Clinical Utility and Cut-Off Scores of the Korean Adult Attention-Deficit/Hyperactivity Disorder Rating Scale

Minha Hong,Young Sik Lee,Bongseog Kim,Yoo Sook Joung,Hanik K Yoo,Eui-Jung Kim,Soyoung Irene Lee,Soo Young Bhang,Seung Yup Lee,Doughyun Han,Geon Ho Bahn 대한소아청소년정신의학회 2019 소아청소년정신의학 Vol.30 No.3

Objectives: This study was conducted to re-validate the clinical efficacy of the Korean Adult Attention-Deficit/Hyperactivity Disorder (ADHD) Rating Scale (K-AARS), which is a self-report scale for ADHD in adults, and to determine the clinical utility and cut-off scores of K-AARS. Methods: The participants were 135 drug naïve adults with ADHD and 144 healthy controls. To diagnose ADHD based on the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, two board-certified pediatric psychiatrists interviewed the participants and completed the Mini International Neuropsychiatric Interview. K-AARS was applied to all participants. K-AARS comprises six clinical subscales, one impairment subscale, and one driving behavior subscale. The receiver operating characteristic analysis was conducted to calculate the cut-off scores of K-AARS. Results: All subscale scores, including six clinical subscale, impairment subscale, and driving behavior subscale scores, were found to be significant in distinguishing adults with ADHD from healthy controls. The sensitivity and specificity of the six clinical subscales were 63.0–77.0% and 66.7–79.9%, respectively. The combined total score of the six clinical subscales, had a sensitivity of 80.0% and specificity of 79.9%. Conclusion: The discriminative power of K-AARS for the diagnosis of ADHD in adults was excellent, and K-AARS and the empirical diagnosis of adults can be useful in diagnosing ADHD in adulthood.

흰쥐의 좌골신경 신경손상에 따른 골격근 중간세사단백의 발현변화 실험적 신경성근병중에서의 desmin과 vimentin으 발현

유기수(YOO K1 Soo),최연주(CHOI Yeon Joo),고서영(KO Seo Young) 대한체질인류학회 1997 대한체질인류학회지 Vol.10 No.1

중간세사단백인 desmin은 성숙한 근성유의 세포골격을 이루며 Vnnentin은 근재생시 중간엽기원 세포에 나타나기 때문에 중간세사단액의 발현여부로 근재생과정을 주석할 수 있다 신경성근영총에 따른 근재생과정을 중간세사의 변화로 알아보고자 흰쥐의 좌골신경을 압궤손상시킨 후 시기별 (2 4 6, 15 20, 27, 69일)로 장딴지근을 정취해 냉동연속조직절편을 제작한 뒤 연역조직화학적 반응을 시켜 desmin 및 Vlmentin 의 발현변화를 조사하여 다음과 같은 결과를 얻었다 l. 정상적인 흰쥐 장딴지근의 근섬유에서 desmin은 약하게 반응한 반연 Vlmentm 은 반응이 없었고 신경 손상 후 2, 4일째까지 같은 현상을 보였다. 2. 신경 손상후 6일째에 처음으로 desmin과 Vlmentin 에 모두 강한 양성연역반응을 보이는 위축된 근섬유들이 관찰되었다. 3. 신경손상 후 15일째에서 위축왼 근섬유을이 증가되었고 정상 근성유보다 desmm 에 강한 면역반응성을 나타내었다. Desmin과 vlmentm 모두에 양성반응율 보인 위쭉왼 근섬유들이 소수 관찰되었다. 4. 신경손상 후 20일째에서 대부분의 근섬유들이 정상 근성유 보다 너 강한 desmin 양성연역반응을 보였다. 일부 근섬유들은 중심핵을 갖고 있었으며 desmin과 Vimentin에 대한 양성연역반응을 동시에 나타내었다 5. 신경손상 후 27일째에서 대부분의 근섬유들은 정상 크기로 회복되었으나 소수의 근섬유들은 위축된 상태였다 위축된 근섬유은 desmin에는 반응성을 보이지 않은 반면 Vlmentm 에 매해서는 은섬유의 일부가 양성반응을 나타내였다. 6. 신경손상후 69일째에서 비대된 근섬유가 많이 관찰되였고 desmin 및 vinentin에 대한 면역반응은 정상근섬유와 동일하였다. 일부 위축된 근섬유들은 desmin 에 양성 면역반응을 보였으나 Vlmentm 에는 양성 면역반응을 보인 근섬유는 관찰되지 않았다. 위의 결과로 미루어 볼 때 약한 desmm 반응 만을 보이는 은섬유는 정상 강한 desmm잔응만을 나타내는 근섬유는 변성 (degeneration), desmm 과 Vlmentm 이 동시에 나타내는 근섬유는 재생 (regenerahon) 중인 근섬유라고 규정지을 수 있겠다 그러므로 중간세사 단액인 desmin 과 Vlinentm 발현 어부로 신경성근육병증에는 물론 다양한 근육병증의 진단 및 근육발생에도 유용하게 이용될 수 있을 것으로 사료된다.

