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In vitro skin absorption assay
( Ju Hee Han ),( Seung Hyeok Seok ),( Min Won Baek ),( Dong Jae Kim ),( Yi Rang Na ),( Kui Lea Park ),( Jae Hak Park ) 한국동물실험대체법학회 2009 한국동물실험대체법학회 학술대회집 Vol.2009 No.1
Various types of chemicals can be contact with skin and have potential for absorption locally or to the systemic circulation. Measures of percutaneous absorption are required for risk assessment of exposure for man to chemicals. These can be obtained by in vivo and in vitro methods. The in vivo method (OECD guideline 428) can provide good information on percutaneous absorption using various laboratory species. The in vitro method (OECD guideline 427) that can use non-viable skin or reconstructed skin have also been used for many years. Recently, changes in the European chemical policy (REACH) require toxicity data to be generated for 30,000 chemicals. It is not appropriated or feasible to do extensive in vivo studies in rodents and this goes against the ethics of the EU (the 3Rs). Therefore, the use of in vitro method in percutaneous absorption is recommended. In the present presentation, a brief overview of skin absorption assay, especially in vitro skin absorption assay is given. Also, we compared split-thickness human skin with full-thickness pig skin in in vitro skin absorption studies.