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레이저 유도방식의 실시간 광음향 단층영상 기술 개발과 팬텀이미지 평가
유상훈(Sang-Hun Ryu),신동호(Dong-Ho Shin),송철규(Chul-Gyu Song) 대한전기학회 2012 전기학회논문지 Vol.61 No.6
Photoacoustic Tomography (PAT) is a promising medical imaging modality by reason of its particularity. It combines optical imaging contrast of optical imaging with the spatial resolution of ultrasound imaging and can demonstrate change of biological feature in an image. For that reason, many studies are in progress to apply this technic for diagnosis. But, real-time PAT system is necessary to confirm a biological reaction induced by external stimulation immediately. Thus, we developed a real-time PAT system using linear array transducer and self-developed Data acquisition board (DAQ) resources, To evaluate the feasibility and performance of our proposed system, two type of phantom test were also performed. As a result of those experiments, the proposed system shows enough performance and confirm its usefulness.
임상연구 : 소아에서 중심정맥도관 삽관 시 Remifentanil과 함께 투여한 Midazolam 또는 Propofol의 효과에 관한 비교 연구
유상훈 ( Sang Hun Ryu ),권재영 ( Jae Young Kwon ),이현정 ( Hyeon Jeong Lee ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.52 No.6
Background: Midazolam or propofol has been used for the procedural sedation in children. However, the combined use of remifentanil have not been widely investigated. The purpose of this study was to evaluate the effectiveness and safety of remifentanil infusion with intravenous anesthetics during the central venous catheterization in children. Methods: After institutional review board approval and written informed consent from patients` parent, 20 children planned central venous catheterization for chemotherapy were randomly assigned into two groups. All patients were infused with remifentanil 0.1μg/kg/min. In M group, 0.3 mg/kg of midazolam bolus was injected and 0.1 mg/kg bolus were injected intermittently if the sedation was inadequate. In P group, 1.0 mg/kg of propofol bolus and 150μg/kg/min were infused. 0.5 mg/kg of propofol was given intermittently if the sedation was inadequate. Hemodynamic variables, end-tidal CO2 (EtCO2), bispectral index score (BIS) were monitored throughout the procedure. Results: There were no significant differences in hemodynamic variables, sedation and recovery times. Oxygen saturation (SpO2) in P group was significantly lower than that of M group at 15 min after the start of infusion. EtCO2 in P group was significantly higher than that of M group at 10 min after the start of infusion. Hypoxemia (SpO2<90%) were occurred in three patients of P group. There was no significant difference in BIS among the groups. Conclusions: The combined infusion of remifentanil 0.1μg/kg/min with midazolam provided successful sedation without airway assistance during the central venous catheterization in children. (Korean J Anesthesiol 2007; 52: 669~74)
역투사 알고리듬과 비촛점 트랜스듀서를 적용한 광음향 단층영상 장치개발과 팬텀실험
유상훈(Sang-Hun Ryu),김도현(Do-Hyun Kim),송철규(Chul-Gyu Song) 대한전기학회 2010 전기학회논문지 Vol.59 No.12
Photo Acoustic Tomography (PAT) is a hybrid imaging modality which combines high contrast of optical imaging and spatial resolution of ultrasound imaging, thus it is suitable to image biological tissue noninvasively. Laser-induced photoacoustic signals were measured from a sample by means of an unfocused ultrasound transducer, then PAT image was reconstructed based on a universal back-projection algorithm. To evaluate the feasibility of our system, phantom test was performed, consequently, the PAT images obtained using our system showed highly analogous shape and volume with those of the phantom. This result demonstrated that our system can provide a powerful tool for imaging the substructure of biological tissue in non-invasive manner.
송철규(Chul Gyu Song),유상훈(Sang Hun Ryu),김도훈(Do Hyun Kim) 대한전기학회 2011 전기학회논문지 Vol.60 No.6
Photoacoustics has been broadly studied in biomedicine, for both human and small animal tissues. Photoacoustics uniquely combines the absorption contrast of light or radio frequency waves with ultrasound resolution. Moreover, it is non-ionizing and non-invasive, and is the fastest growing new biomedical method, with clinical applications on the way. This paper provides a brief recap of recent developments in photoacoustics in biomedicine, from basic principles to applications. The emphasized areas include the new imaging modalities as well as translational research topics. A primary PA application in biomedicine is photoacoustic tomography (PAT). The past decade has seen fast developments in both theoretical reconstruction algorithms and innovative imaging techniques, and PAT has been implemented in imaging different tissues, from centimeter-large breast tumors to several micrometer-large single red blood cels (RBC). PAT now provides structural, functional and molecular imaging. Overall, PA techniques for biomedicine are maturing. They have been widely used to study both animal and human tissues. Recently, more and more research focuses on clinical applications. Commercialized PA systems are expected to be available in the near future, and wide clinical PA applications are foreseen.
김거식(Keo-Sik Kim),서정환(Jeong-Hwan Seo),김민호(Min-Ho Kim),유상훈(Sang-Hun Ryu),송철규(Chul-Gyu Song) 대한전기학회 2011 전기학회논문지 Vol.60 No.4
Bowel sounds (BS) are produced by the movement of the intestinal contents in the lumen of the gastro-intestinal tract during peristalsis and thus, it can be used clinically as useful indicators of bowel motility. We devised an estimation algorithm of bowel motility based on the regression modeling of the jitter and shimmer of BS signals measured by auscultation. Ten healthy males (23.5±2.1 years) were examined. Consequently, the correlation coefficient, coefficient of determination and standard error between the colon transit times (CTT) measured by a conventional radiograph and the values estimated by our algorithm were 0.98, 0.96 and 2.86, respectively. Also, through k-fold cross validation, the average value of the absolute differences between them was 5.0±2.5 hours. This method could be used as a complementary tool for the non-invasive measurement of bowel motility.