Reorganization of highly preorganized hosts upon cation complexation: Ab initio study of fluorospherands

Elroby, Shabaan A. K.,Lee, Kyu Hwan,Oh, Jung Soo,Chung, Hwan Won,Cho, Seung Joo,Paek, Kyungsoo Wiley Subscription Services, Inc., A Wiley Company 2007 International journal of quantum chemistry Vol.107 No.4

<P>Fluorospherands (F-spherands) are highly preorganized hosts composed of fluorobenzene or 4-methylfluorobenzene units attached to one another at their 2,6-positions. To understand the intrinsic factors affecting cation complexation, we investigated the complexation behavior between F-spherands and cations using density functional theory (DFT) at the level of B3LYP/6-31G**. The F6-spherand (C<SUB>6</SUB>H<SUB>3</SUB>F)<SUB>6</SUB>, (1) has a highly preorganized spherical cavity, which can encapsulate Li<SUP>+</SUP> and Na<SUP>+</SUP>. Its cavity is not big enough for K<SUP>+</SUP> and NH<EM><SUP>+</SUP><SUB>4</SUB></EM>, which prefer external binding. Plausible conformations were studied for F8-spherand (C<SUB>6</SUB>H<SUB>3</SUB>F)<SUB>8</SUB>. Conformer of D<SUB>2d</SUB> symmetry (2b) is more stable than that of D<SUB>4d</SUB> (2a), in agreement with NMR experiments. The cavity size of F8-spherand is big enough to encapsulate all cations studied. However, the cavity size of 2b is smaller than that of 2a, which resulted in the guest selectivity. Upon complexation, 2b conformation is more stable for Li<SUP>+</SUP> and Na<SUP>+</SUP>, while 2a conformation is preferred for larger cations such as K<SUP>+</SUP> and NH<EM><SUP>+</SUP><SUB>4</SUB></EM>. Thus, the ab initio calculations over these highly preorganized fluorospherands give important insights into their host–guest chemistry. © 2006 Wiley Periodicals, Inc. Int J Quantum Chem, 2007</P>

IGRINS NEAR-IR HIGH-RESOLUTION SPECTROSCOPY OF MULTIPLE JETS AROUND LkH<i>α</i>234

Oh, Heeyoung,Pyo, Tae-Soo,Yuk, In-Soo,Park, Byeong-Gon,Park, Chan,Chun, Moo-Young,Pak, Soojong,Kim, Kang-Min,Oh, Jae Sok,Jeong, Ueejeong,Yu, Young Sam,Lee, Jae-Joon,Kim, Hwihyun,Hwang, Narae,Kaplan, K American Astronomical Society 2016 The Astrophysical journal Vol.817 No.2

