity using a THF/H₂O/HCl mixture was used to systematically vary the material structure. The influence of the material structure on solar cell performance was then investigated. A solid-state DSSC employing both the graft copolymer templated organized 700 nm-thick TiO₂ films and graft copolymer electrolytes exhibited a solar conversion efficiency of 2.2% at 100 mW/cm². This value was approximately two-fold higher than that attained from a DSSC employing a random mesoporous TiO₂ film. The solar cell performance was maximized at 4.6% when the film thickness was increased to 2.5{mu}m. We believe that this graft copolymer-directed approach introduces a new and simple route toward the synthesis of well-organized metal oxide films as an alternative to a conventional block copolymer-based template.
쾌속조형재료의 강도예측모델 - Fused Deposition Modeling (FDM)
안성훈 ( Sung Hoon Ahn ),이선영 ( Sun Young Lee ),백창일 ( Chang Il Baek ),추원식 ( Won Shik Chu ) 한국복합재료학회 2002 Composites research Vol.15 No.6
쾌속조형(Rapid Prototyping)기술은 다양한 형태의 재료를 사용하여 초기모형을 제작할 수 있다. Stratasys사의 FDM은 플라스틱 재료로 조형물을 제작하는 대표적인 쾌속조형공정이다. 또한 FDM으로 제작된 부품들은 하중을 받는 구조용 재료로도 사용된다. FDM은 약 300㎛ 두께의 가는 필라멘트의 형태로 일정한 방향으로 재료를 적층하므로, FDM으로 제작된 부품들은 이방성 재료의 성질을 나타낸다. 본 연구에서는 FDM 부품의 인장강도를 예측하기 위한 해석방법을 제시하고자 한다. 복합재를 위한 Classical Lamination Theory를 사용하여 컴퓨터 코드를 작성하였다. FDM 제품의 파괴를 예측하기 위하여 계산코드에 Tsai-Wu failure criterion 이론을 도입하였다. 해석방법에 의해 예상되는 인장강도와 실제 실험으로 얻은 수치를 비교하였다. 예상치가 측정치에 근사한 값을 보이므로 본 계산식의 타당성이 입증되었다. 덧붙여서 FDM의 강도계산과 설계규칙이 웹기반의 제안서비스(FDMAS)에서 제공된다. Rapid Prototyping(RP) technologies provide the ability to fabricate initial prototypes from various model materials. Stratasys` Fused Deposition Modeling(FDM) is a typical 게 process that can fabricate prototypes out of plastic materials, and the parts made from FDM were often used as load-carrying elements. Because FDM deposits materials in about 300㎛ thin filament with designated orientation, parts made from FDM show anisotropic material properties. In this paper an analytic model was proposed to predict the tensile strength of FDM parts. Applying the Classical Lamination Theory, which was developed for laminated composite materials, a computer code was implemented. Tsai-Wu failure criterion was added to the code to predict the failure of the FDM parts. The tensile strengths predicted by the analytic model were compared with experimental data. The data and prediction agreed reasonably well to prove the validity of the model. In addition, a web-based advisory service(FDMAS) was developed to provide strength prediction and design rules for FDM parts.