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성제경,윤영민,박지영,오승현,도선길,진희경,현병화,서준교,오양석,Seong, Je-Kyung,Yun, Young-min,Park, Ji-young,Oh, Seung-hyun,Do, Seon-gil,Jin, Hee-kyung,Hyun, Byung-hwa,Suh, Jun-gyo,Oh, Yang-seok 대한수의학회 1999 大韓獸醫學會誌 Vol.39 No.5
The morphometrical characteristics such as external measurements and mandible size assessment in mice and rats have to be highly heritable and sufficiently variable between strains in order to calculate a strain specific profiles. The coat color of Korean wild rats were observed and morphometric analysis of external measurements were carried out on Korean wild rats compared to laboratory strains in order to clarify the genetic characteristics of Korean wild rats and to establish background data as a domestication of Korean wild rats for new laboratory strain. Korean wild rats were captured from Chunchon and Hoengsong. 4 inbred and 1 outbred strains of rats were used in this study for the comparison of genetic characteristic of Korean wild rats. Total body length, head length, tail length, hind foot length and ear length were measured and then statistical analysis were carried out by discrimiant analysis. The coat color of Korean wild rat showed golden white in ventral portion and dark agouti in dorsal portion. Korean wild rats could be distinguished from the other laboratory strains distinctly by morphogenetical analysis. There was significant variations among Korean wild rat compared to those of the other laboratory strains of rat. This study may provide that Korean wild rats have a unique genetic characterization compared to those of other inbred strains of rats based on morphogenetical characteristics by external measurements.
김용호 ( Yong Ho Kim ),도선길 ( Seon Gil Do ),김동선 ( Dong Seon Kim ),우성식 ( Sung Sick Woo ),김옥진 ( Ok Jin Kim ),이혜정 ( Hye Jeong Lee ) 한국식품영양학회 2008 韓國食品營養學會誌 Vol.21 No.4
Over the past few years, anthocyanin has been demonstrated to exert potentially anti-oxidative and bioavailability effects including anti-cardiovascular disease and cancer-preventive effects in humans. This study was conducted to assess the toxicity of anthocyanin extracts from black soybean seed coats via oral administration in a mice feeding test. The final anthocyanin-containing products induced signs of toxicity on mortality in the 4-week feeding test. The incidence of clinical signs and changes in body and organ weight were also not observed in all anthocyanin-treated groups as compared with the control groups. In hematology analysis, RBC indices concluding MCV, MCH, and MCHC and WBC differential counting such a NEU, LYM, MONO, EOS, and BASO evidenced no significant differences between the anthocyanin treatment and control groups. The biochemical parameters in serum analysis-ALT, AST, BUN, Crea etc.-were also not significantly altered in those groups. Absolute and relative organ weights were not increased after 4 weeks of treatment with anthocyanin extracts in mice. In conclusion, anthocyanin extracts from the black soybean has biological activity without any toxic effects, which also suggests that the consumption of soy containing anthocyanin products may be a good source for health and medical supplies.
A Case of Natural Mycoplasmosis in Spontaneously Hypertensive Rats
노인순,오승현,박지영,최경철,한정희,진희경,도선길,서준교,오양석,박성준,성제경,Roh, In-Soon,Oh, Seung Hyun,Park, Ji Young,Choi, Kyung-Chul,Han, Jeong-Hee,Jin, Hee-Kyung,Do, Seon Gil,Suh, Jun Gyo,Oh, Yang Seok,Park, Seong-Jun,Seong, Je- The Korean Society of Veterinary Science 2001 大韓獸醫學會誌 Vol.41 No.4
SHR 랫드 4-21 개월령 colony에서 혈청 및 조직학적으로 정기적인 health monitoring을 실시하던 중 ELISA test에서 21 개체 중 12 개체에서 Mycoplasma pulmonis에 대한 항체가 검출되었다. Mycoplasma 양성 개체군의 부검 소견에서 기관지, 세기관지 주변 림프절의 증식과 전형적인 폐 기관지의 병변 소견을 보였다. 혈청학적 검사와 조직학적 소견에서 SHR 랫드 군의 자연적인 Mycoplasm 감염 예로 진단되어 보고하는 바이다. Twenty one Spontaneously Hypertensive Rats(SHR) that were 4- to 21-month-old were examined histopathologically and serologically during a routine health monitoring of the rat colony. The results of the enzyme linked immunosorbent assay(ELISA) for murine pathogens demonstrated that 14 of 21 SHR rats had antibodies to Mycoplasma pulmonis. Histopathologically, the mycoplasma positive SHR rats were observed to have the typical pulmonary lesions which are characterized by the hyperplasia of the lymphoid tissue around the bronchi, bronchioles and vessels. Based on the histopathological findings and serological results, this case was diagnosed as a murine mycoplasmosis of SHR rats.