<P>We present the results of high-resolution near-IR spectroscopy toward the multiple outflows around the Herbig Be star LkH alpha 234 using the Immersion Grating Infrared Spectrograph. Previous studies indicate that the region around LkHa 234 is complex, with several embedded young stellar objects and the outflows associated with them. In simultaneous H- and K-band spectra from HH 167, we detected 5 [Fe II] and 14 H-2 emission lines. We revealed a new [Fe II] jet driven by radio continuum source VLA 3B. Position-velocity diagrams of the H-2 1-0 S(1) lambda 2.122 mu m line show multiple velocity peaks. The kinematics may be explained by a geometrical bow shock model. We detected a component of H-2 emission at the systemic velocity (V-LSR = -10.2 km s(-1)) along the whole slit in all slit positions, which may arise from the ambient photodissociation region. Low-velocity gas dominates the molecular hydrogen emission from knots A and B in HH 167, which is close to the systemic velocity; [Fe II] emission lines are detected farther from the systemic velocity, at V-LSR = -100--130 km s(-1). We infer that the H-2 emission arises from shocked gas entrained by a high-velocity outflow. Population diagrams of H-2 lines imply that the gas is thermalized at a temperature of 2500-3000 K and the emission results from shock excitation.</P>

Identification of Differentially Expressed Proteins in Imatinib Mesylate-resistant Chronic Myelogenous Cells

Park, Jung-Eun,Kim, Sang-Mi,Oh, Jong-K.,Kim, Jin-Y.,Yoon, Sung-Soo,Lee, Dong-Soon,Kim, Young-Soo Korean Society for Biochemistry and Molecular Biol 2005 Journal of biochemistry and molecular biology Vol.38 No.6

Resistance to imatinib mesylate (also known as Gleevec, Glivec, and STI571) often becomes a barrier to the treatment of chronic myelogenous leukemia (CML). In order to identify markers of the action of imatinib mesylate, we used a mass spectrometry approach to compare protein expression profiles in human leukemia cells (K562) and in imatinib mesylate-resistant human leukemia cells (K562-R) in the presence and absence of imatinib mesylate. We identified 118 differentially regulated proteins in these two leukemia cell-lines, with and without a $1\;{\mu}M$ imatinib mesylate challenge. Nine proteins of unknown function were discovered. This is the first comprehensive report regarding differential protein expression in imatinib mesylate-treated CML cells.

Evaluation of Cytotoxicity, Antimicrobial and Antioxidant Enzyme Activity of Diploid and Tetraploid Platycodon grandiflorum

Hee-Ock Boo,Young-Sun Kim,Hag-Hyun Kim,Soo-Jeong Kwon,Sun-Hee Woo 한국작물학회 2015 Korean journal of crop science Vol.60 No.2

This experiment was conducted to obtain the have higher contents of pharmaceutical constituents as well as higher yield from colchicine induced diploid and tetraploid extracts of Platycodon grandiflorum. In order to determine the biological activity, this study was focused to evaluate the cytotoxicity, antimicrobial on the bronthus disease bacteria, antioxidant enzyme activity of diploid and tetraploid extracts in P. grandiflorum. The activities of antioxidant enzyme according to different solvent extracts were measured as superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and ascorbate peroxidase (APX). The cytotoxicity of methanol extracts of P. grandiflorum showed significant differences between tetraploid and diploid. That is, the cytotoxic effect against human cancer cell was higher in tetraploid than in diploid. At all extracts concentration, tetraploid samples showed high toxicity and the IC50 (concentration causing 50% cell death) value showed the highest on HCT-116 cell (105.91 μg/mL), and exhibited significant activity against the Hep 3B cell (140.67 μg/mL), SNU-1066 cell (154.01 μg/mL), Hela cell (158.37 μg/mL), SNU-601 cell (182.67 μg/mL), Calu-6 cell (190.42 μg/mL), MCF-7 cell (510.19 μg/mL). Antimicrobial activities of diploid P. grandiflorum were relatively low compared to tetraploid P. grandiflorum on most of the bacterial strains. In tetraploid P. grandiflorum, K. pneumoniae showed the clear zone formation (18~19 mm) of growth inhibition, followed by the clear zone formation of 13~15 mm on C. diphtheria and S. pyogenes. The antimicrobial activities in diploid P. grandiflorum were the highest on K. pneumonia (14~15 mm), and showed the clear zone formation of 11~12 mm on C. diphtheria and 12~13 mm on S. pyogenes. The antimicrobial activity is thought to look different depending on the bacterial strains and the polyploidy of P. grandiflorum. The root extract of P. grandiflorum had the highest (97.2%) SOD enzyme activity in ethyl acetate partition layer of tetraploid while water partition layer of diploid showed the lowest (48.6%) SOD enzyme activity. The activity of CAT showed higher values in the root of tetraploid than in the diploid of P. grandiflorum in all partition layers except butyl alcohol. The activities of APX and POD showed higher values in the root of tetraploid than in the diploid of P. grandiflorum in all fraction solvents except water layer. These results indicate that the tetraploid P. grandiflorum can be used as a source for developing cytotoxic agent and antimicrobials which can act against bronchus diseases bacterial strains.

사염화토륨의 기상산소분해

김수식,주목호우위문,좌백웅조 대한금속재료학회(대한금속학회) 1968 대한금속·재료학회지 Vol.5 No.4

Decomposition of gaseous thorium tetrachloride with oxygen was examined. It was observed that ultra fine particle of thorium oxide was obtained by this method.

토륨 세륨 란탄 및 잇트륨의 함수산화물

김수식,주목호우위문,좌백웅조 대한금속재료학회(대한금속학회) 1967 대한금속·재료학회지 Vol.5 No.3

Dehydration processes of the hydrous oxides of thorium, lanthanum and yttrium obtained by addition of ammonium hydroxide to the chloride solutions were examined by thermogravimetric, differential thermal and x-ray diffraction analyses. It was observed that the hydrous oxides of thorium, cerium and yttrium were amorphous and belong to the group of aquated oxides, and hydrous oxide of lanthanum was lanthanum tri-hydroxide. The tri-hydroxide is dehydrated according to the process, La(OH)₃, 270℃ LaOOH 680℃ La₂O₃.

開放性動脈管 : 31例手術報告 Report of 31 Cases

徐景弼,申漢壽,沈台燮,洪彰義,朱東雲,李寧均 최신의학사 1967 最新醫學 Vol.10 No.5

Thirty one cases, 18 females and 13 males, were operated on for patent ductus arteriosus. There were three adult cases. Patent ductus arteriosus alone was present in 27, while in 4 there were significant associated cardiovascular anomalies. No deaths occurred in 24 patients isolated patent ductus a' eriosus without and with mild to moderate pulmonary hypertension. Severe pulmonary hypertension was present in 4 patients with an isolated patent ductus. An operative death occurred in the 2 patients in this group. One of them died as result of the tearing of the ductus during surgery. The remaining case died 3 days postoperatively., Patent ductus arteriosus with congenital cardiovascular anomalies was present in 4 patients. Single operative death occurred 7 days postoperatively because of bronchopneumonia of right lung and atelectasis of the left lung. There was an increased mortality when patent ductus arteriosus was associated with severe pulmonary hypertension. All survival patients showed very satisfactory postoperative results.

표면 결합모델을 이용한 알칼리 처리한 노간주나무의(BTJF)산/염기 그리고 카드뮴 결합특성 조사

민수홍,박재광 경희대학교 2004 環境硏究 論文集 Vol.13 No.-

A simple surface complexation model, the Constant Capacity Model (CCM), was used to describe the sorption of Cd^(2+) on a lignocellulosic which is base treated juniper fiber (BTJF). The binding of protons was studied by potentiometric titrations and conductiometric titrations. The BTJF was represented by two acid sites. From the acid/base titration data, total concentrations of these sites and H^(+) binding constants were obtained by using the NICA-Donnan model (The new Non-Ideal Competitive Adsorption). After identifying the stoichiometry of the surface complexes by potentiometric titrations of the Cd^(2+)/solid system using NICA-Donnan model, the surface complexation model was applied to describe Cd^(2+) binding by the BTJF using FITEQL 4.0. A single set of data was used; the model fit was good and covered a wide range of pH. The surface complexation constants derived from this single metal data set were then used to predict the sorption for increasing metal loading. The predictions agreed well with the experimental data showing the capability for the CCM surface complexation model to describe Cd^(2+) binding to the BTJF.